Registration and query of biophysical parameters using the MyocyteDB platform

Detalhes bibliográficos
Autor(a) principal: Plovas, Ronaldo
Data de Publicação: 2022
Outros Autores: Pimentel, Rodrigo, Bissaco, Márcia Aparecida Silva, Goroso, Daniel Gustavo, Puglisi, Jose Luis, Silva, Robson Rodrigues da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/30712
Resumo: Currently, the research related to the computational modeling of myocytes has been standing out substantially regarding the knowledge of the complex process of cardiac excitation-contraction. In this context, the availability of a data repository of electrophysiological parameters for the development of mathematical models becomes a growing need. The objective of this article is to present the MyocyteDB web platform that's focused on the inclusion and consultation of biophysical parameters and statistical data for computational modeling of the ventricular myocyte. For the development of this platform, cloud computing technologies (Azure) were used. A careful review of the literature in the search for mathematical models of cardiac electrophysiology was carried out on the conductance values of the main ion channels to compose the initial set of data to be inserted into the platform. From the set of collected values available on this platform, it becomes possible to produce statistical data of a descriptive nature, export data in spreadsheet format, and access the dataset via API. It is expected this platform could be a tool capable of helping future modelers in the research and adjustments of biophysical parameters used in the cardiac electrophysiological modeling process. Thus, providing greater dynamics in the search for values of biophysical parameters used in mathematical modeling of myocytes.
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spelling Registration and query of biophysical parameters using the MyocyteDB platformRegistro y consulta de parámetros biofísicos utilizando la plataforma MyocyteDBCadastro e consulta de parâmetros biofísicos utilizando a plataforma MyocyteDBPlataforma webBanco de dadosMiócito ventricularModelagem matemáticaParâmetros biofísicos.Web plataformDatabaseVentricular myocyteMathematical modelingBiophysical parameters.Plataforma webBanco de datosMiocito ventricularModelo matematicoParámetros biofísicos.Currently, the research related to the computational modeling of myocytes has been standing out substantially regarding the knowledge of the complex process of cardiac excitation-contraction. In this context, the availability of a data repository of electrophysiological parameters for the development of mathematical models becomes a growing need. The objective of this article is to present the MyocyteDB web platform that's focused on the inclusion and consultation of biophysical parameters and statistical data for computational modeling of the ventricular myocyte. For the development of this platform, cloud computing technologies (Azure) were used. A careful review of the literature in the search for mathematical models of cardiac electrophysiology was carried out on the conductance values of the main ion channels to compose the initial set of data to be inserted into the platform. From the set of collected values available on this platform, it becomes possible to produce statistical data of a descriptive nature, export data in spreadsheet format, and access the dataset via API. It is expected this platform could be a tool capable of helping future modelers in the research and adjustments of biophysical parameters used in the cardiac electrophysiological modeling process. Thus, providing greater dynamics in the search for values of biophysical parameters used in mathematical modeling of myocytes.Actualmente, la investigación relacionada con el modelado computacional de miocitos ha venido destacándose sustancialmente en cuanto al conocimiento del complejo proceso de excitación-contracción cardiaca. En este contexto, la disponibilidad de un repositorio de datos de parámetros electrofisiológicos para el desarrollo de modelos matemáticos se convierte en una necesidad creciente. El objetivo de este artículo es presentar la plataforma web MyocyteDB que se centra en la inclusión y consulta de parámetros biofísicos y datos estadísticos para el modelado computacional del miocito ventricular. Para el desarrollo de esta plataforma se utilizaron tecnologías de computación en la nube (Azure). Se realizó una cuidadosa revisión de la literatura en la búsqueda de modelos matemáticos de electrofisiología cardíaca sobre los valores de conductancia de los principales canales iónicos para componer el conjunto inicial de datos a serem insertados en la plataforma. A partir del conjunto de valores recopilados disponibles en esta plataforma, es posible producir datos estadísticos de carácter descriptivo, exportar datos en formato de hoja de cálculo y acceder al conjunto de datos a través de API. Se espera que esta plataforma sea una herramienta capaz de ayudar a los futuros modeladores en la investigación y ajustes de parámetros biofísicos utilizados en el proceso de modelado electrofisiológico cardíaco. Aportando así una mayor dinámica en la búsqueda de valores de parámetros biofísicos utilizados en el modelado matemático de miocitos.Atualmente as pesquisas relacionadas à modelagem computacional de miócitos vem se destacando substancialmente no que tange o conhecimento do complexo processo de excitação-contração cardíaca. Neste contexto, a disponibilidade de um repositório de dados de parâmetros eletrofisiológicos para desenvolvimento de modelos matemáticos torna-se uma necessidade crescente. O objetivo deste artigo é apresentar a plataforma web MyocyteDB focada na inclusão e consulta de parâmetros biofísicos e dados estatísticos para modelagem computacional do miócito ventricular. Para o desenvolvimento desta plataforma, foram empregadas as tecnologias de computação em nuvem (Azure). Uma