Preemptive effect of amantadine as adjuvant in postoperative analgesia of ovaryhisterectomy in dogs

Detalhes bibliográficos
Autor(a) principal: Niella, Raquel Vieira
Data de Publicação: 2020
Outros Autores: Sena, Aline Silva, Corrêa, Janaína Maria Xavier, Soares, Priscila Carvalho Lima Rocha, Pinto, Taísa Miranda, Silva Junior, Alex Costa, Costa, Brenda Amaral, Oliveira, Jéssica Natália Silva de, Silva, Elisângela Barboza da, Lavor, Mário Sérgio Lima de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/10128
Resumo: This study aimed to evaluate the preemptive analgesic effect of amantadine on postoperative pain control in female dogs that underwent ovariohysterectomy. Twenty female dog were randomly assigned to two groups of ten. The control group (CONTROL) received oral placebo capsules, while the amantadine (AMANT) group received 5 mg/kg of oral amantadine one hour before sedation. All the animals were premedicated with 3 mg/kg (IM) meperidine, induced with propofol and maintained with isofluorane. The transanesthetic physiological parameters were recorded, and postoperative pain was evaluated every hour after extubation for six hours with the Dynamic Interactive Visual Analog Scale (DIVAS) and mechanical nociceptive threshold (MNT) and when the necessary analgesic rescue was administered (morphine, 0.2 mg/kg (IM)). During the surgical procedure, there was no significant difference in the variables measured between the two groups. Regarding postoperative pain assessment, there was a significant difference in the DIVAS score (p = 0.004) between the groups, in which AMANT required fewer rescues than did CONTROL (p = 0.03). The MNT was significantly higher ​​in AMANT than in CONTROL (p = 0.03). The results suggested that the preoperative administration of amantadine decreased analgesic requirement in female dogs that underwent elective ovariohysterectomy.
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spelling Preemptive effect of amantadine as adjuvant in postoperative analgesia of ovaryhisterectomy in dogsEfecto preventivo de la amantadina como complemento de la analgesia postoperatoria para la ovariohisterectomía en perrosEfeito preemptivo da amantadina como adjuvante na analgesia pós-operatória de ovariohisterectomia em cãesNMDA receptorNociceptionAmantadineVisceral analgesia. AmantadinaAnalgesia visceralNocicepciónReceptor NMDA.AmantadinaAnalgesia visceralNocicepçãoReceptor NMDA.This study aimed to evaluate the preemptive analgesic effect of amantadine on postoperative pain control in female dogs that underwent ovariohysterectomy. Twenty female dog were randomly assigned to two groups of ten. The control group (CONTROL) received oral placebo capsules, while the amantadine (AMANT) group received 5 mg/kg of oral amantadine one hour before sedation. All the animals were premedicated with 3 mg/kg (IM) meperidine, induced with propofol and maintained with isofluorane. The transanesthetic physiological parameters were recorded, and postoperative pain was evaluated every hour after extubation for six hours with the Dynamic Interactive Visual Analog Scale (DIVAS) and mechanical nociceptive threshold (MNT) and when the necessary analgesic rescue was administered (morphine, 0.2 mg/kg (IM)). During the surgical procedure, there was no significant difference in the variables measured between the two groups. Regarding postoperative pain assessment, there was a significant difference in the DIVAS score (p = 0.004) between the groups, in which AMANT required fewer rescues than did CONTROL (p = 0.03). The MNT was significantly higher ​​in AMANT than in CONTROL (p = 0.03). The results suggested that the preoperative administration of amantadine decreased analgesic requirement in female dogs that underwent elective ovariohysterectomy.Este estudio tuvo como objetivo evaluar el efecto preventivo de la amantadina en el control del dolor postoperatorio en perras sometidas a ovariohisterectomía. Se asignaron al azar veinte perras a dos grupos de diez animales. El grupo de control (CONTROL) recibió cápsulas de placebo por vía oral y el grupo de amantadina (AMANTADINA) recibió 5 mg / kg de amantadina por vía oral, una hora antes de la medicación preanestésica. Todos los animales fueron