Is the combination of corticosteroids plus NSAIDs improve the preemptive analgesia after third molars surgery? A systematic review and meta-analysis

Detalhes bibliográficos
Autor(a) principal: Momesso, Gustavo Antonio Correa
Data de Publicação: 2020
Outros Autores: Lemos, Cleidiel Aparecido Araújo, Lima, Valthierre Nunes de, Delanora, Leonardo Alan, Santiago-Júnior, Joel Ferreira, Faverani, Leonardo Perez, Pellizzer, Eduardo Piza
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/7979
Resumo: This study aimed to perform a systematic review and meta-analysis to evaluate the preemptive action of the combination of corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs) or both drugs singly after third molars surgery. It was performed a search on the PubMed/MEDLINE, Scopus, and Cochrane databases, according to the PRISMA criteria, with no time restrictions up to March 2020. The postoperative pain was evaluated, qualitatively, through the visual analogue scale (VAS) and the number of rescue analgesics (NRA). The edema and trismus were evaluated in a qualitative way through linear measures. Besides that, a meta-analysis of the post-operative pain (VAS) was performed. It was found 103 articles, which four articles were selected according to the inclusion and exclusion criteria. A total of 208 patients was evaluated and the combination of corticosteroids and NSAIDs showed great behavior in the preemptive action after third molars surgery for all the parameters evaluated when compared to both drugs singly. Meta-analysis about the VAS showed that the combination of drugs reduced significantly the postoperative pain when compared to the NSAIDs singly (P<0.05). It was concluded that the combination of NSAIDs and corticosteroids improved postoperative pain, edema, and trismus after third molars surgery.
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spelling Is the combination of corticosteroids plus NSAIDs improve the preemptive analgesia after third molars surgery? A systematic review and meta-analysis¿La combinación de corticoesteroides más antiinflamatorios no esteroideos mejora la analgesia preventiva después de la cirugía del tercer molar? Una revisión sistemática y un metanálisisA combinação de corticosteroides mais AINEs melhora a analgesia preemptiva após cirurgia de terceiros molares? Uma revisão sistemática e meta-análiseTerceiros molaresDorCorticosteróidesInflamaçãoMediadores da inflamaçãoAnti-inflamatóriosAnti-inflamatórios não esteroidesTercer molarDolorCorticoesteroidesInflamaciónMediadores de inflamaciónAntiinflamatoriosAntiinflamatorios no esteroideosMolar, ThirdPainAdrenal cortex hormones; InflammationInflammation mediatorsAnti-inflammatory agentsAnti-inflammatory non-steroidalinflammationThis study aimed to perform a systematic review and meta-analysis to evaluate the preemptive action of the combination of corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs) or both drugs singly after third molars surgery. It was performed a search on the PubMed/MEDLINE, Scopus, and Cochrane databases, according to the PRISMA criteria, with no time restrictions up to March 2020. The postoperative pain was evaluated, qualitatively, through the visual analogue scale (VAS) and the number of rescue analgesics (NRA). The edema and trismus were evaluated in a qualitative way through linear measures. Besides that, a meta-analysis of the post-operative pain (VAS) was performed. It was found 103 articles, which four articles were selected according to the inclusion and exclusion criteria. A total of 208 patients was evaluated and the combination of corticosteroids and NSAIDs showed great behavior in the preemptive action after third molars surgery for all the parameters evaluated when compared to both drugs singly. Meta-analysis about the VAS showed that the combination of drugs reduced significantly the postoperative pain when compared to the NSAIDs singly (P<0.05). It was concluded that the combination of NSAIDs and corticosteroids improved postoperative pain, edema, and trismus after third molars surgery.Este estudio tuvo como objetivo realizar una revisión sistemática y un metanálisis para evaluar la acción preventiva de la combinación de corticosteroides y antiinflamatorios no esteroideos (AINE) o ambos fármacos solos después de la cirugía de terceros molares. Se realizó una búsqueda en las bases de datos PubMed / MEDLINE, Scopus y Cochrane, según los criterios PRISMA, sin