Possible pharmacological treatment in study phase for COVID-19 symptomatic patients: An integrative review

Detalhes bibliográficos
Autor(a) principal: Silva, Danielle Guimarães
Data de Publicação: 2021
Outros Autores: Bartaquini, Renan Tripode, Pedrosa, Beatriz Moraes, Ribeiro, Carolina Heitmann Mares Azevedo, Prete, Ana Cristina Lo
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/15579
Resumo: Objective: To perform an integrative review regarding the possible pharmacologic treatment currently being studied as therapeutics strategy for COVID-19 positive patients. Methods: An integrative review was performed using studies in the Medical Literatura Analysis and Retrieval System database, in the PUBMED search engine, in which were selected 58 articles regarding 9 pharmacological classes. Results: The distribution of the 58 articles included in this review was categorized by approached drug type. Were considered treatment with significant improvement the ones which presented viral load decrease, hospital time decrease or with statistically significant clinical improvement according to the criteria of each publication. Conclusion: Considering the urgency of the rapid production of results, a great difficulty of production of blind and double-blind studies was observed, limiting the scientific community to retrospective and observational studies, mostly, which are not as efficient as the mentioned before. Based on the studies observation, an efficient treatment to COVID-19 is not yet available, making the execution of preventive measures crucial, in order to avoid the impact of the disease in the population.
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spelling Possible pharmacological treatment in study phase for COVID-19 symptomatic patients: An integrative reviewPosibles tratamientos farmacológicos en estudio para pacientes sintomáticos de COVID-19: Una revisión integradoraPossíveis tratamentos farmacológicos em fase de estudos para pacientes sintomáticos de COVID-19:Uma revisão integrativaPosibles tratamientosCOVID-19PandemiaNuevo coronavirusSARS-CoV-2.Possíveis TratamentosCOVID-19PandemiaNovo CoronavírusSARS-CoV-2.Possible TreatmentsCOVID-19PandemicNew CoronavirusSARS-CoV-2.Objective: To perform an integrative review regarding the possible pharmacologic treatment currently being studied as therapeutics strategy for COVID-19 positive patients. Methods: An integrative review was performed using studies in the Medical Literatura Analysis and Retrieval System database, in the PUBMED search engine, in which were selected 58 articles regarding 9 pharmacological classes. Results: The distribution of the 58 articles included in this review was categorized by approached drug type. Were considered treatment with significant improvement the ones which presented viral load decrease, hospital time decrease or with statistically significant clinical improvement according to the criteria of each publication. Conclusion: Considering the urgency of the rapid production of results, a great difficulty of production of blind and double-blind studies was observed, limiting the scientific community to retrospective and observational studies, mostly, which are not as efficient as the mentioned before. Based on the studies observation, an efficient treatment to COVID-19 is not yet available, making the execution of preventive measures crucial, in order to avoid the impact of the disease in the population.Objetivo: Realizar una revisión integradora de los posibles tratamientos farmacológicos que se están estudiando actualmente como estratégias terapéuticas para los pacientes COVID-19 positivos. Métodos: Se realizó una revisión integradora de estudios de la base de datos del Medical Literature Analysis and Retrieval System, mediante el sistema de búsqueda PUBMED, en la que se seleccionaron 58 artículos que abarcan 9 clases de fármacos. Resultados: La distribución de los 58 artículos incluidos en la revisión se categorizó por fármaco abordado. Se consideraron tratamientos con mejoría significativa aquellos que observaron una reducción de la carga viral, una reducción del tempo de hospitalización o mejoría clínica estadísticamente relevante según los criterios de cada estudio. Conclusión: Ante la urgencia de producir resultados rápidos, se observó que existe una gran dificultad en la realización de ensayos clínicos ciegos, doble ciego, haciendo con que la comunidad científica se restrinja principalmente a estudios retrospectivos y observacionales, los cuales no son tan eficientes como el anteriormente mencionado. Con base en la observación de los estudios, aún no existe un tratamiento efectivo para COVID-19, y la aplicación de medidas preventivas es crucial para evitar el impacto de la enfermedad en la población.Objetivo: Realizar uma revisão integrativa sobre os possíveis tratamentos farmacológicos estudados atualmente como estratégias terapêuticas para pacientes COVID-19 positivos. Métodos: Foi realizada uma revisão integrativa de estudos da base de dados Medical Literature Analysis and Retrieval System, no sistema de busca PUBMED, na qual foram selecionados 58 artigos abordando 9 classes de fármacos. Resultados: A distribuição dos 58 artigos incluídos na revisão foi categorizada por fármaco abordado. Foram considerados tratamentos com melhoras significativas os que observaram redução de carga viral, redução do tempo de internação ou melhora clínica estatisticamente relevantes de acordo com os critérios de cada estudo. Conclusão: Com a urgência da produção rápida de resultados, foi