premedicados con meperidina 3 mg / kg / IM, inducción con propofol y mantenimiento con isofluorano. Se registraron los parámetros fisiológicos trans-anestésicos y se evaluó el dolor postoperatorio cada hora durante seis horas después de la extubación con la escala analógica visual interactiva y dinámica (EAVID), el umbral nociceptivo mecánico (UNM) y, cuando fue necesario, se administró. rescate analgésico (morfina 0,2 mg / kg (IM)). Durante el procedimiento quirúrgico, no hubo diferencia significativa en las variables medidas entre los dos grupos. Con respecto a la evaluación del dolor postoperatorio, hubo una diferencia significativa en EAVID (p = 0,004) entre los grupos, en los que AMANTADINA requirió menos rescates en comparación con CONTROL. Y el UNM mostró valores más altos en AMANTADINA con una diferencia significativa (p = 0.03) en comparación con CONTROL. Los resultados sugirieron que la administración de amantadina en el período preoperatorio disminuyó la necesidad de analgésicos en las perras sometidas a ovariohisterectomía electiva.Este estudo objetivou avaliar o efeito preemptivo da amantadina no controle da dor pós-operatória em cadelas submetidas a ovariohisterectomia. Vinte cadelas foram distribuídas aleatoriamente em dois grupos de dez animais. O grupo controle (CONTROLE) recebeu cápsulas de placebo via oral e o grupo amantadina (AMANTADINA) recebeu 5 mg/kg de amantadina via oral, uma hora antes da medicação pré-anestésica. Todos os animais foram pré-medicados com meperidina 3 mg/kg/IM, indução com propofol e manutenção com isofluorano. Registraram-se os parâmetros fisiológicos trans-anestésicos e a dor pós-operatória foi avaliada a cada hora durante seis horas após a extubação com a escala analógica visual interativa e dinâmica (EAVID), limiar nociceptivo mecânico (LNM) e quando necessário administrou-se resgate analgésico (morfina 0,2 mg/kg (IM)). Durante o procedimento cirúrgico não houve diferença significativa nas variáveis mensuradas entre os dois grupos. Com relação à avaliação de dor no pós-operatório, houve diferença significativa na EAVID (p = 0,004) entre os grupos, em que AMANTADINA necessitou de menos resgates quando comparado ao CONTROLE. E o LNM apresentou valores mais elevados no AMANTADINA com uma diferença significativa (p = 0,03) comparada ao CONTROLE. Os resultados sugeriram que a administração da amantadina no pré-operatório diminuiu requerimento analgésico em cadelas submetidas a ovariohisterectomia eletiva.Research, Society and Development2020-11-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1012810.33448/rsd-v9i11.10128Research, Society and Development; Vol. 9 No. 11; e68091110128Research, Society and Development; Vol. 9 Núm. 11; e68091110128Research, Society and Development; v. 9 n. 11; e680911101282525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/10128/10122Copyright (c) 2020 Raquel Vieira Niella; Aline Silva Sena; Janaína Maria Xavier Corrêa; Priscila Carvalho Lima Rocha Soares; Taísa Miranda Pinto; Alex Costa Silva Junior; Brenda Amaral Costa; Jéssica Natália Silva de Oliveira; Elisângela Barboza da Silva; Mário Sérgio Lima de Lavorhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessNiella, Raquel VieiraSena, Aline SilvaCorrêa, Janaína Maria XavierSoares, Priscila Carvalho Lima RochaPinto, Taísa MirandaSilva Junior, Alex Costa Costa, Brenda Amaral Oliveira, Jéssica Natália Silva de Silva, Elisângela Barboza daLavor, Mário Sérgio Lima de2020-12-10T23:37:57Zoai:ojs.pkp.sfu.ca:article/10128Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:32:15.401452Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Preemptive effect of amantadine as adjuvant in postoperative analgesia of ovaryhisterectomy in dogs
Efecto preventivo de la amantadina como complemento de la analgesia postoperatoria para la ovariohisterectomía en perros
Efeito preemptivo da amantadina como adjuvante na analgesia pós-operatória de ovariohisterectomia em cães
title Preemptive effect of amantadine as adjuvant in postoperative analgesia of ovaryhisterectomy in dogs
spellingShingle Preemptive effect of amantadine as adjuvant in postoperative analgesia of ovaryhisterectomy in dogs
Niella, Raquel Vieira
NMDA receptor
Nociception
Amantadine
Visceral analgesia.
