Aspidosperma excelsum and its pharmacological potential: in silico studies of pharmacokinetic prediction, toxicological and biological activity
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Research, Society and Development |
| Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/8635 |
Resumo: | Based on ethnobotanical studies, the Aspidosperma excelsum was selected due to its highest claim of popular use for malaria and febrile diseases treatments. This species is rich in secondary metabolites as alkaloids and therefore, the aim of this study was to evaluate the pharmacokinetic, toxicological and biological activity of alkaloids isolated from Aspidosperma excelsum by in silico studies. All substances already isolated from this species were submitted to predictive studies of biological, toxicological and pharmacokinetic activities. Predictive studies of biological activities did not attribute the antimalarial activity to pure substances. However, other activities were found, such as: action on central nervous system and antineoplastic activity. In pharmacokinetic terms, many substances showed an inhibitory action on cytochrome P450 (CYP) and many adverse reactions, highlighting actions on the CNS. Also, several alkaloids, being nitrogenous substances, presented mutagenic or genotoxic activities. Thus, it is demonstrated the species potential for biological activities not yet studied, as well as the importance of investigating its pharmacokinetic and toxicological properties, justifying the accomplishment of the present study. |
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Aspidosperma excelsum and its pharmacological potential: in silico studies of pharmacokinetic prediction, toxicological and biological activityAspidosperma excelsum y su potencial farmacológico: estudios in silico de predicción farmacocinética, actividad toxicológica y biológicaAspidosperma excelsum e seu potencial farmacológico: estudos in silico de predição farmacocinética, atividade toxicológica e biológicaPlantas medicinaisPrediçãoMaláriaAlcaloides.Plantas medicinalesPrediccionesMalariaAlcaloides.Medicinal plantsPredictionMalariaAlkaloids.Based on ethnobotanical studies, the Aspidosperma excelsum was selected due to its highest claim of popular use for malaria and febrile diseases treatments. This species is rich in secondary metabolites as alkaloids and therefore, the aim of this study was to evaluate the pharmacokinetic, toxicological and biological activity of alkaloids isolated from Aspidosperma excelsum by in silico studies. All substances already isolated from this species were submitted to predictive studies of biological, toxicological and pharmacokinetic activities. Predictive studies of biological activities did not attribute the antimalarial activity to pure substances. However, other activities were found, such as: action on central nervous system and antineoplastic activity. In pharmacokinetic terms, many substances showed an inhibitory action on cytochrome P450 (CYP) and many adverse reactions, highlighting actions on the CNS. Also, several alkaloids, being nitrogenous substances, presented mutagenic or genotoxic activities. Thus, it is demonstrated the species potential for biological activities not yet studied, as well as the importance of investigating its pharmacokinetic and toxicological properties, justifying the accomplishment of the present study.De los estudios etnobotánicos, se seleccionó la especie Aspidosperma excelsum, que tiene el mayor reclamo de uso popular en el tratamiento de la malaria y enfermedades febriles. Esta especie es rica en metabolitos secundarios, entre ellos alcaloides, por lo que el objetivo del presente estudio fue evaluar la actividad farmacocinética, toxicológica y biológica de alcaloides aislados de Aspidosperma excelsum mediante estudios in silico. Todas las sustancias ya aisladas de esta especie fueron sometidas a estudios predictivos de actividad biológica, toxicológica y farmacocinética. Los estudios predictivos de actividades biológicas no han atribuido esta actividad antipalúdica a sustancias puras. Sin embargo, se encontraron otras actividades, tales como: acción sobre el sistema nervioso central y antineoplásico. En términos farmacocinéticos, muchas sustancias mostraron una acción inhibidora sobre el citocromo P450 (CYP). Además de muchas reacciones adversas, destacan las acciones sobre el SNC. En cuanto a la toxicidad, varios alcaloides, al ser sustancias nitrogenadas, mostraron actividad mutagénica o genotóxica. Así, demuestra el potencial de esta especie para actividades biológicas aún no estudiadas, así como la importancia de investigar sus propiedades farmacocinéticas y toxicológicas, justificando la realización de este estudio.A partir de estudos etnobotânicos, selecionou-se a espécie Aspidosperma excelsum, que apresenta maior alegação de uso popular no tratamento de malária e doenças febris. Esta espécie é rica em metabólitos secundários, dentre eles os alcaloides e por isso, o objetivo do presente estudo foi avaliar o potencial farmacocinético, toxicológico e atividade biológica de alcaloides isolados de Aspidosperma excelsum por estudos in silico. Todas as substâncias já isoladas desta espécie foram submetidas a estudos preditivos de atividade biológica, toxicológica e farmacocinética. Estudos preditivos de atividades biológicas não atribuíram esta atividade antimalárica às substâncias puras. Porém, outras atividades foram encontradas, tais como: ação no sistema nervoso central e antineoplásico. Em termos farmacocinéticos, muitas substâncias mostraram ação inibitória sobre o citocromo P450 (CYP). Além de muitas reações adversas, destacando-se ações sobre o SNC. Quanto à toxicidade, vários alcaloides, por serem substâncias nitrogenadas, apresentaram atividade mutagênica ou genotóxica. Assim, demonstra-se o potencial desta espécie para atividades biológicas ainda não estudadas, bem como a importância da investigação de suas propriedades farmacocinéticas e toxicológicas, justificando a realização do presente estudo.Research, Society and Development2020-09-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/863510.33448/rsd-v9i10.8635Research, Society and Development; Vol. 9 No. 10; e3629108635Research, Society and Development; Vol. 9 Núm. 10; e3629108635Research, Society and Development; v. 9 n. 10; e36291086352525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/8635/7693Copyright (c) 2020 Juliana Correa-Barbosa; Milena Cristina Martins da Silva; Sandro Percário; Davi do Socorro Barros Brasil; Maria Fâni Dolabela; Valdicley Vieira Valehttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCorrea-Barbosa, JulianaSilva, Milena Cristina Martins daPercário, SandroBrasil, Davi do Socorro BarrosDolabela, Maria FâniVale, Valdicley Vieira 2020-10-31T12:03:23Zoai:ojs.pkp.sfu.ca:article/8635Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:31:04.290803Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
