Risk Factors for Cerebral Palsy in Brazilian Children: A Case-Control Study

Detalhes bibliográficos
Autor(a) principal: Peixoto, Marcus Valerius da Silva
Data de Publicação: 2021
Outros Autores: Duque, Andrezza Marques, Santos, Allan Dantas dos, Lima, Shirley Verônica Melo Almeida, Ribeiro, Caíque Jordan Nunes, Voci, Silvia Maria, Carvalho, Susana de, Nunes, Marco Antônio Prado
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/15075
Resumo: Background: Cerebral palsy is the main cause of physical disability in childhood. Objectives: This study analyzed prenatal and perinatal risk factors that contribute to cerebral palsy in Brazilian children. Methods: A case-control study was conducted with 2- to 10-year-old children in the city of Aracaju, Sergipe, Brazil. The cases were population-based, selected from the Primary Health Care services. The controls were selected from the database of the Brazilian Live Births Information System. Controls were paired with cases by gender, year, and hospital of birth. Results: A total of 570 participants (114 cases and 456 controls) were studied. Most of the participants were male, with bilateral spastic cerebral palsy. Among the prenatal factors examined, the presence of congenital anomalies was significantly different between cases and controls (OR = 54.28, [95% CI 12.55, 234.86]). The analysis of perinatal factors revealed significant differences between cases and controls in low birth weight (OR = 3.8, [95% CI 2.34, 6.16]), preterm birth (OR = 2.31, [95% CI 1.41, 3.80]), and low Apgar scores (OR = 14.73, [95% CI 5.27, 41.15]). Conclusions: The main prenatal and perinatal factors associated with cerebral palsy in our population were congenital anomalies, low Apgar scores, low birth weight, and preterm birth. The perinatal period had more risk factors, demanding a deeper study of their causes and of possible preventive measures.
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spelling Risk Factors for Cerebral Palsy in Brazilian Children: A Case-Control StudyFactores de riesgo de parálisis cerebral en niños brasileños: Un estudio de casos y controlesFatores de risco para paralisia cerebral em crianças brasileiras: Um estudo de caso-controleFactores de RiesgoEstudios de Casos y ControlesParalisís CerebralEpidemiologíaNiños con discapacidad.Paralisia CerebralEpidemiologiaFatores de RiscoEstudos de casos e controlesCrianças com deficiência.Cerebral PalsyEpidemiologyRisk factorsCase-control studiesDisabled children.Background: Cerebral palsy is the main cause of physical disability in childhood. Objectives: This study analyzed prenatal and perinatal risk factors that contribute to cerebral palsy in Brazilian children. Methods: A case-control study was conducted with 2- to 10-year-old children in the city of Aracaju, Sergipe, Brazil. The cases were population-based, selected from the Primary Health Care services. The controls were selected from the database of the Brazilian Live Births Information System. Controls were paired with cases by gender, year, and hospital of birth. Results: A total of 570 participants (114 cases and 456 controls) were studied. Most of the participants were male, with bilateral spastic cerebral palsy. Among the prenatal factors examined, the presence of congenital anomalies was significantly different between cases and controls (OR = 54.28, [95% CI 12.55, 234.86]). The analysis of perinatal factors revealed significant differences between cases and controls in low birth weight (OR = 3.8, [95% CI 2.34, 6.16]), preterm birth (OR = 2.31, [95% CI 1.41, 3.80]), and low Apgar scores (OR = 14.73, [95% CI 5.27, 41.15]). Conclusions: The main prenatal and perinatal factors associated with cerebral palsy in our population were congenital anomalies, low Apgar scores, low birth weight, and preterm birth. The perinatal period had more risk factors, demanding a deeper study of their causes and of possible preventive measures.Antecedentes: la parálisis cerebral es la principal causa de discapacidad física en la infancia. Objetivos: Este estudio analizó los factores de riesgo prenatales y perinatales que contribuyen a la parálisis cerebral en niños brasileños. Métodos: se realizó un estudio de casos y controles con niños de 2 a 10 años de la ciudad de Aracaju, Sergipe, Brasil. Los casos fueron poblacionales, seleccionados de los servicios de Atención