Sensory taste receptors and ageusia associated with SARS-CoV-2 infection: literature review

Detalhes bibliográficos
Autor(a) principal: Santos, Danyelle Cristina Pereira
Data de Publicação: 2022
Outros Autores: Vasconcelos, Marcos Altyeres Coelho, Moreira, Pedro Henrique de Aguiar, Gomes, Paulo Dyago Borges, Bazán, Tamyris Alicely Xavier Noguera, Moraes, Fabiana Pereira, Sousa, Davi Ferreira, Siqueira, Fabiana Suellen Figuerêdo de, Silva, Luís Cláudio Nascimento da, Holanda, Rodrigo Assunção, Galvão, Livia Camara de Carvalho
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/29122
Resumo: Coronavirus Disease-2019 (COVID-19), the largest recorded pandemic of the 21st century, is an acute respiratory infection with potential severity. Among the symptoms resulting from the disease, sensory loss, such as ageusia, represents a challenge among researchers, since the mechanisms related to viral pathophysiology against neurosensitive cells are not yet fully understood. Given this context, this study aimed to review the recent literature on loss of taste sensation and SARS-CoV-2 infection. To this end, a narrative review was carried out, searching articles from the main databases, such as PubMed, Scielo, and Google Scholar, and selecting those that had affinity with the proposed theme. Through the study, it was found that ageusia is a common symptom in patients with COVID-19, mainly due to the significant presence of cell receptors that mediate the viral infection in the oral region. Mechanisms suggested to explain this loss of sensation involve damage to the taste nerves, deficiencies in serum and salivary zinc levels, interaction with sialic acid receptors, and the pro-inflammatory cytokine storm response itself to the viral attack. This review allowed the identification of several mechanisms suggested as potential causes of ageusia in SARS-CoV-2 infected patients, enabling an initial understanding regarding the topic and a direction for further studies.
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spelling Sensory taste receptors and ageusia associated with SARS-CoV-2 infection: literature reviewReceptores sensoriales del gusto y ageusia associada a la infección por SARS-CoV-2: revisión de la literaturaOs receptores sensoriais do sabor e a ageusia associada à infecção por SARS-CoV-2: revisão de literaturaAgeusiaCOVID-19EnseñanzaGusto.AgeusiaCOVID-19EnsinoPaladar.AgeusiaCOVID-19 TeachingTaste.Coronavirus Disease-2019 (COVID-19), the largest recorded pandemic of the 21st century, is an acute respiratory infection with potential severity. Among the symptoms resulting from the disease, sensory loss, such as ageusia, represents a challenge among researchers, since the mechanisms related to viral pathophysiology against neurosensitive cells are not yet fully understood. Given this context, this study aimed to review the recent literature on loss of taste sensation and SARS-CoV-2 infection. To this end, a narrative review was carried out, searching articles from the main databases, such as PubMed, Scielo, and Google Scholar, and selecting those that had affinity with the proposed theme. Through the study, it was found that ageusia is a common symptom in patients with COVID-19, mainly due to the significant presence of cell receptors that mediate the viral infection in the oral region. Mechanisms suggested to explain this loss of sensation involve damage to the taste nerves, deficiencies in serum and salivary zinc levels, interaction with sialic acid receptors, and the pro-inflammatory cytokine storm response itself to the viral attack. This review allowed the identification of several mechanisms suggested as potential causes of ageusia in SARS-CoV-2 infected patients, enabling an initial understanding regarding the topic and a direction for further studies.La enfermedad por Coronavirus-2019 (COVID-19), la mayor pandemia registrada en el siglo XXI, es una infección respiratoria aguda de gravedad potencial. Entre los síntomas decurrentes de la enfermedad, la pérdida sensorial, como la ageusia, representa un desafío entre los investigadores, una vez que los mecanismos relacionados con la fisiopatología viral contra las células neurosensibles aún no están totalmente esclarecidos. Teniendo en cuenta este contexto, el presente estudio tuvo como objetivo revisar la literatura reciente sobre la pérdida de la sensación del gusto y la