Effects of the association of physical stress and chronic use of fluoxetine hydrochloride on the cerebral cortex
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/19509 |
Resumo: | Exposure to stressful factors plays an important role in development of depressive disorders. The deleterious effects of stress on neuroplasticity and apoptosis can be accentuated by chronic use of antidepressants. Thus, this study aims to evaluate and correlate the effects and consequences of physical stress (PS), associated with the treatment of fluoxetine hydrochloride (FC), on brain volume and cortical thickness of three brain areas. Brains of 25 male Wistar rats (Rattus norvegicus) were used. These animals were divided into 5 groups: G1 – control group; G2 – FC and without PS; G3 – PS but without FC; G4 –FC until the day before surgical procedure (PS); and G5 – Animals treated with FC until 30 days after surgical procedure (PS). The results show that groups G3, G4 and G5 had a significant reduction in brain volume. Regarding cortical thickness in limbic area, the data show that groups G4 and G5 had a significant reduction compared to G1, as well as groups G3, G4 and G5 showed a significant difference compared to G2. In the sensitive area, groups G3, G4 and G5 had a significant reduction when compared to G1; the same was observed for G4 and G5 in relation to groups G2 and G3. In the motor area, a similar result was observed in groups G3 and G4 in relation to G1. The data allow to conclude that physical stress, associated or not with chronic use of fluoxetine hydrochloride, decreases the cortical volume of male rats brain and, as a consequence of reduction, there is a significant loss of cortical density in limbic, sensory and motor areas. |
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Effects of the association of physical stress and chronic use of fluoxetine hydrochloride on the cerebral cortexEfectos de la asociación de estrés físico y el uso crónico de clorhidrato de fluoxetina en el cortex cerebral de ratasEfeitos da associação de estresse físico e uso crônico de cloridrato de fluoxetina no córtex cerebral de ratosCorteza cerebralEstrés físicoClorhidrato de fluoxetin. Cerebral cortexPhysical stressFluoxetine hydrochloride. Córtex CerebralEstresse físicoCloridrato de fluoxetina.Exposure to stressful factors plays an important role in development of depressive disorders. The deleterious effects of stress on neuroplasticity and apoptosis can be accentuated by chronic use of antidepressants. Thus, this study aims to evaluate and correlate the effects and consequences of physical stress (PS), associated with the treatment of fluoxetine hydrochloride (FC), on brain volume and cortical thickness of three brain areas. Brains of 25 male Wistar rats (Rattus norvegicus) were used. These animals were divided into 5 groups: G1 – control group; G2 – FC and without PS; G3 – PS but without FC; G4 –FC until the day before surgical procedure (PS); and G5 – Animals treated with FC until 30 days after surgical procedure (PS). The results show that groups G3, G4 and G5 had a significant reduction in brain volume. Regarding cortical thickness in limbic area, the data show that groups G4 and G5 had a significant reduction compared to G1, as well as groups G3, G4 and G5 showed a significant difference compared to G2. In the sensitive area, groups G3, G4 and G5 had a significant reduction when compared to G1; the same was observed for G4 and G5 in relation to groups G2 and G3. In the motor area, a similar result was observed in groups G3 and G4 in relation to G1. The data allow to conclude that physical stress, associated or not with chronic use of fluoxetine hydrochloride, decreases the cortical volume of male rats brain and, as a consequence of reduction, there is a significant loss of cortical density in limbic, sensory and motor areas.La exposición a factores estresantes tiene papel importante en el desarrollo de trastornos depresivos. Los efectos deletéreos del estrés en la neuroplasticidad y la apoptosis pueden verse acentuados por el uso crónico de antidepresivos. Ante esto, este estudio tiene por objetivo evaluar y correlacionar los efectos y consecuencias del estrés físico (EF) asociado al tratamiento con clorhidrato de fluoxetina (CF) en el volumen cerebral y espesura cortical, de tres áreas cerebrales. Fueron