Thermographic evaluation of piroxicam’s effect as an adjuvant treatment in canine mammary tumors
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Research, Society and Development |
| Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/12236 |
Resumo: | Mammary tumors are the second most diagnosed neoplasms in dogs. Canine females are largely affected by malignant mammary tumours. Several factors are involved in the development and determination of the malignancy of these lesions, including the action of cyclooxygenase-2. Use of non-steroidal anti-inflammatory drugs as enzyme-inhibiting drugs has been studied as a promising adjuvant treatment for neoplasms. The aim of this study was to evaluate the effect of piroxicam in reducing inflammation caused by mammary tumours in 25 bitches during 10 days of administration based on the measurement of peritumoral temperature using thermography. The results indicated a significant difference (p=0,003) between the average temperatures at the first and last day of treatment. When performing the evaluation of malignant and benign neoplasms separately, it was possible to observe that, statistically, malignant neoplasms (n=19) showed a significant reduction in peritumoral temperatures (P=<0.001), however, benign neoplasms (n=6) have not obtained a significant difference in temperature after the therapeutic protocol (P=0.954). Therefore, it was possible to demonstrate the efficacy of the medication in reducing the heat caused by inflammation and allowing advances in the development of therapeutic protocols for mammary tumors in bitches, such as the inclusion of the drug in the period prior to the mastectomy surgeries. |
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Thermographic evaluation of piroxicam’s effect as an adjuvant treatment in canine mammary tumorsEvaluación termográfica del efecto del piroxicam como tratamiento adyuvante en tumores mamarios de perrasAvaliação termográfica do efeito do piroxicam como tratamento adjuvante em neoplasias mamárias de cadelasPerrosOncologíaInflamaciónGlándula MamariaInhibidores COX-2.CaninoOncologiaGlândulas MamáriasInflamaçãoInibidores COX-2. CanineOncologyInflammationMammary GlandCOX-2 Inhibitors.Mammary tumors are the second most diagnosed neoplasms in dogs. Canine females are largely affected by malignant mammary tumours. Several factors are involved in the development and determination of the malignancy of these lesions, including the action of cyclooxygenase-2. Use of non-steroidal anti-inflammatory drugs as enzyme-inhibiting drugs has been studied as a promising adjuvant treatment for neoplasms. The aim of this study was to evaluate the effect of piroxicam in reducing inflammation caused by mammary tumours in 25 bitches during 10 days of administration based on the measurement of peritumoral temperature using thermography. The results indicated a significant difference (p=0,003) between the average temperatures at the first and last day of treatment. When performing the evaluation of malignant and benign neoplasms separately, it was possible to observe that, statistically, malignant neoplasms (n=19) showed a significant reduction in peritumoral temperatures (P=<0.001), however, benign neoplasms (n=6) have not obtained a significant difference in temperature after the therapeutic protocol (P=0.954). Therefore, it was possible to demonstrate the efficacy of the medication in reducing the heat caused by inflammation and allowing advances in the development of therapeutic protocols for mammary tumors in bitches, such as the inclusion of the drug in the period prior to the mastectomy surgeries.Los tumores mamarios ocupan el segundo lugar em el ranking de los cánceres más frecuentemente diagnosticados en perros. Las perras son las más afectadas por esta enfermedad que en la mayoría de los casos se presenta de forma maligna. Se sabe que varios factores están involucrados en el desarrollo y determinación de la malignidad de estas lesiones, incluida la acción de la ciclooxigenasa-2. Se estudia la utilización de antiinflamatorios no esteroides que actúan como inhibidores enzimáticos como un tratamiento adyuvante prometedor para neoplasias. Este estudio tuvo como objetivo evaluar el efecto del piroxicam en la reducción de la inflamación causada por la progresión de los tumores de mama en 25 perras, a partir de la medición