Gingival enlargement due to Amlodipine: Case report
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | spa |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/17051 |
Resumo: | Gingival enlargement is an increase in the size of the gum mostly caused by inflammatory changes associated with the prolonged accumulation of biofilm and induced by drugs, among which calcium channel blockers such as amlodipine stands out. Amlodipine is a 3rd generation drug, commonly used to treat conditions such as hypertension, arrhythmias and angina pectoris. The prevalence recorded for amlodipine-induced gingival enlargement, in patients with heart disease, ranges between 3%. Gingival enlargement induced by amlodipine is due to an interaction between gingival fibroblasts, the biochemistry of inflammation mediators and drug metabolites. The following is a case report of a 57-year-old man, hypertensive, with amlodipine-induced gingival enlargement, and with a diagnosis of periodontitis stage 3 grade C, who underwent basic periodontal therapy treatment and amlodipine was replaced by another antihypertensive drug, additionally for the final resolution of the case, a gingivectomy and open flap scaling and root planning in recurrent pockets was performed. It is concluded that the replacement of the drug induced gingival enlargement and adequate periodontal therapy can improve the patient’s gingival health and quality of life. |
id |
UNIFEI_3d067c9bc59739607468aa839cf63cba |
---|---|
oai_identifier_str |
oai:ojs.pkp.sfu.ca:article/17051 |
network_acronym_str |
UNIFEI |
network_name_str |
Research, Society and Development |
repository_id_str |
|
spelling |
Gingival enlargement due to Amlodipine: Case reportAgrandamiento gingival por amlodipina: Reporte de caso Aumento gengival devido à amlodipina: Relato de casoAmlodipineCalcium channel blockersGingival enlargementPeriodontitisBiofilm.AmlodipinaBloqueadores de canales de calcioAgrandamiento gingivalPeriodontitisBiopelícula dental.AmlodipinaBloqueadores dos canais de cálcioAumento gengivalPeriodontiteBiofilme.Gingival enlargement is an increase in the size of the gum mostly caused by inflammatory changes associated with the prolonged accumulation of biofilm and induced by drugs, among which calcium channel blockers such as amlodipine stands out. Amlodipine is a 3rd generation drug, commonly used to treat conditions such as hypertension, arrhythmias and angina pectoris. The prevalence recorded for amlodipine-induced gingival enlargement, in patients with heart disease, ranges between 3%. Gingival enlargement induced by amlodipine is due to an interaction between gingival fibroblasts, the biochemistry of inflammation mediators and drug metabolites. The following is a case report of a 57-year-old man, hypertensive, with amlodipine-induced gingival enlargement, and with a diagnosis of periodontitis stage 3 grade C, who underwent basic periodontal therapy treatment and amlodipine was replaced by another antihypertensive drug, additionally for the final resolution of the case, a gingivectomy and open flap scaling and root planning in recurrent pockets was performed. It is concluded that the replacement of the drug induced gingival enlargement and adequate periodontal therapy can improve the patient’s gingival health and quality of life.El agrandamiento gingival es el aumento del volumen de la encía mayormente ocasionado por cambios inflamatorios asociados a la acumulación prolongada de biopelícula dental e inducido por fármacos, dentro de los cuales los bloqueadores de calcio como la amlodipina se destacan. La amlodipina es un fármaco de 3era generación, comúnmente usado para tratar condiciones como la hipertensión, arritmias y anginas de pecho. La prevalencia registrada para el agrandamiento gingival inducido por amlodipina, en pacientes con cardiopatías, oscila entre un 3%. El agrandamiento gingival inducido por amlodipina se debe a una interacción entre los fibroblastos gingivales, la bioquímica de los mediadores de la inflamación y los metabolitos del medicamento. A continuación, se presenta el reporte de caso de un hombre de 57 años, hipertenso, con agrandamiento gingival inducido por amlodipina, y con diagnóstico de Periodontitis estadio 3 grado C, en el que se realizó tratamiento de terapia básica periodontal y se sustituyó la amlodipina por otro fármaco antihipertensivo, adicionalmente para la resolución final del caso se realizó gingivectomía y raspado y alisado radicular a cielo abierto en bolsas recidivantes. Se concluye que la sustitución del fármaco inductor del agrandamiento gingival y una adecuada terapia periodontal puede mejorar la salud gingival del paciente y su calidad de vida.O aumento gengival é o aumento do volume gengival, causado principalmente por alterações inflamatórias associadas ao acúmulo prolongado de biofilme e induzidas por drogas, entre as quais se destacam os bloqueadores dos canais de cálcio como a amlodipina. A amlodipina é um medicamento de 3ª geração, comumente usados para tratar doenças como hipertensão, arritmias e angina de peito. A prevalência registrada para aumento gengival induzido por amlodipina em pacientes com doença cardíaca varia entre 3%. O aumento gengival induzido por amlodipina é devido a uma interação entre fibroblastos gengivais, a bioquímica de mediadores inflamatórios e metabólitos