Development, characterization, and evaluation by cutaneous bioengineering of a natural emulsion, to provide a standardized vehicle base for topical compounded preparations

Detalhes bibliográficos
Autor(a) principal: Leal, Guilherme Carneiro
Data de Publicação: 2022
Outros Autores: Costa, Isabela Mazarim da, Silva, Jéssica Bassi da, Santos, Rafaela Said dos, Bruschi, Marcos Luciano, Mello, João Carlos Palazzo de, Nakamura, Celso Vataru, Lonni, Audrey Alesandra Stinghen Garcia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/38290
Resumo: The use of products containing natural and sustainable substances has shown a remarkable growth in the pharmaceutical and cosmetic market, such as in the compounding pharmacy. This research aimed to develop, characterize, and evaluate the cutaneous bioengineering of natural and sustainable emulsions, providing a vehicle base for topical preparations. Nine O/W emulsions were developed changing the nonionic self-emulsifying wax (Cetearyl Olivate (and) Sorbitan Olivate, Cetearyl Glucoside (and) Cetearyl Alcohol, Candelilla/Jojoba/Rice Bran Polyglyceryl-3 Esters (and) Glyceryl Stearate (and) Cetearyl Alcohol (and) Sodium Stearoyl Lactylate), with or without the anionic co-emulsifier (Sodium Stearoyl Glutamate). They were characterized through preliminary stability tests, rheology and accelerated physicochemical stability study. Four formulations were approved (FB1, FB2, FB3 and FB5), but only FB1 (Cetearyl Olivate (and) Sorbitan Olivate with Sodium Stearoyl Glutamate) was considered stable, being selected for preservative efficacy evaluation and the cutaneous bioengineering. The hydration and transepidermal water loss (TEWL) of stratum corneum were analyzed comparing with a conventional topical vehicle (Emulsifying Wax NF). The clinical study showed that FB1 improved the skin hydration with no significant changes for TEWL, but demonstrated considered values. The FB1 could be classified as “skin friendly” and represents a promising natural and sustainable vehicle in compounded pharmacy preparations.
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spelling Development, characterization, and evaluation by cutaneous bioengineering of a natural emulsion, to provide a standardized vehicle base for topical compounded preparationsDesarrollo, caracterización y evaluación por bioingeniería cutánea de una emulsión natural para proporcionar una base portadora estandarizada para preparaciones magistrales tópicasDesenvolvimento, caracterização e avaliação por bioengenharia cutânea de uma emulsão natural, a fim de proporcionar uma base veicular padronizada para preparações magistrais tópicasProductos naturalesFarmacia de manipulaciónBioingeniería de la pielEnsayo clínico.Natural productsCompounding pharmacyCutaneous bioengineeringCase study.Produtos naturaisFarmácia de manipulaçãoBioengenharia cutâneaEnsaio clínico.The use of products containing natural and sustainable substances has shown a remarkable growth in the pharmaceutical and cosmetic market, such as in the compounding pharmacy. This research aimed to develop, characterize, and evaluate the cutaneous bioengineering of natural and sustainable emulsions, providing a vehicle base for topical preparations. Nine O/W emulsions were developed changing the nonionic self-emulsifying wax (Cetearyl Olivate (and) Sorbitan Olivate, Cetearyl Glucoside (and) Cetearyl Alcohol, Candelilla/Jojoba/Rice Bran Polyglyceryl-3 Esters (and) Glyceryl Stearate (and) Cetearyl Alcohol (and) Sodium Stearoyl Lactylate), with or without the anionic co-emulsifier (Sodium Stearoyl Glutamate). They were characterized through preliminary stability tests, rheology and accelerated physicochemical stability study. Four formulations were approved (FB1, FB2, FB3 and FB5), but only FB1 (Cetearyl Olivate (and) Sorbitan Olivate with Sodium Stearoyl Glutamate) was considered stable, being selected for preservative efficacy evaluation and the cutaneous bioengineering. The hydration and transepidermal water loss (TEWL) of stratum corneum were analyzed comparing with a conventional topical vehicle (Emulsifying Wax NF). The clinical study showed that FB1 improved the skin hydration with no significant changes for TEWL, but demonstrated considered values. The FB1 could be classified as “skin friendly” and represents a promising natural and sustainable vehicle in compounded pharmacy preparations.O uso de produtos contendo substâncias naturais e sustentáveis tem mostrado um crescimento notável no mercado farmacêutico e cosmético, bem como na farmácia de manipulação. Este trabalho objetivou desenvolver, caracterizar e avaliar a bioengenharia cutânea de emulsões naturais e sustentáveis, proporcionando uma base veicular para preparações tópicas. Nove emulsões O/A foram desenvolvidas mudando a cera autoemulsionante não iônica (Cetearyl Olivate (and) Sorbitan Olivate, Cetearyl