| dc.title.none.fl_str_mv |
Aspidosperma excelsum and its pharmacological potential: in silico studies of pharmacokinetic prediction, toxicological and biological activity Aspidosperma excelsum y su potencial farmacológico: estudios in silico de predicción farmacocinética, actividad toxicológica y biológica Aspidosperma excelsum e seu potencial farmacológico: estudos in silico de predição farmacocinética, atividade toxicológica e biológica |
| title |
Aspidosperma excelsum and its pharmacological potential: in silico studies of pharmacokinetic prediction, toxicological and biological activity |
| spellingShingle |
Aspidosperma excelsum and its pharmacological potential: in silico studies of pharmacokinetic prediction, toxicological and biological activity Correa-Barbosa, Juliana Plantas medicinais Predição Malária Alcaloides. Plantas medicinales Predicciones Malaria Alcaloides. Medicinal plants Prediction Malaria Alkaloids. |
| title_short |
Aspidosperma excelsum and its pharmacological potential: in silico studies of pharmacokinetic prediction, toxicological and biological activity |
| title_full |
Aspidosperma excelsum and its pharmacological potential: in silico studies of pharmacokinetic prediction, toxicological and biological activity |
| title_fullStr |
Aspidosperma excelsum and its pharmacological potential: in silico studies of pharmacokinetic prediction, toxicological and biological activity |
| title_full_unstemmed |
Aspidosperma excelsum and its pharmacological potential: in silico studies of pharmacokinetic prediction, toxicological and biological activity |
| title_sort |
Aspidosperma excelsum and its pharmacological potential: in silico studies of pharmacokinetic prediction, toxicological and biological activity |
| author |
Correa-Barbosa, Juliana |
| author_facet |
Correa-Barbosa, Juliana Silva, Milena Cristina Martins da Percário, Sandro Brasil, Davi do Socorro Barros Dolabela, Maria Fâni Vale, Valdicley Vieira |
| author_role |
author |
| author2 |
Silva, Milena Cristina Martins da Percário, Sandro Brasil, Davi do Socorro Barros Dolabela, Maria Fâni Vale, Valdicley Vieira |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Correa-Barbosa, Juliana Silva, Milena Cristina Martins da Percário, Sandro Brasil, Davi do Socorro Barros Dolabela, Maria Fâni Vale, Valdicley Vieira |
| dc.subject.por.fl_str_mv |
Plantas medicinais Predição Malária Alcaloides. Plantas medicinales Predicciones Malaria Alcaloides. Medicinal plants Prediction Malaria Alkaloids. |
| topic |
Plantas medicinais Predição Malária Alcaloides. Plantas medicinales Predicciones Malaria Alcaloides. Medicinal plants Prediction Malaria Alkaloids. |
| description |
Based on ethnobotanical studies, the Aspidosperma excelsum was selected due to its highest claim of popular use for malaria and febrile diseases treatments. This species is rich in secondary metabolites as alkaloids and therefore, the aim of this study was to evaluate the pharmacokinetic, toxicological and biological activity of alkaloids isolated from Aspidosperma excelsum by in silico studies. All substances already isolated from this species were submitted to predictive studies of biological, toxicological and pharmacokinetic activities. Predictive studies of biological activities did not attribute the antimalarial activity to pure substances. However, other activities were found, such as: action on central nervous system and antineoplastic activity. In pharmacokinetic terms, many substances showed an inhibitory action on cytochrome P450 (CYP) and many adverse reactions, highlighting actions on the CNS. Also, several alkaloids, being nitrogenous substances, presented mutagenic or genotoxic activities. Thus, it is demonstrated the species potential for biological activities not yet studied, as well as the importance of investigating its pharmacokinetic and toxicological properties, justifying the accomplishment of the present study. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-09-30 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
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https://rsdjournal.org/index.php/rsd/article/view/8635 10.33448/rsd-v9i10.8635 |
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https://rsdjournal.org/index.php/rsd/article/view/8635 |
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10.33448/rsd-v9i10.8635 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/8635/7693 |
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https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
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openAccess |
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application/pdf |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development; Vol. 9 No. 10; e3629108635 Research, Society and Development; Vol. 9 Núm. 10; e3629108635 Research, Society and Development; v. 9 n. 10; e3629108635 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
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Universidade Federal de Itajubá (UNIFEI) |
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UNIFEI |
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UNIFEI |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
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rsd.articles@gmail.com |
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1797052660055015424 |