de drogas. A seguir, é relatado o caso de um homem de 57 anos, hipertenso, com aumento gengival induzido por Amlodipina, e com diagnóstico de Periodontite estádio 3 grau C, no qual foi realizado tratamento com terapia periodontal básica e amlodipina foi substituída por outro anti-hipertensivo além disso, para a resolução final do caso, foi realizada gengivectomia e a raspagem e alisamento radicular em campo aberto nas bolsas recorrentes. Conclui-se que a reposição do fármaco que induz aumento gengival e adequada terapia periodontal pode melhorar a saúde gengival e a qualidade de vida do paciente.Research, Society and Development2021-06-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1705110.33448/rsd-v10i7.17051Research, Society and Development; Vol. 10 No. 7; e44910717051Research, Society and Development; Vol. 10 Núm. 7; e44910717051Research, Society and Development; v. 10 n. 7; e449107170512525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIspahttps://rsdjournal.org/index.php/rsd/article/view/17051/15010Copyright (c) 2021 Valentina Martinez Peraza; Katherine Andrea Romero Espinozahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMartinez Peraza, ValentinaRomero Espinoza, Katherine Andrea2021-07-18T21:07:03Zoai:ojs.pkp.sfu.ca:article/17051Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:37:27.130651Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Gingival enlargement due to Amlodipine: Case report Agrandamiento gingival por amlodipina: Reporte de caso Aumento gengival devido à amlodipina: Relato de caso |
title |
Gingival enlargement due to Amlodipine: Case report |
spellingShingle |
Gingival enlargement due to Amlodipine: Case report Martinez Peraza, Valentina Amlodipine Calcium channel blockers Gingival enlargement Periodontitis Biofilm. Amlodipina Bloqueadores de canales de calcio Agrandamiento gingival Periodontitis Biopelícula dental. Amlodipina Bloqueadores dos canais de cálcio Aumento gengival Periodontite Biofilme. |
title_short |
Gingival enlargement due to Amlodipine: Case report |
title_full |
Gingival enlargement due to Amlodipine: Case report |
title_fullStr |
Gingival enlargement due to Amlodipine: Case report |
title_full_unstemmed |
Gingival enlargement due to Amlodipine: Case report |
title_sort |
Gingival enlargement due to Amlodipine: Case report |
author |
Martinez Peraza, Valentina |
author_facet |
Martinez Peraza, Valentina Romero Espinoza, Katherine Andrea |
author_role |
author |
author2 |
Romero Espinoza, Katherine Andrea |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Martinez Peraza, Valentina Romero Espinoza, Katherine Andrea |
dc.subject.por.fl_str_mv |
Amlodipine Calcium channel blockers Gingival enlargement Periodontitis Biofilm. Amlodipina Bloqueadores de canales de calcio Agrandamiento gingival Periodontitis Biopelícula dental. Amlodipina Bloqueadores dos canais de cálcio Aumento gengival Periodontite Biofilme. |
topic |
Amlodipine Calcium channel blockers Gingival enlargement Periodontitis Biofilm. Amlodipina Bloqueadores de canales de calcio Agrandamiento gingival Periodontitis Biopelícula dental. Amlodipina Bloqueadores dos canais de cálcio Aumento gengival Periodontite Biofilme. |
description |
Gingival enlargement is an increase in the size of the gum mostly caused by inflammatory changes associated with the prolonged accumulation of biofilm and induced by drugs, among which calcium channel blockers such as amlodipine stands out. Amlodipine is a 3rd generation drug, commonly used to treat conditions such as hypertension, arrhythmias and angina pectoris. The prevalence recorded for amlodipine-induced gingival enlargement, in patients with heart disease, ranges between 3%. Gingival enlargement induced by amlodipine is due to an interaction between gingival fibroblasts, the biochemistry of inflammation mediators and drug metabolites. The following is a case report of a 57-year-old man, hypertensive, with amlodipine-induced gingival enlargement, and with a diagnosis of periodontitis stage 3 grade C, who underwent basic periodontal therapy treatment and amlodipine was replaced by another antihypertensive drug, additionally for the final resolution of the case, a gingivectomy and open flap scaling and root planning in recurrent pockets was performed. It is concluded that the replacement of the drug induced gingival enlargement and adequate periodontal therapy can improve the patient’s gingival health and quality of life. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-28 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/17051 10.33448/rsd-v10i7.17051 |
url |
https://rsdjournal.org/index.php/rsd/article/view/17051 |
identifier_str_mv |
10.33448/rsd-v10i7.17051 |
dc.language.iso.fl_str_mv |
spa |
language |
spa |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/17051/15010 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Valentina Martinez Peraza; Katherine Andrea Romero Espinoza https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Valentina Martinez Peraza; Katherine Andrea Romero Espinoza https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 7; e44910717051 Research, Society and Development; Vol. 10 Núm. 7; e44910717051 Research, Society and Development; v. 10 n. 7; e44910717051 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
_version_ |
1797052751421636608 |