Glucoside (and) Cetearyl Alcohol, Candelilla/Jojoba/Rice Bran Polyglyceryl-3 Esters (and) Glyceryl Stearate (and) Cetearyl Alcohol (and) Sodium Stearoyl Lactylate), with or without the anionic co-emulsifier (Sodium Stearoyl Glutamate), com ou sem o coemulsificante aniônico (Sodium Stearoyl Glutamate). Elas foram caracterizadas através de testes de estabilidade preliminar, reologia e estudo da estabilidade físico-química acelerada. Quatro formulações foram aprovadas (FB1, FB2, FB3 e FB5), mas apenas FB1 (Cetearyl Olivate (and) Sorbitan Olivate with Sodium Stearoyl Glutamate) foi considerada estável, sendo selecionada para a avaliação de eficácia de preservação, e para a bioengenharia cutânea. A hidratação e a perda de água transepidérmica (TEWL) do estrato córneo foram analisadas comparando com uma base veicular tópica convencional (Emulsifying Wax NF). O estudo clínico mostrou que FB1 melhorou a hidratação cutânea sem mudanças sifnificativas para o TEWL, mas demonstrou valores consideráveis. A FB1 pode ser classificada como “skin friendly” e representa um promissor veículo natural e sustentável para preparações farmacêuticas manipuladas.El uso de productos que contienen sustancias naturales y sostenibles ha mostrado un crecimiento notable en el mercado farmacéutico y cosmético, así como en la farmacia de compuestos. Este trabajo tuvo como objetivo desarrollar, caracterizar y evaluar la bioingeniería cutánea de emulsiones naturales y sostenibles, proporcionando una base vehículo para las preparaciones tópicas. Se desarrollaron nueve emulsiones O/W cambiando la cera autoemulsionante no iónica (Cetearyl Olivate (and) Sorbitan Olivate, Cetearyl Glucoside (and) Cetearyl Alcohol, Candelilla/Jojoba/Rice Bran Polyglyceryl-3 Esters (and) Glyceryl Stearate (and) Cetearyl Alcohol (and) Sodium Stearoyl Lactylate), con o sin el coemulsionante aniônico (Sodium Stearoyl Glutamate), con o sin el coemulsionante aniónico (estearoil glutamato de sodio). Se caracterizaron mediante pruebas preliminares de estabilidad, reología y estudio de estabilidad fisicoquímica acelerada. Se aprobaron cuatro formulaciones (FB1, FB2, FB3 y FB5), pero solo FB1 (Cetearyl Olivate (and) Sorbitan Olivate with Sodium Stearoyl Glutamate) se consideró estable, siendo seleccionada para la evaluación de la eficacia de conservación y para la bioingeniería cutánea. Se analizó la hidratación y pérdida de agua transepidérmica (TEWL) del estrato córneo comparándolo con una base de vehículo tópico convencional (Emulsifying Wax NF). El estudio clínico mostró que FB1 mejoró la hidratación de la piel sin cambios significativos para TEWL, pero mostró valores considerables. FB1 se puede clasificar como "amigable con la piel" y representa un vehículo natural y sostenible prometedor para las preparaciones farmacéuticas manipuladas.Research, Society and Development2022-12-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3829010.33448/rsd-v11i16.38290Research, Society and Development; Vol. 11 No. 16; e509111638290Research, Society and Development; Vol. 11 Núm. 16; e509111638290Research, Society and Development; v. 11 n. 16; e5091116382902525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/38290/31893Copyright (c) 2022 Guilherme Carneiro Leal; Isabela Mazarim da Costa; Jéssica Bassi da Silva; Rafaela Said dos Santos; Marcos Luciano Bruschi; João Carlos Palazzo de Mello; Celso Vataru Nakamura; Audrey Alesandra Stinghen Garcia Lonnihttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessLeal, Guilherme Carneiro Costa, Isabela Mazarim da Silva, Jéssica Bassi da Santos, Rafaela Said dos Bruschi, Marcos LucianoMello, João Carlos Palazzo deNakamura, Celso Vataru Lonni, Audrey Alesandra Stinghen Garcia 2022-12-18T18:26:42Zoai:ojs.pkp.sfu.ca:article/38290Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:52:05.074489Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Development, characterization, and evaluation by cutaneous bioengineering of a natural emulsion, to provide a standardized vehicle base for topical compounded preparations
Desarrollo, caracterización y evaluación por bioingeniería cutánea de una emulsión natural para proporcionar una base portadora estandarizada para preparaciones magistrales tópicas
Desenvolvimento, caracterização e avaliação por bioengenharia cutânea de uma emulsão natural, a fim de proporcionar uma base veicular padronizada para preparações magistrais tópicas
title Development, characterization, and evaluation by cutaneous bioengineering of a natural emulsion, to provide a standardized vehicle base for topical compounded preparations
spellingShingle Development, characterization, and evaluation by cutaneous bioengineering of a natural emulsion, to provide a standardized vehicle base for topical compounded preparations
Leal, Guilherme Carneiro
Productos naturales
Farmacia de manipulación
Bioingeniería de la piel
Ensayo clínico.
