Preemptive effect of amantadine as adjuvant in postoperative analgesia of ovaryhisterectomy in dogs
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/10128 |
Resumo: | This study aimed to evaluate the preemptive analgesic effect of amantadine on postoperative pain control in female dogs that underwent ovariohysterectomy. Twenty female dog were randomly assigned to two groups of ten. The control group (CONTROL) received oral placebo capsules, while the amantadine (AMANT) group received 5 mg/kg of oral amantadine one hour before sedation. All the animals were premedicated with 3 mg/kg (IM) meperidine, induced with propofol and maintained with isofluorane. The transanesthetic physiological parameters were recorded, and postoperative pain was evaluated every hour after extubation for six hours with the Dynamic Interactive Visual Analog Scale (DIVAS) and mechanical nociceptive threshold (MNT) and when the necessary analgesic rescue was administered (morphine, 0.2 mg/kg (IM)). During the surgical procedure, there was no significant difference in the variables measured between the two groups. Regarding postoperative pain assessment, there was a significant difference in the DIVAS score (p = 0.004) between the groups, in which AMANT required fewer rescues than did CONTROL (p = 0.03). The MNT was significantly higher in AMANT than in CONTROL (p = 0.03). The results suggested that the preoperative administration of amantadine decreased analgesic requirement in female dogs that underwent elective ovariohysterectomy. |
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Preemptive effect of amantadine as adjuvant in postoperative analgesia of ovaryhisterectomy in dogsEfecto preventivo de la amantadina como complemento de la analgesia postoperatoria para la ovariohisterectomía en perrosEfeito preemptivo da amantadina como adjuvante na analgesia pós-operatória de ovariohisterectomia em cãesNMDA receptorNociceptionAmantadineVisceral analgesia. AmantadinaAnalgesia visceralNocicepciónReceptor NMDA.AmantadinaAnalgesia visceralNocicepçãoReceptor NMDA.This study aimed to evaluate the preemptive analgesic effect of amantadine on postoperative pain control in female dogs that underwent ovariohysterectomy. Twenty female dog were randomly assigned to two groups of ten. The control group (CONTROL) received oral placebo capsules, while the amantadine (AMANT) group received 5 mg/kg of oral amantadine one hour before sedation. All the animals were premedicated with 3 mg/kg (IM) meperidine, induced with propofol and maintained with isofluorane. The transanesthetic physiological parameters were recorded, and postoperative pain was evaluated every hour after extubation for six hours with the Dynamic Interactive Visual Analog Scale (DIVAS) and mechanical nociceptive threshold (MNT) and when the necessary analgesic rescue was administered (morphine, 0.2 mg/kg (IM)). During the surgical procedure, there was no significant difference in the variables measured between the two groups. Regarding postoperative pain assessment, there was a significant difference in the DIVAS score (p = 0.004) between the groups, in which AMANT required fewer rescues than did CONTROL (p = 0.03). The MNT was significantly higher in AMANT than in CONTROL (p = 0.03). The results suggested that the preoperative administration of amantadine decreased analgesic requirement in female dogs that underwent elective ovariohysterectomy.Este estudio tuvo como objetivo evaluar el efecto preventivo de la amantadina en el control del dolor postoperatorio en perras sometidas a ovariohisterectomía. Se asignaron al azar veinte perras a dos grupos de diez animales. El grupo de control (CONTROL) recibió cápsulas de placebo por vía oral y el grupo de amantadina (AMANTADINA) recibió 5 mg / kg de amantadina por vía oral, una hora antes de la medicación preanestésica. Todos los animales fueron premedicados con meperidina 3 mg / kg / IM, inducción con propofol y mantenimiento con isofluorano. Se registraron los parámetros fisiológicos trans-anestésicos