Technological prospection of Diminazene Aceturate, an Angiotensin II Converting Enzyme activator, in front of diarrheic disorders
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/10755 |
Resumo: | Diarrhea, which is a gastrointestinal disease, has as its main characteristic the rapid passage of gastric contents through the intestine, which leads to the loss of water and electrolytes and consequent dehydration. The most common fluid replacement is the use of oral rehydration solution (ORS) together with the use of the drug loperamide. However, the use of this medication can cause severe bacteremia followed by sepsis and even death. Currently, there is no effective pharmacological treatment for diarrhea, therefore, it is noted the importance of seeking new therapeutic targets for the treatment of this disease. Thus, the aim of the present study was to conduct a research on the biological activities already described for Diminazene Aceturate with a special focus on antidiarrheal agents. For this, a survey was carried out, through patent filing searches, in the USPTO, EPO, WIPO and INPI databases, using keywords and Boolean operators. Thus, it was found in the international patent databases the number of documents referring to the use of Diminazene Aceturate in several areas, mainly in the pharmaceutical industry, but with a relatively low number of documents regarding the description of possible antidiarrheal action of the compound under study , which reinforces the innovative character of research involving the use of Diminazene Aceturate as an antidiarrheal agent. |
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Technological prospection of Diminazene Aceturate, an Angiotensin II Converting Enzyme activator, in front of diarrheic disorders Prospección tecnológica de Diminazene Aceturate, un activador de la Enzima Convertidora de Angiotensina II, frente a los trastornos diarreicosProspecção tecnológica do Aceturato de Diminazeno, um ativador da Enzima Conversora de Angiotensina II, frente a distúrbios diarreicosAngiotensinACE IIDiarrhea.AngiotensinaECA IIDiarrea.AngiotensinaECA IIDiarreia.Diarrhea, which is a gastrointestinal disease, has as its main characteristic the rapid passage of gastric contents through the intestine, which leads to the loss of water and electrolytes and consequent dehydration. The most common fluid replacement is the use of oral rehydration solution (ORS) together with the use of the drug loperamide. However, the use of this medication can cause severe bacteremia followed by sepsis and even death. Currently, there is no effective pharmacological treatment for diarrhea, therefore, it is noted the importance of seeking new therapeutic targets for the treatment of this disease. Thus, the aim of the present study was to conduct a research on the biological activities already described for Diminazene Aceturate with a special focus on antidiarrheal agents. For this, a survey was carried out, through patent filing searches, in the USPTO, EPO, WIPO and INPI databases, using keywords and Boolean operators. Thus, it was found in the international patent databases the number of documents referring to the use of Diminazene Aceturate in several areas, mainly in the pharmaceutical industry, but with a relatively low number of documents regarding the description of possible antidiarrheal action of the compound under study , which reinforces the innovative character of research involving the use of Diminazene Aceturate as an antidiarrheal agent.La diarrea, que es una enfermedad gastrointestinal, tiene como característica principal el rápido paso del contenido gástrico a través del intestino, lo que conduce a la pérdida de agua y electrolitos y la consiguiente deshidratación. El reemplazo de líquidos más común es el uso de solución de rehidratación oral (SRO) junto con el uso del fármaco loperamida, sin embargo, el uso de este medicamento puede causar bacteriemia grave seguida de sepsis e incluso la muerte. Actualmente, no existe un tratamiento farmacológico eficaz para la diarrea, por lo que se destaca la importancia de buscar nuevas dianas terapéuticas para el tratamiento de esta enfermedad. Así, el objetivo del presente estudio fue realizar una investigación sobre las actividades biológicas ya descritas para el Aceturato de Diminazene con un enfoque especial en los agentes antidiarreicos. Para ello, se realizó una encuesta, a través de búsquedas de presentación de patentes, en las bases de datos de la USPTO, EPO, WIPO e INPI, utilizando palabras clave y operadores booleanos. Así, se encontró en las bases de datos internacionales de patentes la cantidad de documentos referentes al uso del Aceturato de Diminazene en varias áreas, principalmente en la industria farmacéutica, pero con un número relativamente bajo de documentos en cuanto a la descripción de la posible acción antidiarreica del compuesto en estudio. , que refuerza el carácter innovador de la investigación que implica el uso de Diminazene Aceturate como agente antidiarreico.A diarreia, que é uma doença gastrointestinal, tem como principal característica a passagem rápida do conteúdo gástrico pelo intestino, o que leva à perda de água e eletrólitos e consequente desidratação. A reposição hídrica mais comum é o uso de solução de reidratação oral (SRO) juntamente com o uso do fármaco loperamida, Porém, o uso deste medicamento pode causar bacteremia grave seguida de sepse e até morte. Atualmente, não existe um tratamento farmacológico eficaz para a diarreia, com isso, nota-se a importância de buscar novos alvos terpêuticos para o tratamento dessa doença. Assim, o objetivo do presente estudo foi