Therapeutic activities of isopulegol related to Dentistry: in silico study

Detalhes bibliográficos
Autor(a) principal: Sousa, Julliany Taverny
Data de Publicação: 2020
Outros Autores: Rolim, Ana Karina Almeida, Delgado, Letícia Ataíde, Araújo, Pedro Henrique de, Silva, Randerson Mattheus Moura da, Santos, Carlus Alberto Oliveira dos, Silva, Diego Filipe Bezerra, Cruz, José Henrique de Araújo, Souza, Smyrna Luiza Ximenes de, Campos, Fernanda de Araújo Trigueiro
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/4874
Resumo: Objective: To describe the therapeutic activities of monoterpene (-)- isopulegol applied to dentistry through an in silico study. Methods: To conduct the study in the in silico model, the software for Prediction of Activity Spectra for Substances (PASS) was used online, which provides the probability of being active (Pa) and the probability of being inactive (Pb) of the compound in question. The activities presented by the software were determined for this research according to the criterion: probability of being active greater than 0.5, with significant performance in dentistry. Results: Eight therapeutic activities with satisfactory indices for dentistry were found, where some of these activities already have studies proving their effectiveness. Conclusions: It is concluded that the compound isopulegol has therapeutic potential mainly as a mucomembranous, anti-inflammatory, antiparasitic and antifungal agent, requiring further research such as in vitro and in vivo studies to better clarify the compound and its respective mechanisms of action.
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spelling Therapeutic activities of isopulegol related to Dentistry: in silico studyActividades terapéuticas del isopulegol relacionadas con la odontología: estudio in silicoAtividades terapêuticas do isopulegol relacionadas à Odontologia: estudo in silicoMonoterpenesPhytotherapyDentistry.MonoterpenoFitoterapiaOdontología.MonoterpenosFitoterapiaOdontologia.Objective: To describe the therapeutic activities of monoterpene (-)- isopulegol applied to dentistry through an in silico study. Methods: To conduct the study in the in silico model, the software for Prediction of Activity Spectra for Substances (PASS) was used online, which provides the probability of being active (Pa) and the probability of being inactive (Pb) of the compound in question. The activities presented by the software were determined for this research according to the criterion: probability of being active greater than 0.5, with significant performance in dentistry. Results: Eight therapeutic activities with satisfactory indices for dentistry were found, where some of these activities already have studies proving their effectiveness. Conclusions: It is concluded that the compound isopulegol has therapeutic potential mainly as a mucomembranous, anti-inflammatory, antiparasitic and antifungal agent, requiring further research such as in vitro and in vivo studies to better clarify the compound and its respective mechanisms of action.Objetivo: describir las actividades terapéuticas del monoterpeno (-) - isopulegol aplicado a la odontología a través de un estudio in silico. Métodos: Para llevar a cabo el estudio en el modelo in silico, se utilizó en línea el software para la Especificación de actividad del espectro para sustancias (PASS), que proporciona la probabilidad de estar activo (Pa) y la probabilidad de estar inactivo (Pb) del compuesto en cuestión. estudiar. Las actividades presentadas por el software se determinaron para esta investigación de acuerdo con el criterio: probabilidad de estar activo mayor a 0.5, con un desempeño significativo en odontología. Resultados: Se encontraron ocho actividades terapéuticas con índices satisfactorios para la odontología, donde algunas de estas actividades ya tienen estudios que prueban su efectividad. Conclusiones: Se concluye que el compuesto isopulegol tiene potencial terapéutico principalmente como un agente mucomembranoso, antiinflamatorio, antiparasitario y antifúngico, que requiere más investigación como estudios in vitro e in vivo para aclarar mejor el compuesto y sus respectivos mecanismos de acción.Objetivo: Descrever as atividades terapêuticas do monoterpeno (-)- isopulegol aplicadas à odontologia por meio de estudo in silico. Métodos: Para a realização do estudo no modelo in silico, foi utilizado o software de Previsão do espectro de atividade para substâncias (PASS) online que fornece a probabilidade de ser ativo (Pa) e a probabilidade de ser inativo (Pb) do composto em estudo. As atividades apresentadas pelo software foram apuradas para esta pesquisa segundo o critério de: probabilidade de ser ativo maior que 0,5, com desempenho significativo na odontologia. Resultados: Foram encontradas oito atividades terapêuticas com índices satisfatórios voltados para a odontologia, onde algumas dessas atividades já apresentam estudos comprovando sua eficácia. Conclusões: Conclui-se que o composto isopulegol apresenta potencial terapêutico principalmente como protetor mucomembranoso, anti-inflamatório, antiparasitário e antifúngico, sendo necessário outras pesquisas como