Analysis of proviral load levels in HTLV-1 carriers with different neurological impairment conditions

• Autor(a) principal: Assis, Izabela Mendonça de
• Data de Publicação: 2021
• Outros Autores: Domingues , Mariângela Moreno, Almeida, Danilo de Souza, Covre, Louise de Souza Canto, La-Roque, Debora Glenda Lima de, Silva, Ingrid Christiane, Nobre, Akim Felipe Santos, Borges, Mariza da Silva, Pereira, Cássia Cristine Costa, Santana, Barbara Brasil, Vallinoto, Antonio Carlos Rosario, Sousa, Maísa Silva de
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Research, Society and Development
• Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/13264
• topic: HTLV-1; Paraparesia Espástica Tropical; Distúrbios neurológicos; Carga proviral.; HTLV-1; Paraparesia espástica tropical; Desórdenes neurológicos; Carga proviral.; HTLV-1; Tropical Spastic Paraparesis; Neurological disorders; Proviral load.

Objectives: To analyze the levels of proviral load (CPV) in patients with HTLV-1 with different conditions of neurological impairment. Methodology: Cross-sectional study, conducted from March to October 2017, with 43 patients with HTLV-1, divided into three groups in decreasing order of neurological involvement, according to the updated proposal of the clinical diagnosis criteria for HAM / TSP: Defined for HAM / TSP (Group 1, n = 7); Probable / Possible for HAM / TSP (Group 2, n = 9); Without HAM / TSP (Group 3, n = 27). The ANOVA test (one criterion) was used to verify the difference between the groups' mean CPV (p-value≤0.05). Results: The groups presented the following average CPV values: G1 = 9.00 ± 11.18; G2 = 1.88 ± 3.92; G3 = 2.81 ± 4.03 copies / 106 PBMC. In the intergroup comparison, of the difference between the means of CPV, a significant difference was observed between groups 1 and 2 and between groups 1 and 3 (p <0.05); a significantly higher mean of CPV was not observed in the HTLV-1 infected groups with neurological impairment, compared to those infected without neurological impairment (p = 0.7063). Conclusion: CPV in patients with HTLV-1 seems to help the clinical evaluation of neurological impairment in the classification of classic cases of HAM/TSP, but it is not an important indicator of initial clinical conditions of HAM/TSP.