realizar uma pesquisa sobre as atividades biológicas já descritas do Aceturato de Diminazeno com foco especial nos agentes antidiarreicos. Para isso, foi realizado um levantamento, por meio de pesquisas de depósito de patentes, nas bases de dados USPTO, EPO, WIPO e INPI, utilizando palavras-chave e operadores booleanos. Assim, constatou-se nas bases de dados internacionais de patentes o número de documentos referentes ao uso do Aceturato de Diminazeno em diversas áreas, principalmente na indústria farmacêutica, mas com número relativamente baixo de documentos quanto à descrição de possível ação antidiarreica do composto em estudo, o que reforça o caráter inovador das pesquisas envolvendo o uso do Aceturato de Diminazeno como agente antidiarreico.Research, Society and Development2020-12-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1075510.33448/rsd-v9i12.10755Research, Society and Development; Vol. 9 No. 12; e1691210755Research, Society and Development; Vol. 9 Núm. 12; e1691210755Research, Society and Development; v. 9 n. 12; e16912107552525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/10755/9602Copyright (c) 2020 Luan Kelves Miranda de Souza; Kerolayne de Melo Nogueira; Jand Venes Rolim Medeiroshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSouza, Luan Kelves Miranda deNogueira, Kerolayne de MeloMedeiros, Jand Venes Rolim2020-12-30T23:32:22Zoai:ojs.pkp.sfu.ca:article/10755Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:32:45.152115Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Technological prospection of Diminazene Aceturate, an Angiotensin II Converting Enzyme activator, in front of diarrheic disorders Prospección tecnológica de Diminazene Aceturate, un activador de la Enzima Convertidora de Angiotensina II, frente a los trastornos diarreicos Prospecção tecnológica do Aceturato de Diminazeno, um ativador da Enzima Conversora de Angiotensina II, frente a distúrbios diarreicos |
title |
Technological prospection of Diminazene Aceturate, an Angiotensin II Converting Enzyme activator, in front of diarrheic disorders |
spellingShingle |
Technological prospection of Diminazene Aceturate, an Angiotensin II Converting Enzyme activator, in front of diarrheic disorders Souza, Luan Kelves Miranda de Angiotensin ACE II Diarrhea. Angiotensina ECA II Diarrea. Angiotensina ECA II Diarreia. |
title_short |
Technological prospection of Diminazene Aceturate, an Angiotensin II Converting Enzyme activator, in front of diarrheic disorders |
title_full |
Technological prospection of Diminazene Aceturate, an Angiotensin II Converting Enzyme activator, in front of diarrheic disorders |
title_fullStr |
Technological prospection of Diminazene Aceturate, an Angiotensin II Converting Enzyme activator, in front of diarrheic disorders |
title_full_unstemmed |
Technological prospection of Diminazene Aceturate, an Angiotensin II Converting Enzyme activator, in front of diarrheic disorders |
title_sort |
Technological prospection of Diminazene Aceturate, an Angiotensin II Converting Enzyme activator, in front of diarrheic disorders |
author |
Souza, Luan Kelves Miranda de |
author_facet |
Souza, Luan Kelves Miranda de Nogueira, Kerolayne de Melo Medeiros, Jand Venes Rolim |
author_role |
author |
author2 |
Nogueira, Kerolayne de Melo Medeiros, Jand Venes Rolim |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Souza, Luan Kelves Miranda de Nogueira, Kerolayne de Melo Medeiros, Jand Venes Rolim |
dc.subject.por.fl_str_mv |
Angiotensin ACE II Diarrhea. Angiotensina ECA II Diarrea. Angiotensina ECA II Diarreia. |
topic |
Angiotensin ACE II Diarrhea. Angiotensina ECA II Diarrea. Angiotensina ECA II Diarreia. |
description |
Diarrhea, which is a gastrointestinal disease, has as its main characteristic the rapid passage of gastric contents through the intestine, which leads to the loss of water and electrolytes and consequent dehydration. The most common fluid replacement is the use of oral rehydration solution (ORS) together with the use of the drug loperamide. However, the use of this medication can cause severe bacteremia followed by sepsis and even death. Currently, there is no effective pharmacological treatment for diarrhea, therefore, it is noted the importance of seeking new therapeutic targets for the treatment of this disease. Thus, the aim of the present study was to conduct a research on the biological activities already described for Diminazene Aceturate with a special focus on antidiarrheal agents. For this, a survey was carried out, through patent filing searches, in the USPTO, EPO, WIPO and INPI databases, using keywords and Boolean operators. Thus, it was found in the international patent databases the number of documents referring to the use of Diminazene Aceturate in several areas, mainly in the pharmaceutical industry, but with a relatively low number of documents regarding the description of possible antidiarrheal action of the compound under study , which reinforces the innovative character of research involving the use of Diminazene Aceturate as an antidiarrheal agent. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-11 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/10755 10.33448/rsd-v9i12.10755 |
url |
https://rsdjournal.org/index.php/rsd/article/view/10755 |
identifier_str_mv |
10.33448/rsd-v9i12.10755 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/10755/9602 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 9 No. 12; e1691210755 Research, Society and Development; Vol. 9 Núm. 12; e1691210755 Research, Society and Development; v. 9 n. 12; e1691210755 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052665813794816 |