Way Angiotensin Converting Enzyme (ACE) II/Ang 1-7/Mas receptor activation as a pharmacological target in cardiac pathologies: a systematic review

Detalhes bibliográficos
Autor(a) principal: Silva, Igor Matheus Oliveira da
Data de Publicação: 2021
Outros Autores: Caroba , Júlia de Sousa, Thorpe , Matheus Almeida, Souza, Luan Kelves Miranda de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/13553
Resumo: Objective: To understand the activation of the ECA II / Ang 1-7 / Receptor Mas route as a pharmacological target in cardiac pathologies. Methodology: This is a systematic literature review, researched in the EMBASE, MEDLINE and SCIELO databases, which used the PRISMA protocol to extract primary data and transform it into secondary data. Results: The Renina Angiotensin System is an essential component for the proper physiological functioning and homeostasis of the cardiovascular system. Being divided into two axes, the classic, which is currently used in the pharmacotherapy of hypertension and cardiovascular diseases. It is the non-classical axis that, via the angiotensin II converting enzyme (ACE II), angiotensin (1-7) and Mas receptor pathway, has demonstrated an important vasodilator and cardioprotective effect. They demonstrate a promising outcome and reinforce the effective action of MasR as a vasodilator, cardioprotection and reduction of myocardial remodeling. Final Considerations: The non-classical axis has potential in the development of drugs to expand new pharmacological strategies for cardiovascular diseases.
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spelling Way Angiotensin Converting Enzyme (ACE) II/Ang 1-7/Mas receptor activation as a pharmacological target in cardiac pathologies: a systematic reviewVía Enzima Convertidora de Angiotensina (ECA) II/Ang 1-7 /Activación del receptor pero como objetivo farmacológico en patologías cardíacas: una revisión sistemáticaAtivação da via Enzima Conversora de Angiotensina (ECA) II/Ang 1-7/Receptor Mas como alvo farmacológico em patologias cardíacas: uma revisão sistemáticaEnfermedades CardiovascularesAngiotensinaSistema Renina-AngiotensinaReceptores de angiotensinaDesarrollo de medicamentos.Doenças CardiovascularesAngiotensinaSistema Renina-AngiotensinaReceptores de angiotensinaDesenvolvimento de medicamentos.Cardiovascular DiseasesAngiotensinRenin-Angiotensin SystemReceptors, AngiotensinDrug development.Objective: To understand the activation of the ECA II / Ang 1-7 / Receptor Mas route as a pharmacological target in cardiac pathologies. Methodology: This is a systematic literature review, researched in the EMBASE, MEDLINE and SCIELO databases, which used the PRISMA protocol to extract primary data and transform it into secondary data. Results: The Renina Angiotensin System is an essential component for the proper physiological functioning and homeostasis of the cardiovascular system. Being divided into two axes, the classic, which is currently used in the pharmacotherapy of hypertension and cardiovascular diseases. It is the non-classical axis that, via the angiotensin II converting enzyme (ACE II), angiotensin (1-7) and Mas receptor pathway, has demonstrated an important vasodilator and cardioprotective effect. They demonstrate a promising outcome and reinforce the effective action of MasR as a vasodilator, cardioprotection and reduction of myocardial remodeling. Final Considerations: The non-classical axis has potential in the development of drugs to expand new pharmacological strategies for cardiovascular diseases.Objetivo: Comprender la activación de la ruta ECA II / Ang 1-7 / Receptor Mas como diana farmacológica en patologías cardíacas. Metodología: Se trata de una revisión sistemática de la literatura, investigada en las bases de datos EMBASE, MEDLINE y SCIELO, que utilizó el protocolo PRISMA para extraer datos primarios y transformarlos en datos secundarios. Resultados: El Sistema Renina Angiotensin es un componente esencial para el correcto funcionamiento fisiológico y homeostasis del sistema cardiovascular. Estando dividido en dos ejes, el clásico, que actualmente se utiliza en la farmacoterapia de la hipertensión y las enfermedades cardiovasculares. Es el eje no clásico que, a través de la enzima convertidora de angiotensina II (ECA II), la vía del receptor de angiotensina (1-7) y Mas, ha demostrado un importante efecto vasodilatador y cardioprotector. Demuestran un resultado prometedor y refuerzan la acción eficaz de MasR como vasodilatador, cardioprotector y reductor del remodelado miocárdico. Consideraciones finales: El eje no clásico tiene potencial en el desarrollo de fármacos para expandir nuevas estrategias farmacológicas para las enfermedades cardiovasculares.Objetivo: Compreender a ativação da via ECA II/ Ang 1-7/Receptor Mas como alvo farmacológico em patologias cardíacas. Metodologia: Trata-se de uma revisão de literatura sistemática, pesquisadas nas bases de dados EMBASE, MEDLINE e SCIELO, que para extração dos dados primários e transformação em dados secundários, foi utilizado o protocolo PRISMA. Resultados: O Sistema Renina Angiotensina é um integrante imprescindível para o adequado funcionamento fisiológico e homeostasia do sistema cardiovascular. Sendo divido em dois eixos, o clássico, que é o usado na atualidade na farmacoterapia da hipertensão e doenças cardiovasculares. E o eixo não clássico que através da via da enzima conversora de angiotensina II (ECA II), angiotensina (1-7) e receptor Mas, que tem demonstrado importante efeito vasodilatador e cardioprotetor. Demonstram um desfecho promissor e reforçam a ação efetiva do MasR como vasodilatador, cardioproteção e redução da remodelagem miocárdica. Considerações Finais: O eixo não clássico possui potencial no desenvolvimento de drogas para expansão de novas estratégias farmacológicas para as doenças cardiovasculares.Research, Society and Development2021-03-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1355310.33448/rsd-v10i3.13553Research, Society and Development; Vol. 10 No. 3; e44410313553Research, Society and Development; Vol. 10 Núm. 3; e44410313553Research, Society and Development; v. 10 n. 3; e444103135532525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/13553/12163Copyright (c) 2021 Igor Matheus Oliveira da Silva; Júlia de Sousa Caroba ; Matheus Almeida Thorpe ; Luan Kelves Miranda de Souzahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSilva, Igor Matheus Oliveira da Caroba , Júlia de Sousa Thorpe , Matheus Almeida Souza, Luan Kelves Miranda de 2021-03-28T12:03:35Zoai:ojs.pkp.sfu.ca:article/13553Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:34:52.136329Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Way Angiotensin Converting Enzyme (ACE) II/Ang 1-7/Mas receptor activation as a pharmacological target in cardiac pathologies: a systematic review
Vía Enzima Convertidora de Angiotensina (ECA) II/Ang 1-7 /Activación del receptor pero como objetivo farmacológico en patologías cardíacas: una revisión sistemática
Ativação da via Enzima Conversora de Angiotensina (ECA) II/Ang 1-7/Receptor Mas como alvo farmacológico em patologias cardíacas: uma revisão sistemática
title Way Angiotensin Converting Enzyme (ACE) II/Ang 1-7/Mas receptor activation as a pharmacological target in cardiac pathologies: a systematic review
spellingShingle Way Angiotensin Converting Enzyme (ACE) II/Ang 1-7/Mas receptor activation as a pharmacological target in cardiac pathologies: a systematic review
Silva, Igor Matheus Oliveira da
Enfermedades Cardiovasculares
Angiotensina
Sistema Renina-Angiotensina
Receptores de angiotensina
Desarrollo de medicamentos.