utilizados cerebros de 25 ratas (Rattus novegicus) machos del linaje Wistar. Los animales, fueron divididos en 5 grupos: G1 – grupo control; G2 – CF y sin EF; G3 – EF, pero sin CF; G4 – CF, hasta el día anterior al procedimiento quirúrgico (EF); G5 – CF, hasta 30 días después del procedimiento quirúrgico (EF). Los resultados obtenidos apuntaron que los grupos G3, G4 y G5 sufrieron reducción significativa en el volumen cerebral. En relación a la espesura cortical en el área límbica, los datos muestran que los grupos G4 y G5 tuvieron una reducción significativa en relación al G1, así como los grupos G3, G4 y G5, también presentaron una diferencia significativa en relación al G2. En el área sensitiva: los grupos G3, G4 y G5, tuvieron una reducción expresiva, cuando comparados al G1; lo mismo se observó para G4 y G5 en relación a los grupos G2 y G3. En el área motora, lo mismo se observó en los grupos G3 y G4 en relación al G1. Así, estos datos nos permiten concluir que: el estrés físico, así como el estrés físico asociado al uso crónico de clorhidrato de fluoxetina disminuye el volumen cortical del cerebro de machos de rata. A consecuencia de esta reducción de volumen, ocurre una reducción significativa de la densidad cortical de las áreas límbica, sensitiva y motora.A exposição a fatores estressantes tem papel importante no desenvolvimento de transtornos depressivos. Os efeitos deletérios do estresse na neuroplasticidade e a apoptose podem ser acentuados pelo uso crônico de antidepressivos. Este estudo tem como objetivo avaliar e correlacionar os efeitos e as consequências do estresse físico (EF) associado ao tratamento de cloridrato de fluoxetina (CF) no volume cerebral e espessura cortical de três áreas cerebrais. Foram utilizados cérebros de 25 ratos (Rattus norvegicus) machos da linhagem Wistar. Os animais foram divididos em 5 grupos: G1 – grupo controle; G2 - CF e sem EF; G3 - EF porém sem CF; G4 – CF até o dia anterior ao procedimento cirúrgico (EF) e G5 –CF até 30 dias após o procedimento cirúrgico (EF). Os resultados obtidos mostram que os grupos G3, G4 e G5 tiveram uma redução significativa no volume cerebral. Com relação a espessura cortical na área límbica os dados mostram que os grupos G4 e G5 tiveram uma redução significativa em relação ao G1, assim como os grupos G3, G4 e G5 também apresentaram uma diferença significativa em relação ao G2. Na área sensitiva os grupos G3, G4 e G5 tiveram uma redução expressiva quando comparados ao G1; o mesmo foi observado para G4 e G5 em relação aos grupos G2 e G3. Já em relação a área motora observou-se o mesmo para os grupos G3 e G4 em relação ao G1. Estes dados nos permitem concluir que, o estresse físico associado ou não ao uso crônico de cloridrato de fluoxetina diminui o volume cortical do cérebro de ratos machos como consequência desta redução de volume tem-se uma redução significativa da densidade cortical das áreas límbica, sensitiva e motora.Research, Society and Development2021-08-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1950910.33448/rsd-v10i11.19509Research, Society and Development; Vol. 10 No. 11; e114101119509Research, Society and Development; Vol. 10 Núm. 11; e114101119509Research, Society and Development; v. 10 n. 11; e1141011195092525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/19509/17344Copyright (c) 2021 Reginaldo Moreira de Castro ; Wagner Costa Rossi Junior; Wagner Corsini; Leticia da Costa Siqueira; Ítalo Augusto Silva Ferreira; Karinne da Costa Souza; Micaella Rodrigues Guimarães Leite; Alessandra Esteveshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCastro , Reginaldo Moreira de Rossi Junior, Wagner Costa Corsini, WagnerSiqueira, Leticia da Costa Ferreira, Ítalo Augusto Silva Souza, Karinne da Costa Leite, Micaella Rodrigues Guimarães Esteves, Alessandra 2021-10-23T19:01:11Zoai:ojs.pkp.sfu.ca:article/19509Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:39:23.131367Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Effects of the association of physical stress and chronic use of fluoxetine hydrochloride on the cerebral cortex Efectos de la asociación de estrés físico y el uso crónico de clorhidrato de fluoxetina en el cortex cerebral de ratas Efeitos da associação de estresse físico e uso crônico de cloridrato de fluoxetina no córtex cerebral de ratos |
title |