Natural products
Compounding pharmacy
Cutaneous bioengineering
Case study.
Produtos naturais
Farmácia de manipulação
Bioengenharia cutânea
Ensaio clínico.
title_short Development, characterization, and evaluation by cutaneous bioengineering of a natural emulsion, to provide a standardized vehicle base for topical compounded preparations
title_full Development, characterization, and evaluation by cutaneous bioengineering of a natural emulsion, to provide a standardized vehicle base for topical compounded preparations
title_fullStr Development, characterization, and evaluation by cutaneous bioengineering of a natural emulsion, to provide a standardized vehicle base for topical compounded preparations
title_full_unstemmed Development, characterization, and evaluation by cutaneous bioengineering of a natural emulsion, to provide a standardized vehicle base for topical compounded preparations
title_sort Development, characterization, and evaluation by cutaneous bioengineering of a natural emulsion, to provide a standardized vehicle base for topical compounded preparations
author Leal, Guilherme Carneiro
author_facet Leal, Guilherme Carneiro
Costa, Isabela Mazarim da
Silva, Jéssica Bassi da
Santos, Rafaela Said dos
Bruschi, Marcos Luciano
Mello, João Carlos Palazzo de
Nakamura, Celso Vataru
Lonni, Audrey Alesandra Stinghen Garcia
author_role author
author2 Costa, Isabela Mazarim da
Silva, Jéssica Bassi da
Santos, Rafaela Said dos
Bruschi, Marcos Luciano
Mello, João Carlos Palazzo de
Nakamura, Celso Vataru
Lonni, Audrey Alesandra Stinghen Garcia
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Leal, Guilherme Carneiro
Costa, Isabela Mazarim da
Silva, Jéssica Bassi da
Santos, Rafaela Said dos
Bruschi, Marcos Luciano
Mello, João Carlos Palazzo de
Nakamura, Celso Vataru
Lonni, Audrey Alesandra Stinghen Garcia
dc.subject.por.fl_str_mv Productos naturales
Farmacia de manipulación
Bioingeniería de la piel
Ensayo clínico.
Natural products
Compounding pharmacy
Cutaneous bioengineering
Case study.
Produtos naturais
Farmácia de manipulação
Bioengenharia cutânea
Ensaio clínico.
topic Productos naturales
Farmacia de manipulación
Bioingeniería de la piel
Ensayo clínico.
Natural products
Compounding pharmacy
Cutaneous bioengineering
Case study.
Produtos naturais
Farmácia de manipulação
Bioengenharia cutânea
Ensaio clínico.
description The use of products containing natural and sustainable substances has shown a remarkable growth in the pharmaceutical and cosmetic market, such as in the compounding pharmacy. This research aimed to develop, characterize, and evaluate the cutaneous bioengineering of natural and sustainable emulsions, providing a vehicle base for topical preparations. Nine O/W emulsions were developed changing the nonionic self-emulsifying wax (Cetearyl Olivate (and) Sorbitan Olivate, Cetearyl Glucoside (and) Cetearyl Alcohol, Candelilla/Jojoba/Rice Bran Polyglyceryl-3 Esters (and) Glyceryl Stearate (and) Cetearyl Alcohol (and) Sodium Stearoyl Lactylate), with or without the anionic co-emulsifier (Sodium Stearoyl Glutamate). They were characterized through preliminary stability tests, rheology and accelerated physicochemical stability study. Four formulations were approved (FB1, FB2, FB3 and FB5), but only FB1 (Cetearyl Olivate (and) Sorbitan Olivate with Sodium Stearoyl Glutamate) was considered stable, being selected for preservative efficacy evaluation and the cutaneous bioengineering. The hydration and transepidermal water loss (TEWL) of stratum corneum were analyzed comparing with a conventional topical vehicle (Emulsifying Wax NF). The clinical study showed that FB1 improved the skin hydration with no significant changes for TEWL, but demonstrated considered values. The FB1 could be classified as “skin friendly” and represents a promising natural and sustainable vehicle in compounded pharmacy preparations.
publishDate 2022
dc.date.none.fl_str_mv 2022-12-16
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/38290
10.33448/rsd-v11i16.38290
url https://rsdjournal.org/index.php/rsd/article/view/38290
identifier_str_mv 10.33448/rsd-v11i16.38290
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/38290/31893
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 16; e509111638290
Research, Society and Development; Vol. 11 Núm. 16; e509111638290
Research, Society and Development; v. 11 n. 16; e509111638290
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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