Therapeutic simplification with lamivudine and dolutegravir in patients living with HIV in Ceará (LAMDO study)
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Research, Society and Development |
| Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/32251 |
Resumo: | The Ministry of Health approved dual therapy (lamivudine associated with a second antiretroviral) as a therapeutic option in the contraindication to the use of other available Nucleoside Analog Reverse Transcriptase Inhibitors - NRTIs (tenofovir, abacavir and zidovudine) due to toxicity, if patients are virological suppression. This study aims to evaluate the effectiveness of therapeutic simplification with lamivudine/dolutegravir (3TC/DTG) in HIV patients on antiretroviral therapy (ART). Retrospective study of the real-life experience in the clinical practice of a simplified scheme with 3TC/DTG in a referral hospital for infectious diseases. We evaluated 76 patients using 3TC/DTG, with a mean age of 56.4 years, 50 (65.8%) of whom were male, mean use of the simplified regimen of 12 months, mean CD4 count = 669.5 cells/ mm3 and average CD8 = 941.5 cells/mm3. Evaluation of viral load after simplification in 67 patients, 63 (94.0%) with maintained virological suppression (<40 copies) and 4 (6.0%) with detected viral load. Among these patients without complete virological suppression, two reported good adherence and the other two described poor adherence in the medical records. The current study confirms the effectiveness of virological suppression in real-life therapeutic simplification with 3TC/DTG. Therapeutic simplification with this regimen is a safe strategy as an option for patients with toxicity or intolerance to regimens containing NRTIs. Long-term studies are needed to confirm the maintenance of efficacy for longer periods of time. |
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Therapeutic simplification with lamivudine and dolutegravir in patients living with HIV in Ceará (LAMDO study)Simplificación terapéutica con lamivudina y dolutegravir en pacientes que viven con VIH en Ceará (LAMDO estudio)Simplificação terapêutica com lamivudina e dolutegravir em pacientes vivendo com HIV no Ceará (Estudo LAMDO)AntirretroviralesSimplificaciónVirus de la Inmunodeficiencia HumanaCarga viralDolutegravir.AntirretroviraisSimplificaçãoVírus da imunodeficiência humanaCarga viralDolutegravir.AntiretroviralsSimplificationHuman immunodeficiency virusViral loadDolutegravir.The Ministry of Health approved dual therapy (lamivudine associated with a second antiretroviral) as a therapeutic option in the contraindication to the use of other available Nucleoside Analog Reverse Transcriptase Inhibitors - NRTIs (tenofovir, abacavir and zidovudine) due to toxicity, if patients are virological suppression. This study aims to evaluate the effectiveness of therapeutic simplification with lamivudine/dolutegravir (3TC/DTG) in HIV patients on antiretroviral therapy (ART). Retrospective study of the real-life experience in the clinical practice of a simplified scheme with 3TC/DTG in a referral hospital for infectious diseases. We evaluated 76 patients using 3TC/DTG, with a mean age of 56.4 years, 50 (65.8%) of whom were male, mean use of the simplified regimen of 12 months, mean CD4 count = 669.5 cells/ mm3 and average CD8 = 941.5 cells/mm3. Evaluation of viral load after simplification in 67 patients, 63 (94.0%) with maintained virological suppression (<40 copies) and 4 (6.0%) with detected viral load. Among these patients without complete virological suppression, two reported good adherence and the other two described poor adherence in the medical records. The current study confirms the effectiveness of virological suppression in real-life therapeutic simplification with 3TC/DTG. Therapeutic simplification with this regimen is a safe strategy as an option for patients with toxicity or intolerance to regimens containing NRTIs. Long-term studies are needed to confirm the maintenance of efficacy for longer periods of time.El Ministerio de Salud aprobó la terapia dual (lamivudina asociada a un segundo antirretroviral) como opción terapéutica en la contraindicación del uso de otros Inhibidores de la Transcriptasa Inversa Análogos de Nucleósidos - NRTIs (tenofovir, abacavir y zidovudina) disponibles por toxicidad, siempre que los pacientes estén supresión virológica. Este estudio tiene como objetivo evaluar la efectividad de la simplificación terapéutica con lamivudina/dolutegravir (3TC/DTG) en pacientes con VIH en terapia antirretroviral (TAR). Estudio retrospectivo de la experiencia real en la práctica clínica de