Risks associated with undirected use of hormonal anabolizers

Detalhes bibliográficos
Autor(a) principal: Souza , Denise Santos de
Data de Publicação: 2021
Outros Autores: Souza, Ederson Ferreira de, Pereira, Swemy Oliveira
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/22552
Resumo: Introduction: Testosterone, the so-called male hormone, is the most important androgen in the body. In men, most testosterone is produced in the testes by Leydigin cells. In women, testosterone levels are much lower than in men. However, it also has an important effect on the female body. Hormonal regulation of testosterone is maintained and controlled by the hypothalamic-pituitary-gonad axis. Objective: To demonstrate the risks associated with the unguided use of anabolic androgen steroids for muscle hypertrophy purposes. Methods: This is a systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (Prism) technique. The bibliographic research was carried out in the following databases: Medline (via PubMed), Scientific Electronic Library Online (Scielo) and the Virtual Health Library (VHL), published between 2014 and 2021 with exploratory objectives and a qualitative approach. The following descriptors were used: anabolic androgenic steroids and testosterone, anabolic androgenic steroids and indiscriminate use, anabolic androgenic steroids and adverse effects, indiscriminate use and testosterone, adverse effects and testosterone. Results: Initially, 56 studies were selected in the PUBMED, Scielo and BVS databases, after a more detailed reading, 9 articles used in this article were chosen. As a result of long-term androgen use, the testes can be significantly reduced. Conclusions: The negative effects of the use of anabolic steroids do not disappear completely after discontinuing their use, among the undesirable effects such as the risk of cardiovascular diseases, masculinity in women, muscle hypertrophy and liver damage, among others.
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spelling Risks associated with undirected use of hormonal anabolizersRiesgos asociados con el uso no dirigido de anabolizantes hormonalesOs riscos associados pelo uso não orientado de anabolizantes hormonaisEsteroides Anabólicos AndrogênicosRiscosFarmacêutico.Esteroides Androgénicos AnabólicosRiesgosFarmacéuticos.Anabolic Androgenic SteroidsRisksPharmaceutical.Introduction: Testosterone, the so-called male hormone, is the most important androgen in the body. In men, most testosterone is produced in the testes by Leydigin cells. In women, testosterone levels are much lower than in men. However, it also has an important effect on the female body. Hormonal regulation of testosterone is maintained and controlled by the hypothalamic-pituitary-gonad axis. Objective: To demonstrate the risks associated with the unguided use of anabolic androgen steroids for muscle hypertrophy purposes. Methods: This is a systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (Prism) technique. The bibliographic research was carried out in the following databases: Medline (via PubMed), Scientific Electronic Library Online (Scielo) and the Virtual Health Library (VHL), published between 2014 and 2021 with exploratory objectives and a qualitative approach. The following descriptors were used: anabolic androgenic steroids and testosterone, anabolic androgenic steroids and indiscriminate use, anabolic androgenic steroids and adverse effects, indiscriminate use and testosterone, adverse effects and testosterone. Results: Initially, 56 studies were selected in the PUBMED, Scielo and BVS databases, after a more detailed reading, 9 articles used in this article were chosen. As a result of long-term androgen use, the testes can be significantly reduced. Conclusions: The negative effects of the use of anabolic steroids do not disappear completely after discontinuing their use, among the undesirable effects such as the risk of cardiovascular diseases, masculinity in women, muscle hypertrophy and liver damage, among others.Introducción: La testosterona, la llamada hormona masculina, es el andrógeno más importante del organismo. En los hombres, la mayor parte de la testosterona es producida en los testículos por las células de Leydigin. En las mujeres, los niveles de testosterona son mucho más bajos que en los hombres. Sin embargo, también tiene un efecto importante en el cuerpo femenino. La regulación hormonal de la testosterona se mantiene