Pharmaceutical formulation based on chitosan and Schinus terebinthifolius Raddi extract: development and technological study
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/25006 |
Resumo: | Aroeira-vermelha, as Schinus terebinthifolius Raddi is known, is a plant species from the Anacardiaceae family, present in almost all Brazilian territory. There is scientific evidence that the species has bioactive compounds, for example, flavonoid, tannins, terpenes and phenols groups in their composition, which suggests a broad spectrum of pharmacological activities for the plant, such as anti-inflammatory, antioxidant, anticancer and healing. Thus, aroeira presents great potential for the production of phytotherapics. Therefore, this work aimed at the development and production of gel formulations containing the extract of S. terebinthifolius together with chitosan and Carbopol, as well as characterizing them. The stability tests were applied to both formulations, the results demonstrate that they did not suffer any interference in their organoleptic characteristics, however regarding the pH and electrical conductivity there were some changes in the gel with chitosan. This studyelaborated formulations, after technological tests, demonstrated stability in all stages of development, for both excipients. Given these results, this phytopharmaceutical proved to be an excellent therapeutic alternative for topical use. |
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Pharmaceutical formulation based on chitosan and Schinus terebinthifolius Raddi extract: development and technological studyFormulación farmacéutica a base de quitosano y extracto de Schinus terebinthifolius Raddi: desarrollo y estudio tecnológicoFormulação farmacêutica a base de quitosana e extrato de Schinus terebinthifolius Raddi: desenvolvimento e estudo tecnológicoAroreiraGelEstabilityHealing.AroeiraGelEstabilidadCicatrización.AroeiraGelEstabilidadeCicatrização.Aroeira-vermelha, as Schinus terebinthifolius Raddi is known, is a plant species from the Anacardiaceae family, present in almost all Brazilian territory. There is scientific evidence that the species has bioactive compounds, for example, flavonoid, tannins, terpenes and phenols groups in their composition, which suggests a broad spectrum of pharmacological activities for the plant, such as anti-inflammatory, antioxidant, anticancer and healing. Thus, aroeira presents great potential for the production of phytotherapics. Therefore, this work aimed at the development and production of gel formulations containing the extract of S. terebinthifolius together with chitosan and Carbopol, as well as characterizing them. The stability tests were applied to both formulations, the results demonstrate that they did not suffer any interference in their organoleptic characteristics, however regarding the pH and electrical conductivity there were some changes in the gel with chitosan. This studyelaborated formulations, after technological tests, demonstrated stability in all stages of development, for both excipients. Given these results, this phytopharmaceutical proved to be an excellent therapeutic alternative for topical use.Aroeira-vermelha, como se conoce a Schinus terebinthifolius Raddi, es una planta de la familia Anacardiaceae presente en casi todo el territorio brasileño. Existe evidencia científica de que la especie posee compuestos bioactivos como grupos flavonoides, taninos, terpenos y fenoles en su composición, lo que sugiere un amplio espectro de actividades farmacológicas para la planta, como antiinflamatoria, antioxidante, anticancerígena y cicatrizante. Por lo tanto, la aroeira tiene un gran potencial para la producción de medicamentos a base de hierbas. Por tanto, este trabajo tuvo como objetivo el desarrollo y estudio tecnológico de formulaciones en gel que contienen extracto de S. terebinthifolius junto con quitosano y con Carbopol. Se aplicaron pruebas de estabilidad a ambas formulaciones, donde los resultados muestran que no sufrieron interferencia en sus características organolépticas, sin embargo en cuanto al pH y la conductividad eléctrica se presentaron algunos cambios en el gel con quitosano. Las formulaciones elaboradas en este estudio, luego de pruebas tecnológicas, demostraron estabilidad en todas las etapas de desarrollo, en ambos excipientes. Dados estos resultados, el fitofármaco demostró ser una excelente alternativa terapéutica para uso tópico.A aroeira-vermelha, como é conhecida a Schinus terebinthifolius Raddi, é uma planta da família Anacardiaceae que está presente em quase todo território brasileiro. Há evidências científicas que a espécie apresenta compostos bioativos como os grupos flavonóides, taninos, terpenos e fenóis em sua composição, o que sugere um espectro amplo de atividades farmacológicas para o vegetal como, anti-inflamatória, antioxidante, anticâncer e cicatrizante. Dessa forma, a aroeira apresenta grande potencial para a produção de fitoterápicos. Sendo assim, este trabalho objetivou o desenvolvimento e estudo tecnológico de formulações em gel contendo o extrato da S. terebinthifolius juntamente com quitosana e Carbopol. Os testes de estabilidade foram aplicados para ambas as formulações, os resultados demostram que as mesmas não sofreram interferências em suas características organolépticas, porém quanto ao pH e condutividade elétrica existiram algumas alterações no gel com quitosana. As formulações elaboradas nesse estudo, após os testes tecnológicos, demonstraram estabilidade em todas as fases de