y se evaluó el dolor postoperatorio cada hora durante seis horas después de la extubación con la escala analógica visual interactiva y dinámica (EAVID), el umbral nociceptivo mecánico (UNM) y, cuando fue necesario, se administró. rescate analgésico (morfina 0,2 mg / kg (IM)). Durante el procedimiento quirúrgico, no hubo diferencia significativa en las variables medidas entre los dos grupos. Con respecto a la evaluación del dolor postoperatorio, hubo una diferencia significativa en EAVID (p = 0,004) entre los grupos, en los que AMANTADINA requirió menos rescates en comparación con CONTROL. Y el UNM mostró valores más altos en AMANTADINA con una diferencia significativa (p = 0.03) en comparación con CONTROL. Los resultados sugirieron que la administración de amantadina en el período preoperatorio disminuyó la necesidad de analgésicos en las perras sometidas a ovariohisterectomía electiva.Este estudo objetivou avaliar o efeito preemptivo da amantadina no controle da dor pós-operatória em cadelas submetidas a ovariohisterectomia. Vinte cadelas foram distribuídas aleatoriamente em dois grupos de dez animais. O grupo controle (CONTROLE) recebeu cápsulas de placebo via oral e o grupo amantadina (AMANTADINA) recebeu 5 mg/kg de amantadina via oral, uma hora antes da medicação pré-anestésica. Todos os animais foram pré-medicados com meperidina 3 mg/kg/IM, indução com propofol e manutenção com isofluorano. Registraram-se os parâmetros fisiológicos trans-anestésicos e a dor pós-operatória foi avaliada a cada hora durante seis horas após a extubação com a escala analógica visual interativa e dinâmica (EAVID), limiar nociceptivo mecânico (LNM) e quando necessário administrou-se resgate analgésico (morfina 0,2 mg/kg (IM)). Durante o procedimento cirúrgico não houve diferença significativa nas variáveis mensuradas entre os dois grupos. Com relação à avaliação de dor no pós-operatório, houve diferença significativa na EAVID (p = 0,004) entre os grupos, em que AMANTADINA necessitou de menos resgates quando comparado ao CONTROLE. E o LNM apresentou valores mais elevados no AMANTADINA com uma diferença significativa (p = 0,03) comparada ao CONTROLE. Os resultados sugeriram que a administração da amantadina no pré-operatório diminuiu requerimento analgésico em cadelas submetidas a ovariohisterectomia eletiva.Research, Society and Development2020-11-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1012810.33448/rsd-v9i11.10128Research, Society and Development; Vol. 9 No. 11; e68091110128Research, Society and Development; Vol. 9 Núm. 11; e68091110128Research, Society and Development; v. 9 n. 11; e680911101282525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/10128/10122Copyright (c) 2020 Raquel Vieira Niella; Aline Silva Sena; Janaína Maria Xavier Corrêa; Priscila Carvalho Lima Rocha Soares; Taísa Miranda Pinto; Alex Costa Silva Junior; Brenda Amaral Costa; Jéssica Natália Silva de Oliveira; Elisângela Barboza da Silva; Mário Sérgio Lima de Lavorhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessNiella, Raquel VieiraSena, Aline SilvaCorrêa, Janaína Maria XavierSoares, Priscila Carvalho Lima RochaPinto, Taísa MirandaSilva Junior, Alex Costa Costa, Brenda Amaral Oliveira, Jéssica Natália Silva de Silva, Elisângela Barboza daLavor, Mário Sérgio Lima de2020-12-10T23:37:57Zoai:ojs.pkp.sfu.ca:article/10128Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:32:15.401452Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Preemptive effect of amantadine as adjuvant in postoperative analgesia of ovaryhisterectomy in dogs Efecto preventivo de la amantadina como complemento de la analgesia postoperatoria para la ovariohisterectomía en perros Efeito preemptivo da amantadina como adjuvante na analgesia pós-operatória de ovariohisterectomia em cães |
title |
Preemptive effect of amantadine as adjuvant in postoperative analgesia of ovaryhisterectomy in dogs |
spellingShingle |
