Registration and query of biophysical parameters using the MyocyteDB platform
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/30712 |
Resumo: | Currently, the research related to the computational modeling of myocytes has been standing out substantially regarding the knowledge of the complex process of cardiac excitation-contraction. In this context, the availability of a data repository of electrophysiological parameters for the development of mathematical models becomes a growing need. The objective of this article is to present the MyocyteDB web platform that's focused on the inclusion and consultation of biophysical parameters and statistical data for computational modeling of the ventricular myocyte. For the development of this platform, cloud computing technologies (Azure) were used. A careful review of the literature in the search for mathematical models of cardiac electrophysiology was carried out on the conductance values of the main ion channels to compose the initial set of data to be inserted into the platform. From the set of collected values available on this platform, it becomes possible to produce statistical data of a descriptive nature, export data in spreadsheet format, and access the dataset via API. It is expected this platform could be a tool capable of helping future modelers in the research and adjustments of biophysical parameters used in the cardiac electrophysiological modeling process. Thus, providing greater dynamics in the search for values of biophysical parameters used in mathematical modeling of myocytes. |
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Registration and query of biophysical parameters using the MyocyteDB platformRegistro y consulta de parámetros biofísicos utilizando la plataforma MyocyteDBCadastro e consulta de parâmetros biofísicos utilizando a plataforma MyocyteDBPlataforma webBanco de dadosMiócito ventricularModelagem matemáticaParâmetros biofísicos.Web plataformDatabaseVentricular myocyteMathematical modelingBiophysical parameters.Plataforma webBanco de datosMiocito ventricularModelo matematicoParámetros biofísicos.Currently, the research related to the computational modeling of myocytes has been standing out substantially regarding the knowledge of the complex process of cardiac excitation-contraction. In this context, the availability of a data repository of electrophysiological parameters for the development of mathematical models becomes a growing need. The objective of this article is to present the MyocyteDB web platform that's focused on the inclusion and consultation of biophysical parameters and statistical data for computational modeling of the ventricular myocyte. For the development of this platform, cloud computing technologies (Azure) were used. A careful review of the literature in the search for mathematical models of cardiac electrophysiology was carried out on the conductance values of the main ion channels to compose the initial set of data to be inserted into the platform. From the set of collected values available on this platform, it becomes possible to produce statistical data of a descriptive nature, export data in spreadsheet format, and access the dataset via API. It is expected this platform could be a tool capable of helping future modelers in the research and adjustments of biophysical parameters used in the cardiac electrophysiological modeling process. Thus, providing greater dynamics in the search for values of biophysical parameters used in mathematical modeling of myocytes.Actualmente, la investigación relacionada con el modelado computacional de miocitos ha venido destacándose sustancialmente en cuanto al conocimiento del complejo proceso de excitación-contracción cardiaca. En este contexto, la disponibilidad de un repositorio de datos de parámetros electrofisiológicos para el desarrollo de modelos matemáticos se convierte en una necesidad creciente. El objetivo de este artículo es presentar la plataforma web MyocyteDB que se centra en la inclusión y consulta de parámetros biofísicos y datos estadísticos para el modelado computacional del miocito ventricular. Para el desarrollo de esta plataforma se utilizaron tecnologías de computación en la nube (Azure). Se realizó una cuidadosa revisión de la literatura en la búsqueda de modelos matemáticos de electrofisiología cardíaca sobre los valores de conductancia de los principales canales iónicos para componer el conjunto inicial de datos a serem insertados en la plataforma. A partir del conjunto de valores recopilados disponibles en esta plataforma, es posible producir datos estadísticos de carácter descriptivo, exportar datos en formato de hoja de cálculo y acceder al conjunto de datos a través de API. Se espera que esta plataforma sea una herramienta capaz de ayudar a los futuros modeladores en la investigación y ajustes de parámetros biofísicos utilizados en el proceso de modelado electrofisiológico cardíaco. Aportando así una mayor dinámica en la búsqueda de valores de parámetros biofísicos utilizados en el modelado matemático de miocitos.Atualmente as pesquisas relacionadas à modelagem computacional de miócitos vem se destacando substancialmente no que tange o conhecimento do complexo processo de excitação-contração cardíaca. Neste contexto, a disponibilidade de um repositório de dados de parâmetros eletrofisiológicos para desenvolvimento de modelos matemáticos torna-se uma necessidade crescente. O objetivo deste artigo é apresentar a plataforma web MyocyteDB focada na inclusão e consulta de parâmetros biofísicos e dados estatísticos para modelagem computacional do miócito ventricular. Para o desenvolvimento desta plataforma, foram empregadas as tecnologias de computação em nuvem (Azure). Uma criteriosa revisão da literatura na busca de modelos matemáticos da eletrofisiologia cardíaca, foi realizada sobre os valores de condutância