Wollastonite and tricalcium phosphate composites for bone regeneration
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/31662 |
Resumo: | In recent decades, researchers in bone tissue bioengineering have focused on developing and improving bioceramics efficient in presenting physical-chemical characteristics similar to bone tissue, aiming to mimic cellular events and mechanisms involved in osteogenesis. Among the materials used, wollastonite (W) has stood out in recent years, mainly due to its bioactivity. Besides, tricalcium phosphate (TCP) is also used primarily due to its osteoinductivity and osteoconductivity. Given their ionic compositions and the physical-chemical properties of W and TCP, scientists have associated these two materials during the synthesis of bioceramics that unite the characteristics of each material into a single biomaterial, called composite. This design enables a variety of association that allows improvements in the biological behavior of these materials. Therefore, W/TCP composites have shown excellent performance, in vitro and in vivo, as they start to exhibit fundamental properties for bone regeneration. These characteristics indicate the use of these new biomaterials in future clinical applications, especially in cases of extensive bone losses, which remain a significant challenge for scientists and biomedical professionals. Nevertheless, despite the advances achieved, many questions must be clarified, and essential to comprehend the mechanisms involved in osteogenesis after implantation. Thus, this study aimed to contextualize the use of W/TCP composites for bone regeneration, to support further studies necessary to identify the biological behavior of these bioceramics and ensure use in clinical practice. |
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Wollastonite and tricalcium phosphate composites for bone regenerationCompuestos de wollastonita y fosfato tricálcico para la regeneración óseaCompósitos de wollastonita e fosfato de tricálcio para a regeneração ósseaBiomateriaisRegeneração ÓsseaFosfatos de cálcioSilicato de cálcio.BiomaterialesRegeneración óseaFosfatos de calcioSilicato de calcio.BiomaterialsBone RegenerationCalcium phosphatesCalcium silicate.In recent decades, researchers in bone tissue bioengineering have focused on developing and improving bioceramics efficient in presenting physical-chemical characteristics similar to bone tissue, aiming to mimic cellular events and mechanisms involved in osteogenesis. Among the materials used, wollastonite (W) has stood out in recent years, mainly due to its bioactivity. Besides, tricalcium phosphate (TCP) is also used primarily due to its osteoinductivity and osteoconductivity. Given their ionic compositions and the physical-chemical properties of W and TCP, scientists have associated these two materials during the synthesis of bioceramics that unite the characteristics of each material into a single biomaterial, called composite. This design enables a variety of association that allows improvements in the biological behavior of these materials. Therefore, W/TCP composites have shown excellent performance, in vitro and in vivo, as they start to exhibit fundamental properties for bone regeneration. These characteristics indicate the use of these new biomaterials in future clinical applications, especially in cases of extensive bone losses, which remain a significant challenge for scientists and biomedical professionals. Nevertheless, despite the advances achieved, many questions must be clarified, and essential to comprehend the mechanisms involved in osteogenesis after implantation. Thus, this study aimed to contextualize the use of W/TCP composites for bone regeneration, to support further studies necessary to identify the biological behavior of these bioceramics and ensure use in clinical practice.En las últimas décadas, los investigadores de la bioingeniería aplicadas al tejido óseo se han volcado en el desarrollo y perfeccionamiento de biocerámicas capaces de presentar características físico-químicas similares a las del tejido óseo, con el objetivo de imitar los eventos y mecanismos celulares implicados en la osteogénesis. Entre los materiales utilizados, han destacado en los últimos años la wollastonita (W), principalmente por su bioactividad; y en particular, el fosfato tricálcico (TCP) por su osteoinductividad y osteoconductividad. En vista de sus composiciones iónicas y de las propiedades físico-químicas del W y del TCP, los científicos han vinculado estos dos materiales durante la síntesis de biocerámicas que unen las características de cada material en un único biomaterial, llamado composite. Esta concepción permite una variedad de asociación que permite mejorar el comportamiento biológico de estos materiales. En consecuencia, los composites W/TCP han presentado un excelente rendimiento, in vitro e in vivo, pues estos empiezan a exhibir propiedades fundamentales para la regeneración ósea. Estas características indican el uso de estos nuevos biomateriales en futuras aplicaciones clínicas, especialmente en casos de pérdida ósea extensa, las cuales siguen siendo un gran reto para los científicos y profesionales biomédicos. Sin embargo, a pesar de los avances logrados, es necesario aclarar muchas cuestiones que son cruciales para comprender los mecanismos implicados en la osteogénesis posterior a la implementación. Conforme a lo expuesto, el presente trabajo tiene como objetivo contextualizar el uso de los compuestos de W/TCP para la regeneración ósea, con el fin de subsidiar nuevos estudios necesarios para identificar el comportamiento biológico de estos biocerámicos y asegurar su uso en la práctica clínica.Nas últimas décadas, os pesquisadores da bioengenharia tecidual óssea têm se voltado para o desenvolvimento e aperfeiçoamento de biocerâmicas capazes de apresentar características físico-químicas semelhantes ao tecido ósseo, visando a mimetizar os eventos celulares e mecanismos envolvidos na osteogênese. Dentre os materiais utilizados, a wollastonita (W) tem se destacado nos últimos anos, principalmente em função da sua bioatividade; e o fosfato de tricálcio (TCP), em especial devido à sua osteoindutividade e osteocondutividade. Tendo em vista as suas composições iônicas e as propriedades físico-químicas da W e do TCP, os