LGALS3 +191A and +292C polymorphisms are associated with a reduction in serum gal-3 levels, but not with the clinical events of individuals with sickle cell anemia

• Autor(a) principal: Ó, Kleyton Palmeira do
• Data de Publicação: 2020
• Outros Autores: Mendonça-Belmont, Taciana Furtado de, Farias, Isabela Cristina Cordeiro, Silva, Andreia Soares da, Freire, Ana Karla da Silva, Moura, Patrícia Muniz Mendes Freire de, Vasconcelos, Luydson Richardson Silva, Araújo, Aderson da Silva, Arcanjo, Gabriela da Silva, Falcão, Diego Arruda, Hatzlhofer, Betânia Lucena Domingues, Lucena-Araújo , Antônio Roberto, Bezerra, Marcos André Cavalcanti, Cavalcanti, Maria do Socorro de Mendonça
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Research, Society and Development
• Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/7314
• topic: Galectin-3; LGALS3; Polymorphism; Sickle cell anemia.; Galectin-3; LGALS3; Polimorfismo; Anemia falciforme.; Galectina-3; LGALS3; Polimorfismo; Anemia falciforme.

Objective: This study aimed to evaluate whether the single nucleotide polymorphisms (SNPs) +191 C>A (rs4644) and +292 A>C (rs4652) of the LGALS3 gene and the serum levels of galectin-3 (gal-3) are associated with clinical events in patients with sickle cell anemia (SCA). Methods: SNP +191 and +292 of the LGALS3 gene were detected by the TaqMan PCR system in real time. Gal-3 levels were measured in serum by ELISA. The study included 322 patients, mean age 36 (21-84). Results: AA and CA genotypes of the +191 region were related to lower levels of gal-3 when compared to CC genotype (p=0.0296). Lower level of gal-3 was also associated with the +191/+292 (AA/CC; CA/CC) diplotypes (p=0.0137) compared to the diplotypes (CC/AA; CC/CC; CC/AC; CA/AC). There was no association between serum levels of galectin-3 and genotype frequencies of the LGALS3 +191 and +292 polymorphisms with clinical events in SCA. Conclusion: The polymorphisms +191 and +292 of the LGALS3 are associated to decrease in serum levels of gal-3. However, no association of polymorphisms and levels of gal-3 with clinical events was observed in patients SCA.