dos principais canais iônicos para compor o conjunto inicial de dados a ser inserido na plataforma. A partir do conjunto de valores coletados à disposição nesta plataforma, foi possível apresentar dados estatísticos de natureza descritiva, a exportação de dados em formato de planilha e o acesso via API do conjunto de dados. Espera-se que esta plataforma seja uma ferramenta capaz de auxiliar futuros modeladores na pesquisa e ajustes de parâmetros biofísicos utilizados no processo de modelagem eletrofisiológica cardíaca. Deste modo, proporcionando uma maior dinâmica na busca de valores de parâmetros biofísicos utilizados na modelagem matemática de miócitos.Research, Society and Development2022-06-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3071210.33448/rsd-v11i8.30712Research, Society and Development; Vol. 11 No. 8; e14711830712Research, Society and Development; Vol. 11 Núm. 8; e14711830712Research, Society and Development; v. 11 n. 8; e147118307122525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/30712/26356Copyright (c) 2022 Ronaldo Plovas; Rodrigo Pimentel; Márcia Aparecida Silva Bissaco; Daniel Gustavo Goroso; Jose Luis Puglisi; Robson Rodrigues da Silvahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessPlovas, RonaldoPimentel, RodrigoBissaco, Márcia Aparecida SilvaGoroso, Daniel GustavoPuglisi, Jose LuisSilva, Robson Rodrigues da2022-07-01T13:34:06Zoai:ojs.pkp.sfu.ca:article/30712Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:47:22.939260Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Registration and query of biophysical parameters using the MyocyteDB platform Registro y consulta de parámetros biofísicos utilizando la plataforma MyocyteDB Cadastro e consulta de parâmetros biofísicos utilizando a plataforma MyocyteDB |
title |
Registration and query of biophysical parameters using the MyocyteDB platform |
spellingShingle |
Registration and query of biophysical parameters using the MyocyteDB platform Plovas, Ronaldo Plataforma web Banco de dados Miócito ventricular Modelagem matemática Parâmetros biofísicos. Web plataform Database Ventricular myocyte Mathematical modeling Biophysical parameters. Plataforma web Banco de datos Miocito ventricular Modelo matematico Parámetros biofísicos. |
title_short |
Registration and query of biophysical parameters using the MyocyteDB platform |
title_full |
Registration and query of biophysical parameters using the MyocyteDB platform |
title_fullStr |
Registration and query of biophysical parameters using the MyocyteDB platform |
title_full_unstemmed |
Registration and query of biophysical parameters using the MyocyteDB platform |
title_sort |
Registration and query of biophysical parameters using the MyocyteDB platform |
author |
Plovas, Ronaldo |
author_facet |
Plovas, Ronaldo Pimentel, Rodrigo Bissaco, Márcia Aparecida Silva Goroso, Daniel Gustavo Puglisi, Jose Luis Silva, Robson Rodrigues da |
author_role |
author |
author2 |
Pimentel, Rodrigo Bissaco, Márcia Aparecida Silva Goroso, Daniel Gustavo Puglisi, Jose Luis Silva, Robson Rodrigues da |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Plovas, Ronaldo Pimentel, Rodrigo Bissaco, Márcia Aparecida Silva Goroso, Daniel Gustavo Puglisi, Jose Luis Silva, Robson Rodrigues da |
dc.subject.por.fl_str_mv |
Plataforma web Banco de dados Miócito ventricular Modelagem matemática Parâmetros biofísicos. Web plataform Database Ventricular myocyte Mathematical modeling Biophysical parameters. Plataforma web Banco de datos Miocito ventricular Modelo matematico Parámetros biofísicos. |
topic |
Plataforma web Banco de dados Miócito ventricular Modelagem matemática Parâmetros biofísicos. Web plataform Database Ventricular myocyte Mathematical modeling Biophysical parameters. Plataforma web Banco de datos Miocito ventricular Modelo matematico Parámetros biofísicos. |
description |
Currently, the research related to the computational modeling of myocytes has been standing out substantially regarding the knowledge of the complex process of cardiac excitation-contraction. In this context, the availability of a data repository of electrophysiological parameters for the development of mathematical models becomes a growing need. The objective of this article is to present the MyocyteDB web platform that's focused on the inclusion and consultation of biophysical parameters and statistical data for computational modeling of the ventricular myocyte. For the development of this platform, cloud computing technologies (Azure) were used. A careful review of the literature in the search for mathematical models of cardiac electrophysiology was carried out on the conductance values of the main ion channels to compose the initial set of data to be inserted into the platform. From the set of collected values available on this platform, it becomes possible to produce statistical data of a descriptive nature, export data in spreadsheet format, and access the dataset via API. It is expected this platform could be a tool capable of helping future modelers in the research and adjustments of biophysical parameters used in the cardiac electrophysiological modeling process. Thus, providing greater dynamics in the search for values of biophysical parameters used in mathematical modeling of myocytes. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-06-13 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/30712 10.33448/rsd-v11i8.30712 |
url |
https://rsdjournal.org/index.php/rsd/article/view/30712 |
identifier_str_mv |
10.33448/rsd-v11i8.30712 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/30712/26356 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 8; e14711830712 Research, Society and Development; Vol. 11 Núm. 8; e14711830712 Research, Society and Development; v. 11 n. 8; e14711830712 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
_version_ |
1797052836711759872 |