Immunomodulatory potential of ethanolic extract from Momordica charantia L. in mastic cow's milk

Detalhes bibliográficos
Autor(a) principal: Cunha, Carolina Ferrari Luz
Data de Publicação: 2021
Outros Autores: Marchi, Patrícia Gelli Feres de, Messias, Cassio Toledo, Cotrim, Aron Carlos de Melo, Fujimori, Mahmi, Amorim, Sara Lucena de, Araújo, Danielle Saldanha de Souza
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/14267
Resumo: Milk cattle farming is one of the main pillars of the Brazilian economy. Unfortunately, several factors affect the quality and quantity of milk produced in a milk units, among them a mastitis. Mastitis is a disease characterized by inflammation in the mammary glands, having several causes. The control of mastitis is done from preventive handling and with the use of intramammary antibiotic. Frequent use of antibiotics can cause resistance, making subsequent treatments difficult. Therefore, the study of phytotherapics in the control of mastitis has become more frequent and with promising results. Several plants and natural extracts have already been tested in mastitis control. The studied plant in question is called Momordica charantia, popularly known as Melão de São Caetano. This plant has demonstrated numerous medicinal effects for different purposes. This work aims to analyze the immunomodulatory potential of Momordica charantia on milk cells of mastitic cows. Twenty samples of cow's milk were collected, ten of which were healthy cows and ten cows with clinical mastitis. Subsequently, cell viability analysis, superoxide anion release, superoxide dismutase enzyme dosage, phagocytosis and microbicidal activity were performed. In samples containing extract a decrease in superoxide anion and superoxide dismutase enzyme was probably due to the escape mechanism of bacteria, and an increase in microbicidal activity and phagocytosis suggesting that the extract of Momordica charantia is an immunomodulatory potential against mastitis bovine.
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spelling Immunomodulatory potential of ethanolic extract from Momordica charantia L. in mastic cow's milkPotencial inmunomodulatorio del extracto etanólico de Momordica charantia L. en mastic leche de vacaPotencial imunomodulador de extrato etanólico de Momordica charantia L. em leite de vacas mastíticasMastitisSt Caetano melonStaphylococcus aureus.MastitisMelón São CaetanoStaphylococcus aureus.MastiteMelão de São CaetanoStaphylococcus aureus.Milk cattle farming is one of the main pillars of the Brazilian economy. Unfortunately, several factors affect the quality and quantity of milk produced in a milk units, among them a mastitis. Mastitis is a disease characterized by inflammation in the mammary glands, having several causes. The control of mastitis is done from preventive handling and with the use of intramammary antibiotic. Frequent use of antibiotics can cause resistance, making subsequent treatments difficult. Therefore, the study of phytotherapics in the control of mastitis has become more frequent and with promising results. Several plants and natural extracts have already been tested in mastitis control. The studied plant in question is called Momordica charantia, popularly known as Melão de São Caetano. This plant has demonstrated numerous medicinal effects for different purposes. This work aims to analyze the immunomodulatory potential of Momordica charantia on milk cells of mastitic cows. Twenty samples of cow's milk were collected, ten of which were healthy cows and ten cows with clinical mastitis. Subsequently, cell viability analysis, superoxide anion release, superoxide dismutase enzyme dosage, phagocytosis and microbicidal activity were performed. In samples containing extract a decrease in superoxide anion and superoxide dismutase enzyme was probably due to the escape mechanism of bacteria, and an increase in microbicidal activity and phagocytosis suggesting that the extract of Momordica charantia is an immunomodulatory potential against mastitis bovine.La ganadería lechera es uno de los principales pilares de la economía brasileña. Desafortunadamente, varios factores afectan la calidad y cantidad de leche producida en las lecherías, incluida la mastitis. La mastitis es una enfermedad caracterizada por la inflamación de las glándulas mamarias, que tiene varias causas. El control de la mastitis se basa en el manejo preventivo y el uso de antibióticos intramamarios. El uso frecuente