Estudo sobre a atividade biológica da melitina e apamina

Detalhes bibliográficos
Autor(a) principal: Santos, Rhaysa Akemi Takeda
Data de Publicação: 2023
Outros Autores: Kottwitz, Luciana Bill Mikito
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/40897
Resumo: The venom of bees of the genus Appis, called Apitoxin, is a complex of bioactive substances, which has shown several benefits and applications in terms of biological activities. Among these bioactive substances is melittin, which corresponds to 50% of the total dry weight of the venom, being the most active toxin in the complex. Literature strongly applies to melittin a hemolytic activity, anti-inflammatory, antifungal, antibacterial and antitumor action. Also apamin, considered the smallest known neurotoxin, acts on the postsynaptic membranes of the central and peripheral nervous system, blocking the transmission of certain inhibitory impulses. Both substances demonstrated biological activities with potential for application in health, so the present work aimed to gather previously published studies and present the discussions and results obtained regarding the research of these two substances.
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spelling Estudo sobre a atividade biológica da melitina e apaminaStudy on biological activity of melitin and apaminEstudio de la actividad biológica de la melitina y la apaminaAbejasApitoxinaSubstancias bioactivas.BeesApitoxinBioactive substances.AbelhasApitoxinaSubstâncias bioativas.The venom of bees of the genus Appis, called Apitoxin, is a complex of bioactive substances, which has shown several benefits and applications in terms of biological activities. Among these bioactive substances is melittin, which corresponds to 50% of the total dry weight of the venom, being the most active toxin in the complex. Literature strongly applies to melittin a hemolytic activity, anti-inflammatory, antifungal, antibacterial and antitumor action. Also apamin, considered the smallest known neurotoxin, acts on the postsynaptic membranes of the central and peripheral nervous system, blocking the transmission of certain inhibitory impulses. Both substances demonstrated biological activities with potential for application in health, so the present work aimed to gather previously published studies and present the discussions and results obtained regarding the research of these two substances.O veneno de abelhas do gênero Appis, chamada Apitoxina, é um complexo de substâncias bioativas, das quais demonstrou-se diversos benefícios e aplicações quanto às atividades biológicas. Dentre essas substâncias está a melitina, que corresponde a 50% do peso seco total do veneno, sendo a toxina mais ativa do complexo. A literatura aplica fortemente à melitina uma atividade hemolítica, ação anti-inflamatória, antifúngica, antibacteriana e ainda ação anti-tumoral. E também a apamina, considerada a menor neurotoxina conhecida, age nas membranas pós-sinápticas do sistema nervoso central e periférico, bloqueando a transmissão de determinados impulsos inibitórios. Ambas as substâncias demonstraram atividades biológicas com potencial de aplicação em saúde, portanto o presente trabalho teve como objetivo reunir estudos previamente publicados e expor as discussões e resultados obtidos acerca da pesquisa dessas duas subtâncias.El veneno de las abejas del género Appis, denominado Apitoxina, es un complejo de sustancias bioactivas, que ha mostrado diversos beneficios y aplicaciones en cuanto a actividades biológicas. Entre estas sustancias bioactivas se encuentra la melitina, que corresponde al 50% del peso seco total del veneno, siendo la toxina más activa del complejo. La literatura aplica fuertemente a la melitina una actividad hemolítica, antiinflamatoria, antifúngica, antibacteriana y antitumoral. También la apamina, considerada la neurotoxina más pequeña conocida, actúa sobre las membranas postsinápticas del sistema nervioso central y periférico, bloqueando la transmisión de ciertos impulsos inhibidores. Ambas sustancias demostraron actividades biológicas con potencial de aplicación en salud, por lo que el presente trabajo tuvo como objetivo recopilar estudios publicados anteriormente y presentar las discusiones y resultados obtenidos con respecto a la investigación de estas dos sustancias.Research, Society and Development2023-03-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/4089710.33448/rsd-v12i4.40897Research, Society and Development; Vol. 12 No. 4; e5912440897Research, Society and Development; Vol. 12 Núm. 4; e5912440897Research, Society and Development; v. 12 n. 4; e59124408972525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/40897/33366Copyright (c) 2023 Rhaysa Akemi Takeda Santos; Luciana Bill Mikito Kottwitzhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSantos, Rhaysa Akemi Takeda Kottwitz, Luciana Bill Mikito 2023-04-21T18:13:32Zoai:ojs.pkp.sfu.ca:article/40897Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2023-04-21T18:13:32Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Estudo sobre a atividade biológica da melitina e apamina
Study on biological activity of melitin and apamin
Estudio de la actividad biológica de la melitina y la apamina
title Estudo sobre a atividade biológica da melitina e apamina
spellingShingle Estudo sobre a atividade biológica da melitina e apamina
Santos, Rhaysa Akemi Takeda
Abejas
Apitoxina
Substancias bioactivas.
Bees
Apitoxin
Bioactive substances.
Abelhas
Apitoxina
Substâncias bioativas.
title_short Estudo sobre a atividade biológica da melitina e apamina
title_full Estudo sobre a atividade biológica da melitina e apamina
title_fullStr Estudo sobre a atividade biológica da melitina e apamina
title_full_unstemmed Estudo sobre a atividade biológica da melitina e apamina
title_sort Estudo sobre a atividade biológica da melitina e apamina
author Santos, Rhaysa Akemi Takeda
author_facet Santos, Rhaysa Akemi Takeda
Kottwitz, Luciana Bill Mikito
author_role author
author2 Kottwitz, Luciana Bill Mikito
author2_role author
dc.contributor.author.fl_str_mv Santos, Rhaysa Akemi Takeda
Kottwitz, Luciana Bill Mikito
dc.subject.por.fl_str_mv Abejas
Apitoxina
Substancias bioactivas.
Bees
Apitoxin
Bioactive substances.
Abelhas
Apitoxina
Substâncias bioativas.
topic Abejas
Apitoxina
Substancias bioactivas.
Bees
Apitoxin
Bioactive substances.
Abelhas
Apitoxina
Substâncias bioativas.
description The venom of bees of the genus Appis, called Apitoxin, is a complex of bioactive substances, which has shown several benefits and applications in terms of biological activities. Among these bioactive substances is melittin, which corresponds to 50% of the total dry weight of the venom, being the most active toxin in the complex. Literature strongly applies to melittin a hemolytic activity, anti-inflammatory, antifungal, antibacterial and antitumor action. Also apamin, considered the smallest known neurotoxin, acts on the postsynaptic membranes of the central and peripheral nervous system, blocking the transmission of certain inhibitory impulses. Both substances demonstrated biological activities with potential for application in health, so the present work aimed to gather previously published studies and present the discussions and results obtained regarding the research of these two substances.
publishDate 2023
dc.date.none.fl_str_mv 2023-03-27
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/40897
10.33448/rsd-v12i4.40897
url https://rsdjournal.org/index.php/rsd/article/view/40897
identifier_str_mv 10.33448/rsd-v12i4.40897
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/40897/33366
dc.rights.driver.fl_str_mv Copyright (c) 2023 Rhaysa Akemi Takeda Santos; Luciana Bill Mikito Kottwitz
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Rhaysa Akemi Takeda Santos; Luciana Bill Mikito Kottwitz
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 12 No. 4; e5912440897
Research, Society and Development; Vol. 12 Núm. 4; e5912440897
Research, Society and Development; v. 12 n. 4; e5912440897
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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