Clinical and perinatal outcomes of unvaccinated pregnant women with and without Covid-19 undergoing cesarean delivery: a retrospective cohort study

Detalhes bibliográficos
Autor(a) principal: Yamada, Eduardo Jorge
Data de Publicação: 2023
Outros Autores: Rohden, Guilherme Barasuol, Petró, Gabriel de Sousa, Marques, Clandio Timm, Schwarzbold, Alexandre Vargas, Backes, Dirce Stein
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/40495
Resumo: Objective: To describe the clinical and perinatal outcomes of unvaccinated pregnant women with Covid-19 who underwent cesarean delivery in a reference maternity hospital in southern Brazil, and compare them with those of unvaccinated pregnant women with similar characteristics, without Covid-19 infection. 19. Methods: This was a retrospective cohort study, carried out between December 2021 and August 2022. The studied population consisted of pregnant women with Covid-19 who were not immunized with the vaccine against Covid-19 (n=91), compared to a control group of unvaccinated pregnant women without evidence of previous or current infection with Covid-19 (n= 57). The tests used for statistical analysis were: t test for unpaired independent samples, Mann-Whitney test, chi-square test and two-tailed Fisher's exact test with Freeman-Halton extension. As outcomes, ICU admission and deaths of pregnant women and newborns in both groups were investigated. Results: there was a greater tendency towards ICU admission and death in pregnant women with Covid-19 (RR= 9.4; 95% CI: 0.55 – 162.5) and (RR = 3.15; 95% CI: 0.15 – 64.50), respectively. Newborns had a higher risk of admission to the Neonatal ICU (RR = 1.73; 95% CI: 0.73 – 4.14) and a greater chance of death (RR = 2.45, 95% CI: 0.28 – 21.40). Conclusions: pregnant women with Covid-19 and their newborns had a higher risk of hospitalization in the ICU/Neonatal ICU and a higher risk of death.
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spelling Clinical and perinatal outcomes of unvaccinated pregnant women with and without Covid-19 undergoing cesarean delivery: a retrospective cohort studyResultados clínicos y perinatales de mujeres embarazadas no vacunadas con y sin Covid-19 sometidas a parto por cesárea: un estudio de cohorte retrospectivoDesfechos clínicos e perinatais de gestantes com e sem Covid-19 não vacinadas submetidas a parto cesariano: estudo de coorte retrospectivoCovid-19EmbarazadasAnestesia espinalCesárea.Covid-19PregnancySpinal anesthesiaCesarean section.Covid-19RaquianestesiaGestantesCesárea.Objective: To describe the clinical and perinatal outcomes of unvaccinated pregnant women with Covid-19 who underwent cesarean delivery in a reference maternity hospital in southern Brazil, and compare them with those of unvaccinated pregnant women with similar characteristics, without Covid-19 infection. 19. Methods: This was a retrospective cohort study, carried out between December 2021 and August 2022. The studied population consisted of pregnant women with Covid-19 who were not immunized with the vaccine against Covid-19 (n=91), compared to a control group of unvaccinated pregnant women without evidence of previous or current infection with Covid-19 (n= 57). The tests used for statistical analysis were: t test for unpaired independent samples, Mann-Whitney test, chi-square test and two-tailed Fisher's exact test with Freeman-Halton extension. As outcomes, ICU admission and deaths of pregnant women and newborns in both groups were investigated. Results: there was a greater tendency towards ICU admission and death in pregnant women with Covid-19 (RR= 9.4; 95% CI: 0.55 – 162.5) and (RR = 3.15; 95% CI: 0.15 – 64.50), respectively. Newborns had a higher risk of admission to the Neonatal ICU (RR = 1.73; 95% CI: 0.73 – 4.14) and a greater chance of death (RR = 2.45, 95% CI: 0.28 – 21.40). Conclusions: pregnant women with Covid-19 and their newborns had a higher risk of hospitalization in the ICU/Neonatal ICU and a higher risk of death.Meta: Describir los resultados clínicos y perinatales de gestantes no vacunadas con Covid-19 que se sometieron a parto por cesárea en una maternidad de referencia en el sur de Brasil, y compararlos con los de gestantes no vacunadas de similares características, sin infección por Covid-1919.  