y controla mediante el eje hipotalámico-pituitario-gónada. Objetivo: Demostrar los riesgos asociados con el uso no guiado de esteroides andrógenos anabólicos con fines de hipertrofia muscular. Métodos: Ésta es una revisión sistemática que utiliza la técnica de elementos de informe preferidos para revisiones sistemáticas y metanálisis (Prism). La investigación bibliográfica se realizó en las siguientes bases de datos: Medline (vía PubMed), Scientific Electronic Library Online (Scielo) y Virtual Health Library (BVS), publicadas entre 2014 y 2021 con objetivos exploratorios y un enfoque cualitativo. Se utilizaron los siguientes descriptores: esteroides androgénicos anabólicos y testosterona, esteroides androgénicos anabólicos y uso indiscriminado, esteroides androgénicos anabólicos y efectos adversos, uso indiscriminado y testosterona, efectos adversos y testosterona. Resultados: Inicialmente se seleccionaron 56 estudios en las bases de datos PUBMED, Scielo y BVS, luego de una lectura más detallada se eligieron 9 artículos utilizados en este artículo. Como resultado del uso prolongado de andrógenos, los testículos pueden reducirse significativamente. Conclusiones: Los efectos negativos del uso de esteroides anabólicos no desaparecen por completo después de suspender su uso, entre los efectos indeseables como el riesgo de enfermedad cardiovascular, masculinización en la mujer, hipertrofia muscular y daño hepático, entre otros.Introdução: A testosterona, o chamado hormônio masculino, é o andrógeno mais importante do corpo. Nos homens, a maior parte da testosterona é produzida nos testículos pelas células de Leydigin. Nas mulheres, os níveis de testosterona são muito mais baixos do que nos homens. No entanto, também tem um efeito importante no corpo feminino. A regulação hormonal da testosterona é mantida e controlada pelo eixo hipotálamo-hipófise-gônada. Objetivo: Evidenciar os riscos associados ao uso não orientado dos esteroides anabolizantes andrógenos para fins de hipertrofia muscular. Métodos: Refere-se a uma revisão sistemática, com o uso da técnica Preferred Reporting Items for Systematic Reviews and Meta-analyses (Prisma). A pesquisa bibliográfica foi realizada nas bases de dados: Medline (via PubMed), Scientific Electronic Library Online (Scielo) e na Biblioteca Virtual da Saúde (BVS), publicados entre 2014 e 2021 com objetivos exploratórios e abordagem qualitativa. Utilizou-se como descritores: esteroides anabolizantes androgênicos e testosterona, esteroides anabolizantes androgênicos e uso indiscriminado, esteroides anabolizantes androgênicos e efeitos adversos, uso indiscriminado e testosterona, efeitos adversos e testosterona. Resultados: Inicialmente selecionou-se 56 estudos nas bases de dados PUBMED, Scielo e BVS, após uma leitura mais detalhada elegeu-se 9 artigos utilizados nesse artigo. Como resultado do uso de andrógenos a longo prazo, os testículos podem ser significativamente reduzidos. Conclusões: Os efeitos negativos do uso de anabolizantes esteróides não desaparecem totalmente após a suspensão do seu uso, entre os efeitos indesejáveis como o risco de acometimento de doenças cardiovasculares, masculinazação em mulheres, hipertrofia muscular e lesões hepáticas entre outras.Research, Society and Development2021-11-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2255210.33448/rsd-v10i14.22552Research, Society and Development; Vol. 10 No. 14; e551101422552Research, Society and Development; Vol. 10 Núm. 14; e551101422552Research, Society and Development; v. 10 n. 14; e5511014225522525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/22552/19886Copyright (c) 2021 Denise Santos de Souza ; Ederson Ferreira de Souza; Swemy Oliveira Pereirahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSouza , Denise Santos de Souza, Ederson Ferreira de Pereira, Swemy Oliveira 2021-12-04T11:48:39Zoai:ojs.pkp.sfu.ca:article/22552Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:41:41.175289Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Risks associated with undirected use of hormonal anabolizers
Riesgos asociados con el uso no dirigido de anabolizantes hormonales
Os riscos associados pelo uso não orientado de anabolizantes hormonais
title Risks associated with undirected use of hormonal anabolizers
spellingShingle Risks associated with undirected use of hormonal anabolizers
Souza , Denise Santos de
Esteroides Anabólicos Androgênicos
Riscos
Farmacêutico.