observado que há uma grande dificuldade de produção de ensaios clínicos cego, duplo cego, fazendo com que a comunidade científica se restrinja principalmente a estudos retrospectivos e observacionais, que não são tão eficientes quanto os citados anteriormente. Com base na observação dos estudos, ainda não há um tratamento eficaz para a COVID-19, sendo crucial a aplicação de medidas preventivas, a fim de evitar o impacto da doença na população.Research, Society and Development2021-06-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1557910.33448/rsd-v10i6.15579Research, Society and Development; Vol. 10 No. 6; e37910615579Research, Society and Development; Vol. 10 Núm. 6; e37910615579Research, Society and Development; v. 10 n. 6; e379106155792525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/15579/14192Copyright (c) 2021 Danielle Guimarães Silva; Renan Tripode Bartaquini; Beatriz Moraes Pedrosa; Carolina Heitmann Mares Azevedo Ribeiro; Ana Cristina Lo Pretehttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSilva, Danielle Guimarães Bartaquini, Renan Tripode Pedrosa, Beatriz Moraes Ribeiro, Carolina Heitmann Mares AzevedoPrete, Ana Cristina Lo 2021-06-10T22:51:46Zoai:ojs.pkp.sfu.ca:article/15579Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:36:22.441626Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Possible pharmacological treatment in study phase for COVID-19 symptomatic patients: An integrative review
Posibles tratamientos farmacológicos en estudio para pacientes sintomáticos de COVID-19: Una revisión integradora
Possíveis tratamentos farmacológicos em fase de estudos para pacientes sintomáticos de COVID-19:Uma revisão integrativa
title Possible pharmacological treatment in study phase for COVID-19 symptomatic patients: An integrative review
spellingShingle Possible pharmacological treatment in study phase for COVID-19 symptomatic patients: An integrative review
Silva, Danielle Guimarães
Posibles tratamientos
COVID-19
Pandemia
Nuevo coronavirus
SARS-CoV-2.
Possíveis Tratamentos
COVID-19
Pandemia
Novo Coronavírus
SARS-CoV-2.
Possible Treatments
COVID-19
Pandemic
New Coronavirus
SARS-CoV-2.
title_short Possible pharmacological treatment in study phase for COVID-19 symptomatic patients: An integrative review
title_full Possible pharmacological treatment in study phase for COVID-19 symptomatic patients: An integrative review
title_fullStr Possible pharmacological treatment in study phase for COVID-19 symptomatic patients: An integrative review
title_full_unstemmed Possible pharmacological treatment in study phase for COVID-19 symptomatic patients: An integrative review
title_sort Possible pharmacological treatment in study phase for COVID-19 symptomatic patients: An integrative review
author Silva, Danielle Guimarães
author_facet Silva, Danielle Guimarães
Bartaquini, Renan Tripode
Pedrosa, Beatriz Moraes
Ribeiro, Carolina Heitmann Mares Azevedo
Prete, Ana Cristina Lo
author_role author
author2 Bartaquini, Renan Tripode
Pedrosa, Beatriz Moraes
Ribeiro, Carolina Heitmann Mares Azevedo
Prete, Ana Cristina Lo
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Silva, Danielle Guimarães
Bartaquini, Renan Tripode
Pedrosa, Beatriz Moraes
Ribeiro, Carolina Heitmann Mares Azevedo
Prete, Ana Cristina Lo
dc.subject.por.fl_str_mv Posibles tratamientos
COVID-19
Pandemia
Nuevo coronavirus
SARS-CoV-2.
Possíveis Tratamentos
COVID-19
Pandemia
Novo Coronavírus
SARS-CoV-2.
Possible Treatments
COVID-19
Pandemic
New Coronavirus
SARS-CoV-2.
topic Posibles tratamientos
COVID-19
Pandemia
Nuevo coronavirus
SARS-CoV-2.
Possíveis Tratamentos
COVID-19
Pandemia
Novo Coronavírus
SARS-CoV-2.
Possible Treatments
COVID-19
Pandemic
New Coronavirus
SARS-CoV-2.
description Objective: To perform an integrative review regarding the possible pharmacologic treatment currently being studied as therapeutics strategy for COVID-19 positive patients. Methods: An integrative review was performed using studies in the Medical Literatura Analysis and Retrieval System database, in the PUBMED search engine, in which were selected 58 articles regarding 9 pharmacological classes. Results: The distribution of the 58 articles included in this review was categorized by approached drug type. Were considered treatment with significant improvement the ones which presented viral load decrease, hospital time decrease or with statistically significant clinical improvement according to the criteria of each publication. Conclusion: Considering the urgency of the rapid production of results, a great difficulty of production of blind and double-blind studies was observed, limiting the scientific community to retrospective and observational studies, mostly, which are not as efficient as the mentioned before. Based on the studies observation, an efficient treatment to COVID-19 is not yet available, making the execution of preventive measures crucial, in order to avoid the impact of the disease in the population.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-03
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/15579
10.33448/rsd-v10i6.15579
url https://rsdjournal.org/index.php/rsd/article/view/15579
identifier_str_mv 10.33448/rsd-v10i6.15579
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/15579/14192
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 6; e37910615579
Research, Society and Development; Vol. 10 Núm. 6; e37910615579
Research, Society and Development; v. 10 n. 6; e37910615579
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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