Inhibitory Effect of (-)-myrtenol alone and in combination with antifungal agents on Candida spp.

Detalhes bibliográficos
Autor(a) principal: Cavalcanti, Bruno Bezerra
Data de Publicação: 2021
Outros Autores: Diniz Neto, Hermes, Silva-Rocha, Walicyranison Plinio da, Lima, Edeltrudes de Oliveira, Barbosa Filho, José Maria, Castro, Ricardo Dias de, Sampaio, Fabio Correia, Guerra, Felipe Queiroga Sarmento
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/22434
Resumo: The aim of this study was to examine the effects of (-)-myrtenol alone and combined with antifungal agents against Candida spp. The Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration of (-)-myrtenol and fluconazole against C. albicans and C. parapsilosis strains was obtained using CLSI guidelines. Combination of (-)-myrtenol with antifungal drugs was determined by checkboard test. The (-) myrtenol showed MIC ranging from 256 to 512 µg/mL against both species assay. And the MFC was 512 µg/mL, demonstrated nature fungicidal (MFC/MIC < 4). In addition, combination of antifungal agents (amphotericin B and fluconazole) and (-) myrtenol showed synergistic and additive effects on strains assays. Based on these results, the present study demonstrates that (-) myrtenol showed strong fungicide activity against Candida spp. In addition, Combination of antifungal agents and (-) myrtenol reduces the effective concentrations of both the agents with synergistic to additive effects. Therefore, (-) myrtenol has potential to be developed into an antifungal agent.
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spelling Inhibitory Effect of (-)-myrtenol alone and in combination with antifungal agents on Candida spp.Efecto inhibidor del (-)-myrtenol solo y en combinación con agentes antifúngicos sobre Candida spp.Efeito inibitório do (-)-myrtenol sozinho e em combinação com agentes antifúngicos sobre Candida spp.MonoterpenesAntifungal activityNatural productsAlternative therapy.MonoterpenoAtividade antifúngicaProduto naturalTerapia alternativa.MonoterpenoActividad antifúngicaProducto naturalTerapia alternativa.The aim of this study was to examine the effects of (-)-myrtenol alone and combined with antifungal agents against Candida spp. The Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration of (-)-myrtenol and fluconazole against C. albicans and C. parapsilosis strains was obtained using CLSI guidelines. Combination of (-)-myrtenol with antifungal drugs was determined by checkboard test. The (-) myrtenol showed MIC ranging from 256 to 512 µg/mL against both species assay. And the MFC was 512 µg/mL, demonstrated nature fungicidal (MFC/MIC < 4). In addition, combination of antifungal agents (amphotericin B and fluconazole) and (-) myrtenol showed synergistic and additive effects on strains assays. Based on these results, the present study demonstrates that (-) myrtenol showed strong fungicide activity against Candida spp. In addition, Combination of antifungal agents and (-) myrtenol reduces the effective concentrations of both the agents with synergistic to additive effects. Therefore, (-) myrtenol has potential to be developed into an antifungal agent.El objetivo de este estudio fue analizar los efectos del (-) - myrtenol solo y combinado con agentes antifúngicos contra Candida spp. La Concentración Inhibitoria Mínima (MIC) y la Concentración Fungicida Mínima de (-) - myrtenol y fluconazol contra cepas de C. albicans y C. parapsilosis se obtuvieron utilizando las pautas de CLSI. La combinación de (-) - myrtenol con fármacos antimicóticos se determinó mediante la prueba del tablero de ajedrez. El (-) myrtenol mostró una CIM que varió de 256 a 512 µg / mL contra ambas especies. Y la MFC fue de 512 µg / mL, demostró naturaleza fungicida (MFC / MIC <4). Además, la combinación de agentes antifúngicos (anfotericina B y fluconazol) y (-) myrtenol contra las cepas probadas mostró efectos sinérgicos y aditivos. Con base en estos resultados, el presente estudio demuestra que el (-) myrtenol tenía una fuerte actividad fungicida contra Candida spp. Además, la combinación de agentes antifúngicos y (-) myrtenol mostró efectos sinérgicos con los aditivos, con una reducción de la CMI de ambos agentes. Por lo tanto, el (-) myrtenol tiene el potencial de desarrollarse como un agente antifúngico.O objetivo deste estudo foi analisar os efeitos do (-) - mirtenol sozinho e combinado com agentes antifúngicos frente Candida spp. A Concentração Inibitória Mínima (CIM) e a Concentração Fungicida Mínima de (-) - mirtenol e fluconazol frente as cepas de C. albicans e C. parapsilosis foram obtidas usando as diretrizes de CLSI. A combinação de (-) - mirtenol com drogas antifúngicas foi determinada pelo teste de checkboard. (-) mirtenol apresentou CIM variando de 256 a 512 µg / mL frente ambas as espécies. E o MFC foi de 512 µg / mL, demonstrado natureza fungicida (MFC / MIC <4). Além disso, a combinação de agentes antifúngicos (anfotericina B e fluconazol) e (-) mirtenol frente as cepas ensaiadas apresentou efeitos sinérgicos e aditivos. Com base nesses resultados, o presente estudo demonstra que (-) mirtenol apresentou forte atividade fungicida contra Candida spp. Além disso, a combinação de agentes antifúngicos e (-) mirtenol demonstraram efeitos sinérgicos a aditivos, com redução da CIM de ambos agentes. Portanto, o (-) mirtenol tem potencial para ser desenvolvido como um agente antifúngico.Research, Society and Development2021-11-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2243410.33448/rsd-v10i15.22434Research, Society and Development; Vol. 10 No. 15; e35101522434Research, Society and Development; Vol. 10 Núm. 15; e35101522434Research, Society and Development; v. 10 n. 15; e351015224342525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/22434/20007Copyright (c) 2021 Bruno Bezerra Cavalcanti; Hermes Diniz Neto; Walicyranison Plinio da Silva-Rocha; Edeltrudes de Oliveira Lima; José Maria Barbosa Filho; Ricardo Dias de Castro; Fabio Correia Sampaio; Felipe Queiroga Sarmento Guerrahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCavalcanti, Bruno BezerraDiniz Neto, Hermes Silva-Rocha, Walicyranison Plinio da Lima, Edeltrudes de OliveiraBarbosa Filho, José MariaCastro, Ricardo Dias deSampaio, Fabio Correia Guerra, Felipe Queiroga Sarmento 2021-12-06T10:13:53Zoai:ojs.pkp.sfu.ca:article/22434Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:41:36.013440Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Inhibitory Effect of (-)-myrtenol alone and in combination with antifungal agents on Candida spp.
