The potential effect of resveratrol in the treatment of endometriosis

Detalhes bibliográficos
Autor(a) principal: Uchoa, Silvia Neide da Silva
Data de Publicação: 2022
Outros Autores: Figueira, Larissa Lima, Dias, Daniela de Araújo Medeiros
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/31262
Resumo: Endometriosis is a gynecological disorder characterized by the presence of endometrial tissue outside the uterine cavity related to genetic predisposition, estrogen dependence, progesterone resistance, and inflammation. The retrograde menstruation theory, formulated by Sampson, is the most scientifically acceptable etiology due to similar mechanisms occurring in healthy women. However, several other theories have been raised with different pathophysiological focuses. The pathogenesis of the disease contributes to an immune imbalance, culminating in increased expression of inflammatory and angiogenic mediators and changes in several metabolic pathways. Resveratrol is a polyphenol that has been widely studied for its benefits in controlling inflammatory mediators. In this review, we summarized the most recent findings linking the effects of resveratrol and possible improvements in disease symptomatology. Experimental and in vitro studies have shown beneficial results when evaluated in endometriotic models. However, the same results were not obtained in humans, especially when assessing pain thresholds before and after resveratrol supplementation. In conclusion, the results for clinical practice are still inconclusive.
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spelling The potential effect of resveratrol in the treatment of endometriosisEl efecto potencial del resveratrol en el tratamiento de la endometriosisO potencial efeito do resveratrol no tratamento da endometrioseEndometriosisResveratrolPolifenolesEndometrioCompuestos fenólicosEnfermedades ginecológicas.EndometriosisResveratrolPolyphenols EndometriumPhenolic CompoundsGynecological diseases.EndometrioseResveratrolPolifenóisEndométrioCompostos FenólicosDoenças ginecológicas.Endometriosis is a gynecological disorder characterized by the presence of endometrial tissue outside the uterine cavity related to genetic predisposition, estrogen dependence, progesterone resistance, and inflammation. The retrograde menstruation theory, formulated by Sampson, is the most scientifically acceptable etiology due to similar mechanisms occurring in healthy women. However, several other theories have been raised with different pathophysiological focuses. The pathogenesis of the disease contributes to an immune imbalance, culminating in increased expression of inflammatory and angiogenic mediators and changes in several metabolic pathways. Resveratrol is a polyphenol that has been widely studied for its benefits in controlling inflammatory mediators. In this review, we summarized the most recent findings linking the effects of resveratrol and possible improvements in disease symptomatology. Experimental and in vitro studies have shown beneficial results when evaluated in endometriotic models. However, the same results were not obtained in humans, especially when assessing pain thresholds before and after resveratrol supplementation. In conclusion, the results for clinical practice are still inconclusive.La endometriosis es un trastorno ginecológico caracterizado por la presencia de tejido endometrial fuera de la cavidad uterina relacionado con la predisposición genética, la dependencia de los estrógenos, la resistencia a la progesterona y la inflamación. La teoría de la menstruación retrógrada, formulada por Sampson, es la etiología científicamente más aceptable debido a los mecanismos similares que se producen en las mujeres sanas. Sin embargo, se han planteado otras teorías con diferentes focos fisiopatológicos. La patogénesis de la enfermedad contribuye a un desequilibrio inmunológico, que culmina en un aumento de la expresión de mediadores inflamatorios y angiogénicos y en cambios en varias vías metabólicas. El resveratrol es un polifenol que ha sido ampliamente estudiado por sus beneficios en el control de los mediadores inflamatorios. En esta revisión, resumimos los hallazgos más recientes que relacionan los efectos del resveratrol y las posibles mejoras en la sintomatología de la enfermedad objetivo. Los estudios experimentales e in vitro han demostrado resultados beneficiosos cuando se evalúan en modelos endometriósicos. Sin embargo, no se obtuvieron los mismos resultados en humanos, especialmente al evaluar los umbrales de dolor antes y después de la suplementación con resveratrol. En conclusión, los resultados para la práctica clínica aún no son concluyentes.A endometriose é uma desordem ginecológica caracterizada pela presença de tecido endometrial fora da cavidade uterina relacionado com predisposição genética, dependência de estrogênio, resistência à progesterona e inflamação. A teoria da menstruação retrógrada, formulada por Sampson, é a etiologia cientificamente mais aceitável devido mecanismos semelhantes que ocorreram em mulheres saudáveis. Entretanto, diversas outras teorias foram levantadas com diferentes focos fisiopatológicos. A patogênese da doença contribui para um desequilíbrio imunológico, culminando no aumento da expressão de mediadores inflamatórios, angiogênicos e alterações