desenvolvimento, em ambos os excipientes. Diante desses resultados, o fitofármaco demonstrou ser uma excelente alternativa terapêutica para utilização tópica.Research, Society and Development2022-06-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2500610.33448/rsd-v11i8.25006Research, Society and Development; Vol. 11 No. 8; e50311825006Research, Society and Development; Vol. 11 Núm. 8; e50311825006Research, Society and Development; v. 11 n. 8; e503118250062525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/25006/26740Copyright (c) 2022 Robson Edney Mariano Nascimento e Silva; Julia Samara Pereira de Souza; Jaleska Santos Olinto Trindade; Kalline Alves de Araújo; João Carlos da Silva; Cypriano Galvão da Trindade Neto; Heryka Myrna Maia Ramalhohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSilva, Robson Edney Mariano Nascimento e Souza, Julia Samara Pereira de Trindade, Jaleska Santos Olinto Araújo, Kalline Alves de Silva, João Carlos da Trindade Neto, Cypriano Galvão da Ramalho, Heryka Myrna Maia2022-07-01T13:34:06Zoai:ojs.pkp.sfu.ca:article/25006Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:43:23.401479Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Pharmaceutical formulation based on chitosan and Schinus terebinthifolius Raddi extract: development and technological study Formulación farmacéutica a base de quitosano y extracto de Schinus terebinthifolius Raddi: desarrollo y estudio tecnológico Formulação farmacêutica a base de quitosana e extrato de Schinus terebinthifolius Raddi: desenvolvimento e estudo tecnológico |
title |
Pharmaceutical formulation based on chitosan and Schinus terebinthifolius Raddi extract: development and technological study |
spellingShingle |
Pharmaceutical formulation based on chitosan and Schinus terebinthifolius Raddi extract: development and technological study Silva, Robson Edney Mariano Nascimento e Aroreira Gel Estability Healing. Aroeira Gel Estabilidad Cicatrización. Aroeira Gel Estabilidade Cicatrização. |
title_short |
Pharmaceutical formulation based on chitosan and Schinus terebinthifolius Raddi extract: development and technological study |
title_full |
Pharmaceutical formulation based on chitosan and Schinus terebinthifolius Raddi extract: development and technological study |
title_fullStr |
Pharmaceutical formulation based on chitosan and Schinus terebinthifolius Raddi extract: development and technological study |
title_full_unstemmed |
Pharmaceutical formulation based on chitosan and Schinus terebinthifolius Raddi extract: development and technological study |
title_sort |
Pharmaceutical formulation based on chitosan and Schinus terebinthifolius Raddi extract: development and technological study |
author |
Silva, Robson Edney Mariano Nascimento e |
author_facet |
Silva, Robson Edney Mariano Nascimento e Souza, Julia Samara Pereira de Trindade, Jaleska Santos Olinto Araújo, Kalline Alves de Silva, João Carlos da Trindade Neto, Cypriano Galvão da Ramalho, Heryka Myrna Maia |
author_role |
author |
author2 |
Souza, Julia Samara Pereira de Trindade, Jaleska Santos Olinto Araújo, Kalline Alves de Silva, João Carlos da Trindade Neto, Cypriano Galvão da Ramalho, Heryka Myrna Maia |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Robson Edney Mariano Nascimento e Souza, Julia Samara Pereira de Trindade, Jaleska Santos Olinto Araújo, Kalline Alves de Silva, João Carlos da Trindade Neto, Cypriano Galvão da Ramalho, Heryka Myrna Maia |
dc.subject.por.fl_str_mv |
Aroreira Gel Estability Healing. Aroeira Gel Estabilidad Cicatrización. Aroeira Gel Estabilidade Cicatrização. |
topic |
Aroreira Gel Estability Healing. Aroeira Gel Estabilidad Cicatrización. Aroeira Gel Estabilidade Cicatrização. |
description |
Aroeira-vermelha, as Schinus terebinthifolius Raddi is known, is a plant species from the Anacardiaceae family, present in almost all Brazilian territory. There is scientific evidence that the species has bioactive compounds, for example, flavonoid, tannins, terpenes and phenols groups in their composition, which suggests a broad spectrum of pharmacological activities for the plant, such as anti-inflammatory, antioxidant, anticancer and healing. Thus, aroeira presents great potential for the production of phytotherapics. Therefore, this work aimed at the development and production of gel formulations containing the extract of S. terebinthifolius together with chitosan and Carbopol, as well as characterizing them. The stability tests were applied to both formulations, the results demonstrate that they did not suffer any interference in their organoleptic characteristics, however regarding the pH and electrical conductivity there were some changes in the gel with chitosan. This studyelaborated formulations, after technological tests, demonstrated stability in all stages of development, for both excipients. Given these results, this phytopharmaceutical proved to be an excellent therapeutic alternative for topical use. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-06-27 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/25006 10.33448/rsd-v11i8.25006 |
url |
https://rsdjournal.org/index.php/rsd/article/view/25006 |
identifier_str_mv |
10.33448/rsd-v11i8.25006 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/25006/26740 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 8; e50311825006 Research, Society and Development; Vol. 11 Núm. 8; e50311825006 Research, Society and Development; v. 11 n. 8; e50311825006 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
_version_ |
1797052791922884608 |