restricción de tiempo hasta marzo de 2020. Se evaluó el dolor postoperatorio, cualitativamente, mediante la escala visual analógica (EVA) y del número de analgésicos de rescate (ANR). El edema y el trismo se evaluaron cualitativamente mediante medidas lineales. Además, se realizó un metanálisis de dolor postoperatorio (EVA). Se encontraron 103 artículos, de los cuales se seleccionaron cuatro artículos según los criterios de inclusión y exclusión. Se evaluaron 208 pacientes y la combinación de corticosteroides y AINE mostró un excelente comportamiento en la acción preventiva después de la cirugía de terceros molares para todos los parámetros evaluados en comparación con los dos fármacos solos. El metanálisis en VAS mostró que la combinación de fármacos redujo significativamente el dolor posoperatorio en comparación con los AINE solos (P <0,05). Se concluyó que la combinación de AINE y corticosteroides mejoró el dolor postoperatorio, el edema y el trismo después de la cirugía de terceros molares.Este estudo teve como objetivo realizar uma revisão sistemática e metanálise para avaliar a ação preemptiva da combinação de corticosteroides e antiinflamatórios não esteroidais (AINEs) ou ambos os fármacos isoladamente após cirurgia de terceiros molares. Foi realizada uma busca nas bases de dados PubMed / MEDLINE, Scopus e Cochrane, segundo os critérios PRISMA, sem restrição de tempo até março de 2020. A dor pós-operatória foi avaliada, qualitativamente, por meio da escala visual analógica (EVA) e do número de analgésicos de resgate (NRA). O edema e o trismo foram avaliados de forma qualitativa por meio de medidas lineares. Além disso, foi realizada uma meta-análise da dor pós-operatória (EVA). Foram encontrados 103 artigos, dos quais quatro artigos foram selecionados de acordo com os critérios de inclusão e exclusão. Foram avaliados 208 pacientes e a combinação de corticosteroides e AINEs apresentou ótimo comportamento na ação preemptiva após cirurgia de terceiros molares para todos os parâmetros avaliados quando comparados aos dois fármacos isoladamente. Meta-análise sobre a VAS mostrou que a combinação de drogas reduziu significativamente a dor pós-operatória quando comparada aos AINEs isoladamente (P <0,05). Concluiu-se que a combinação de AINEs e corticosteroides melhorou a dor pós-operatória, o edema e o trismo após a cirurgia dos terceiros molares.Research, Society and Development2020-09-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/797910.33448/rsd-v9i9.7979Research, Society and Development; Vol. 9 No. 9; e968997979Research, Society and Development; Vol. 9 Núm. 9; e968997979Research, Society and Development; v. 9 n. 9; e9689979792525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/7979/7252Copyright (c) 2020 Gustavo Antonio Correa Momesso; Cleidiel Aparecido Araújo Lemos; Valthierre Nunes de Lima; Leonardo Alan Delanora; Joel Ferreira Santiago-Júnior; Leonardo Perez Faverani; Eduardo Piza Pellizzerhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMomesso, Gustavo Antonio Correa Lemos, Cleidiel Aparecido AraújoLima, Valthierre Nunes de Delanora, Leonardo AlanSantiago-Júnior, Joel Ferreira Faverani, Leonardo Perez Pellizzer, Eduardo Piza 2020-09-18T01:42:11Zoai:ojs.pkp.sfu.ca:article/7979Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:30:33.802649Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Is the combination of corticosteroids plus NSAIDs improve the preemptive analgesia after third molars surgery? A systematic review and meta-analysis
¿La combinación de corticoesteroides más antiinflamatorios no esteroideos mejora la analgesia preventiva después de la cirugía del tercer molar? Una revisión sistemática y un metanálisis
A combinação de corticosteroides mais AINEs melhora a analgesia preemptiva após cirurgia de terceiros molares? Uma revisão sistemática e meta-análise
title Is the combination of corticosteroids plus NSAIDs improve the preemptive analgesia after third molars surgery? A systematic review and meta-analysis
spellingShingle Is the combination of corticosteroids plus NSAIDs improve the preemptive analgesia after third molars surgery? A systematic review and meta-analysis
Momesso, Gustavo Antonio Correa
Terceiros molares
Dor
Corticosteróides
Inflamação
Mediadores da inflamação
Anti-inflamatórios
Anti-inflamatórios não esteroides
Tercer molar
Dolor
Corticoesteroides
Inflamación
Mediadores de inflamación
Antiinflamatorios
Antiinflamatorios no esteroideos