de la temperatura peritumoral, mediante termografía, durante 10 días de administración del fármaco. Los resultados indicaron una diferencia significativa (p=0,003) entre las temperaturas medias del primer y último día de tratamiento. Al realizar la evaluación de neoplasias malignas y benignas por separado, se pudo observar que, estadísticamente, neoplasias malignas (n=19) mostraron una reducción significativa de las temperaturas peritumorales (P=<0,001), sin embargo, neoplasias benignas (n=6) no obtuvieron una diferencia significativa de temperatura después del protocolo terapéutico (P=0,954). Así, se pudo demostrar la eficacia de la medicación en la reducción del calor provocado por la inflamación y permitiendo avances en el desarrollo de protocolos terapéuticos para los tumores mamarios, como la inclusión del fármaco en el período previo a la realización de la mastectomía.As neoplasias mamárias estão em segundo no ranking das neoplasias mais diagnosticadas em cães. As fêmeas caninas são amplamente acometidas por esta doença que, na maioria dos casos, apresenta-se na forma maligna. Sabe-se que diversos fatores estão envolvidos no desenvolvimento e determinação da malignidade destas lesões, incluindo a ação da ciclo-oxigenase-2. A utilização de anti-inflamatórios não esteroidais atuantes como inibidores desta enzima é estudada como um promissor tratamento adjuvante das neoplasias. Este estudo teve como objetivo avaliar o efeito do piroxicam na diminuição da inflamação causada pela progressão dos tumores mamários em 25 cadelas, a partir da aferição da temperatura peritumoral utilizando o recurso da termografia, durante 10 dias de administração do fármaco. Os resultados indicaram diferença significativa (p=0,003) entre as temperaturas médias do primeiro e último dia de tratamento. Ao realizar a avaliação das neoplasias malignas e benignas separadamente, foi possível observar que, estatisticamente, as neoplasias malignas (n=19) apresentaram redução significativa das temperaturas peritumorais (P=<0,001), contudo, as neoplasias benignas (n=6) não obtiveram diferença significativa da temperatura após o protocolo terapêutico (P=0,954). Dessa forma, foi possível demonstrar a eficácia da medicação em reduzir o calor causado pela inflamação e permitir avanços na elaboração de protolocos terapêuticos destinados às neoplasias mamárias em cadelas, como a inclusão do fármaco no período que antecede a realização das cirurgias de mastectomia.Research, Society and Development2021-02-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1223610.33448/rsd-v10i2.12236Research, Society and Development; Vol. 10 No. 2; e18710212236Research, Society and Development; Vol. 10 Núm. 2; e18710212236Research, Society and Development; v. 10 n. 2; e187102122362525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/12236/11249Copyright (c) 2021 Julia Rodrigues Greghi; Maíra Planzo Fernandes, Aline Groth, Letícia Amanda dos Santos Silva, Josiana de Fátima Schnitzer, Giovana Wingeter Di Santis, Maria Isabel Mello Martinshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessGreghi, Julia RodriguesFernandes, Maíra PlanzoGroth, AlineSilva, Letícia Amanda dos SantosSchnitzer, Josiana de FátimaDi Santis, Giovana Wingeter Martins, Maria Isabel Mello2021-03-02T09:32:39Zoai:ojs.pkp.sfu.ca:article/12236Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:33:52.027576Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
| dc.title.none.fl_str_mv |
Thermographic evaluation of piroxicam’s effect as an adjuvant treatment in canine mammary tumors Evaluación termográfica del efecto del piroxicam como tratamiento adyuvante en tumores mamarios de perras Avaliação termográfica do efeito do piroxicam como tratamento adjuvante em neoplasias mamárias de cadelas |
| title |
Thermographic evaluation of piroxicam’s effect as an adjuvant treatment in canine mammary tumors |
| spellingShingle |
Thermographic evaluation of piroxicam’s effect as an adjuvant treatment in canine mammary tumors Greghi, Julia Rodrigues Perros Oncología Inflamación Glándula Mamaria Inhibidores COX-2. Canino Oncologia Glândulas Mamárias Inflamação Inibidores COX-2. Canine Oncology Inflammation Mammary Gland COX-2 Inhibitors. |
| title_short |
Thermographic evaluation of piroxicam’s effect as an adjuvant treatment in canine mammary tumors |
| title_full |
