Bromazepam changes performance during target shooting but does not affect the interhemispheric coupling in the theta rhythm of the electroencephalography
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Publication Date: | 2021 |
Other Authors: | , , , , , , , , , , , |
Format: | Article |
Language: | eng |
Source: | Research, Society and Development |
Download full: | https://rsdjournal.org/index.php/rsd/article/view/18174 |
Summary: | Bromazepam emulates the inhibitory effect of the neurotransmitter gamma-aminobutyric acid (GABA) and can lead to impaired visuomotor performance. However, few studies have evaluated its effects on cortical coupling in target shooting activities. The present study aimed to analyze the acute effects of bromazepam administration in a target shooting task and the EEG theta rhythm coherence between frontal, temporal, and motor cortical areas in four shooting preparation periods. Thus, a double blind, crossover study was conducted with 30 subjects under two conditions: bromazepam (6mg) and placebo, with electroencephalographic analysis to simultaneously study the theta rhythm coherence in frontal, temporal, and motor cortex in a target shooting task; and the possible interferences of bromazepam administration. Subjects in the bromazepam group showed lower performance on the task compared to placebo (p=0.001). In addition, our analysis showed decreased coherence between regions in the same hemisphere, increased theta rhythm coherence in interhemispheric regions in frontal, temporal and motor cortex at different intervals in the preparation preceding the shooting (p=0.001). The use of bromazepam may influence task execution, possibly due to neurochemical modulation, during decision making, developing shooting preparation strategies, as well as interfering with the flow of information at the level of attention during task execution. |
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Bromazepam changes performance during target shooting but does not affect the interhemispheric coupling in the theta rhythm of the electroencephalographyEl bromazepam altera el rendimiento durante el tiro al blanco pero no afecta al acoplamiento interhemisférico en la electroencefalografía del ritmo thetaBromazepam altera o desempenho durante o tiro ao alvo, mas não afeta o acoplamento interhemisférico no ritmo teta da eletroencefalografiaElectroencefalografíaCoherenciaRitmo ThetaBromazepamTiro al blanco.ElectroencefalografiaCoerênciaRitmo ThetaBromazepamTiro ao alvo.ElectroencephalographyCoherenceTheta RhythmBromazepamTarget shooting.Bromazepam emulates the inhibitory effect of the neurotransmitter gamma-aminobutyric acid (GABA) and can lead to impaired visuomotor performance. However, few studies have evaluated its effects on cortical coupling in target shooting activities. The present study aimed to analyze the acute effects of bromazepam administration in a target shooting task and the EEG theta rhythm coherence between frontal, temporal, and motor cortical areas in four shooting preparation periods. Thus, a double blind, crossover study was conducted with 30 subjects under two conditions: bromazepam (6mg) and placebo, with electroencephalographic analysis to simultaneously study the theta rhythm coherence in frontal, temporal, and motor cortex in a target shooting task; and the possible interferences of bromazepam administration. Subjects in the bromazepam group showed lower performance on the task compared to placebo (p=0.001). In addition, our analysis showed decreased coherence between regions in the same hemisphere, increased theta rhythm coherence in interhemispheric regions in frontal, temporal and motor cortex at different intervals in the preparation preceding the shooting (p=0.001). The use of bromazepam may influence task execution, possibly due to neurochemical modulation, during decision making, developing shooting preparation strategies, as well as interfering with the flow of information at the level of attention during task execution.El bromazepam imita el efecto inhibidor del neurotransmisor ácido gamma-aminobutírico (GABA) y puede provocar un deterioro del rendimiento visuomotor. Sin embargo, pocos estudios han evaluado sus efectos sobre el acoplamiento cortical en las actividades de tiro al blanco. El presente estudio tuvo como objetivo analizar los efectos agudos de la administración de bromazepam en una tarea de tiro al blanco y la coherencia del ritmo theta del EEG entre las áreas corticales frontales, temporales y motoras en cuatro períodos de preparación de tiro. Así, se realizó un estudio