Preemptive effect of amantadine as adjuvant in postoperative analgesia of ovaryhisterectomy in dogs Niella, Raquel Vieira NMDA receptor Nociception Amantadine Visceral analgesia. Amantadina Analgesia visceral Nocicepción Receptor NMDA. Amantadina Analgesia visceral Nocicepção Receptor NMDA. |
title_short |
Preemptive effect of amantadine as adjuvant in postoperative analgesia of ovaryhisterectomy in dogs |
title_full |
Preemptive effect of amantadine as adjuvant in postoperative analgesia of ovaryhisterectomy in dogs |
title_fullStr |
Preemptive effect of amantadine as adjuvant in postoperative analgesia of ovaryhisterectomy in dogs |
title_full_unstemmed |
Preemptive effect of amantadine as adjuvant in postoperative analgesia of ovaryhisterectomy in dogs |
title_sort |
Preemptive effect of amantadine as adjuvant in postoperative analgesia of ovaryhisterectomy in dogs |
author |
Niella, Raquel Vieira |
author_facet |
Niella, Raquel Vieira Sena, Aline Silva Corrêa, Janaína Maria Xavier Soares, Priscila Carvalho Lima Rocha Pinto, Taísa Miranda Silva Junior, Alex Costa Costa, Brenda Amaral Oliveira, Jéssica Natália Silva de Silva, Elisângela Barboza da Lavor, Mário Sérgio Lima de |
author_role |
author |
author2 |
Sena, Aline Silva Corrêa, Janaína Maria Xavier Soares, Priscila Carvalho Lima Rocha Pinto, Taísa Miranda Silva Junior, Alex Costa Costa, Brenda Amaral Oliveira, Jéssica Natália Silva de Silva, Elisângela Barboza da Lavor, Mário Sérgio Lima de |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Niella, Raquel Vieira Sena, Aline Silva Corrêa, Janaína Maria Xavier Soares, Priscila Carvalho Lima Rocha Pinto, Taísa Miranda Silva Junior, Alex Costa Costa, Brenda Amaral Oliveira, Jéssica Natália Silva de Silva, Elisângela Barboza da Lavor, Mário Sérgio Lima de |
dc.subject.por.fl_str_mv |
NMDA receptor Nociception Amantadine Visceral analgesia. Amantadina Analgesia visceral Nocicepción Receptor NMDA. Amantadina Analgesia visceral Nocicepção Receptor NMDA. |
topic |
NMDA receptor Nociception Amantadine Visceral analgesia. Amantadina Analgesia visceral Nocicepción Receptor NMDA. Amantadina Analgesia visceral Nocicepção Receptor NMDA. |
description |
This study aimed to evaluate the preemptive analgesic effect of amantadine on postoperative pain control in female dogs that underwent ovariohysterectomy. Twenty female dog were randomly assigned to two groups of ten. The control group (CONTROL) received oral placebo capsules, while the amantadine (AMANT) group received 5 mg/kg of oral amantadine one hour before sedation. All the animals were premedicated with 3 mg/kg (IM) meperidine, induced with propofol and maintained with isofluorane. The transanesthetic physiological parameters were recorded, and postoperative pain was evaluated every hour after extubation for six hours with the Dynamic Interactive Visual Analog Scale (DIVAS) and mechanical nociceptive threshold (MNT) and when the necessary analgesic rescue was administered (morphine, 0.2 mg/kg (IM)). During the surgical procedure, there was no significant difference in the variables measured between the two groups. Regarding postoperative pain assessment, there was a significant difference in the DIVAS score (p = 0.004) between the groups, in which AMANT required fewer rescues than did CONTROL (p = 0.03). The MNT was significantly higher in AMANT than in CONTROL (p = 0.03). The results suggested that the preoperative administration of amantadine decreased analgesic requirement in female dogs that underwent elective ovariohysterectomy. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-11-29 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/10128 10.33448/rsd-v9i11.10128 |
url |
https://rsdjournal.org/index.php/rsd/article/view/10128 |
identifier_str_mv |
10.33448/rsd-v9i11.10128 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/10128/10122 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 9 No. 11; e68091110128 Research, Society and Development; Vol. 9 Núm. 11; e68091110128 Research, Society and Development; v. 9 n. 11; e68091110128 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
_version_ |
1797052742782418944 |