Primaria de Salud. Los controles fueron seleccionados de la base de datos del Sistema Brasileño de Información de Nacidos Vivos. Los controles se emparejaron con casos por sexo, año y hospital de nacimiento. Resultados: Se estudiaron un total de 570 participantes (114 casos y 456 controles). La mayoría de los participantes eran hombres, con parálisis cerebral espástica bilateral. Entre los factores prenatales examinados, la presencia de anomalías congénitas fue significativamente diferente entre casos y controles (OR = 54,28, [IC 95% 12,55, 234,86]). El análisis de factores perinatales reveló diferencias significativas entre casos y controles en bajo peso al nacer (OR = 3,8, [IC 95% 2,34, 6,16]), parto prematuro (OR = 2,31, [IC 95% 1,41, 3,80]) y bajo Puntuaciones de Apgar (OR = 14,73; [IC del 95%: 5,27; 41,15]). Conclusiones: Los principales factores prenatales y perinatales asociados a la parálisis cerebral en nuestra población fueron las anomalías congénitas, el Apgar bajo, el bajo peso al nacer y el parto prematuro. El período perinatal presentó más factores de riesgo, exigiendo un estudio más profundo de sus causas y de posibles medidas preventivas.Introdução: A paralisia cerebral é a principal causa de deficiência física na infância. Objetivos: Este estudo analisou os fatores de risco pré-natal e perinatal que contribuem para a paralisia cerebral em crianças brasileiras. Métodos: Foi realizado um estudo caso-controle com crianças de 2 a 10 anos de idade na cidade de Aracaju, Sergipe, Brasil. Os casos eram de base populacional, selecionados nos serviços de Atenção Básica à Saúde. Os controles foram selecionados no banco de dados do Sistema de Informações sobre Nascidos Vivos do Brasil. Os controles foram pareados com os casos por sexo, ano e hospital de nascimento. Resultados: Um total de 570 participantes (114 casos e 456 controles) foram estudados. A maioria dos participantes era do sexo masculino, com paralisia cerebral espástica bilateral. Entre os fatores pré-natais examinados, a presença de anomalias congênitas foi significativamente diferente entre casos e controles (OR = 54,28, [IC 95% 12,55, 234,86]). A análise dos fatores perinatais revelou diferenças significativas entre casos e controles em baixo peso ao nascer (OR = 3,8, [IC 95% 2,34, 6,16]), parto prematuro (OR = 2,31, [IC 95% 1,41, 3,80]) e baixo Pontuações de Ápgar (OR = 14,73, [IC 95% 5,27, 41,15]). Conclusões: Os principais fatores pré-natais e perinatais associados à paralisia cerebral em nossa população foram anomalias congênitas, baixo índice de Ápgar, baixo peso ao nascer e prematuridade. O período perinatal apresentou mais fatores de risco, exigindo um estudo mais aprofundado de suas causas e de possíveis medidas preventivas.Research, Society and Development2021-05-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1507510.33448/rsd-v10i5.15075Research, Society and Development; Vol. 10 No. 5; e35710515075Research, Society and Development; Vol. 10 Núm. 5; e35710515075Research, Society and Development; v. 10 n. 5; e357105150752525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/15075/13480Copyright (c) 2021 Marcus Valerius da Silva Peixoto; Andrezza Marques Duque; Allan Dantas dos Santos; Shirley Verônica Melo Almeida Lima; Caíque Jordan Nunes Ribeiro; Silvia Maria Voci; Susana de Carvalho; Marco Antônio Prado Nuneshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessPeixoto, Marcus Valerius da SilvaDuque, Andrezza Marques Santos, Allan Dantas dos Lima, Shirley Verônica Melo Almeida Ribeiro, Caíque Jordan Nunes Voci, Silvia Maria Carvalho, Susana deNunes, Marco Antônio Prado 2021-05-17T18:20:49Zoai:ojs.pkp.sfu.ca:article/15075Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:35:59.524892Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Risk Factors for Cerebral Palsy in Brazilian Children: A Case-Control Study
Factores de riesgo de parálisis cerebral en niños brasileños: Un estudio de casos y controles
Fatores de risco para paralisia cerebral em crianças brasileiras: Um estudo de caso-controle
title Risk Factors for Cerebral Palsy in Brazilian Children: A Case-Control Study
spellingShingle Risk Factors for Cerebral Palsy in Brazilian Children: A Case-Control Study
Peixoto, Marcus Valerius da Silva
Factores de Riesgo
Estudios de Casos y Controles
Paralisís Cerebral
Epidemiología
Niños con discapacidad.