Efecto inhibidor del (-)-myrtenol solo y en combinación con agentes antifúngicos sobre Candida spp.
Efeito inibitório do (-)-myrtenol sozinho e em combinação com agentes antifúngicos sobre Candida spp.
title Inhibitory Effect of (-)-myrtenol alone and in combination with antifungal agents on Candida spp.
spellingShingle Inhibitory Effect of (-)-myrtenol alone and in combination with antifungal agents on Candida spp.
Cavalcanti, Bruno Bezerra
Monoterpenes
Antifungal activity
Natural products
Alternative therapy.
Monoterpeno
Atividade antifúngica
Produto natural
Terapia alternativa.
Monoterpeno
Actividad antifúngica
Producto natural
Terapia alternativa.
title_short Inhibitory Effect of (-)-myrtenol alone and in combination with antifungal agents on Candida spp.
title_full Inhibitory Effect of (-)-myrtenol alone and in combination with antifungal agents on Candida spp.
title_fullStr Inhibitory Effect of (-)-myrtenol alone and in combination with antifungal agents on Candida spp.
title_full_unstemmed Inhibitory Effect of (-)-myrtenol alone and in combination with antifungal agents on Candida spp.
title_sort Inhibitory Effect of (-)-myrtenol alone and in combination with antifungal agents on Candida spp.
author Cavalcanti, Bruno Bezerra
author_facet Cavalcanti, Bruno Bezerra
Diniz Neto, Hermes
Silva-Rocha, Walicyranison Plinio da
Lima, Edeltrudes de Oliveira
Barbosa Filho, José Maria
Castro, Ricardo Dias de
Sampaio, Fabio Correia
Guerra, Felipe Queiroga Sarmento
author_role author
author2 Diniz Neto, Hermes
Silva-Rocha, Walicyranison Plinio da
Lima, Edeltrudes de Oliveira
Barbosa Filho, José Maria
Castro, Ricardo Dias de
Sampaio, Fabio Correia
Guerra, Felipe Queiroga Sarmento
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cavalcanti, Bruno Bezerra
Diniz Neto, Hermes
Silva-Rocha, Walicyranison Plinio da
Lima, Edeltrudes de Oliveira
Barbosa Filho, José Maria
Castro, Ricardo Dias de
Sampaio, Fabio Correia
Guerra, Felipe Queiroga Sarmento
dc.subject.por.fl_str_mv Monoterpenes
Antifungal activity
Natural products
Alternative therapy.
Monoterpeno
Atividade antifúngica
Produto natural
Terapia alternativa.
Monoterpeno
Actividad antifúngica
Producto natural
Terapia alternativa.
topic Monoterpenes
Antifungal activity
Natural products
Alternative therapy.
Monoterpeno
Atividade antifúngica
Produto natural
Terapia alternativa.
Monoterpeno
Actividad antifúngica
Producto natural
Terapia alternativa.
description The aim of this study was to examine the effects of (-)-myrtenol alone and combined with antifungal agents against Candida spp. The Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration of (-)-myrtenol and fluconazole against C. albicans and C. parapsilosis strains was obtained using CLSI guidelines. Combination of (-)-myrtenol with antifungal drugs was determined by checkboard test. The (-) myrtenol showed MIC ranging from 256 to 512 µg/mL against both species assay. And the MFC was 512 µg/mL, demonstrated nature fungicidal (MFC/MIC < 4). In addition, combination of antifungal agents (amphotericin B and fluconazole) and (-) myrtenol showed synergistic and additive effects on strains assays. Based on these results, the present study demonstrates that (-) myrtenol showed strong fungicide activity against Candida spp. In addition, Combination of antifungal agents and (-) myrtenol reduces the effective concentrations of both the agents with synergistic to additive effects. Therefore, (-) myrtenol has potential to be developed into an antifungal agent.
publishDate 2021
dc.date.none.fl_str_mv 2021-11-17
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/22434
10.33448/rsd-v10i15.22434
url https://rsdjournal.org/index.php/rsd/article/view/22434
identifier_str_mv 10.33448/rsd-v10i15.22434
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/22434/20007
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 15; e35101522434
Research, Society and Development; Vol. 10 Núm. 15; e35101522434
Research, Society and Development; v. 10 n. 15; e35101522434
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
_version_ 1797052790450683904

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