Antibacterial activity of chitosan and zinc oxide impregnated in PVA-based membranes
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/40720 |
Resumo: | The development of alternatives to conventional antibiotics against superbugs represents an important step to avoid the increasing resistance of bacteria observed in conventional treatments. Herein, it was evaluated the influence of different combinations of two active antibacterial components (chitosan and zinc oxide) and a host poly (vinyl alcohol - PVA) in membranes produced by the solvent casting technique. Those systems were evaluated in terms of the biofilm inactivation, kill-time assays and inhibition haloes against S. aureus (ATCC 25923) in membranes that must release reactive components while preserving their integrity and favoring the generation of reactive species to improve the antibacterial activity. The results suggest the potential of the combination of chitosan, zinc oxide and poly (vinyl alcohol) to inhibit the growth of S. aureus colonies since the PVA improved the dispersion of the components, whereas chitosan-ZnO chelate improves the mutual activity of the metal oxide and the natural polymer template. |
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Antibacterial activity of chitosan and zinc oxide impregnated in PVA-based membranesActividad antibacteriana de membranas de PVA impregnadas con quitosano y óxido de zincAtividade antibacteriana de membranas de PVA impregnadas com quitosana e óxido de zincoMembranasBiomateriaisSuperfícies e interfacesMisturas.MembranasBiomaterialesSuperficies e interfacesMezclas.MembranesBiomaterialsSurfaces and interfacesBlends.The development of alternatives to conventional antibiotics against superbugs represents an important step to avoid the increasing resistance of bacteria observed in conventional treatments. Herein, it was evaluated the influence of different combinations of two active antibacterial components (chitosan and zinc oxide) and a host poly (vinyl alcohol - PVA) in membranes produced by the solvent casting technique. Those systems were evaluated in terms of the biofilm inactivation, kill-time assays and inhibition haloes against S. aureus (ATCC 25923) in membranes that must release reactive components while preserving their integrity and favoring the generation of reactive species to improve the antibacterial activity. The results suggest the potential of the combination of chitosan, zinc oxide and poly (vinyl alcohol) to inhibit the growth of S. aureus colonies since the PVA improved the dispersion of the components, whereas chitosan-ZnO chelate improves the mutual activity of the metal oxide and the natural polymer template.El desarrollo de alternativas a los antibióticos convencionales contra las superbacterias representa un paso importante para evitar la creciente resistencia de las bacterias observada en los tratamientos convencionales. En esta invención, se evaluó la influencia de diferentes combinaciones de dos componentes antibacterianos activos (quitosano y óxido de zinc) y una base de alcohol polivinílico (PVA) en membranas producidas por la técnica de evaporación de disolvente. Estos sistemas se evaluaron en términos de inactivación de biopelículas, ensayos de tiempo de muerte y halos de inhibición contra S. aureus (ATCC 25923) en membranas que deben liberar componentes reactivos preservando su integridad y favoreciendo la generación de especies reactivas para mejorar la actividad antibacteriana. Los resultados sugieren el potencial de la combinación de quitosano, óxido de zinc y alcohol polivinílico para inhibir el crecimiento de S. aureus, ya que el PVA mejoró la dispersión de los componentes, mientras que el quelato de quitosano-ZnO mejora la actividad mutua del óxido metálico y el polímero natural.O desenvolvimento de alternativas aos antibióticos convencionais contra superbactérias representa um passo importante para evitar o aumento da resistência das bactérias diante dos tratamentos convencionais. Neste trabalho, avaliou-se a influência de diferentes combinações de dois componentes antibacterianos ativos (quitosana e óxido de zinco) e uma matriz de álcool polivinílico (PVA) em membranas produzidas pela técnica de evaporação de solvente. Esses sistemas foram avaliados em termos de inativação do biofilme, ensaios de tempo de morte e halos de inibição contra S. aureus (ATCC 25923) em membranas que devem liberar componentes reativos, preservando a integridade do material e favorecendo a geração de espécies reativas para melhorar a atividade antibacteriana. Os resultados sugerem o potencial da combinação de quitosana, óxido de zinco e álcool polivinílico para inibir o crescimento de S. aureus, uma vez que o PVA melhorou a dispersão dos componentes, enquanto o quelato de quitosana-ZnO melhora a atividade mútua do óxido metálico e do polímero