Current pharmacotherapy of antineoplastic-induced nausea and vomiting
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/18435 |
Resumo: | Chemotherapy-induced nausea and vomiting (CINV) are common adverse drug reactions with the use of anticancer drugs. Although there are advances in prophylactic therapy, the management of antiemetic drugs in clinical practice is still a challenge to be faced. The aim of this study was to search the scientific literature for the main pharmacological therapies used in this condition. A systematic review was carried out, in which scientific articles indexed in PubMed, ScienseDirect and Web of Science were searched, using the following descriptors: chemotherapy; nausea; vomiting; drug therapy; serotonin 5-HT3 receptor antagonists, neurokinin-1 receptor antagonist. The degree of emetogenicity is increased by antineoplastic agents directly in the treatment of CINV, which include serotonin (5-HT3) receptor antagonists, neurokinin (NK-1) receptor antagonists. This treatment can be done individually, however, if it is not responsive, it is possible to make the association between these two classes. In more complicated cases, triple therapy is indicated, consisting of a combination of 5-HT3 receptor antagonists with NK-1 and dexamethasone receptor antagonists. Therefore, an efficacy of antiemetic therapy is increased in this triad when compared to drug treatment individually. First-generation 5-HT3 receptor antagonists are very effective, however, second-generation palonosetron is more effective and safer. A portion of netupitant and palonosetron, when given together with a dexamethasone, has been a good option for the treatment of CINV. |
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Current pharmacotherapy of antineoplastic-induced nausea and vomitingFarmacoterapia actual de náuseas y vómitos inducidos por antineoplásticosFarmacoterapia atual das náuseas e vômitos induzidos por antineoplásicosAntagonistas dos receptores 5-HT3Antagonistas dos receptores NK-1CorticosteroideNáuseas e vômitos induzidos por quimioterapia.5-HT3 receptor antagonistsNK-1 receptor antagonistsCorticosteroidChemotherapy-induced nausea and vomiting.Antagonistas del receptor 5-HT3Antagonistas del receptor NK-1CorticosteroideNáuseas y vómitos inducidos por quimioterapia.Chemotherapy-induced nausea and vomiting (CINV) are common adverse drug reactions with the use of anticancer drugs. Although there are advances in prophylactic therapy, the management of antiemetic drugs in clinical practice is still a challenge to be faced. The aim of this study was to search the scientific literature for the main pharmacological therapies used in this condition. A systematic review was carried out, in which scientific articles indexed in PubMed, ScienseDirect and Web of Science were searched, using the following descriptors: chemotherapy; nausea; vomiting; drug therapy; serotonin 5-HT3 receptor antagonists, neurokinin-1 receptor antagonist. The degree of emetogenicity is increased by antineoplastic agents directly in the treatment of CINV, which include serotonin (5-HT3) receptor antagonists, neurokinin (NK-1) receptor antagonists. This treatment can be done individually, however, if it is not responsive, it is possible to make the association between these two classes. In more complicated cases, triple therapy is indicated, consisting of a combination of 5-HT3 receptor antagonists with NK-1 and dexamethasone receptor antagonists. Therefore, an efficacy of antiemetic therapy is increased in this triad when compared to drug treatment individually. First-generation 5-HT3 receptor antagonists are very effective, however, second-generation palonosetron is more effective and safer. A portion of netupitant and palonosetron, when given together with a dexamethasone, has been a good option for the treatment of CINV.Las náuseas y los vómitos inducidos por la quimioterapia (NVIQ) son reacciones adversas comunes a los medicamentos con el uso de medicamentos contra el cáncer. Aunque existen avances en la terapia profiláctica, el manejo de los fármacos antieméticos en la práctica clínica sigue siendo un desafío por afrontar. El objetivo de este estudio fue buscar en la literatura científica las principales terapias farmacológicas utilizadas en esta patología. Se