In silico Studies on the anticancerigenic activities of Eugenol in the Indian Carnation (Syzygium aromaticum)

Detalhes bibliográficos
Autor(a) principal: Oliveira, Natália Sakuray
Data de Publicação: 2021
Outros Autores: Arruda, Evilanna Lima
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/14165
Resumo: Objective: To investigate the anti-cancer properties of eugenol using In Silico methods. Methodology: it is an original article using the In silico methodology through PASS (Prediction of activity spectra for plants) software online and GUSAR available for free and acessful. Results: The results of the online PASS operating system demonstrated several positive biological activities, such as antimutagenic effect, caspase stimulant, pre-neoplasic treatment and apoptosis agonist having a probability of activity (BP) well above 0.700. Such findings reinforce the others in the literature that show an antineoplastic potential because the component has antioxidant effects, and is linked to an expression of genes involved in apoptosis and inflammation. Such as effects on the negative regulation of Bcl-2, COX-2 and IL-1ß, and actions on the positive regulation of P53, Bax and active expression of Caspase-3, caspase-9 in addition to inducing the pathway of mitochondrial apoptosis. As for the GUSAR software, toxicity was observed, demonstrating that in category 4, they are intravenous, oral, and subcutaneous routes of administration, indicating that it is not very toxic. In category 5, the intraperitoneal route is relatively non-toxic. This finding is still obscure and there are few scientific articles to support it. Conclusion: Eugenol has favorable effects for the treatment and prevention of various cancers and mutagenic cells, but there is still little knowledge about the toxicity of this component. Thus, it needs to go deeper into the theme.
id UNIFEI_1be676782ee4cd273ab03fec41702577
oai_identifier_str oai:ojs.pkp.sfu.ca:article/14165
network_acronym_str UNIFEI
network_name_str Research, Society and Development
repository_id_str
spelling In silico Studies on the anticancerigenic activities of Eugenol in the Indian Carnation (Syzygium aromaticum)En Estudios In silico sobre las actividades anticancerigénicas del Eugenol en el Clavel Indio (Syzygium aromaticum)Estudos In silico sobre as atividades anticancerígenas do Eugenol presente no Cravo Da Índia (Syzygium aromaticum)EugenolAnticancerígenoAntimutagênicoIn silico.EugenolAnticancerígenoAntimutagénicoIn silico.EugenolAnticancerigenAntimutagenicIn silico.Objective: To investigate the anti-cancer properties of eugenol using In Silico methods. Methodology: it is an original article using the In silico methodology through PASS (Prediction of activity spectra for plants) software online and GUSAR available for free and acessful. Results: The results of the online PASS operating system demonstrated several positive biological activities, such as antimutagenic effect, caspase stimulant, pre-neoplasic treatment and apoptosis agonist having a probability of activity (BP) well above 0.700. Such findings reinforce the others in the literature that show an antineoplastic potential because the component has antioxidant effects, and is linked to an expression of genes involved in apoptosis and inflammation. Such as effects on the negative regulation of Bcl-2, COX-2 and IL-1ß, and actions on the positive regulation of P53, Bax and active expression of Caspase-3, caspase-9 in addition to inducing the pathway of mitochondrial apoptosis. As for the GUSAR software, toxicity was observed, demonstrating that in category 4, they are intravenous, oral, and subcutaneous routes of administration, indicating that it is not very toxic. In category 5, the intraperitoneal route is relatively non-toxic. This finding is still obscure and there are few scientific articles to support it. Conclusion: Eugenol has favorable effects for the treatment and prevention of various cancers and mutagenic cells, but there is still little knowledge about the toxicity of this component. Thus, it needs to go deeper into the theme.Objetivo: Investigar las propiedades anticancerígenas del eugenol utilizando métodos In silico. Metodología: se trata de un artículo original utilizando la metodología In silico a través del software PASS (Predicción de espectros de actividad para