cruzado y a doble ciego con 30 sujetos en dos condiciones: bromazepam (6 mg) y placebo, con análisis electroencefalográfico para estudiar simultáneamente la coherencia del ritmo theta en la corteza frontal, temporal y motora en una tarea de tiro al blanco; y las posibles interferencias de la administración de bromazepam. Los sujetos del grupo de bromazepam mostraron un menor rendimiento en la tarea en comparación con el placebo (p=0,001). Además, nuestro análisis mostró una disminución de la coherencia entre regiones del mismo hemisferio y un aumento de la coherencia del ritmo theta en regiones interhemisféricas de la corteza frontal, temporal y motora a diferentes intervalos en la preparación que precede al disparo (p=0,001). El uso de bromazepam puede influir en la ejecución de la tarea, posiblemente debido a la modulación neuroquímica, durante la toma de decisiones, el desarrollo de estrategias para preparar el tiro, así como la interferencia en el flujo de información a nivel de la atención durante la ejecución de la tarea.O bromazepam imita o efeito inibidor do neurotransmissor ácido gama-aminobutírico (GABA) e podem levar ao prejuízo do desempenho visuomotor. No entanto, poucos estudos avaliaram seus efeitos no acoplamento cortical em atividades de tiro ao alvo. O presente estudo objetivou analisar os efeitos agudo da administração de bromazepam numa tarefa de tiro ao alvo e a coerência do ritmo teta do EEG entre as áreas da cortical frontal, temporal, e motora em quatro períodos preparatórios de tiro. Desse modo, foi realizado um estudo crossover e duplo cego, com 30 sujeitos sob duas condições: bromazepam (6mg) e placebo, com análise eletroencefalográfica para estudar simultaneamente a coerência do ritmo teta no córtex frontal, temporal e motor, numa tarefa de tiro ao alvo; e as possíveis interferências da administração do bromazepam. Os sujeitos do grupo bromazepam apresentaram um desempenho inferior na tarefa em comparação com o placebo (p=0,001). Além disso, a nossa análise mostrou uma diminuição da coerência entre regiões no mesmo hemisfério, um aumento da coerência do ritmo teta nas regiões interhemisféricas no córtex frontal, temporal e motor em diferentes intervalos na preparação que antecedeu o tiroteio (p=0,001). O uso de bromazepam pode influenciar a execução da tarefa, possivelmente devido à modulação neuroquímica, durante a tomada de decisões, desenvolvendo estratégias de preparação do tiro, além de interferir com o fluxo de informação ao nível da atenção durante a execução da tarefa.Research, Society and Development2021-07-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1817410.33448/rsd-v10i9.18174Research, Society and Development; Vol. 10 No. 9; e33110918174Research, Society and Development; Vol. 10 Núm. 9; e33110918174Research, Society and Development; v. 10 n. 9; e331109181742525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/18174/16207Copyright (c) 2021 Thayaná Ribeiro Silva Fernandes; Kaline de Melo Rocha; Daya Gupta; Victor Marinho; Iris Moura; Jacks Renan Neves Fernandes; Francisco Elezier Xavier Magalhães; Valécia Natália Carvalho da Silva; Even Herlany Pereira Alves; Pedro Ribeiro; Bruna Velasques; Victor Hugo do Vale Bastos; Silmar Silva Teixeirahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessFernandes, Thayaná Ribeiro Silva Rocha, Kaline de Melo Gupta, DayaMarinho, VictorMoura, IrisFernandes, Jacks Renan Neves Magalhães, Francisco Elezier XavierCarvalho da Silva, Valécia Natália Alves, Even Herlany Pereira Ribeiro, PedroVelasques, BrunaBastos, Victor Hugo do Vale Teixeira, Silmar Silva 2021-09-12T14:28:06Zoai:ojs.pkp.sfu.ca:article/18174Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:38:21.543174Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Bromazepam changes performance during target shooting but does not affect the interhemispheric coupling in the theta rhythm of the electroencephalography El bromazepam altera el rendimiento durante el tiro al blanco pero no afecta al acoplamiento interhemisférico en la electroencefalografía del ritmo theta Bromazepam altera o desempenho durante o tiro ao alvo, mas não afeta o acoplamento interhemisférico no ritmo teta da eletroencefalografia |
title |
Bromazepam changes performance during target shooting but does not affect the interhemispheric coupling in the theta rhythm of the electroencephalography |
spellingShingle |
Bromazepam changes performance during target shooting but does not affect the interhemispheric coupling in the theta rhythm of the electroencephalography Fernandes, Thayaná Ribeiro Silva Electroencefalografía Coherencia Ritmo Theta Bromazepam Tiro al blanco. Electroencefalografia Coerência Ritmo Theta Bromazepam Tiro ao alvo. Electroencephalography Coherence Theta Rhythm Bromazepam Target shooting. |