realizó una revisión sistemática, en la que se buscaron artículos científicos indexados en PubMed, ScienseDirect y Web of Science, utilizando los siguientes descriptores: quimioterapia; náusea; vómitos terapia de drogas; antagonistas del receptor de serotonina 5-HT3, antagonistas del receptor de neuroquinina-1. El grado de emetogenicidad causado por agentes antineoplásicos influye directamente en el tratamiento de las NVIQ, que incluyen antagonistas del receptor de serotonina (5-HT3) y antagonistas del receptor de neuroquinina (NK-1). Este tratamiento se puede realizar de forma individual, sin embargo, si no responde, es posible realizar la asociación entre estas dos clases. En casos más complicados, está indicada la terapia triple, que consiste en una combinación de antagonistas del receptor 5-HT3 con antagonistas del receptor NK-1 y dexametasona. Por tanto, la eficacia de la terapia antiemética aumenta en esta tríada en comparación con el tratamiento de estos fármacos de forma individual. Los antagonistas del receptor 5-HT3 de primera generación son muy eficaces; sin embargo, el palonosetrón de segunda generación es más eficaz y seguro. Una formulación de netupitant y palonosetron, cuando se administra junto con dexametasona, ha sido una buena opción para el tratamiento de las NVIQ.As náuseas e vômitos induzidos por quimioterapia (NVIQ) são reações adversas à medicamentos comuns com o uso de antineoplásicos. Embora existam avanços na terapêutica profilática, o manejo de medicamentos antieméticos na prática clínica ainda tem sido um desafio a ser enfrentado. O objetivo do presente estudo foi buscar na literatura científica as principais terapias farmacológicas utilizadas nesta condição. Uma revisão sistemática foi realizada, no qual buscou-se artigos científicos indexados no PubMed, ScienseDirect e Web of Science, utilizando os seguintes descritores: chemotherapy; nausea; vomiting; drug therapy; serotonin 5-HT3 receptor antagonists, neurokinin-1 receptor antagonista. O grau de emetogenicidade causado pelos agentes antineoplásicos influencia diretamente no tratamento das NVIQ, que incluem os antagonistas dos receptores de serotonina (5-HT3), antagonistas dos receptores de neurocinina (NK-1). Este tratamento pode ser feito de forma individualizada, porém, caso ele não seja responsivo, é possível fazer a associação entre essas duas classes. Em casos mais complicados é indicado uma terapia tripla que é composta pela combinação de antagonistas dos receptores de 5-HT3 com antagonistas dos receptores de NK-1 e dexametasona. Portanto, a eficácia da terapia antiemética é aumentada nessa tríadequando comparados ao tratamento desses medicamentos de forma individualizada. Os antagonistas dos receptores de 5-HT3 de primeira geração são muito eficazes, contudo, a palonosetrona, de segunda geração, é mais eficaz e seguro. Uma formulação de netupitanto e palonosetrona, quando administrado juntamente com a dexametasona, tem sido uma boa opção para o tratamento de NVIQ.Research, Society and Development2021-08-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1843510.33448/rsd-v10i9.18435Research, Society and Development; Vol. 10 No. 9; e58910918435Research, Society and Development; Vol. 10 Núm. 9; e58910918435Research, Society and Development; v. 10 n. 9; e589109184352525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/18435/16475Copyright (c) 2021 Aline Kely Felício de Sousa Santos; Anaís Bezerra de Gusmão; Lucas Nóbrega de Oliveira; Richard Morrinson Couras de Carvalho; Cibério Landim Macedohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSantos, Aline Kely Felício de SousaGusmão, Anaís Bezerra de Oliveira, Lucas Nóbrega de Carvalho, Richard Morrinson Couras de Macedo, Cibério Landim 2021-09-12T14:28:06Zoai:ojs.pkp.sfu.ca:article/18435Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:38:34.754672Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Current pharmacotherapy of antineoplastic-induced nausea and vomiting Farmacoterapia actual de náuseas y vómitos inducidos por antineoplásticos Farmacoterapia atual das náuseas e vômitos induzidos por antineoplásicos |
title |
Current pharmacotherapy of antineoplastic-induced nausea and vomiting |
spellingShingle |