em diversas vias metabólicas. O resveratrol é um polifenol que tem sido amplamente estudado pelos seus benefícios no controle de mediadores inflamatórios. Nesta revisão, nós resumimos os achados mais recentes que interligam os efeitos do resveratrol e possíveis melhorias na sintomatologia da doença alvo. Estudos experimentais e in vitro mostraram resultados benéficos quando avaliados em modelos endometrióticos. No entanto, os mesmos resultados não foram obtidos em humanos, especialmente quando avaliaram os limiares de dor antes e depois da suplementação do resveratrol. Em conclusão, os resultados para a prática clínica ainda são inconclusivos.Research, Society and Development2022-06-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3126210.33448/rsd-v11i8.31262Research, Society and Development; Vol. 11 No. 8; e52111831262Research, Society and Development; Vol. 11 Núm. 8; e52111831262Research, Society and Development; v. 11 n. 8; e521118312622525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/31262/26757Copyright (c) 2022 Silvia Neide da Silva Uchoa; Larissa Lima Figueira; Daniela de Araújo Medeiros Diashttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessUchoa, Silvia Neide da Silva Figueira, Larissa LimaDias, Daniela de Araújo Medeiros 2022-07-01T13:34:06Zoai:ojs.pkp.sfu.ca:article/31262Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:47:40.121627Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv The potential effect of resveratrol in the treatment of endometriosis
El efecto potencial del resveratrol en el tratamiento de la endometriosis
O potencial efeito do resveratrol no tratamento da endometriose
title The potential effect of resveratrol in the treatment of endometriosis
spellingShingle The potential effect of resveratrol in the treatment of endometriosis
Uchoa, Silvia Neide da Silva
Endometriosis
Resveratrol
Polifenoles
Endometrio
Compuestos fenólicos
Enfermedades ginecológicas.
Endometriosis
Resveratrol
Polyphenols
Endometrium
Phenolic Compounds
Gynecological diseases.
Endometriose
Resveratrol
Polifenóis
Endométrio
Compostos Fenólicos
Doenças ginecológicas.
title_short The potential effect of resveratrol in the treatment of endometriosis
title_full The potential effect of resveratrol in the treatment of endometriosis
title_fullStr The potential effect of resveratrol in the treatment of endometriosis
title_full_unstemmed The potential effect of resveratrol in the treatment of endometriosis
title_sort The potential effect of resveratrol in the treatment of endometriosis
author Uchoa, Silvia Neide da Silva
author_facet Uchoa, Silvia Neide da Silva
Figueira, Larissa Lima
Dias, Daniela de Araújo Medeiros
author_role author
author2 Figueira, Larissa Lima
Dias, Daniela de Araújo Medeiros
author2_role author
author
dc.contributor.author.fl_str_mv Uchoa, Silvia Neide da Silva
Figueira, Larissa Lima
Dias, Daniela de Araújo Medeiros
dc.subject.por.fl_str_mv Endometriosis
Resveratrol
Polifenoles
Endometrio
Compuestos fenólicos
Enfermedades ginecológicas.
Endometriosis
Resveratrol
Polyphenols
Endometrium
Phenolic Compounds
Gynecological diseases.
Endometriose
Resveratrol
Polifenóis
Endométrio
Compostos Fenólicos
Doenças ginecológicas.
topic Endometriosis
Resveratrol
Polifenoles
Endometrio
Compuestos fenólicos
Enfermedades ginecológicas.
Endometriosis
Resveratrol
Polyphenols
Endometrium
Phenolic Compounds
Gynecological diseases.
Endometriose
Resveratrol
Polifenóis
Endométrio
Compostos Fenólicos
Doenças ginecológicas.
description Endometriosis is a gynecological disorder characterized by the presence of endometrial tissue outside the uterine cavity related to genetic predisposition, estrogen dependence, progesterone resistance, and inflammation. The retrograde menstruation theory, formulated by Sampson, is the most scientifically acceptable etiology due to similar mechanisms occurring in healthy women. However, several other theories have been raised with different pathophysiological focuses. The pathogenesis of the disease contributes to an immune imbalance, culminating in increased expression of inflammatory and angiogenic mediators and changes in several metabolic pathways. Resveratrol is a polyphenol that has been widely studied for its benefits in controlling inflammatory mediators. In this review, we summarized the most recent findings linking the effects of resveratrol and possible improvements in disease symptomatology. Experimental and in vitro studies have shown beneficial results when evaluated in endometriotic models. However, the same results were not obtained in humans, especially when assessing pain thresholds before and after resveratrol supplementation. In conclusion, the results for clinical practice are still inconclusive.
publishDate 2022
dc.date.none.fl_str_mv 2022-06-28
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/31262
10.33448/rsd-v11i8.31262
url https://rsdjournal.org/index.php/rsd/article/view/31262
identifier_str_mv 10.33448/rsd-v11i8.31262
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/31262/26757
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 8; e52111831262
Research, Society and Development; Vol. 11 Núm. 8; e52111831262
Research, Society and Development; v. 11 n. 8; e52111831262
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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