Métodos: Este fue un estudio de cohorte retrospectivo, realizado entre diciembre de 2021 y agosto de 2022. La población estudiada estuvo conformada por gestantes con Covid-19 que no fueron inmunizadas con la vacuna contra el Covid-19 (n=91), frente a un grupo control de gestantes no vacunadas sin evidencia de infección previa o actual por Covid-19 (n = 57). Las pruebas utilizadas para el análisis estadístico fueron: prueba t para muestras independientes no apareadas, prueba de Mann-Whitney, prueba de chi-cuadrado y prueba exacta de Fisher de dos colas con extensión de Freeman-Halton. Como desenlaces se investigó el ingreso en la UCI y la muerte de gestantes y recién nacidos en ambos grupos. Resultados: hubo mayor tendencia al ingreso en UCI y muerte en gestantes con Covid-19 (RR= 9,4; IC 95%: 0,55 – 162,5) y (RR = 3,15; IC 95%: 0,15 – 64,50), respectivamente. Los recién nacidos tuvieron mayor riesgo de ingreso a UCI Neonatal (RR = 1,73; IC 95%: 0,73 – 4,14) y mayor probabilidad de muerte (RR = 2,45, IC 95%: 0,28 – 21,40). Conclusiones: las gestantes con Covid-19 y sus recién nacidos tuvieron mayor riesgo de hospitalización en UCI/UCI Neonatal y mayor riesgo de muerte.Objetivo: Descrever os desfechos clínicos e perinatais de gestantes com Covid-19 não vacinadas submetidas a parto cesariano em uma maternidade de referência do Sul do Brasil, e compará-los com os de gestantes não vacinadas, de características similares, sem infecção por Covid-19. Métodos: Tratou-se de um estudo de coorte retrospectivo, realizado entre dezembro de 2021 a agosto de 2022. A população estudada foi constituída de gestantes com Covid-19 que não foram imunizadas com vacina contra Covid-19 (n=91), em relação a grupo controle de gestantes não vacinadas sem indícios de infecção prévia ou atual por Covid-19 (n=57). Os testes utilizados para análise estatística foram: teste t para amostras independentes não pareadas, teste de Mann-Whitne, teste do Qui-Quadrado e teste exato de Fisher bi-caudado com extensão de Freeman-Halton. Como desfechos, pesquisou-se a internação em UTI e óbito de gestantes e recém-nascidos nos dois grupos. Resultados: encontrou-se uma maior tendência de internação em UTI e óbito nas gestantes com Covid-19 (RR= 9,4; 95% CI: 0,55 – 162,5) e (RR = 3,15; 95% CI: 0,15 – 64,50), respectivamente. Os recém-nascidos apresentaram maior risco de internação na UTI Neonatal (RR = 1,73; 95% CI: 0,73 – 4,14) e maior possibilidade de morte (RR = 2,45, 95% CI: 0,28 – 21,40). Conclusões: as gestantes com Covid-19 e seus recém-nascidos apresentaram um maior risco de internação em UTI/UTI Neonatal e maior risco de óbito.Research, Society and Development2023-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/4049510.33448/rsd-v12i3.40495Research, Society and Development; Vol. 12 No. 3; e12312340495Research, Society and Development; Vol. 12 Núm. 3; e12312340495Research, Society and Development; v. 12 n. 3; e123123404952525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/40495/33107Copyright (c) 2023 Eduardo Jorge Yamada; Guilherme Barasuol Rohden; Gabriel de Sousa Petró; Clandio Timm Marques; Alexandre Vargas Schwarzbold; Dirce Stein Backeshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessYamada, Eduardo Jorge Rohden, Guilherme Barasuol Petró, Gabriel de Sousa Marques, Clandio Timm Schwarzbold, Alexandre Vargas Backes, Dirce Stein 2023-03-23T08:33:38Zoai:ojs.pkp.sfu.ca:article/40495Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2023-03-23T08:33:38Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Clinical and perinatal outcomes of unvaccinated pregnant women with and without Covid-19 undergoing cesarean delivery: a retrospective cohort study
Resultados clínicos y perinatales de mujeres embarazadas no vacunadas con y sin Covid-19 sometidas a parto por cesárea: un estudio de cohorte retrospectivo
Desfechos clínicos e perinatais de gestantes com e sem Covid-19 não vacinadas submetidas a parto cesariano: estudo de coorte retrospectivo
title Clinical and perinatal outcomes of unvaccinated pregnant women with and without Covid-19 undergoing cesarean delivery: a retrospective cohort study
spellingShingle Clinical and perinatal outcomes of unvaccinated pregnant women with and without Covid-19 undergoing cesarean delivery: a retrospective cohort study
Yamada, Eduardo Jorge
Covid-19
Embarazadas
Anestesia espinal
Cesárea.