infección por el SARS-CoV-2. Para ello, se realizó una revisión narrativa, buscando artículos en las principales bases de datos, como PubMed, Scielo y Google Académico, y seleccionando aquellos que tuvieran afinidad con el tema propuesto. A través del estudio, se encontró que la ageusia es un síntoma común en los pacientes con COVID-19, principalmente debido a la presencia significativa de receptores celulares que median la infección viral en la región oral. Los mecanismos sugeridos para explicar esta pérdida de sensibilidad implican el daño a los nervios del gusto, las deficiencias en los niveles de zinc sérico y salival, la interacción con los receptores de ácido siálico y la propia respuesta de la tormenta de citoquinas proinflamatorias al ataque viral. Esta revisión ha permitido identificar varios mecanismos sugeridos como posibles causas de la ageusia en pacientes infectados por el SARS-CoV-2, lo que ha permitido realizar una comprensión inicial en relación con el tema y una guía para estudios más profundos.A Doença do Coronavírus-2019 (COVID-19), maior pandemia registrada no século XXI, se trata de uma infecção respiratória aguda com potencial gravidade. Dentre os sintomas decorrentes da doença, a perda sensorial, como a ageusia, representa um desafio entre pesquisadores, uma vez que os mecanismos relacionados à fisiopatologia viral contra as células neurosensitivas ainda não estão totalmente esclarecidos. Diante desse contexto, esse estudo visou revisar a literatura recente sobre a perda da sensação do paladar e a infecção por SARS-CoV-2. Para isso, foi realizado uma revisão narrativa, pesquisando artigos das principais bases de dados, como PubMed, Scielo e Google Acadêmico, e selecionando os que possuíam afinidade com a temática proposta. Através do estudo, verificou-se que a ageusia é um sintoma comum em pacientes com COVID-19, devido, principalmente, à presença significativa dos receptores celulares que medeiam a infecção viral na região oral. Os mecanismos sugeridos para explicar essa perda de sensibilidade envolve danos nos nervos gustativos, deficiências nos níveis séricos e salivares de zinco, interação com os receptores do ácido siálico e a própria resposta pró-inflamatória da tempestade de citocinas ao ataque viral. Esta revisão permitiu a identificação de vários mecanismos sugeridos como potenciais causas de ageusia em pacientes infectados por SARS-CoV-2, possibilitando uma compreensão inicial a respeito da temática e um norteamento para estudos mais aprofundados.Research, Society and Development2022-06-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2912210.33448/rsd-v11i8.29122Research, Society and Development; Vol. 11 No. 8; e32811829122Research, Society and Development; Vol. 11 Núm. 8; e32811829122Research, Society and Development; v. 11 n. 8; e328118291222525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/29122/26566Copyright (c) 2022 Danyelle Cristina Pereira Santos; Marcos Altyeres Coelho Vasconcelos; Pedro Henrique de Aguiar Moreira; Paulo Dyago Borges Gomes; Tamyris Alicely Xavier Noguera Bazán; Fabiana Pereira Moraes; Davi Ferreira Sousa; Fabiana Suellen Figuerêdo de Siqueira; Luís Cláudio Nascimento da Silva; Rodrigo Assunção Holanda; Livia Camara de Carvalho Galvãohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSantos, Danyelle Cristina PereiraVasconcelos, Marcos Altyeres Coelho Moreira, Pedro Henrique de AguiarGomes, Paulo Dyago Borges Bazán, Tamyris Alicely Xavier NogueraMoraes, Fabiana PereiraSousa, Davi Ferreira Siqueira, Fabiana Suellen Figuerêdo deSilva, Luís Cláudio Nascimento daHolanda, Rodrigo AssunçãoGalvão, Livia Camara de Carvalho2022-07-01T13:34:06Zoai:ojs.pkp.sfu.ca:article/29122Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:46:17.203616Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Sensory taste receptors and ageusia associated with SARS-CoV-2 infection: literature review
Receptores sensoriales del gusto y ageusia associada a la infección por SARS-CoV-2: revisión de la literatura
Os receptores sensoriais do sabor e a ageusia associada à infecção por SARS-CoV-2: revisão de literatura
title Sensory taste receptors and ageusia associated with SARS-CoV-2 infection: literature review
spellingShingle Sensory taste receptors and ageusia associated with SARS-CoV-2 infection: literature review
Santos, Danyelle Cristina Pereira
Ageusia
COVID-19
Enseñanza
Gusto.