title_short |
Bromazepam changes performance during target shooting but does not affect the interhemispheric coupling in the theta rhythm of the electroencephalography |
title_full |
Bromazepam changes performance during target shooting but does not affect the interhemispheric coupling in the theta rhythm of the electroencephalography |
title_fullStr |
Bromazepam changes performance during target shooting but does not affect the interhemispheric coupling in the theta rhythm of the electroencephalography |
title_full_unstemmed |
Bromazepam changes performance during target shooting but does not affect the interhemispheric coupling in the theta rhythm of the electroencephalography |
title_sort |
Bromazepam changes performance during target shooting but does not affect the interhemispheric coupling in the theta rhythm of the electroencephalography |
author |
Fernandes, Thayaná Ribeiro Silva |
author_facet |
Fernandes, Thayaná Ribeiro Silva Rocha, Kaline de Melo Gupta, Daya Marinho, Victor Moura, Iris Fernandes, Jacks Renan Neves Magalhães, Francisco Elezier Xavier Carvalho da Silva, Valécia Natália Alves, Even Herlany Pereira Ribeiro, Pedro Velasques, Bruna Bastos, Victor Hugo do Vale Teixeira, Silmar Silva |
author_role |
author |
author2 |
Rocha, Kaline de Melo Gupta, Daya Marinho, Victor Moura, Iris Fernandes, Jacks Renan Neves Magalhães, Francisco Elezier Xavier Carvalho da Silva, Valécia Natália Alves, Even Herlany Pereira Ribeiro, Pedro Velasques, Bruna Bastos, Victor Hugo do Vale Teixeira, Silmar Silva |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Fernandes, Thayaná Ribeiro Silva Rocha, Kaline de Melo Gupta, Daya Marinho, Victor Moura, Iris Fernandes, Jacks Renan Neves Magalhães, Francisco Elezier Xavier Carvalho da Silva, Valécia Natália Alves, Even Herlany Pereira Ribeiro, Pedro Velasques, Bruna Bastos, Victor Hugo do Vale Teixeira, Silmar Silva |
dc.subject.por.fl_str_mv |
Electroencefalografía Coherencia Ritmo Theta Bromazepam Tiro al blanco. Electroencefalografia Coerência Ritmo Theta Bromazepam Tiro ao alvo. Electroencephalography Coherence Theta Rhythm Bromazepam Target shooting. |
topic |
Electroencefalografía Coherencia Ritmo Theta Bromazepam Tiro al blanco. Electroencefalografia Coerência Ritmo Theta Bromazepam Tiro ao alvo. Electroencephalography Coherence Theta Rhythm Bromazepam Target shooting. |
description |
Bromazepam emulates the inhibitory effect of the neurotransmitter gamma-aminobutyric acid (GABA) and can lead to impaired visuomotor performance. However, few studies have evaluated its effects on cortical coupling in target shooting activities. The present study aimed to analyze the acute effects of bromazepam administration in a target shooting task and the EEG theta rhythm coherence between frontal, temporal, and motor cortical areas in four shooting preparation periods. Thus, a double blind, crossover study was conducted with 30 subjects under two conditions: bromazepam (6mg) and placebo, with electroencephalographic analysis to simultaneously study the theta rhythm coherence in frontal, temporal, and motor cortex in a target shooting task; and the possible interferences of bromazepam administration. Subjects in the bromazepam group showed lower performance on the task compared to placebo (p=0.001). In addition, our analysis showed decreased coherence between regions in the same hemisphere, increased theta rhythm coherence in interhemispheric regions in frontal, temporal and motor cortex at different intervals in the preparation preceding the shooting (p=0.001). The use of bromazepam may influence task execution, possibly due to neurochemical modulation, during decision making, developing shooting preparation strategies, as well as interfering with the flow of information at the level of attention during task execution. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07-27 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/18174 10.33448/rsd-v10i9.18174 |
url |
https://rsdjournal.org/index.php/rsd/article/view/18174 |
identifier_str_mv |
10.33448/rsd-v10i9.18174 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/18174/16207 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 9; e33110918174 Research, Society and Development; Vol. 10 Núm. 9; e33110918174 Research, Society and Development; v. 10 n. 9; e33110918174 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052684499419136 |