sustancias) online y GUSAR disponible de forma gratuita y accesible. Resultados: Los resultados de los sistemas operativos PASS en línea demostraron varias actividades biológicas positivas, como efecto antimutagénico, estimulante de caspasa, tratamiento preneoplásico y agonista de apoptosis con una probabilidad de actividad (PA) muy superior a 0,700. Dichos hallazgos refuerzan los descritos en la literatura, que muestran un potencial antineoplásico debido a que el componente tiene efectos antioxidantes y está ligado a la expresión de genes involucrados en la apoptosis y la inflamación. Tales como efectos sobre la regulación negativa de Bcl-2, COX-2 e IL-1ß, y acciones sobre la regulación positiva de P53, Bax y expresión activa de Caspasa-3, caspasa-9 además de inducir la vía de apoptosis mitocondrial. En cuanto al software GUSAR, se observó toxicidad, demostrando que en la categoría 4, se encuentran las vías de administración intravenosa, oral y subcutánea, lo que indica que no es muy tóxico. En la categoría 5, la vía intraperitoneal es relativamente no tóxica. Este hallazgo aún es oscuro y hay pocos artículos científicos que lo respalden. Conclusión: El eugenol tiene efectos favorables para el tratamiento y prevención de varios cánceres y células mutagénicas, pero aún hay poco conocimiento sobre la toxicidad de este componente. Por tanto, es necesario profundizar en el tema.Objetivo: Investigar as propriedades anticancerígenas do eugenol usando métodos In silico. Metodologia: é um artigo original utilizando a metodologia In silico atraves dos softwares PASS (Prediction of activity spectra for substances) online e GUSAR disponíveis de forma gratuita e livre. Resultados: Os resultados do sistema operacional online PASS demonstraram diversas atividades biológicas positiva, tais quais efeito antimutagênico, estimulante de caspase, tratamento pré neoplásico e agonista de apoptose tendo uma probabilidade de atividade (PA) bem superior a 0,700. Tais achados reforçam aos descritos na literatura que evidenciam um potencial antineoplásico devido o componente ter efeitos antioxidante, e estar vinculado a expressão de genes envolvidos na apoptose e inflamação. Tal como efeitos na regulação negativa de Bcl-2, COX-2 e IL-1ß, e ações na regulação positiva de P53, Bax e expressão ativa de Caspase-3, caspase-9 além de induzir a via da apoptose mitocondrial. Já pelo software GUSAR, foi observado a toxicidade, demonstrando que na categoria 4, estão as vias de administração intravenosa, oral, e subcutânea, indicando que é pouco tóxico. Já na categoria 5 enquadra-se a via intraperitoneal é relativamente atóxico. Tal achado ainda é obscuro e possui poucos artigos científicos para o embasamento. Conclusão: O Eugenol possui efeitos favoráveis para o tratamento e prevenção de diversos canceres e células mutagênicas, porém ainda há pouco conhecimento sobre a toxicidade deste componente. Assim, necessita de um maior aprofundamento sobre a temática.Research, Society and Development2021-04-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1416510.33448/rsd-v10i4.14165Research, Society and Development; Vol. 10 No. 4; e27910414165Research, Society and Development; Vol. 10 Núm. 4; e27910414165Research, Society and Development; v. 10 n. 4; e279104141652525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/14165/12680Copyright (c) 2021 Natália Sakuray Oliveira; Evilanna Lima Arrudahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessOliveira, Natália Sakuray Arruda, Evilanna Lima 2021-04-25T11:21:26Zoai:ojs.pkp.sfu.ca:article/14165Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:35:21.178322Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv In silico Studies on the anticancerigenic activities of Eugenol in the Indian Carnation (Syzygium aromaticum)
En Estudios In silico sobre las actividades anticancerigénicas del Eugenol en el Clavel Indio (Syzygium aromaticum)
Estudos In silico sobre as atividades anticancerígenas do Eugenol presente no Cravo Da Índia (Syzygium aromaticum)
title In silico Studies on the anticancerigenic activities of Eugenol in the Indian Carnation (Syzygium aromaticum)
spellingShingle In silico Studies on the anticancerigenic activities of Eugenol in the Indian Carnation (Syzygium aromaticum)
Oliveira, Natália Sakuray
Eugenol
Anticancerígeno
Antimutagênico
In silico.
