Adjuvant therapy using ozonated saline in a dog with persistent thrombocytopenia - case report

Detalhes bibliográficos
Autor(a) principal: Gonçalves, Bruna Pereira
Data de Publicação: 2020
Outros Autores: Castro, Larissa Magalhães de, Pinto, Helena Gomes Ferreira, Santos Filho, Mário dos
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/7234
Resumo: The aim of this paper is to describe the platelet increase in a dog with persistent thrombocytopenia, when it was subjected to adjuvant ozone therapy, correlating the effects of this gas on metabolism and its cellular mobilization. Thrombocytopenia is characterized by hematological changes, with a reduction in the number of platelets in the blood. There are several diseases related to thrombocytopenia, among them we can mention hemoparasitosis, where thrombocytopenia appears as a result of megakaryocytic hypoplasia, or due to immune causes, related to the presence of antiplatelet antibodies, which cause accelerated destruction of platelets by macrophages of the phagocytic mononuclear system. Several therapies can be instituted, according to their underlying cause. However, there are few descriptions of the association of adjuvant therapies, such as the use of ozone as a therapeutic form. Ozone (O3) has been shown to be promising in medicinal use, being used in the treatment of several diseases, including those of a hematological nature, requiring further studies for its validation and scientific proof. A 10-month-old canine patient was seen with suspected hemoparasitosis, with a history of contact with ectoparasites and lack of appetite. The clinical signs observed were pale mucous membranes and epistaxis. Treatment was instituted, using doxycycline-based antibiotics, for a period of 28 days, in addition to blood transfusion and use of erythropoietin, but without success. In view of this situation, we opted for the institution of adjuvant ozone therapy, through the infusion of ozonated saline solution, intravenously. After 15 days of association, the patient improved his persistent thrombocytopenia, evidenced after new tests, as well as clinical improvement of the signs previously presented.
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spelling Adjuvant therapy using ozonated saline in a dog with persistent thrombocytopenia - case reportTerapia adyuvante con solución salina ozonizada en un perro con trombocitopenia persistente: reporte de un casoTerapia adjuvante com uso de solução fisiológica ozonizada em cão com trombocitopenia persistente - relato de casoPerrosEhrlichiosisOzonoterapiaTerapia adyuvante.DogsOzonetherapyEhrlichiosisAdjuvant therapy.CãesErliquioseOzonioterapiaTerapia adjuvanteThe aim of this paper is to describe the platelet increase in a dog with persistent thrombocytopenia, when it was subjected to adjuvant ozone therapy, correlating the effects of this gas on metabolism and its cellular mobilization. Thrombocytopenia is characterized by hematological changes, with a reduction in the number of platelets in the blood. There are several diseases related to thrombocytopenia, among them we can mention hemoparasitosis, where thrombocytopenia appears as a result of megakaryocytic hypoplasia, or due to immune causes, related to the presence of antiplatelet antibodies, which cause accelerated destruction of platelets by macrophages of the phagocytic mononuclear system. Several therapies can be instituted, according to their underlying cause. However, there are few descriptions of the association of adjuvant therapies, such as the use of ozone as a therapeutic form. Ozone (O3) has been shown to be promising in medicinal use, being used in the treatment of several diseases, including those of a hematological nature, requiring further studies for its validation and scientific proof. A 10-month-old canine patient was seen with suspected hemoparasitosis, with a history of contact with ectoparasites and lack of appetite. The clinical signs observed were pale mucous membranes and epistaxis. Treatment was instituted, using doxycycline-based antibiotics, for a period of 28 days, in addition to blood transfusion and use of erythropoietin, but without success. In view of this situation, we opted for the institution of adjuvant ozone therapy, through the infusion of ozonated saline solution, intravenously. After 15 days of association, the patient improved his persistent thrombocytopenia, evidenced after new tests, as well as clinical improvement of the signs previously presented.El objetivo de este trabajo es describir el aumento de plaquetas en un perro con trombocitopenia persistente, cuando fue sometido a ozonoterapia adyuvante, correlacionando los efectos de este gas sobre el metabolismo y su movilización celular. La trombocitopenia se caracteriza por cambios hematológicos, con una reducción del número