Therapeutic activities of isopulegol related to Dentistry: in silico study
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/4874 |
Resumo: | Objective: To describe the therapeutic activities of monoterpene (-)- isopulegol applied to dentistry through an in silico study. Methods: To conduct the study in the in silico model, the software for Prediction of Activity Spectra for Substances (PASS) was used online, which provides the probability of being active (Pa) and the probability of being inactive (Pb) of the compound in question. The activities presented by the software were determined for this research according to the criterion: probability of being active greater than 0.5, with significant performance in dentistry. Results: Eight therapeutic activities with satisfactory indices for dentistry were found, where some of these activities already have studies proving their effectiveness. Conclusions: It is concluded that the compound isopulegol has therapeutic potential mainly as a mucomembranous, anti-inflammatory, antiparasitic and antifungal agent, requiring further research such as in vitro and in vivo studies to better clarify the compound and its respective mechanisms of action. |
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Therapeutic activities of isopulegol related to Dentistry: in silico studyActividades terapéuticas del isopulegol relacionadas con la odontología: estudio in silicoAtividades terapêuticas do isopulegol relacionadas à Odontologia: estudo in silicoMonoterpenesPhytotherapyDentistry.MonoterpenoFitoterapiaOdontología.MonoterpenosFitoterapiaOdontologia.Objective: To describe the therapeutic activities of monoterpene (-)- isopulegol applied to dentistry through an in silico study. Methods: To conduct the study in the in silico model, the software for Prediction of Activity Spectra for Substances (PASS) was used online, which provides the probability of being active (Pa) and the probability of being inactive (Pb) of the compound in question. The activities presented by the software were determined for this research according to the criterion: probability of being active greater than 0.5, with significant performance in dentistry. Results: Eight therapeutic activities with satisfactory indices for dentistry were found, where some of these activities already have studies proving their effectiveness. Conclusions: It is concluded that the compound isopulegol has therapeutic potential mainly as a mucomembranous, anti-inflammatory, antiparasitic and antifungal agent, requiring further research such as in vitro and in vivo studies to better clarify the compound and its respective mechanisms of action.Objetivo: describir las actividades terapéuticas del monoterpeno (-) - isopulegol aplicado a la odontología a través de un estudio in silico. Métodos: Para llevar a cabo el estudio en el modelo in silico, se utilizó en línea el software para la Especificación de actividad del espectro para sustancias (PASS), que proporciona la probabilidad de estar activo (Pa) y la probabilidad de estar inactivo (Pb) del compuesto en cuestión. estudiar. Las actividades presentadas por el software se determinaron para esta investigación de acuerdo con el criterio: probabilidad de estar activo mayor a 0.5, con un desempeño significativo en odontología. Resultados: Se encontraron ocho actividades terapéuticas con índices satisfactorios para la odontología, donde algunas de estas actividades ya tienen estudios que prueban su efectividad. Conclusiones: Se concluye que el compuesto isopulegol tiene potencial terapéutico principalmente como un agente mucomembranoso, antiinflamatorio, antiparasitario y antifúngico, que requiere más investigación como estudios in vitro e in vivo para aclarar mejor el compuesto y sus respectivos mecanismos de acción.Objetivo: Descrever as atividades terapêuticas do monoterpeno (-)- isopulegol aplicadas à odontologia por meio de estudo in silico. Métodos: Para a realização do estudo no modelo in silico, foi utilizado o software de Previsão do espectro de atividade para substâncias (PASS) online que fornece a probabilidade de ser ativo (Pa) e a probabilidade de ser inativo (Pb) do composto em estudo. As atividades apresentadas pelo software foram apuradas para esta pesquisa segundo o critério de: probabilidade de ser ativo maior que 0,5, com desempenho significativo na odontologia. Resultados: Foram encontradas oito atividades terapêuticas com índices satisfatórios voltados para a odontologia, onde algumas dessas atividades já apresentam estudos comprovando sua eficácia. Conclusões: Conclui-se que o composto isopulegol apresenta potencial terapêutico principalmente como protetor mucomembranoso, anti-inflamatório, antiparasitário e antifúngico, sendo necessário outras pesquisas como estudos in vitro e in vivo para melhor esclarecimento do composto e de seus respectivos mecanismos de ação.Research, Society and Development2020-06-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/487410.33448/rsd-v9i7.4874Research, Society