Thermographic evaluation of piroxicam’s effect as an adjuvant treatment in canine mammary tumors |
| title_fullStr |
Thermographic evaluation of piroxicam’s effect as an adjuvant treatment in canine mammary tumors |
| title_full_unstemmed |
Thermographic evaluation of piroxicam’s effect as an adjuvant treatment in canine mammary tumors |
| title_sort |
Thermographic evaluation of piroxicam’s effect as an adjuvant treatment in canine mammary tumors |
| author |
Greghi, Julia Rodrigues |
| author_facet |
Greghi, Julia Rodrigues Fernandes, Maíra Planzo Groth, Aline Silva, Letícia Amanda dos Santos Schnitzer, Josiana de Fátima Di Santis, Giovana Wingeter Martins, Maria Isabel Mello |
| author_role |
author |
| author2 |
Fernandes, Maíra Planzo Groth, Aline Silva, Letícia Amanda dos Santos Schnitzer, Josiana de Fátima Di Santis, Giovana Wingeter Martins, Maria Isabel Mello |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Greghi, Julia Rodrigues Fernandes, Maíra Planzo Groth, Aline Silva, Letícia Amanda dos Santos Schnitzer, Josiana de Fátima Di Santis, Giovana Wingeter Martins, Maria Isabel Mello |
| dc.subject.por.fl_str_mv |
Perros Oncología Inflamación Glándula Mamaria Inhibidores COX-2. Canino Oncologia Glândulas Mamárias Inflamação Inibidores COX-2. Canine Oncology Inflammation Mammary Gland COX-2 Inhibitors. |
| topic |
Perros Oncología Inflamación Glándula Mamaria Inhibidores COX-2. Canino Oncologia Glândulas Mamárias Inflamação Inibidores COX-2. Canine Oncology Inflammation Mammary Gland COX-2 Inhibitors. |
| description |
Mammary tumors are the second most diagnosed neoplasms in dogs. Canine females are largely affected by malignant mammary tumours. Several factors are involved in the development and determination of the malignancy of these lesions, including the action of cyclooxygenase-2. Use of non-steroidal anti-inflammatory drugs as enzyme-inhibiting drugs has been studied as a promising adjuvant treatment for neoplasms. The aim of this study was to evaluate the effect of piroxicam in reducing inflammation caused by mammary tumours in 25 bitches during 10 days of administration based on the measurement of peritumoral temperature using thermography. The results indicated a significant difference (p=0,003) between the average temperatures at the first and last day of treatment. When performing the evaluation of malignant and benign neoplasms separately, it was possible to observe that, statistically, malignant neoplasms (n=19) showed a significant reduction in peritumoral temperatures (P=<0.001), however, benign neoplasms (n=6) have not obtained a significant difference in temperature after the therapeutic protocol (P=0.954). Therefore, it was possible to demonstrate the efficacy of the medication in reducing the heat caused by inflammation and allowing advances in the development of therapeutic protocols for mammary tumors in bitches, such as the inclusion of the drug in the period prior to the mastectomy surgeries. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-02-10 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://rsdjournal.org/index.php/rsd/article/view/12236 10.33448/rsd-v10i2.12236 |
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https://rsdjournal.org/index.php/rsd/article/view/12236 |
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10.33448/rsd-v10i2.12236 |
| dc.language.iso.fl_str_mv |
por |
| language |
por |
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https://rsdjournal.org/index.php/rsd/article/view/12236/11249 |
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https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
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openAccess |
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application/pdf |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development; Vol. 10 No. 2; e18710212236 Research, Society and Development; Vol. 10 Núm. 2; e18710212236 Research, Society and Development; v. 10 n. 2; e18710212236 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
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Universidade Federal de Itajubá (UNIFEI) |
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Research, Society and Development |
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Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
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