Non-invasive versus invasive method to measure blood pressure in rodents: an integrative literature review

• Autor(a) principal: Valério, Mariana da Palma
• Data de Publicação: 2022
• Outros Autores: Martini, Silvia Cristina, Boschi, Silvia Regina Matos da Silva, Scardovelli, Terigi Augusto, Silva, Alessandro Pereira da
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Research, Society and Development
• Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/30789
• topic: Medição de pressão arterial; Roedores; Métodos invasivos; Métodos não invasivos.; Medición de la presión arterial; Roedores; Métodos invasivos; Métodos no invasivos.; Blood pressure measurement; Rodents; Invasive methods; Non-Invasive methods.

Blood pressure (BP) measurement is the main monitoring parameter related to the cardiac system, and the use of animals is vital for understanding the physiological mechanism and studying pathologies related to this system. The most recommended measurement procedures in rodents in the literature are: The non-invasive method (tail cuff) and the invasive methods (catheter with fluid and telemetry). The objective of this study was to verify the main arterial measurement techniques in rodents, evaluate their positive and negative points and classify which is the most viable and effective technique for initial experimental tests. An integrative literature review was carried out using the descriptors and their respective synonyms, “real time device”, “blood pressure measurements”, “rats” using the Boolean “AND” in PubMed, Scielo and Medline databases. As inclusion criteria, articles that addressed the aforementioned theme, in Portuguese, English or Spanish, complete, from experimental trials on rodents, published within the last 21 years were adopted. As exclusion criteria were articles that were not available for full reading and studies that did not use rodents as a sample. Thirteen articles were selected that met the criteria. The results demonstrate that invasive methods can be advantageous for continuous measurements, but that it would be preferable to use the non-invasive method as it is safer and easier to perform. It is concluded that for initial experimental trials, the procedure to be chosen would be the non-invasive method, tail cuff.