de plaquetas en la sangre. Existen varias enfermedades relacionadas con la trombocitopenia, entre ellas podemos mencionar la hemoparasitosis, donde la trombocitopenia aparece como consecuencia de hipoplasia megacariocítica, o por causas inmunes, relacionadas con la presencia de anticuerpos antiplaquetarios, que provocan la destrucción acelerada de las plaquetas por macrófagos del sistema mononuclear fagocítico. Se pueden instituir varias terapias, según su causa subyacente. Sin embargo, existen pocas descripciones de la asociación de terapias adyuvantes, como el uso del ozono como forma terapéutica. El ozono (O3) ha demostrado ser prometedor en uso medicinal, siendo utilizado en el tratamiento de diversas enfermedades, incluidas las de naturaleza hematológica, que requieren más estudios para su validación y prueba científica. Se consultó a un paciente canino de 10 meses con sospecha de hemoparasitosis, con antecedente de contacto con ectoparásitos y falta de apetito. Los signos clínicos observados fueron mucosas pálidas y epistaxis. Se instauró tratamiento con antibióticos a base de doxiciclina, por un período de 28 días, además de transfusión de sangre y uso de eritropoyetina, pero sin éxito. Ante esta situación, optamos por la institución de la ozonoterapia adyuvante, mediante la infusión de solución salina ozonizada, por vía intravenosa. A los 15 días de asociación, el paciente mejoró su trombocitopenia persistente, evidenciada tras nuevas pruebas, así como mejoría clínica de los signos presentados previamente.Objetiva-se com este trabalho a descrição do aumento plaquetário em um cão com trombocitopenia persistente, quando este foi submetido à ozonioterapia adjuvante, fazendo-se correlação dos efeitos desse gás sobre o metabolismo e sua mobilização celular. A trombocitopenia caracteriza-se por alteração hematológica, com redução do número de plaquetas do sangue. Há diversas doenças relacionadas às trombocitopenias, dentre elas podemos citar hemoparasitoses, onde a trombocitopenia aparece como resultado da hipoplasia megacariocítica, ou por causas imunitárias, relacionada a presença de anticorpos antiplaquetários, que causam destruição acelerada de plaquetas pelos macrófagos do sistema mononuclear fagocitário. Diversas terapias podem ser instituídas, de acordo com sua causa base. Contudo, existem poucas descrições da associação de terapias adjuvantes, como por exemplo, o uso do ozônio como forma terapêutica. O ozônio (O3), têm se mostrado promissor no uso medicinal, sendo empregado no tratamento de diversas doenças, dentre elas as de caráter hematológico, necessitando de novos estudos para sua validação e comprovação científica. Um paciente canino, com 10 meses de idade, foi atendido com suspeita de hemoparasitose, apresentando histórico de contato com ectoparasitas e inapetência. Os sinais clínicos observados foram mucosas hipocoradas e epistaxe. Foi instituído o tratamento, com uso de antibiótico à base de doxiciclina, por período de 28 dias, além de transfusão sanguínea e uso de eritropoetina, porém sem sucesso. Diante deste quadro, optou-se pela instituição da ozonioterapia adjuvante, por meio da infusão de solução fisiológica ozonizada, por via intravenosa. Passados 15 dias da associação, o paciente obteve melhora do quadro de trombocitopenia persistente, evidenciada após realização de novos exames, bem como melhora clínica dos sinais antes apresentados.Research, Society and Development2020-08-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/723410.33448/rsd-v9i9.7234Research, Society and Development; Vol. 9 No. 9; e167997234Research, Society and Development; Vol. 9 Núm. 9; e167997234Research, Society and Development; v. 9 n. 9; e1679972342525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/7234/6298Copyright (c) 2020 Bruna Pereira Gonçalves; Larissa Magalhães de Castro; Helena Gomes Ferreira Pinto; Mário dos Santos Filhohttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessGonçalves, Bruna PereiraCastro, Larissa Magalhães dePinto, Helena Gomes Ferreira Santos Filho, Mário dos2020-09-18T01:42:11Zoai:ojs.pkp.sfu.ca:article/7234Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:30:01.655582Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Adjuvant therapy using ozonated saline in a dog with persistent thrombocytopenia - case report
Terapia adyuvante con solución salina ozonizada en un perro con trombocitopenia persistente: reporte de un caso
Terapia adjuvante com uso de solução fisiológica ozonizada em cão com trombocitopenia persistente - relato de caso
title Adjuvant therapy using ozonated saline in a dog with persistent thrombocytopenia - case report
spellingShingle Adjuvant therapy using ozonated saline in a dog with persistent thrombocytopenia - case report
Gonçalves, Bruna Pereira
Perros
Ehrlichiosis
Ozonoterapia
Terapia adyuvante.