natural.Research, Society and Development2023-03-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/4072010.33448/rsd-v12i3.40720Research, Society and Development; Vol. 12 No. 3; e23812340720Research, Society and Development; Vol. 12 Núm. 3; e23812340720Research, Society and Development; v. 12 n. 3; e238123407202525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/40720/33233Copyright (c) 2023 Edmo Henrique Martins Cavalcante; Fernando Antônio Gomes da Silva Junior; Monica Aparecida Tomé Pereira; Paulo José Pereira; Mateus Matiuzzi da Costa; Helinando Pequeno de Oliveirahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCavalcante, Edmo Henrique Martins Silva Junior, Fernando Antônio Gomes da Pereira, Monica Aparecida Tomé Pereira, Paulo José Costa, Mateus Matiuzzi da Oliveira, Helinando Pequeno de 2023-03-23T08:33:38Zoai:ojs.pkp.sfu.ca:article/40720Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2023-03-23T08:33:38Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Antibacterial activity of chitosan and zinc oxide impregnated in PVA-based membranes Actividad antibacteriana de membranas de PVA impregnadas con quitosano y óxido de zinc Atividade antibacteriana de membranas de PVA impregnadas com quitosana e óxido de zinco |
title |
Antibacterial activity of chitosan and zinc oxide impregnated in PVA-based membranes |
spellingShingle |
Antibacterial activity of chitosan and zinc oxide impregnated in PVA-based membranes Cavalcante, Edmo Henrique Martins Membranas Biomateriais Superfícies e interfaces Misturas. Membranas Biomateriales Superficies e interfaces Mezclas. Membranes Biomaterials Surfaces and interfaces Blends. |
title_short |
Antibacterial activity of chitosan and zinc oxide impregnated in PVA-based membranes |
title_full |
Antibacterial activity of chitosan and zinc oxide impregnated in PVA-based membranes |
title_fullStr |
Antibacterial activity of chitosan and zinc oxide impregnated in PVA-based membranes |
title_full_unstemmed |
Antibacterial activity of chitosan and zinc oxide impregnated in PVA-based membranes |
title_sort |
Antibacterial activity of chitosan and zinc oxide impregnated in PVA-based membranes |
author |
Cavalcante, Edmo Henrique Martins |
author_facet |
Cavalcante, Edmo Henrique Martins Silva Junior, Fernando Antônio Gomes da Pereira, Monica Aparecida Tomé Pereira, Paulo José Costa, Mateus Matiuzzi da Oliveira, Helinando Pequeno de |
author_role |
author |
author2 |
Silva Junior, Fernando Antônio Gomes da Pereira, Monica Aparecida Tomé Pereira, Paulo José Costa, Mateus Matiuzzi da Oliveira, Helinando Pequeno de |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Cavalcante, Edmo Henrique Martins Silva Junior, Fernando Antônio Gomes da Pereira, Monica Aparecida Tomé Pereira, Paulo José Costa, Mateus Matiuzzi da Oliveira, Helinando Pequeno de |
dc.subject.por.fl_str_mv |
Membranas Biomateriais Superfícies e interfaces Misturas. Membranas Biomateriales Superficies e interfaces Mezclas. Membranes Biomaterials Surfaces and interfaces Blends. |
topic |
Membranas Biomateriais Superfícies e interfaces Misturas. Membranas Biomateriales Superficies e interfaces Mezclas. Membranes Biomaterials Surfaces and interfaces Blends. |
description |
The development of alternatives to conventional antibiotics against superbugs represents an important step to avoid the increasing resistance of bacteria observed in conventional treatments. Herein, it was evaluated the influence of different combinations of two active antibacterial components (chitosan and zinc oxide) and a host poly (vinyl alcohol - PVA) in membranes produced by the solvent casting technique. Those systems were evaluated in terms of the biofilm inactivation, kill-time assays and inhibition haloes against S. aureus (ATCC 25923) in membranes that must release reactive components while preserving their integrity and favoring the generation of reactive species to improve the antibacterial activity. The results suggest the potential of the combination of chitosan, zinc oxide and poly (vinyl alcohol) to inhibit the growth of S. aureus colonies since the PVA improved the dispersion of the components, whereas chitosan-ZnO chelate improves the mutual activity of the metal oxide and the natural polymer template. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-03-14 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/40720 10.33448/rsd-v12i3.40720 |
url |
https://rsdjournal.org/index.php/rsd/article/view/40720 |
identifier_str_mv |
10.33448/rsd-v12i3.40720 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/40720/33233 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 12 No. 3; e23812340720 Research, Society and Development; Vol. 12 Núm. 3; e23812340720 Research, Society and Development; v. 12 n. 3; e23812340720 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
_version_ |
1797052620466028544 |