criteriosa revisão da literatura na busca de modelos matemáticos da eletrofisiologia cardíaca, foi realizada sobre os valores de condutância dos principais canais iônicos para compor o conjunto inicial de dados a ser inserido na plataforma. A partir do conjunto de valores coletados à disposição nesta plataforma, foi possível apresentar dados estatísticos de natureza descritiva, a exportação de dados em formato de planilha e o acesso via API do conjunto de dados. Espera-se que esta plataforma seja uma ferramenta capaz de auxiliar futuros modeladores na pesquisa e ajustes de parâmetros biofísicos utilizados no processo de modelagem eletrofisiológica cardíaca. Deste modo, proporcionando uma maior dinâmica na busca de valores de parâmetros biofísicos utilizados na modelagem matemática de miócitos.Research, Society and Development2022-06-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3071210.33448/rsd-v11i8.30712Research, Society and Development; Vol. 11 No. 8; e14711830712Research, Society and Development; Vol. 11 Núm. 8; e14711830712Research, Society and Development; v. 11 n. 8; e147118307122525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/30712/26356Copyright (c) 2022 Ronaldo Plovas; Rodrigo Pimentel; Márcia Aparecida Silva Bissaco; Daniel Gustavo Goroso; Jose Luis Puglisi; Robson Rodrigues da Silvahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessPlovas, RonaldoPimentel, RodrigoBissaco, Márcia Aparecida SilvaGoroso, Daniel GustavoPuglisi, Jose LuisSilva, Robson Rodrigues da2022-07-01T13:34:06Zoai:ojs.pkp.sfu.ca:article/30712Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:47:22.939260Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Registration and query of biophysical parameters using the MyocyteDB platform
Registro y consulta de parámetros biofísicos utilizando la plataforma MyocyteDB
Cadastro e consulta de parâmetros biofísicos utilizando a plataforma MyocyteDB
title Registration and query of biophysical parameters using the MyocyteDB platform
spellingShingle Registration and query of biophysical parameters using the MyocyteDB platform
Plovas, Ronaldo
Plataforma web
Banco de dados
Miócito ventricular
Modelagem matemática
Parâmetros biofísicos.
Web plataform
Database
Ventricular myocyte
Mathematical modeling
Biophysical parameters.
Plataforma web
Banco de datos
Miocito ventricular
Modelo matematico
Parámetros biofísicos.
title_short Registration and query of biophysical parameters using the MyocyteDB platform
title_full Registration and query of biophysical parameters using the MyocyteDB platform
title_fullStr Registration and query of biophysical parameters using the MyocyteDB platform
title_full_unstemmed Registration and query of biophysical parameters using the MyocyteDB platform
title_sort Registration and query of biophysical parameters using the MyocyteDB platform
author Plovas, Ronaldo
author_facet Plovas, Ronaldo
Pimentel, Rodrigo
Bissaco, Márcia Aparecida Silva
Goroso, Daniel Gustavo
Puglisi, Jose Luis
Silva, Robson Rodrigues da
author_role author
author2 Pimentel, Rodrigo
Bissaco, Márcia Aparecida Silva
Goroso, Daniel Gustavo
Puglisi, Jose Luis
Silva, Robson Rodrigues da
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Plovas, Ronaldo
Pimentel, Rodrigo
Bissaco, Márcia Aparecida Silva
Goroso, Daniel Gustavo
Puglisi, Jose Luis
Silva, Robson Rodrigues da
dc.subject.por.fl_str_mv Plataforma web
Banco de dados
Miócito ventricular
Modelagem matemática
Parâmetros biofísicos.
Web plataform
Database
Ventricular myocyte
Mathematical modeling
Biophysical parameters.
Plataforma web
Banco de datos
Miocito ventricular
Modelo matematico
Parámetros biofísicos.
topic Plataforma web
Banco de dados
Miócito ventricular
Modelagem matemática
Parâmetros biofísicos.
Web plataform
Database
Ventricular myocyte
Mathematical modeling
Biophysical parameters.
Plataforma web
Banco de datos
Miocito ventricular
Modelo matematico
Parámetros biofísicos.
description Currently, the research related to the computational modeling of myocytes has been standing out substantially regarding the knowledge of the complex process of cardiac excitation-contraction. In this context, the availability of a data repository of electrophysiological parameters for the development of mathematical models becomes a growing need. The objective of this article is to present the MyocyteDB web platform that's focused on the inclusion and consultation of biophysical parameters and statistical data for computational modeling of the ventricular myocyte. For the development of this platform, cloud computing technologies (Azure) were used. A careful review of the literature in the search for mathematical models of cardiac electrophysiology was carried out on the conductance values of the main ion channels to compose the initial set of data to be inserted into the platform. From the set of collected values available on this platform, it becomes possible to produce statistical data of a descriptive nature, export data in spreadsheet format, and access the dataset via API. It is expected this platform could be a tool capable of helping future modelers in the research and adjustments of biophysical parameters used in the cardiac electrophysiological modeling process. Thus, providing greater dynamics in the search for values of biophysical parameters used in mathematical modeling of myocytes.
publishDate 2022
dc.date.none.fl_str_mv 2022-06-13
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/30712
10.33448/rsd-v11i8.30712
url https://rsdjournal.org/index.php/rsd/article/view/30712
identifier_str_mv 10.33448/rsd-v11i8.30712
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/30712/26356
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 8; e14711830712
Research, Society and Development; Vol. 11 Núm. 8; e14711830712
Research, Society and Development; v. 11 n. 8; e14711830712
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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