Eugenol
Anticancerígeno
Antimutagénico
In silico.
Eugenol
Anticancerigen
Antimutagenic
In silico.
title_short In silico Studies on the anticancerigenic activities of Eugenol in the Indian Carnation (Syzygium aromaticum)
title_full In silico Studies on the anticancerigenic activities of Eugenol in the Indian Carnation (Syzygium aromaticum)
title_fullStr In silico Studies on the anticancerigenic activities of Eugenol in the Indian Carnation (Syzygium aromaticum)
title_full_unstemmed In silico Studies on the anticancerigenic activities of Eugenol in the Indian Carnation (Syzygium aromaticum)
title_sort In silico Studies on the anticancerigenic activities of Eugenol in the Indian Carnation (Syzygium aromaticum)
author Oliveira, Natália Sakuray
author_facet Oliveira, Natália Sakuray
Arruda, Evilanna Lima
author_role author
author2 Arruda, Evilanna Lima
author2_role author
dc.contributor.author.fl_str_mv Oliveira, Natália Sakuray
Arruda, Evilanna Lima
dc.subject.por.fl_str_mv Eugenol
Anticancerígeno
Antimutagênico
In silico.
Eugenol
Anticancerígeno
Antimutagénico
In silico.
Eugenol
Anticancerigen
Antimutagenic
In silico.
topic Eugenol
Anticancerígeno
Antimutagênico
In silico.
Eugenol
Anticancerígeno
Antimutagénico
In silico.
Eugenol
Anticancerigen
Antimutagenic
In silico.
description Objective: To investigate the anti-cancer properties of eugenol using In Silico methods. Methodology: it is an original article using the In silico methodology through PASS (Prediction of activity spectra for plants) software online and GUSAR available for free and acessful. Results: The results of the online PASS operating system demonstrated several positive biological activities, such as antimutagenic effect, caspase stimulant, pre-neoplasic treatment and apoptosis agonist having a probability of activity (BP) well above 0.700. Such findings reinforce the others in the literature that show an antineoplastic potential because the component has antioxidant effects, and is linked to an expression of genes involved in apoptosis and inflammation. Such as effects on the negative regulation of Bcl-2, COX-2 and IL-1ß, and actions on the positive regulation of P53, Bax and active expression of Caspase-3, caspase-9 in addition to inducing the pathway of mitochondrial apoptosis. As for the GUSAR software, toxicity was observed, demonstrating that in category 4, they are intravenous, oral, and subcutaneous routes of administration, indicating that it is not very toxic. In category 5, the intraperitoneal route is relatively non-toxic. This finding is still obscure and there are few scientific articles to support it. Conclusion: Eugenol has favorable effects for the treatment and prevention of various cancers and mutagenic cells, but there is still little knowledge about the toxicity of this component. Thus, it needs to go deeper into the theme.
publishDate 2021
dc.date.none.fl_str_mv 2021-04-10
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/14165
10.33448/rsd-v10i4.14165
url https://rsdjournal.org/index.php/rsd/article/view/14165
identifier_str_mv 10.33448/rsd-v10i4.14165
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/14165/12680
dc.rights.driver.fl_str_mv Copyright (c) 2021 Natália Sakuray Oliveira; Evilanna Lima Arruda
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Natália Sakuray Oliveira; Evilanna Lima Arruda
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 4; e27910414165
Research, Society and Development; Vol. 10 Núm. 4; e27910414165
Research, Society and Development; v. 10 n. 4; e27910414165
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
_version_ 1797052806048251904

Registros relacionados