de antibióticos puede causar resistencia, lo que dificulta el tratamiento posterior. Por lo tanto, los estudios de medicamentos a base de hierbas para el control de la mastitis son cada vez más frecuentes y con resultados prometedores. Ya se han probado varias plantas y extractos naturales para controlar la mastitis. La planta estudiada en cuestión se llama Momordica charantia, conocida popularmente como Melão de São Caetano. Tal planta ya ha mostrado numerosos efectos medicinales para diferentes propósitos. El objetivo de este trabajo es analizar el potencial inmunomodulador de Momordica charantia en células de la leche de vacas con mastitis. Se recolectaron veinte muestras de leche, diez de vacas sanas y diez de vacas con mastitis clínica. Posteriormente, se realizaron análisis de viabilidad celular, liberación de anión superóxido, dosificación de la enzima superóxido dismutasa, fagocitosis y actividad microbicida. Las muestras que contienen extracto mostraron una disminución en el anión superóxido y la enzima superóxido dismutasa, probablemente debido al mecanismo de escape de las bacterias, y un aumento en la actividad microbicida y fagocitosis, lo que sugiere que el extracto de Momordica charantia es un potencial inmunomodulador contra la mastitis bovina.A bovinocultura de leite é um importante setor da economia brasileira. Infelizmente, diversos fatores afetam a qualidade e a quantidade de leite produzido em unidades leiteiras, dentre eles a mastite. A mastite é uma doença caracterizada por inflamações nas glândulas mamárias, tendo diversas causas. O controle da mastite é feito a partir de manejo preventivo e uso de antibiótico intramamário. O uso frequente de antibióticos pode causar resistência, dificultando tratamentos posteriores. Portanto, estudos de fitoterápicos no controle da mastite vem se tornando mais frequente e com resultados promissores. Diversas plantas e extratos naturais já foram testados no controle da mastite. A planta estudada em questão é chamada de Momordica charantia L., conhecida popularmente como melão de São Caetano. Tal planta já demostrou inúmeros efeitos medicinais para diferentes finalidades. O objetivo deste trabalho consiste em analisar o potencial imunomodulador de Momordica charantia sobre células de leite de vacas mastíticas. Foram coletadas 20 amostras de leite, sendo dez de vacas sadias e dez de vacas com mastite clínica. Posteriormente, foram realizadas analises quanto a viabilidade celular, liberação de ânion superóxido, dosagem da enzima superóxido dismutase, fagocitose e atividade microbicida. Nas amostras que continham extrato observou-se uma diminuição do ânion superóxido e da enzima superóxido dismutase provavelmente devido ao mecanismo de escape das bactérias, e um aumento na atividade microbicida e na fagocitose sugerindo que o extrato de Momordica charantia seja um potencial imunomodulador contra a mastite bovina.Research, Society and Development2021-06-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1426710.33448/rsd-v10i6.14267Research, Society and Development; Vol. 10 No. 6; e36010614267Research, Society and Development; Vol. 10 Núm. 6; e36010614267Research, Society and Development; v. 10 n. 6; e360106142672525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/14267/14193Copyright (c) 2021 Carolina Ferrari Luz Cunha; Patrícia Gelli Feres de Marchi; Cassio Toledo Messias; Aron Carlos de Melo Cotrim; Mahmi Fujimori; Sara Lucena de Amorim; Danielle Saldanha de Souza Araújohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCunha, Carolina Ferrari LuzMarchi, Patrícia Gelli Feres deMessias, Cassio ToledoCotrim, Aron Carlos de MeloFujimori, MahmiAmorim, Sara Lucena deAraújo, Danielle Saldanha de Souza2021-06-10T22:51:46Zoai:ojs.pkp.sfu.ca:article/14267Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:35:25.869919Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Immunomodulatory potential of ethanolic extract from Momordica charantia L. in mastic cow's milk
Potencial inmunomodulatorio del extracto etanólico de Momordica charantia L. en mastic leche de vaca
Potencial imunomodulador de extrato etanólico de Momordica charantia L. em leite de vacas mastíticas
title Immunomodulatory potential of ethanolic extract from Momordica charantia L. in mastic cow's milk
spellingShingle Immunomodulatory potential of ethanolic extract from Momordica charantia L. in mastic cow's milk
Cunha, Carolina Ferrari Luz
Mastitis
St Caetano melon
Staphylococcus aureus.