Covid-19
Pregnancy
Spinal anesthesia
Cesarean section.
Covid-19
Raquianestesia
Gestantes
Cesárea.
title_short Clinical and perinatal outcomes of unvaccinated pregnant women with and without Covid-19 undergoing cesarean delivery: a retrospective cohort study
title_full Clinical and perinatal outcomes of unvaccinated pregnant women with and without Covid-19 undergoing cesarean delivery: a retrospective cohort study
title_fullStr Clinical and perinatal outcomes of unvaccinated pregnant women with and without Covid-19 undergoing cesarean delivery: a retrospective cohort study
title_full_unstemmed Clinical and perinatal outcomes of unvaccinated pregnant women with and without Covid-19 undergoing cesarean delivery: a retrospective cohort study
title_sort Clinical and perinatal outcomes of unvaccinated pregnant women with and without Covid-19 undergoing cesarean delivery: a retrospective cohort study
author Yamada, Eduardo Jorge
author_facet Yamada, Eduardo Jorge
Rohden, Guilherme Barasuol
Petró, Gabriel de Sousa
Marques, Clandio Timm
Schwarzbold, Alexandre Vargas
Backes, Dirce Stein
author_role author
author2 Rohden, Guilherme Barasuol
Petró, Gabriel de Sousa
Marques, Clandio Timm
Schwarzbold, Alexandre Vargas
Backes, Dirce Stein
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Yamada, Eduardo Jorge
Rohden, Guilherme Barasuol
Petró, Gabriel de Sousa
Marques, Clandio Timm
Schwarzbold, Alexandre Vargas
Backes, Dirce Stein
dc.subject.por.fl_str_mv Covid-19
Embarazadas
Anestesia espinal
Cesárea.
Covid-19
Pregnancy
Spinal anesthesia
Cesarean section.
Covid-19
Raquianestesia
Gestantes
Cesárea.
topic Covid-19
Embarazadas
Anestesia espinal
Cesárea.
Covid-19
Pregnancy
Spinal anesthesia
Cesarean section.
Covid-19
Raquianestesia
Gestantes
Cesárea.
description Objective: To describe the clinical and perinatal outcomes of unvaccinated pregnant women with Covid-19 who underwent cesarean delivery in a reference maternity hospital in southern Brazil, and compare them with those of unvaccinated pregnant women with similar characteristics, without Covid-19 infection. 19. Methods: This was a retrospective cohort study, carried out between December 2021 and August 2022. The studied population consisted of pregnant women with Covid-19 who were not immunized with the vaccine against Covid-19 (n=91), compared to a control group of unvaccinated pregnant women without evidence of previous or current infection with Covid-19 (n= 57). The tests used for statistical analysis were: t test for unpaired independent samples, Mann-Whitney test, chi-square test and two-tailed Fisher's exact test with Freeman-Halton extension. As outcomes, ICU admission and deaths of pregnant women and newborns in both groups were investigated. Results: there was a greater tendency towards ICU admission and death in pregnant women with Covid-19 (RR= 9.4; 95% CI: 0.55 – 162.5) and (RR = 3.15; 95% CI: 0.15 – 64.50), respectively. Newborns had a higher risk of admission to the Neonatal ICU (RR = 1.73; 95% CI: 0.73 – 4.14) and a greater chance of death (RR = 2.45, 95% CI: 0.28 – 21.40). Conclusions: pregnant women with Covid-19 and their newborns had a higher risk of hospitalization in the ICU/Neonatal ICU and a higher risk of death.
publishDate 2023
dc.date.none.fl_str_mv 2023-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/40495
10.33448/rsd-v12i3.40495
url https://rsdjournal.org/index.php/rsd/article/view/40495
identifier_str_mv 10.33448/rsd-v12i3.40495
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/40495/33107
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 12 No. 3; e12312340495
Research, Society and Development; Vol. 12 Núm. 3; e12312340495
Research, Society and Development; v. 12 n. 3; e12312340495
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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