Therapeutic potential of selective serotonin reuptake inhibitor and anti-inflammatory COX-2 inhibitors drugs for epilepsy

Detalhes bibliográficos
Autor(a) principal: Carvalho, Matheus dos Santos do Nascimento
Data de Publicação: 2022
Outros Autores: Moraes, Rafael Ragazzi de, Trindade Filho, Euclides Mauricio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/31319
Resumo: Epilepsy is a neurological disease caused by disturbances in the electrical propagation between neurons, which causes great damage to patients' lives, and can even lead to death. There are several proposals to understand its biochemical functioning, so current pharmacological treatments are based on the interruption of electrical conduction or modulation of neurotransmitters, such as phenobarbital and phenytoin. Thus, the present work aims to analyze the therapeutic potential of drugs such as COX-2 inhibitors and selective serotonin reuptake inhibitors (SSRIs) in the control of epilepsy. Thus, a narrative review of the literature was carried out using the “PubMed” database in order to find the theoretical bases and experimental works that demonstrate the mechanism of such drugs. The work concludes that SSRIs and COX-2 inhibitors have several mechanisms that can theoretically treat epilepsy, this is due to the establishment of a higher concentration of the neurotransmitter serotonin, as well as a reduction in the formation of quinolinic acid, which is a potential neurotoxic agent. which contributes to epileptogenesis.
id UNIFEI_3229d0a2c4812945cc2f5d53be15d88a
oai_identifier_str oai:ojs.pkp.sfu.ca:article/31319
network_acronym_str UNIFEI
network_name_str Research, Society and Development
repository_id_str
spelling Therapeutic potential of selective serotonin reuptake inhibitor and anti-inflammatory COX-2 inhibitors drugs for epilepsyPotencial terapéutico de los fármacos inhibidores selectivos de la recaptación de serotonina y los antiinflamatorios inhibidores de la COX-2 para la epilepsiaPotencial terapêutico de fármacos inibidores seletivos da recaptação de serotonina e anti-inflamatórios inibidores da COX-2 para epilepsia EpilepsiaAntiinflamatórioInhibidor selectivo de la recaptación de serotoninaSerotoninaQuinurenina.EpilepsiaAnti-inflamatórioInibidor seletivo da recaptação da serotoninaSerotoninaQuinurenina.EpilepsyAnti-inflammatorySSRISerotoninKynurenine.Epilepsy is a neurological disease caused by disturbances in the electrical propagation between neurons, which causes great damage to patients' lives, and can even lead to death. There are several proposals to understand its biochemical functioning, so current pharmacological treatments are based on the interruption of electrical conduction or modulation of neurotransmitters, such as phenobarbital and phenytoin. Thus, the present work aims to analyze the therapeutic potential of drugs such as COX-2 inhibitors and selective serotonin reuptake inhibitors (SSRIs) in the control of epilepsy. Thus, a narrative review of the literature was carried out using the “PubMed” database in order to find the theoretical bases and experimental works that demonstrate the mechanism of such drugs. The work concludes that SSRIs and COX-2 inhibitors have several mechanisms that can theoretically treat epilepsy, this is due to the establishment of a higher concentration of the neurotransmitter serotonin, as well as a reduction in the formation of quinolinic acid, which is a potential neurotoxic agent. which contributes to epileptogenesis.La epilepsia es una enfermedad neurológica causada por alteraciones en la propagación eléctrica entre las neuronas, lo que provoca grandes daños en la vida de los pacientes, pudiendo llegar incluso a la muerte. Existen varias propuestas para entender su funcionamiento bioquímico, por lo que los tratamientos farmacológicos actuales se basan en la interrupción de la conducción eléctrica o la modulación de neurotransmisores, como el fenobarbital y la fenitoína. Así, el presente trabajo tiene como objetivo analizar el potencial terapéutico de fármacos como los inhibidores de la COX-2 y los inhibidores selectivos de la recaptación de serotonina (ISRS) en el control de la epilepsia. Así, se realizó una revisión narrativa de la literatura utilizando la base de datos “PubMed” con el fin de encontrar las bases teóricas y trabajos experimentales que demuestran el mecanismo de tales fármacos. El trabajo concluye que los ISRS y los inhibidores de la COX-2 tienen varios mecanismos que teóricamente pueden tratar la epilepsia, esto se debe al establecimiento de una mayor concentración del neurotransmisor serotonina, así como a una reducción en la formación de ácido quinolínico, que es un potencial agente neurotóxico que contribuye a la epileptogénesis.A epilepsia é uma doença neurológica causada por distúrbios na propagação elétrica entre os neurônios, e que cursa com grandes prejuízos na vida dos pacientes, podendo até mesmo levar à morte. Há diversas propostas para entender seu funcionamento bioquímico, de modo que os tratamentos farmacológicos atuais se baseiam na interrupção da condução elétrica ou modulação de neurotransmissores, como o fenobarbital e a fenitoína. Desse modo, o presente trabalho objetiva analisar o potencial terapêutico que medicamentos como os anti-inflamatórios inibidores de COX-2 e os inibidores seletivos da recaptação de serotonina (ISRS) no controle da epilepsia. Assim, foi realizada uma revisão narrativa da literatura usando a base de dados “PubMed” a fim de encontrar as bases teóricas e trabalhos experimentais que