estudos in vitro e in vivo para melhor esclarecimento do composto e de seus respectivos mecanismos de ação.Research, Society and Development2020-06-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/487410.33448/rsd-v9i7.4874Research, Society and Development; Vol. 9 No. 7; e807974874Research, Society and Development; Vol. 9 Núm. 7; e807974874Research, Society and Development; v. 9 n. 7; e8079748742525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/4874/4231Copyright (c) 2020 Julliany Taverny Sousa, Ana Karina Almeida Rolim, Letícia Ataíde Delgado, Pedro Henrique de Araújo, Randerson Mattheus Moura da Silva, Carlus Alberto Oliveira dos Santos, Diego Filipe Bezerra Silva, José Henrique de Araújo Cruz, Smyrna Luiza Ximenes de Souza, Fernanda de Araújo Trigueiro Camposinfo:eu-repo/semantics/openAccessSousa, Julliany TavernyRolim, Ana Karina AlmeidaDelgado, Letícia AtaídeAraújo, Pedro Henrique deSilva, Randerson Mattheus Moura daSantos, Carlus Alberto Oliveira dosSilva, Diego Filipe BezerraCruz, José Henrique de AraújoSouza, Smyrna Luiza Ximenes deCampos, Fernanda de Araújo Trigueiro2020-08-20T18:05:03Zoai:ojs.pkp.sfu.ca:article/4874Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:28:35.098207Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Therapeutic activities of isopulegol related to Dentistry: in silico study
Actividades terapéuticas del isopulegol relacionadas con la odontología: estudio in silico
Atividades terapêuticas do isopulegol relacionadas à Odontologia: estudo in silico
title Therapeutic activities of isopulegol related to Dentistry: in silico study
spellingShingle Therapeutic activities of isopulegol related to Dentistry: in silico study
Sousa, Julliany Taverny
Monoterpenes
Phytotherapy
Dentistry.
Monoterpeno
Fitoterapia
Odontología.
Monoterpenos
Fitoterapia
Odontologia.
title_short Therapeutic activities of isopulegol related to Dentistry: in silico study
title_full Therapeutic activities of isopulegol related to Dentistry: in silico study
title_fullStr Therapeutic activities of isopulegol related to Dentistry: in silico study
title_full_unstemmed Therapeutic activities of isopulegol related to Dentistry: in silico study
title_sort Therapeutic activities of isopulegol related to Dentistry: in silico study
author Sousa, Julliany Taverny
author_facet Sousa, Julliany Taverny
Rolim, Ana Karina Almeida
Delgado, Letícia Ataíde
Araújo, Pedro Henrique de
Silva, Randerson Mattheus Moura da
Santos, Carlus Alberto Oliveira dos
Silva, Diego Filipe Bezerra
Cruz, José Henrique de Araújo
Souza, Smyrna Luiza Ximenes de
Campos, Fernanda de Araújo Trigueiro
author_role author
author2 Rolim, Ana Karina Almeida
Delgado, Letícia Ataíde
Araújo, Pedro Henrique de
Silva, Randerson Mattheus Moura da
Santos, Carlus Alberto Oliveira dos
Silva, Diego Filipe Bezerra
Cruz, José Henrique de Araújo
Souza, Smyrna Luiza Ximenes de
Campos, Fernanda de Araújo Trigueiro
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sousa, Julliany Taverny
Rolim, Ana Karina Almeida
Delgado, Letícia Ataíde
Araújo, Pedro Henrique de
Silva, Randerson Mattheus Moura da
Santos, Carlus Alberto Oliveira dos
Silva, Diego Filipe Bezerra
Cruz, José Henrique de Araújo
Souza, Smyrna Luiza Ximenes de
Campos, Fernanda de Araújo Trigueiro
dc.subject.por.fl_str_mv Monoterpenes
Phytotherapy
Dentistry.
Monoterpeno
Fitoterapia
Odontología.
Monoterpenos
Fitoterapia
Odontologia.
topic Monoterpenes
Phytotherapy
Dentistry.
Monoterpeno
Fitoterapia
Odontología.
Monoterpenos
Fitoterapia
Odontologia.
description Objective: To describe the therapeutic activities of monoterpene (-)- isopulegol applied to dentistry through an in silico study. Methods: To conduct the study in the in silico model, the software for Prediction of Activity Spectra for Substances (PASS) was used online, which provides the probability of being active (Pa) and the probability of being inactive (Pb) of the compound in question. The activities presented by the software were determined for this research according to the criterion: probability of being active greater than 0.5, with significant performance in dentistry. Results: Eight therapeutic activities with satisfactory indices for dentistry were found, where some of these activities already have studies proving their effectiveness. Conclusions: It is concluded that the compound isopulegol has therapeutic potential mainly as a mucomembranous, anti-inflammatory, antiparasitic and antifungal agent, requiring further research such as in vitro and in vivo studies to better clarify the compound and its respective mechanisms of action.
publishDate 2020
dc.date.none.fl_str_mv 2020-06-16
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/4874
10.33448/rsd-v9i7.4874
url https://rsdjournal.org/index.php/rsd/article/view/4874
identifier_str_mv 10.33448/rsd-v9i7.4874
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/4874/4231
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 9 No. 7; e807974874
Research, Society and Development; Vol. 9 Núm. 7; e807974874
Research, Society and Development; v. 9 n. 7; e807974874
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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