un esquema simplificado con 3TC/DTG en un hospital de referencia de enfermedades infecciosas. Se evaluaron 76 pacientes utilizando 3TC/DTG, con una edad media de 56,4 años, de los cuales 50 (65,8%) eran del sexo masculino, uso medio del régimen simplificado de 12 meses, recuento medio de CD4 = 669,5 células/mm3 y promedio de CD8 = 941,5 células/mm3. Evaluación de carga viral tras simplificación en 67 pacientes, 63 (94,0%) con supresión virológica mantenida (<40 copias) y 4 (6,0%) con carga viral detectada. Entre estos pacientes sin supresión virológica completa, dos reportaron buena adherencia y los otros dos describieron mala adherencia en la historia clínica. El estudio actual confirma la eficacia de la supresión virológica en la simplificación terapéutica de la vida real con 3TC/DTG. La simplificación terapéutica con este régimen es una estrategia segura como opción para pacientes con toxicidad o intolerancia a esquemas que contienen NRTI. Se necesitan estudios a largo plazo para confirmar el mantenimiento de la eficacia durante períodos de tiempo más prolongados.O Ministério da Saúde aprovou a dupla terapia (lamivudina associado a um segundo antirretroviral) como opção terapêutica na contraindicação ao uso de outros Inibidores da Transcriptase Reversa Análogos Nucleosídeos - ITRN disponíveis (tenofovir, abacavir e zidovudina) por toxicidade, desde que os pacientes estejam com supressão virológica. Esse trabalho tem o objetivo de avaliar a eficácia na simplificação terapêutica com lamivudina/dolutegravir (3TC/DTG) em pacientes com HIV em terapia antirretroviral (TARV). Estudo retrospectivo da experiência em vida real na prática clínica de esquema simplificado com 3TC/DTG em hospital de referência em doenças infecciosas. Foram avaliados 76 pacientes em uso de 3TC/DTG, com idade média de 56,4 anos, sendo 50 (65,8%) do sexo masculino, média de uso do esquema simplificado de 12 meses, CD4 médio = 669,5 cels/mm3 e CD8 médio = 941,5 cels/mm3. Avaliaçnao de carga viral após simplificação em 67 pacientes, estando 63 (94,0%) com supressão virológica mantida (<40 cópias) e 4 (6,0%) com carga viral detectada. Dentre esses os pacientes sem supressão virológica completa, dois apresentavam relato de boa adesão e os outros dois com descrição de baixa adesão no prontuário. O estudo atual confirma a eficácia na supressão virológica em simplificação terapêutica na vida real com 3TC/DTG. Sendo a simplificação terapêutica com esse esquema uma estratégia segura como opção para pacientes com toxicidade ou intolerância a esquemas contendo ITRNs. Estudos a longo prazo são necessários para confirmar a manutenção de eficácia por maiores períodos de tempo.Research, Society and Development2022-07-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3225110.33448/rsd-v11i9.32251Research, Society and Development; Vol. 11 No. 9; e59711932251Research, Society and Development; Vol. 11 Núm. 9; e59711932251Research, Society and Development; v. 11 n. 9; e597119322512525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/32251/27486Copyright (c) 2022 Melina Maria Loiola Melo Vasconcelos ; Erico Antonio Gomes Arruda; Amanda Pinheiro Ibiapina ; Lara Farias Lustosa da Costa; Ana Luiza Maria Viana de Araújo ; Melissa Soares Medeiroshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessVasconcelos , Melina Maria Loiola MeloArruda, Erico Antonio Gomes Ibiapina , Amanda Pinheiro Costa, Lara Farias Lustosa da Araújo , Ana Luiza Maria Viana de Medeiros, Melissa Soares 2022-07-21T12:36:16Zoai:ojs.pkp.sfu.ca:article/32251Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:48:18.582280Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
| dc.title.none.fl_str_mv |
Therapeutic simplification with lamivudine and dolutegravir in patients living with HIV in Ceará (LAMDO study) Simplificación terapéutica con lamivudina y dolutegravir en pacientes que viven con VIH en Ceará (LAMDO estudio) Simplificação terapêutica com lamivudina e dolutegravir em pacientes vivendo com HIV no Ceará (Estudo LAMDO) |
| title |
Therapeutic simplification with lamivudine and dolutegravir in patients living with HIV in Ceará (LAMDO study) |
| spellingShingle |
Therapeutic simplification with lamivudine and dolutegravir in patients living with HIV in Ceará (LAMDO study) Vasconcelos , Melina Maria Loiola Melo Antirretrovirales Simplificación Virus de la Inmunodeficiencia Humana Carga viral Dolutegravir. Antirretrovirais Simplificação Vírus da imunodeficiência humana Carga viral Dolutegravir. Antiretrovirals Simplification Human immunodeficiency virus Viral load Dolutegravir. |
| title_short |