Dogs
Ozonetherapy
Ehrlichiosis
Adjuvant therapy.
Cães
Erliquiose
Ozonioterapia
Terapia adjuvante
title_short Adjuvant therapy using ozonated saline in a dog with persistent thrombocytopenia - case report
title_full Adjuvant therapy using ozonated saline in a dog with persistent thrombocytopenia - case report
title_fullStr Adjuvant therapy using ozonated saline in a dog with persistent thrombocytopenia - case report
title_full_unstemmed Adjuvant therapy using ozonated saline in a dog with persistent thrombocytopenia - case report
title_sort Adjuvant therapy using ozonated saline in a dog with persistent thrombocytopenia - case report
author Gonçalves, Bruna Pereira
author_facet Gonçalves, Bruna Pereira
Castro, Larissa Magalhães de
Pinto, Helena Gomes Ferreira
Santos Filho, Mário dos
author_role author
author2 Castro, Larissa Magalhães de
Pinto, Helena Gomes Ferreira
Santos Filho, Mário dos
author2_role author
author
author
dc.contributor.author.fl_str_mv Gonçalves, Bruna Pereira
Castro, Larissa Magalhães de
Pinto, Helena Gomes Ferreira
Santos Filho, Mário dos
dc.subject.por.fl_str_mv Perros
Ehrlichiosis
Ozonoterapia
Terapia adyuvante.
Dogs
Ozonetherapy
Ehrlichiosis
Adjuvant therapy.
Cães
Erliquiose
Ozonioterapia
Terapia adjuvante
topic Perros
Ehrlichiosis
Ozonoterapia
Terapia adyuvante.
Dogs
Ozonetherapy
Ehrlichiosis
Adjuvant therapy.
Cães
Erliquiose
Ozonioterapia
Terapia adjuvante
description The aim of this paper is to describe the platelet increase in a dog with persistent thrombocytopenia, when it was subjected to adjuvant ozone therapy, correlating the effects of this gas on metabolism and its cellular mobilization. Thrombocytopenia is characterized by hematological changes, with a reduction in the number of platelets in the blood. There are several diseases related to thrombocytopenia, among them we can mention hemoparasitosis, where thrombocytopenia appears as a result of megakaryocytic hypoplasia, or due to immune causes, related to the presence of antiplatelet antibodies, which cause accelerated destruction of platelets by macrophages of the phagocytic mononuclear system. Several therapies can be instituted, according to their underlying cause. However, there are few descriptions of the association of adjuvant therapies, such as the use of ozone as a therapeutic form. Ozone (O3) has been shown to be promising in medicinal use, being used in the treatment of several diseases, including those of a hematological nature, requiring further studies for its validation and scientific proof. A 10-month-old canine patient was seen with suspected hemoparasitosis, with a history of contact with ectoparasites and lack of appetite. The clinical signs observed were pale mucous membranes and epistaxis. Treatment was instituted, using doxycycline-based antibiotics, for a period of 28 days, in addition to blood transfusion and use of erythropoietin, but without success. In view of this situation, we opted for the institution of adjuvant ozone therapy, through the infusion of ozonated saline solution, intravenously. After 15 days of association, the patient improved his persistent thrombocytopenia, evidenced after new tests, as well as clinical improvement of the signs previously presented.
publishDate 2020
dc.date.none.fl_str_mv 2020-08-14
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/7234
10.33448/rsd-v9i9.7234
url https://rsdjournal.org/index.php/rsd/article/view/7234
identifier_str_mv 10.33448/rsd-v9i9.7234
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/7234/6298
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 9 No. 9; e167997234
Research, Society and Development; Vol. 9 Núm. 9; e167997234
Research, Society and Development; v. 9 n. 9; e167997234
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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