Current pharmacotherapy of antineoplastic-induced nausea and vomiting Santos, Aline Kely Felício de Sousa Antagonistas dos receptores 5-HT3 Antagonistas dos receptores NK-1 Corticosteroide Náuseas e vômitos induzidos por quimioterapia. 5-HT3 receptor antagonists NK-1 receptor antagonists Corticosteroid Chemotherapy-induced nausea and vomiting. Antagonistas del receptor 5-HT3 Antagonistas del receptor NK-1 Corticosteroide Náuseas y vómitos inducidos por quimioterapia. |
title_short |
Current pharmacotherapy of antineoplastic-induced nausea and vomiting |
title_full |
Current pharmacotherapy of antineoplastic-induced nausea and vomiting |
title_fullStr |
Current pharmacotherapy of antineoplastic-induced nausea and vomiting |
title_full_unstemmed |
Current pharmacotherapy of antineoplastic-induced nausea and vomiting |
title_sort |
Current pharmacotherapy of antineoplastic-induced nausea and vomiting |
author |
Santos, Aline Kely Felício de Sousa |
author_facet |
Santos, Aline Kely Felício de Sousa Gusmão, Anaís Bezerra de Oliveira, Lucas Nóbrega de Carvalho, Richard Morrinson Couras de Macedo, Cibério Landim |
author_role |
author |
author2 |
Gusmão, Anaís Bezerra de Oliveira, Lucas Nóbrega de Carvalho, Richard Morrinson Couras de Macedo, Cibério Landim |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Santos, Aline Kely Felício de Sousa Gusmão, Anaís Bezerra de Oliveira, Lucas Nóbrega de Carvalho, Richard Morrinson Couras de Macedo, Cibério Landim |
dc.subject.por.fl_str_mv |
Antagonistas dos receptores 5-HT3 Antagonistas dos receptores NK-1 Corticosteroide Náuseas e vômitos induzidos por quimioterapia. 5-HT3 receptor antagonists NK-1 receptor antagonists Corticosteroid Chemotherapy-induced nausea and vomiting. Antagonistas del receptor 5-HT3 Antagonistas del receptor NK-1 Corticosteroide Náuseas y vómitos inducidos por quimioterapia. |
topic |
Antagonistas dos receptores 5-HT3 Antagonistas dos receptores NK-1 Corticosteroide Náuseas e vômitos induzidos por quimioterapia. 5-HT3 receptor antagonists NK-1 receptor antagonists Corticosteroid Chemotherapy-induced nausea and vomiting. Antagonistas del receptor 5-HT3 Antagonistas del receptor NK-1 Corticosteroide Náuseas y vómitos inducidos por quimioterapia. |
description |
Chemotherapy-induced nausea and vomiting (CINV) are common adverse drug reactions with the use of anticancer drugs. Although there are advances in prophylactic therapy, the management of antiemetic drugs in clinical practice is still a challenge to be faced. The aim of this study was to search the scientific literature for the main pharmacological therapies used in this condition. A systematic review was carried out, in which scientific articles indexed in PubMed, ScienseDirect and Web of Science were searched, using the following descriptors: chemotherapy; nausea; vomiting; drug therapy; serotonin 5-HT3 receptor antagonists, neurokinin-1 receptor antagonist. The degree of emetogenicity is increased by antineoplastic agents directly in the treatment of CINV, which include serotonin (5-HT3) receptor antagonists, neurokinin (NK-1) receptor antagonists. This treatment can be done individually, however, if it is not responsive, it is possible to make the association between these two classes. In more complicated cases, triple therapy is indicated, consisting of a combination of 5-HT3 receptor antagonists with NK-1 and dexamethasone receptor antagonists. Therefore, an efficacy of antiemetic therapy is increased in this triad when compared to drug treatment individually. First-generation 5-HT3 receptor antagonists are very effective, however, second-generation palonosetron is more effective and safer. A portion of netupitant and palonosetron, when given together with a dexamethasone, has been a good option for the treatment of CINV. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08-02 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/18435 10.33448/rsd-v10i9.18435 |
url |
https://rsdjournal.org/index.php/rsd/article/view/18435 |
identifier_str_mv |
10.33448/rsd-v10i9.18435 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/18435/16475 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 9; e58910918435 Research, Society and Development; Vol. 10 Núm. 9; e58910918435 Research, Society and Development; v. 10 n. 9; e58910918435 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052808040546304 |