Therapeutic simplification with lamivudine and dolutegravir in patients living with HIV in Ceará (LAMDO study) |
| title_full |
Therapeutic simplification with lamivudine and dolutegravir in patients living with HIV in Ceará (LAMDO study) |
| title_fullStr |
Therapeutic simplification with lamivudine and dolutegravir in patients living with HIV in Ceará (LAMDO study) |
| title_full_unstemmed |
Therapeutic simplification with lamivudine and dolutegravir in patients living with HIV in Ceará (LAMDO study) |
| title_sort |
Therapeutic simplification with lamivudine and dolutegravir in patients living with HIV in Ceará (LAMDO study) |
| author |
Vasconcelos , Melina Maria Loiola Melo |
| author_facet |
Vasconcelos , Melina Maria Loiola Melo Arruda, Erico Antonio Gomes Ibiapina , Amanda Pinheiro Costa, Lara Farias Lustosa da Araújo , Ana Luiza Maria Viana de Medeiros, Melissa Soares |
| author_role |
author |
| author2 |
Arruda, Erico Antonio Gomes Ibiapina , Amanda Pinheiro Costa, Lara Farias Lustosa da Araújo , Ana Luiza Maria Viana de Medeiros, Melissa Soares |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Vasconcelos , Melina Maria Loiola Melo Arruda, Erico Antonio Gomes Ibiapina , Amanda Pinheiro Costa, Lara Farias Lustosa da Araújo , Ana Luiza Maria Viana de Medeiros, Melissa Soares |
| dc.subject.por.fl_str_mv |
Antirretrovirales Simplificación Virus de la Inmunodeficiencia Humana Carga viral Dolutegravir. Antirretrovirais Simplificação Vírus da imunodeficiência humana Carga viral Dolutegravir. Antiretrovirals Simplification Human immunodeficiency virus Viral load Dolutegravir. |
| topic |
Antirretrovirales Simplificación Virus de la Inmunodeficiencia Humana Carga viral Dolutegravir. Antirretrovirais Simplificação Vírus da imunodeficiência humana Carga viral Dolutegravir. Antiretrovirals Simplification Human immunodeficiency virus Viral load Dolutegravir. |
| description |
The Ministry of Health approved dual therapy (lamivudine associated with a second antiretroviral) as a therapeutic option in the contraindication to the use of other available Nucleoside Analog Reverse Transcriptase Inhibitors - NRTIs (tenofovir, abacavir and zidovudine) due to toxicity, if patients are virological suppression. This study aims to evaluate the effectiveness of therapeutic simplification with lamivudine/dolutegravir (3TC/DTG) in HIV patients on antiretroviral therapy (ART). Retrospective study of the real-life experience in the clinical practice of a simplified scheme with 3TC/DTG in a referral hospital for infectious diseases. We evaluated 76 patients using 3TC/DTG, with a mean age of 56.4 years, 50 (65.8%) of whom were male, mean use of the simplified regimen of 12 months, mean CD4 count = 669.5 cells/ mm3 and average CD8 = 941.5 cells/mm3. Evaluation of viral load after simplification in 67 patients, 63 (94.0%) with maintained virological suppression (<40 copies) and 4 (6.0%) with detected viral load. Among these patients without complete virological suppression, two reported good adherence and the other two described poor adherence in the medical records. The current study confirms the effectiveness of virological suppression in real-life therapeutic simplification with 3TC/DTG. Therapeutic simplification with this regimen is a safe strategy as an option for patients with toxicity or intolerance to regimens containing NRTIs. Long-term studies are needed to confirm the maintenance of efficacy for longer periods of time. |
| publishDate |
2022 |
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2022-07-20 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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https://rsdjournal.org/index.php/rsd/article/view/32251 10.33448/rsd-v11i9.32251 |
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https://rsdjournal.org/index.php/rsd/article/view/32251 |
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10.33448/rsd-v11i9.32251 |
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por |
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por |
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https://rsdjournal.org/index.php/rsd/article/view/32251/27486 |
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https://creativecommons.org/licenses/by/4.0 |
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openAccess |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development; Vol. 11 No. 9; e59711932251 Research, Society and Development; Vol. 11 Núm. 9; e59711932251 Research, Society and Development; v. 11 n. 9; e59711932251 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
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