Esteroides Androgénicos Anabólicos
Riesgos
Farmacéuticos.
Anabolic Androgenic Steroids
Risks
Pharmaceutical.
title_short Risks associated with undirected use of hormonal anabolizers
title_full Risks associated with undirected use of hormonal anabolizers
title_fullStr Risks associated with undirected use of hormonal anabolizers
title_full_unstemmed Risks associated with undirected use of hormonal anabolizers
title_sort Risks associated with undirected use of hormonal anabolizers
author Souza , Denise Santos de
author_facet Souza , Denise Santos de
Souza, Ederson Ferreira de
Pereira, Swemy Oliveira
author_role author
author2 Souza, Ederson Ferreira de
Pereira, Swemy Oliveira
author2_role author
author
dc.contributor.author.fl_str_mv Souza , Denise Santos de
Souza, Ederson Ferreira de
Pereira, Swemy Oliveira
dc.subject.por.fl_str_mv Esteroides Anabólicos Androgênicos
Riscos
Farmacêutico.
Esteroides Androgénicos Anabólicos
Riesgos
Farmacéuticos.
Anabolic Androgenic Steroids
Risks
Pharmaceutical.
topic Esteroides Anabólicos Androgênicos
Riscos
Farmacêutico.
Esteroides Androgénicos Anabólicos
Riesgos
Farmacéuticos.
Anabolic Androgenic Steroids
Risks
Pharmaceutical.
description Introduction: Testosterone, the so-called male hormone, is the most important androgen in the body. In men, most testosterone is produced in the testes by Leydigin cells. In women, testosterone levels are much lower than in men. However, it also has an important effect on the female body. Hormonal regulation of testosterone is maintained and controlled by the hypothalamic-pituitary-gonad axis. Objective: To demonstrate the risks associated with the unguided use of anabolic androgen steroids for muscle hypertrophy purposes. Methods: This is a systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (Prism) technique. The bibliographic research was carried out in the following databases: Medline (via PubMed), Scientific Electronic Library Online (Scielo) and the Virtual Health Library (VHL), published between 2014 and 2021 with exploratory objectives and a qualitative approach. The following descriptors were used: anabolic androgenic steroids and testosterone, anabolic androgenic steroids and indiscriminate use, anabolic androgenic steroids and adverse effects, indiscriminate use and testosterone, adverse effects and testosterone. Results: Initially, 56 studies were selected in the PUBMED, Scielo and BVS databases, after a more detailed reading, 9 articles used in this article were chosen. As a result of long-term androgen use, the testes can be significantly reduced. Conclusions: The negative effects of the use of anabolic steroids do not disappear completely after discontinuing their use, among the undesirable effects such as the risk of cardiovascular diseases, masculinity in women, muscle hypertrophy and liver damage, among others.
publishDate 2021
dc.date.none.fl_str_mv 2021-11-13
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/22552
10.33448/rsd-v10i14.22552
url https://rsdjournal.org/index.php/rsd/article/view/22552
identifier_str_mv 10.33448/rsd-v10i14.22552
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/22552/19886
dc.rights.driver.fl_str_mv Copyright (c) 2021 Denise Santos de Souza ; Ederson Ferreira de Souza; Swemy Oliveira Pereira
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Denise Santos de Souza ; Ederson Ferreira de Souza; Swemy Oliveira Pereira
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 14; e551101422552
Research, Society and Development; Vol. 10 Núm. 14; e551101422552
Research, Society and Development; v. 10 n. 14; e551101422552
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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