cientistas têm associado estes dois materiais durante a síntese de biocerâmicas que unem as características de cada material em um único biomaterial, denominado compósito. Esta concepção possibilita uma variedade de associação que viabiliza melhorias no comportamento biológico destes materiais. Consequentemente, os compósitos de W/TCP têm apresentado excelente desempenho, in vitro e in vivo, pois passam a exibir propriedades fundamentais para a regeneração óssea. Estas características indicam o uso destes novos biomateriais em aplicações clínicas futuras, em especial nos casos de perdas ósseas extensas, que permanecem sendo um grande desafio para os cientistas e profissionais da área biomédica. Contudo, apesar dos avanços alcançados, muitas questões precisam ser esclarecidas, determinantes para compreender os mecanismos envolvidos na osteogênese, após implantação. Diante do exposto, o presente trabalho tem por objetivo contextualizar a utilização dos compósitos de W/TCP para a regeneração óssea, a fim de subsidiar novos estudos necessários para identificar o comportamento biológico destas biocerâmicas e assegurar a utilização na prática clínica.Research, Society and Development2022-07-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3166210.33448/rsd-v11i9.31662Research, Society and Development; Vol. 11 No. 9; e12011931662Research, Society and Development; Vol. 11 Núm. 9; e12011931662Research, Society and Development; v. 11 n. 9; e120119316622525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/31662/26980Copyright (c) 2022 George Gonçalves dos Santos; Luisa Queiroz Vasconcelos; Isabela Cerqueira Barreto; Fúlvio Borges Miguel; Roberto Paulo Correia de Araújohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSantos, George Gonçalves dosVasconcelos, Luisa Queiroz Barreto, Isabela Cerqueira Miguel, Fúlvio Borges Araújo, Roberto Paulo Correia de 2022-07-21T12:36:16Zoai:ojs.pkp.sfu.ca:article/31662Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:47:55.414487Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Wollastonite and tricalcium phosphate composites for bone regeneration Compuestos de wollastonita y fosfato tricálcico para la regeneración ósea Compósitos de wollastonita e fosfato de tricálcio para a regeneração óssea |
title |
Wollastonite and tricalcium phosphate composites for bone regeneration |
spellingShingle |
Wollastonite and tricalcium phosphate composites for bone regeneration Santos, George Gonçalves dos Biomateriais Regeneração Óssea Fosfatos de cálcio Silicato de cálcio. Biomateriales Regeneración ósea Fosfatos de calcio Silicato de calcio. Biomaterials Bone Regeneration Calcium phosphates Calcium silicate. |
title_short |
Wollastonite and tricalcium phosphate composites for bone regeneration |
title_full |
Wollastonite and tricalcium phosphate composites for bone regeneration |
title_fullStr |
Wollastonite and tricalcium phosphate composites for bone regeneration |
title_full_unstemmed |
Wollastonite and tricalcium phosphate composites for bone regeneration |
title_sort |
Wollastonite and tricalcium phosphate composites for bone regeneration |
author |
Santos, George Gonçalves dos |
author_facet |
Santos, George Gonçalves dos Vasconcelos, Luisa Queiroz Barreto, Isabela Cerqueira Miguel, Fúlvio Borges Araújo, Roberto Paulo Correia de |
author_role |
author |
author2 |
Vasconcelos, Luisa Queiroz Barreto, Isabela Cerqueira Miguel, Fúlvio Borges Araújo, Roberto Paulo Correia de |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Santos, George Gonçalves dos Vasconcelos, Luisa Queiroz Barreto, Isabela Cerqueira Miguel, Fúlvio Borges Araújo, Roberto Paulo Correia de |
dc.subject.por.fl_str_mv |
Biomateriais Regeneração Óssea Fosfatos de cálcio Silicato de cálcio. Biomateriales Regeneración ósea Fosfatos de calcio Silicato de calcio. Biomaterials Bone Regeneration Calcium phosphates Calcium silicate. |
topic |
Biomateriais Regeneração Óssea Fosfatos de cálcio Silicato de cálcio. Biomateriales Regeneración ósea Fosfatos de calcio Silicato de calcio. Biomaterials Bone Regeneration Calcium phosphates Calcium silicate. |
description |
In recent decades, researchers in bone tissue bioengineering have focused on developing and improving bioceramics efficient in presenting physical-chemical characteristics similar to bone tissue, aiming to mimic cellular events and mechanisms involved in osteogenesis. Among the materials used, wollastonite (W) has stood out in recent years, mainly due to its bioactivity. Besides, tricalcium phosphate (TCP) is also used primarily due to its osteoinductivity and osteoconductivity. Given their ionic compositions and the physical-chemical properties of W and TCP, scientists have associated these two materials during the synthesis of bioceramics that unite the characteristics of each material into a single biomaterial, called composite. This design enables a variety of association that allows improvements in the biological behavior of these materials. Therefore, W/TCP composites have shown excellent performance, in vitro and in vivo, as they start to exhibit fundamental properties for bone regeneration. These characteristics indicate the use of these new biomaterials in future clinical applications, especially in cases of extensive bone losses, which remain a significant challenge for scientists and biomedical professionals. Nevertheless, despite the advances achieved, many questions must be clarified, and essential to comprehend the mechanisms involved in osteogenesis after implantation. Thus, this study aimed to contextualize the use of W/TCP composites for bone regeneration, to support further studies necessary to identify the biological behavior of these bioceramics and ensure use in clinical practice. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-07-04 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/31662 10.33448/rsd-v11i9.31662 |
url |
https://rsdjournal.org/index.php/rsd/article/view/31662 |
identifier_str_mv |
10.33448/rsd-v11i9.31662 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/31662/26980 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 9; e12011931662 Research, Society and Development; Vol. 11 Núm. 9; e12011931662 Research, Society and Development; v. 11 n. 9; e12011931662 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052836779917312 |