demonstram o mecanismo de tais medicamentos. O trabalho conclui que os ISRSs e inibidores da COX-2 possuem diversos mecanismos que teoricamente podem tratar a epilepsia, isso se deve ao estabelecimento de maior concentração do neurotransmissor serotonina, bem como redução da formação do ácido quinolínico, o qual é um potencial agente neurotóxico que contribui para a epileptogênese.Research, Society and Development2022-06-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3131910.33448/rsd-v11i8.31319Research, Society and Development; Vol. 11 No. 8; e55411831319Research, Society and Development; Vol. 11 Núm. 8; e55411831319Research, Society and Development; v. 11 n. 8; e554118313192525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/31319/26792Copyright (c) 2022 Matheus dos Santos do Nascimento Carvalho; Rafael Ragazzi de Moraes; Euclides Mauricio Trindade Filhohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCarvalho, Matheus dos Santos do NascimentoMoraes, Rafael Ragazzi deTrindade Filho, Euclides Mauricio 2022-07-01T13:34:06Zoai:ojs.pkp.sfu.ca:article/31319Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:47:42.455624Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Therapeutic potential of selective serotonin reuptake inhibitor and anti-inflammatory COX-2 inhibitors drugs for epilepsy
Potencial terapéutico de los fármacos inhibidores selectivos de la recaptación de serotonina y los antiinflamatorios inhibidores de la COX-2 para la epilepsia
Potencial terapêutico de fármacos inibidores seletivos da recaptação de serotonina e anti-inflamatórios inibidores da COX-2 para epilepsia
title Therapeutic potential of selective serotonin reuptake inhibitor and anti-inflammatory COX-2 inhibitors drugs for epilepsy
spellingShingle Therapeutic potential of selective serotonin reuptake inhibitor and anti-inflammatory COX-2 inhibitors drugs for epilepsy
Carvalho, Matheus dos Santos do Nascimento
Epilepsia
Antiinflamatório
Inhibidor selectivo de la recaptación de serotonina
Serotonina
Quinurenina.
Epilepsia
Anti-inflamatório
Inibidor seletivo da recaptação da serotonina
Serotonina
Quinurenina.
Epilepsy
Anti-inflammatory
SSRI
Serotonin
Kynurenine.
title_short Therapeutic potential of selective serotonin reuptake inhibitor and anti-inflammatory COX-2 inhibitors drugs for epilepsy
title_full Therapeutic potential of selective serotonin reuptake inhibitor and anti-inflammatory COX-2 inhibitors drugs for epilepsy
title_fullStr Therapeutic potential of selective serotonin reuptake inhibitor and anti-inflammatory COX-2 inhibitors drugs for epilepsy
title_full_unstemmed Therapeutic potential of selective serotonin reuptake inhibitor and anti-inflammatory COX-2 inhibitors drugs for epilepsy
title_sort Therapeutic potential of selective serotonin reuptake inhibitor and anti-inflammatory COX-2 inhibitors drugs for epilepsy
author Carvalho, Matheus dos Santos do Nascimento
author_facet Carvalho, Matheus dos Santos do Nascimento
Moraes, Rafael Ragazzi de
Trindade Filho, Euclides Mauricio
author_role author
author2 Moraes, Rafael Ragazzi de
Trindade Filho, Euclides Mauricio
author2_role author
author
dc.contributor.author.fl_str_mv Carvalho, Matheus dos Santos do Nascimento
Moraes, Rafael Ragazzi de
Trindade Filho, Euclides Mauricio
dc.subject.por.fl_str_mv Epilepsia
Antiinflamatório
Inhibidor selectivo de la recaptación de serotonina
Serotonina
Quinurenina.
Epilepsia
Anti-inflamatório
Inibidor seletivo da recaptação da serotonina
Serotonina
Quinurenina.
Epilepsy
Anti-inflammatory
SSRI
Serotonin
Kynurenine.
topic Epilepsia
Antiinflamatório
Inhibidor selectivo de la recaptación de serotonina
Serotonina
Quinurenina.
Epilepsia
Anti-inflamatório
Inibidor seletivo da recaptação da serotonina
Serotonina
Quinurenina.
Epilepsy
Anti-inflammatory
SSRI
Serotonin
Kynurenine.
description Epilepsy is a neurological disease caused by disturbances in the electrical propagation between neurons, which causes great damage to patients' lives, and can even lead to death. There are several proposals to understand its biochemical functioning, so current pharmacological treatments are based on the interruption of electrical conduction or modulation of neurotransmitters, such as phenobarbital and phenytoin. Thus, the present work aims to analyze the therapeutic potential of drugs such as COX-2 inhibitors and selective serotonin reuptake inhibitors (SSRIs) in the control of epilepsy. Thus, a narrative review of the literature was carried out using the “PubMed” database in order to find the theoretical bases and experimental works that demonstrate the mechanism of such drugs. The work concludes that SSRIs and COX-2 inhibitors have several mechanisms that can theoretically treat epilepsy, this is due to the establishment of a higher concentration of the neurotransmitter serotonin, as well as a reduction in the formation of quinolinic acid, which is a potential neurotoxic agent. which contributes to epileptogenesis.
publishDate 2022
dc.date.none.fl_str_mv 2022-06-29
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/31319
10.33448/rsd-v11i8.31319
url https://rsdjournal.org/index.php/rsd/article/view/31319
identifier_str_mv 10.33448/rsd-v11i8.31319
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/31319/26792
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 8; e55411831319
Research, Society and Development; Vol. 11 Núm. 8; e55411831319
Research, Society and Development; v. 11 n. 8; e55411831319
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
_version_ 1797052767969214464

Registros relacionados