and Development; Vol. 9 No. 7; e807974874Research, Society and Development; Vol. 9 Núm. 7; e807974874Research, Society and Development; v. 9 n. 7; e8079748742525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/4874/4231Copyright (c) 2020 Julliany Taverny Sousa, Ana Karina Almeida Rolim, Letícia Ataíde Delgado, Pedro Henrique de Araújo, Randerson Mattheus Moura da Silva, Carlus Alberto Oliveira dos Santos, Diego Filipe Bezerra Silva, José Henrique de Araújo Cruz, Smyrna Luiza Ximenes de Souza, Fernanda de Araújo Trigueiro Camposinfo:eu-repo/semantics/openAccessSousa, Julliany TavernyRolim, Ana Karina AlmeidaDelgado, Letícia AtaídeAraújo, Pedro Henrique deSilva, Randerson Mattheus Moura daSantos, Carlus Alberto Oliveira dosSilva, Diego Filipe BezerraCruz, José Henrique de AraújoSouza, Smyrna Luiza Ximenes deCampos, Fernanda de Araújo Trigueiro2020-08-20T18:05:03Zoai:ojs.pkp.sfu.ca:article/4874Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:28:35.098207Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Therapeutic activities of isopulegol related to Dentistry: in silico study Actividades terapéuticas del isopulegol relacionadas con la odontología: estudio in silico Atividades terapêuticas do isopulegol relacionadas à Odontologia: estudo in silico |
title |
Therapeutic activities of isopulegol related to Dentistry: in silico study |
spellingShingle |
Therapeutic activities of isopulegol related to Dentistry: in silico study Sousa, Julliany Taverny Monoterpenes Phytotherapy Dentistry. Monoterpeno Fitoterapia Odontología. Monoterpenos Fitoterapia Odontologia. |
title_short |
Therapeutic activities of isopulegol related to Dentistry: in silico study |
title_full |
Therapeutic activities of isopulegol related to Dentistry: in silico study |
title_fullStr |
Therapeutic activities of isopulegol related to Dentistry: in silico study |
title_full_unstemmed |
Therapeutic activities of isopulegol related to Dentistry: in silico study |
title_sort |
Therapeutic activities of isopulegol related to Dentistry: in silico study |
author |
Sousa, Julliany Taverny |
author_facet |
Sousa, Julliany Taverny Rolim, Ana Karina Almeida Delgado, Letícia Ataíde Araújo, Pedro Henrique de Silva, Randerson Mattheus Moura da Santos, Carlus Alberto Oliveira dos Silva, Diego Filipe Bezerra Cruz, José Henrique de Araújo Souza, Smyrna Luiza Ximenes de Campos, Fernanda de Araújo Trigueiro |
author_role |
author |
author2 |
Rolim, Ana Karina Almeida Delgado, Letícia Ataíde Araújo, Pedro Henrique de Silva, Randerson Mattheus Moura da Santos, Carlus Alberto Oliveira dos Silva, Diego Filipe Bezerra Cruz, José Henrique de Araújo Souza, Smyrna Luiza Ximenes de Campos, Fernanda de Araújo Trigueiro |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Sousa, Julliany Taverny Rolim, Ana Karina Almeida Delgado, Letícia Ataíde Araújo, Pedro Henrique de Silva, Randerson Mattheus Moura da Santos, Carlus Alberto Oliveira dos Silva, Diego Filipe Bezerra Cruz, José Henrique de Araújo Souza, Smyrna Luiza Ximenes de Campos, Fernanda de Araújo Trigueiro |
dc.subject.por.fl_str_mv |
Monoterpenes Phytotherapy Dentistry. Monoterpeno Fitoterapia Odontología. Monoterpenos Fitoterapia Odontologia. |
topic |
Monoterpenes Phytotherapy Dentistry. Monoterpeno Fitoterapia Odontología. Monoterpenos Fitoterapia Odontologia. |
description |
Objective: To describe the therapeutic activities of monoterpene (-)- isopulegol applied to dentistry through an in silico study. Methods: To conduct the study in the in silico model, the software for Prediction of Activity Spectra for Substances (PASS) was used online, which provides the probability of being active (Pa) and the probability of being inactive (Pb) of the compound in question. The activities presented by the software were determined for this research according to the criterion: probability of being active greater than 0.5, with significant performance in dentistry. Results: Eight therapeutic activities with satisfactory indices for dentistry were found, where some of these activities already have studies proving their effectiveness. Conclusions: It is concluded that the compound isopulegol has therapeutic potential mainly as a mucomembranous, anti-inflammatory, antiparasitic and antifungal agent, requiring further research such as in vitro and in vivo studies to better clarify the compound and its respective mechanisms of action. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-06-16 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/4874 10.33448/rsd-v9i7.4874 |
url |
https://rsdjournal.org/index.php/rsd/article/view/4874 |
identifier_str_mv |
10.33448/rsd-v9i7.4874 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/4874/4231 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 9 No. 7; e807974874 Research, Society and Development; Vol. 9 Núm. 7; e807974874 Research, Society and Development; v. 9 n. 7; e807974874 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052815783231488 |