Ageusia
COVID-19
Ensino
Paladar.
Ageusia
COVID-19
Teaching
Taste.
title_short Sensory taste receptors and ageusia associated with SARS-CoV-2 infection: literature review
title_full Sensory taste receptors and ageusia associated with SARS-CoV-2 infection: literature review
title_fullStr Sensory taste receptors and ageusia associated with SARS-CoV-2 infection: literature review
title_full_unstemmed Sensory taste receptors and ageusia associated with SARS-CoV-2 infection: literature review
title_sort Sensory taste receptors and ageusia associated with SARS-CoV-2 infection: literature review
author Santos, Danyelle Cristina Pereira
author_facet Santos, Danyelle Cristina Pereira
Vasconcelos, Marcos Altyeres Coelho
Moreira, Pedro Henrique de Aguiar
Gomes, Paulo Dyago Borges
Bazán, Tamyris Alicely Xavier Noguera
Moraes, Fabiana Pereira
Sousa, Davi Ferreira
Siqueira, Fabiana Suellen Figuerêdo de
Silva, Luís Cláudio Nascimento da
Holanda, Rodrigo Assunção
Galvão, Livia Camara de Carvalho
author_role author
author2 Vasconcelos, Marcos Altyeres Coelho
Moreira, Pedro Henrique de Aguiar
Gomes, Paulo Dyago Borges
Bazán, Tamyris Alicely Xavier Noguera
Moraes, Fabiana Pereira
Sousa, Davi Ferreira
Siqueira, Fabiana Suellen Figuerêdo de
Silva, Luís Cláudio Nascimento da
Holanda, Rodrigo Assunção
Galvão, Livia Camara de Carvalho
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Santos, Danyelle Cristina Pereira
Vasconcelos, Marcos Altyeres Coelho
Moreira, Pedro Henrique de Aguiar
Gomes, Paulo Dyago Borges
Bazán, Tamyris Alicely Xavier Noguera
Moraes, Fabiana Pereira
Sousa, Davi Ferreira
Siqueira, Fabiana Suellen Figuerêdo de
Silva, Luís Cláudio Nascimento da
Holanda, Rodrigo Assunção
Galvão, Livia Camara de Carvalho
dc.subject.por.fl_str_mv Ageusia
COVID-19
Enseñanza
Gusto.
Ageusia
COVID-19
Ensino
Paladar.
Ageusia
COVID-19
Teaching
Taste.
topic Ageusia
COVID-19
Enseñanza
Gusto.
Ageusia
COVID-19
Ensino
Paladar.
Ageusia
COVID-19
Teaching
Taste.
description Coronavirus Disease-2019 (COVID-19), the largest recorded pandemic of the 21st century, is an acute respiratory infection with potential severity. Among the symptoms resulting from the disease, sensory loss, such as ageusia, represents a challenge among researchers, since the mechanisms related to viral pathophysiology against neurosensitive cells are not yet fully understood. Given this context, this study aimed to review the recent literature on loss of taste sensation and SARS-CoV-2 infection. To this end, a narrative review was carried out, searching articles from the main databases, such as PubMed, Scielo, and Google Scholar, and selecting those that had affinity with the proposed theme. Through the study, it was found that ageusia is a common symptom in patients with COVID-19, mainly due to the significant presence of cell receptors that mediate the viral infection in the oral region. Mechanisms suggested to explain this loss of sensation involve damage to the taste nerves, deficiencies in serum and salivary zinc levels, interaction with sialic acid receptors, and the pro-inflammatory cytokine storm response itself to the viral attack. This review allowed the identification of several mechanisms suggested as potential causes of ageusia in SARS-CoV-2 infected patients, enabling an initial understanding regarding the topic and a direction for further studies.
publishDate 2022
dc.date.none.fl_str_mv 2022-06-20
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/29122
10.33448/rsd-v11i8.29122
url https://rsdjournal.org/index.php/rsd/article/view/29122
identifier_str_mv 10.33448/rsd-v11i8.29122
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/29122/26566
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 8; e32811829122
Research, Society and Development; Vol. 11 Núm. 8; e32811829122
Research, Society and Development; v. 11 n. 8; e32811829122
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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