Doenças Cardiovasculares
Angiotensina
Sistema Renina-Angiotensina
Receptores de angiotensina
Desenvolvimento de medicamentos.
Cardiovascular Diseases
Angiotensin
Renin-Angiotensin System
Receptors, Angiotensin
Drug development.
title_short Way Angiotensin Converting Enzyme (ACE) II/Ang 1-7/Mas receptor activation as a pharmacological target in cardiac pathologies: a systematic review
title_full Way Angiotensin Converting Enzyme (ACE) II/Ang 1-7/Mas receptor activation as a pharmacological target in cardiac pathologies: a systematic review
title_fullStr Way Angiotensin Converting Enzyme (ACE) II/Ang 1-7/Mas receptor activation as a pharmacological target in cardiac pathologies: a systematic review
title_full_unstemmed Way Angiotensin Converting Enzyme (ACE) II/Ang 1-7/Mas receptor activation as a pharmacological target in cardiac pathologies: a systematic review
title_sort Way Angiotensin Converting Enzyme (ACE) II/Ang 1-7/Mas receptor activation as a pharmacological target in cardiac pathologies: a systematic review
author Silva, Igor Matheus Oliveira da
author_facet Silva, Igor Matheus Oliveira da
Caroba , Júlia de Sousa
Thorpe , Matheus Almeida
Souza, Luan Kelves Miranda de
author_role author
author2 Caroba , Júlia de Sousa
Thorpe , Matheus Almeida
Souza, Luan Kelves Miranda de
author2_role author
author
author
dc.contributor.author.fl_str_mv Silva, Igor Matheus Oliveira da
Caroba , Júlia de Sousa
Thorpe , Matheus Almeida
Souza, Luan Kelves Miranda de
dc.subject.por.fl_str_mv Enfermedades Cardiovasculares
Angiotensina
Sistema Renina-Angiotensina
Receptores de angiotensina
Desarrollo de medicamentos.
Doenças Cardiovasculares
Angiotensina
Sistema Renina-Angiotensina
Receptores de angiotensina
Desenvolvimento de medicamentos.
Cardiovascular Diseases
Angiotensin
Renin-Angiotensin System
Receptors, Angiotensin
Drug development.
topic Enfermedades Cardiovasculares
Angiotensina
Sistema Renina-Angiotensina
Receptores de angiotensina
Desarrollo de medicamentos.
Doenças Cardiovasculares
Angiotensina
Sistema Renina-Angiotensina
Receptores de angiotensina
Desenvolvimento de medicamentos.
Cardiovascular Diseases
Angiotensin
Renin-Angiotensin System
Receptors, Angiotensin
Drug development.
description Objective: To understand the activation of the ECA II / Ang 1-7 / Receptor Mas route as a pharmacological target in cardiac pathologies. Methodology: This is a systematic literature review, researched in the EMBASE, MEDLINE and SCIELO databases, which used the PRISMA protocol to extract primary data and transform it into secondary data. Results: The Renina Angiotensin System is an essential component for the proper physiological functioning and homeostasis of the cardiovascular system. Being divided into two axes, the classic, which is currently used in the pharmacotherapy of hypertension and cardiovascular diseases. It is the non-classical axis that, via the angiotensin II converting enzyme (ACE II), angiotensin (1-7) and Mas receptor pathway, has demonstrated an important vasodilator and cardioprotective effect. They demonstrate a promising outcome and reinforce the effective action of MasR as a vasodilator, cardioprotection and reduction of myocardial remodeling. Final Considerations: The non-classical axis has potential in the development of drugs to expand new pharmacological strategies for cardiovascular diseases.
publishDate 2021
dc.date.none.fl_str_mv 2021-03-21
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/13553
10.33448/rsd-v10i3.13553
url https://rsdjournal.org/index.php/rsd/article/view/13553
identifier_str_mv 10.33448/rsd-v10i3.13553
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/13553/12163
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 3; e44410313553
Research, Society and Development; Vol. 10 Núm. 3; e44410313553
Research, Society and Development; v. 10 n. 3; e44410313553
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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