Amantadina
Analgesia visceral
Nocicepción
Receptor NMDA.
Amantadina
Analgesia visceral
Nocicepção
Receptor NMDA.
title_short Preemptive effect of amantadine as adjuvant in postoperative analgesia of ovaryhisterectomy in dogs
title_full Preemptive effect of amantadine as adjuvant in postoperative analgesia of ovaryhisterectomy in dogs
title_fullStr Preemptive effect of amantadine as adjuvant in postoperative analgesia of ovaryhisterectomy in dogs
title_full_unstemmed Preemptive effect of amantadine as adjuvant in postoperative analgesia of ovaryhisterectomy in dogs
title_sort Preemptive effect of amantadine as adjuvant in postoperative analgesia of ovaryhisterectomy in dogs
author Niella, Raquel Vieira
author_facet Niella, Raquel Vieira
Sena, Aline Silva
Corrêa, Janaína Maria Xavier
Soares, Priscila Carvalho Lima Rocha
Pinto, Taísa Miranda
Silva Junior, Alex Costa
Costa, Brenda Amaral
Oliveira, Jéssica Natália Silva de
Silva, Elisângela Barboza da
Lavor, Mário Sérgio Lima de
author_role author
author2 Sena, Aline Silva
Corrêa, Janaína Maria Xavier
Soares, Priscila Carvalho Lima Rocha
Pinto, Taísa Miranda
Silva Junior, Alex Costa
Costa, Brenda Amaral
Oliveira, Jéssica Natália Silva de
Silva, Elisângela Barboza da
Lavor, Mário Sérgio Lima de
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Niella, Raquel Vieira
Sena, Aline Silva
Corrêa, Janaína Maria Xavier
Soares, Priscila Carvalho Lima Rocha
Pinto, Taísa Miranda
Silva Junior, Alex Costa
Costa, Brenda Amaral
Oliveira, Jéssica Natália Silva de
Silva, Elisângela Barboza da
Lavor, Mário Sérgio Lima de
dc.subject.por.fl_str_mv NMDA receptor
Nociception
Amantadine
Visceral analgesia.
Amantadina
Analgesia visceral
Nocicepción
Receptor NMDA.
Amantadina
Analgesia visceral
Nocicepção
Receptor NMDA.
topic NMDA receptor
Nociception
Amantadine
Visceral analgesia.
Amantadina
Analgesia visceral
Nocicepción
Receptor NMDA.
Amantadina
Analgesia visceral
Nocicepção
Receptor NMDA.
description This study aimed to evaluate the preemptive analgesic effect of amantadine on postoperative pain control in female dogs that underwent ovariohysterectomy. Twenty female dog were randomly assigned to two groups of ten. The control group (CONTROL) received oral placebo capsules, while the amantadine (AMANT) group received 5 mg/kg of oral amantadine one hour before sedation. All the animals were premedicated with 3 mg/kg (IM) meperidine, induced with propofol and maintained with isofluorane. The transanesthetic physiological parameters were recorded, and postoperative pain was evaluated every hour after extubation for six hours with the Dynamic Interactive Visual Analog Scale (DIVAS) and mechanical nociceptive threshold (MNT) and when the necessary analgesic rescue was administered (morphine, 0.2 mg/kg (IM)). During the surgical procedure, there was no significant difference in the variables measured between the two groups. Regarding postoperative pain assessment, there was a significant difference in the DIVAS score (p = 0.004) between the groups, in which AMANT required fewer rescues than did CONTROL (p = 0.03). The MNT was significantly higher ​​in AMANT than in CONTROL (p = 0.03). The results suggested that the preoperative administration of amantadine decreased analgesic requirement in female dogs that underwent elective ovariohysterectomy.
publishDate 2020
dc.date.none.fl_str_mv 2020-11-29
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/10128
10.33448/rsd-v9i11.10128
url https://rsdjournal.org/index.php/rsd/article/view/10128
identifier_str_mv 10.33448/rsd-v9i11.10128
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/10128/10122
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 9 No. 11; e68091110128
Research, Society and Development; Vol. 9 Núm. 11; e68091110128
Research, Society and Development; v. 9 n. 11; e68091110128
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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