Paralisia Cerebral
Epidemiologia
Fatores de Risco
Estudos de casos e controles
Crianças com deficiência.
Cerebral Palsy
Epidemiology
Risk factors
Case-control studies
Disabled children.
title_short Risk Factors for Cerebral Palsy in Brazilian Children: A Case-Control Study
title_full Risk Factors for Cerebral Palsy in Brazilian Children: A Case-Control Study
title_fullStr Risk Factors for Cerebral Palsy in Brazilian Children: A Case-Control Study
title_full_unstemmed Risk Factors for Cerebral Palsy in Brazilian Children: A Case-Control Study
title_sort Risk Factors for Cerebral Palsy in Brazilian Children: A Case-Control Study
author Peixoto, Marcus Valerius da Silva
author_facet Peixoto, Marcus Valerius da Silva
Duque, Andrezza Marques
Santos, Allan Dantas dos
Lima, Shirley Verônica Melo Almeida
Ribeiro, Caíque Jordan Nunes
Voci, Silvia Maria
Carvalho, Susana de
Nunes, Marco Antônio Prado
author_role author
author2 Duque, Andrezza Marques
Santos, Allan Dantas dos
Lima, Shirley Verônica Melo Almeida
Ribeiro, Caíque Jordan Nunes
Voci, Silvia Maria
Carvalho, Susana de
Nunes, Marco Antônio Prado
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Peixoto, Marcus Valerius da Silva
Duque, Andrezza Marques
Santos, Allan Dantas dos
Lima, Shirley Verônica Melo Almeida
Ribeiro, Caíque Jordan Nunes
Voci, Silvia Maria
Carvalho, Susana de
Nunes, Marco Antônio Prado
dc.subject.por.fl_str_mv Factores de Riesgo
Estudios de Casos y Controles
Paralisís Cerebral
Epidemiología
Niños con discapacidad.
Paralisia Cerebral
Epidemiologia
Fatores de Risco
Estudos de casos e controles
Crianças com deficiência.
Cerebral Palsy
Epidemiology
Risk factors
Case-control studies
Disabled children.
topic Factores de Riesgo
Estudios de Casos y Controles
Paralisís Cerebral
Epidemiología
Niños con discapacidad.
Paralisia Cerebral
Epidemiologia
Fatores de Risco
Estudos de casos e controles
Crianças com deficiência.
Cerebral Palsy
Epidemiology
Risk factors
Case-control studies
Disabled children.
description Background: Cerebral palsy is the main cause of physical disability in childhood. Objectives: This study analyzed prenatal and perinatal risk factors that contribute to cerebral palsy in Brazilian children. Methods: A case-control study was conducted with 2- to 10-year-old children in the city of Aracaju, Sergipe, Brazil. The cases were population-based, selected from the Primary Health Care services. The controls were selected from the database of the Brazilian Live Births Information System. Controls were paired with cases by gender, year, and hospital of birth. Results: A total of 570 participants (114 cases and 456 controls) were studied. Most of the participants were male, with bilateral spastic cerebral palsy. Among the prenatal factors examined, the presence of congenital anomalies was significantly different between cases and controls (OR = 54.28, [95% CI 12.55, 234.86]). The analysis of perinatal factors revealed significant differences between cases and controls in low birth weight (OR = 3.8, [95% CI 2.34, 6.16]), preterm birth (OR = 2.31, [95% CI 1.41, 3.80]), and low Apgar scores (OR = 14.73, [95% CI 5.27, 41.15]). Conclusions: The main prenatal and perinatal factors associated with cerebral palsy in our population were congenital anomalies, low Apgar scores, low birth weight, and preterm birth. The perinatal period had more risk factors, demanding a deeper study of their causes and of possible preventive measures.
publishDate 2021
dc.date.none.fl_str_mv 2021-05-09
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/15075
10.33448/rsd-v10i5.15075
url https://rsdjournal.org/index.php/rsd/article/view/15075
identifier_str_mv 10.33448/rsd-v10i5.15075
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/15075/13480
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 5; e35710515075
Research, Society and Development; Vol. 10 Núm. 5; e35710515075
Research, Society and Development; v. 10 n. 5; e35710515075
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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