Mastitis
Melón São Caetano
Staphylococcus aureus.
Mastite
Melão de São Caetano
Staphylococcus aureus.
title_short Immunomodulatory potential of ethanolic extract from Momordica charantia L. in mastic cow's milk
title_full Immunomodulatory potential of ethanolic extract from Momordica charantia L. in mastic cow's milk
title_fullStr Immunomodulatory potential of ethanolic extract from Momordica charantia L. in mastic cow's milk
title_full_unstemmed Immunomodulatory potential of ethanolic extract from Momordica charantia L. in mastic cow's milk
title_sort Immunomodulatory potential of ethanolic extract from Momordica charantia L. in mastic cow's milk
author Cunha, Carolina Ferrari Luz
author_facet Cunha, Carolina Ferrari Luz
Marchi, Patrícia Gelli Feres de
Messias, Cassio Toledo
Cotrim, Aron Carlos de Melo
Fujimori, Mahmi
Amorim, Sara Lucena de
Araújo, Danielle Saldanha de Souza
author_role author
author2 Marchi, Patrícia Gelli Feres de
Messias, Cassio Toledo
Cotrim, Aron Carlos de Melo
Fujimori, Mahmi
Amorim, Sara Lucena de
Araújo, Danielle Saldanha de Souza
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cunha, Carolina Ferrari Luz
Marchi, Patrícia Gelli Feres de
Messias, Cassio Toledo
Cotrim, Aron Carlos de Melo
Fujimori, Mahmi
Amorim, Sara Lucena de
Araújo, Danielle Saldanha de Souza
dc.subject.por.fl_str_mv Mastitis
St Caetano melon
Staphylococcus aureus.
Mastitis
Melón São Caetano
Staphylococcus aureus.
Mastite
Melão de São Caetano
Staphylococcus aureus.
topic Mastitis
St Caetano melon
Staphylococcus aureus.
Mastitis
Melón São Caetano
Staphylococcus aureus.
Mastite
Melão de São Caetano
Staphylococcus aureus.
description Milk cattle farming is one of the main pillars of the Brazilian economy. Unfortunately, several factors affect the quality and quantity of milk produced in a milk units, among them a mastitis. Mastitis is a disease characterized by inflammation in the mammary glands, having several causes. The control of mastitis is done from preventive handling and with the use of intramammary antibiotic. Frequent use of antibiotics can cause resistance, making subsequent treatments difficult. Therefore, the study of phytotherapics in the control of mastitis has become more frequent and with promising results. Several plants and natural extracts have already been tested in mastitis control. The studied plant in question is called Momordica charantia, popularly known as Melão de São Caetano. This plant has demonstrated numerous medicinal effects for different purposes. This work aims to analyze the immunomodulatory potential of Momordica charantia on milk cells of mastitic cows. Twenty samples of cow's milk were collected, ten of which were healthy cows and ten cows with clinical mastitis. Subsequently, cell viability analysis, superoxide anion release, superoxide dismutase enzyme dosage, phagocytosis and microbicidal activity were performed. In samples containing extract a decrease in superoxide anion and superoxide dismutase enzyme was probably due to the escape mechanism of bacteria, and an increase in microbicidal activity and phagocytosis suggesting that the extract of Momordica charantia is an immunomodulatory potential against mastitis bovine.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-03
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/14267
10.33448/rsd-v10i6.14267
url https://rsdjournal.org/index.php/rsd/article/view/14267
identifier_str_mv 10.33448/rsd-v10i6.14267
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/14267/14193
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 6; e36010614267
Research, Society and Development; Vol. 10 Núm. 6; e36010614267
Research, Society and Development; v. 10 n. 6; e36010614267
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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