Effects of the association of physical stress and chronic use of fluoxetine hydrochloride on the cerebral cortex |
spellingShingle |
Effects of the association of physical stress and chronic use of fluoxetine hydrochloride on the cerebral cortex Castro , Reginaldo Moreira de Corteza cerebral Estrés físico Clorhidrato de fluoxetin. Cerebral cortex Physical stress Fluoxetine hydrochloride. Córtex Cerebral Estresse físico Cloridrato de fluoxetina. |
title_short |
Effects of the association of physical stress and chronic use of fluoxetine hydrochloride on the cerebral cortex |
title_full |
Effects of the association of physical stress and chronic use of fluoxetine hydrochloride on the cerebral cortex |
title_fullStr |
Effects of the association of physical stress and chronic use of fluoxetine hydrochloride on the cerebral cortex |
title_full_unstemmed |
Effects of the association of physical stress and chronic use of fluoxetine hydrochloride on the cerebral cortex |
title_sort |
Effects of the association of physical stress and chronic use of fluoxetine hydrochloride on the cerebral cortex |
author |
Castro , Reginaldo Moreira de |
author_facet |
Castro , Reginaldo Moreira de Rossi Junior, Wagner Costa Corsini, Wagner Siqueira, Leticia da Costa Ferreira, Ítalo Augusto Silva Souza, Karinne da Costa Leite, Micaella Rodrigues Guimarães Esteves, Alessandra |
author_role |
author |
author2 |
Rossi Junior, Wagner Costa Corsini, Wagner Siqueira, Leticia da Costa Ferreira, Ítalo Augusto Silva Souza, Karinne da Costa Leite, Micaella Rodrigues Guimarães Esteves, Alessandra |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Castro , Reginaldo Moreira de Rossi Junior, Wagner Costa Corsini, Wagner Siqueira, Leticia da Costa Ferreira, Ítalo Augusto Silva Souza, Karinne da Costa Leite, Micaella Rodrigues Guimarães Esteves, Alessandra |
dc.subject.por.fl_str_mv |
Corteza cerebral Estrés físico Clorhidrato de fluoxetin. Cerebral cortex Physical stress Fluoxetine hydrochloride. Córtex Cerebral Estresse físico Cloridrato de fluoxetina. |
topic |
Corteza cerebral Estrés físico Clorhidrato de fluoxetin. Cerebral cortex Physical stress Fluoxetine hydrochloride. Córtex Cerebral Estresse físico Cloridrato de fluoxetina. |
description |
Exposure to stressful factors plays an important role in development of depressive disorders. The deleterious effects of stress on neuroplasticity and apoptosis can be accentuated by chronic use of antidepressants. Thus, this study aims to evaluate and correlate the effects and consequences of physical stress (PS), associated with the treatment of fluoxetine hydrochloride (FC), on brain volume and cortical thickness of three brain areas. Brains of 25 male Wistar rats (Rattus norvegicus) were used. These animals were divided into 5 groups: G1 – control group; G2 – FC and without PS; G3 – PS but without FC; G4 –FC until the day before surgical procedure (PS); and G5 – Animals treated with FC until 30 days after surgical procedure (PS). The results show that groups G3, G4 and G5 had a significant reduction in brain volume. Regarding cortical thickness in limbic area, the data show that groups G4 and G5 had a significant reduction compared to G1, as well as groups G3, G4 and G5 showed a significant difference compared to G2. In the sensitive area, groups G3, G4 and G5 had a significant reduction when compared to G1; the same was observed for G4 and G5 in relation to groups G2 and G3. In the motor area, a similar result was observed in groups G3 and G4 in relation to G1. The data allow to conclude that physical stress, associated or not with chronic use of fluoxetine hydrochloride, decreases the cortical volume of male rats brain and, as a consequence of reduction, there is a significant loss of cortical density in limbic, sensory and motor areas. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08-25 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/19509 10.33448/rsd-v10i11.19509 |
url |
https://rsdjournal.org/index.php/rsd/article/view/19509 |
identifier_str_mv |
10.33448/rsd-v10i11.19509 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/19509/17344 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 11; e114101119509 Research, Society and Development; Vol. 10 Núm. 11; e114101119509 Research, Society and Development; v. 10 n. 11; e114101119509 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052788437417984 |