Molar, Third
Pain
Adrenal cortex hormones; Inflammation
Inflammation mediators
Anti-inflammatory agents
Anti-inflammatory non-steroidal
inflammation
title_short Is the combination of corticosteroids plus NSAIDs improve the preemptive analgesia after third molars surgery? A systematic review and meta-analysis
title_full Is the combination of corticosteroids plus NSAIDs improve the preemptive analgesia after third molars surgery? A systematic review and meta-analysis
title_fullStr Is the combination of corticosteroids plus NSAIDs improve the preemptive analgesia after third molars surgery? A systematic review and meta-analysis
title_full_unstemmed Is the combination of corticosteroids plus NSAIDs improve the preemptive analgesia after third molars surgery? A systematic review and meta-analysis
title_sort Is the combination of corticosteroids plus NSAIDs improve the preemptive analgesia after third molars surgery? A systematic review and meta-analysis
author Momesso, Gustavo Antonio Correa
author_facet Momesso, Gustavo Antonio Correa
Lemos, Cleidiel Aparecido Araújo
Lima, Valthierre Nunes de
Delanora, Leonardo Alan
Santiago-Júnior, Joel Ferreira
Faverani, Leonardo Perez
Pellizzer, Eduardo Piza
author_role author
author2 Lemos, Cleidiel Aparecido Araújo
Lima, Valthierre Nunes de
Delanora, Leonardo Alan
Santiago-Júnior, Joel Ferreira
Faverani, Leonardo Perez
Pellizzer, Eduardo Piza
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Momesso, Gustavo Antonio Correa
Lemos, Cleidiel Aparecido Araújo
Lima, Valthierre Nunes de
Delanora, Leonardo Alan
Santiago-Júnior, Joel Ferreira
Faverani, Leonardo Perez
Pellizzer, Eduardo Piza
dc.subject.por.fl_str_mv Terceiros molares
Dor
Corticosteróides
Inflamação
Mediadores da inflamação
Anti-inflamatórios
Anti-inflamatórios não esteroides
Tercer molar
Dolor
Corticoesteroides
Inflamación
Mediadores de inflamación
Antiinflamatorios
Antiinflamatorios no esteroideos
Molar, Third
Pain
Adrenal cortex hormones; Inflammation
Inflammation mediators
Anti-inflammatory agents
Anti-inflammatory non-steroidal
inflammation
topic Terceiros molares
Dor
Corticosteróides
Inflamação
Mediadores da inflamação
Anti-inflamatórios
Anti-inflamatórios não esteroides
Tercer molar
Dolor
Corticoesteroides
Inflamación
Mediadores de inflamación
Antiinflamatorios
Antiinflamatorios no esteroideos
Molar, Third
Pain
Adrenal cortex hormones; Inflammation
Inflammation mediators
Anti-inflammatory agents
Anti-inflammatory non-steroidal
inflammation
description This study aimed to perform a systematic review and meta-analysis to evaluate the preemptive action of the combination of corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs) or both drugs singly after third molars surgery. It was performed a search on the PubMed/MEDLINE, Scopus, and Cochrane databases, according to the PRISMA criteria, with no time restrictions up to March 2020. The postoperative pain was evaluated, qualitatively, through the visual analogue scale (VAS) and the number of rescue analgesics (NRA). The edema and trismus were evaluated in a qualitative way through linear measures. Besides that, a meta-analysis of the post-operative pain (VAS) was performed. It was found 103 articles, which four articles were selected according to the inclusion and exclusion criteria. A total of 208 patients was evaluated and the combination of corticosteroids and NSAIDs showed great behavior in the preemptive action after third molars surgery for all the parameters evaluated when compared to both drugs singly. Meta-analysis about the VAS showed that the combination of drugs reduced significantly the postoperative pain when compared to the NSAIDs singly (P<0.05). It was concluded that the combination of NSAIDs and corticosteroids improved postoperative pain, edema, and trismus after third molars surgery.
publishDate 2020
dc.date.none.fl_str_mv 2020-09-14
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/7979
10.33448/rsd-v9i9.7979
url https://rsdjournal.org/index.php/rsd/article/view/7979
identifier_str_mv 10.33448/rsd-v9i9.7979
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/7979/7252
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 9 No. 9; e968997979
Research, Society and Development; Vol. 9 Núm. 9; e968997979
Research, Society and Development; v. 9 n. 9; e968997979
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
_version_ 1797052658322767872

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