Use of metformin hydrochloride in gestational diabetes: a systematic review

Detalhes bibliográficos
Autor(a) principal: Torres, Ellys Cristina Eleonor Pereira
Data de Publicação: 2020
Outros Autores: Oliveira, Jéssica Costa de, Nunes, Luanne Eugênia, Souza Neto, Franciso Ernesto de, Oliveira-Filho, Rosueti Diógenes de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/6988
Resumo: Gestational Diabetes Mellitus is a condition characterized by an increase in blood glucose levels, which can be initiated or diagnosed during pregnancy. This process occurs due to the production of high levels of hormones by the placenta, most of which are harmful to the action of insulin in the cells increasing the blood sugar level and can affect the growth and well-being of the fetus. Among the drugs used, Metformin Hydrochloride is an oral hypoglycemic drug used to treat Diabetes Mellitus. The present study aimed to elaborate a systematic review on the use of metformin hydrochloride in the treatment of gestational diabetes mellitus. The searches were carried out in the SciElo and Google Acadêmico databases. 763 articles were found in the initial research and after the analysis of the pre-analytical phases, only 6 were selected, since they met the inclusion criteria. After extracting the data, a relationship was made between the use of metformin with the various forms of therapy used in the studies and it was shown that metformin is a drug well applied as monotherapy, being used by 40 % of individuals in one of the studies analyzed and it is also well accepted in combination therapy with insulin in patients who have resistance to it, due to metformin being a drug with easy access and easy dosage. It is concluded that metformin is a safe, effective, low-cost and widely accepted drug for pregnant women who use it in the treatment of gestational Diabetes Mellitus.
id UNIFEI_581545df1da5a2949fd019da82c95f44
oai_identifier_str oai:ojs.pkp.sfu.ca:article/6988
network_acronym_str UNIFEI
network_name_str Research, Society and Development
repository_id_str
spelling Use of metformin hydrochloride in gestational diabetes: a systematic review Uso de clorhidrato de metformina en diabetes gestacional: una revisión sistemáticaUtilização do cloridrato de metformina no diabetes gestacional: uma revisão sistemática Diabetes gestacionalMetforminaGestantesRevisão sistemática.Gestational DiabetesMetforminPregnant womenSystematic review.Diabetes gestacionalMetforminaMujeres embarazadasRevisión sistemática.Gestational Diabetes Mellitus is a condition characterized by an increase in blood glucose levels, which can be initiated or diagnosed during pregnancy. This process occurs due to the production of high levels of hormones by the placenta, most of which are harmful to the action of insulin in the cells increasing the blood sugar level and can affect the growth and well-being of the fetus. Among the drugs used, Metformin Hydrochloride is an oral hypoglycemic drug used to treat Diabetes Mellitus. The present study aimed to elaborate a systematic review on the use of metformin hydrochloride in the treatment of gestational diabetes mellitus. The searches were carried out in the SciElo and Google Acadêmico databases. 763 articles were found in the initial research and after the analysis of the pre-analytical phases, only 6 were selected, since they met the inclusion criteria. After extracting the data, a relationship was made between the use of metformin with the various forms of therapy used in the studies and it was shown that metformin is a drug well applied as monotherapy, being used by 40 % of individuals in one of the studies analyzed and it is also well accepted in combination therapy with insulin in patients who have resistance to it, due to metformin being a drug with easy access and easy dosage. It is concluded that metformin is a safe, effective, low-cost and widely accepted drug for pregnant women who use it in the treatment of gestational Diabetes Mellitus.La Diabetes Mellitus gestacional es una afección caracterizada por un aumento en los niveles de glucosa en sangre, que puede iniciarse o diagnosticarse durante el embarazo. Este proceso ocurre debido a la producción de altos niveles de hormonas por la placenta, la mayoría de los cuales son perjudiciales para la acción de la insulina en las células, lo que aumenta el nivel de azúcar en la sangre y puede afectar el crecimiento y el bienestar del feto. Entre los medicamentos utilizados, el clorhidrato de metformina es un agente hipoglucemiante oral que se usa para tratar la Diabetes Mellitus. El presente estudio tuvo como objetivo elaborar una revisión sistemática sobre el uso de clorhidrato de metformina en el tratamiento de la diabetes mellitus gestacional. Las búsquedas se llevaron a cabo en las bases de datos SciElo y Google Acadêmico. Se encontraron 763 artículos en la investigación inicial y después del análisis de las fases preanalíticas, solo se seleccionaron 6, ya que cumplían con los criterios de inclusión. Después de extraer los datos, se estableció una relación entre el uso de metformina con las diversas formas de terapia utilizadas en los estudios y se demostró que la metformina es un fármaco bien aplicado como monoterapia, siendo utilizado por el 40 % de las personas en un de los estudios analizados y también es bien aceptado en la terapia de combinación con insulina en pacientes que tienen resistencia a ella, debido a que la metformina es un medicamento con fácil acceso y dosificación fácil. Se concluye que la metformina es un medicamento seguro, efectivo, de bajo costo y ampliamente aceptado para mujeres embarazadas que lo usan en el tratamiento de la Diabetes Mellitus gestacional.O Diabetes Mellitus Gestacional é uma condição caracterizada pelo aumento dos níveis de glicose no sangue, que pode ser iniciada ou diagnosticada durante a gestação. Esse processo ocorre devido à produção de altos níveis de hormônios pela placenta, sendo a maioria prejudicial à ação da insulina nas células, aumentando o nível de açúcar no sangue podendo afetar o crescimento e o bem-estar do feto. Dentre os medicamentos aplicados, o Cloridrato de Metformina é um hipoglicemiante oral usado no tratamento do Diabetes Mellitus. O presente trabalho teve como objetivo a elaboração de uma revisão sistemática sobre o uso do cloridrato de metformina no tratamento do diabetes mellitus gestacional. As buscas foram realizadas nas bases de dados SciElo e Google Acadêmico. Foram encontrados 763 artigos na pesquisa inicial e após as análises das fases pré-analíticas, apenas 6 foram selecionados, uma vez que atendiam aos critérios de inclusão. Após a extração dos dados, fez-se uma relação entre o uso da metformina com as diversas formas de terapia utilizadas nos estudos e evidenciou-se que a metformina é um fármaco bem aplicado como monoterapia chegando a ser utilizado por 40 % dos indivíduos em um dos estudos analisados, sendo também bem aceito em terapia combinada com insulina em pacientes que possuem resistência à mesma, devido a metformina ser um fármaco de fácil acesso e de fácil posologia. Conclui-se então que a metformina é um fármaco seguro, eficaz, de baixo custo e de muita aceitação pelas gestantes que o usam no tratamento do Diabetes Mellitus gestacional.Research, Society and Development2020-08-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/698810.33448/rsd-v9i9.6988Research, Society and Development; Vol. 9 No. 9; e122996988Research, Society and Development; Vol. 9 Núm. 9; e122996988Research, Society and Development; v. 9 n. 9; e1229969882525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/6988/6247Copyright (c) 2020 Ellys Cristina Eleonor Pereira Torres, Jéssica Costa de Oliveira, Luanne Eugênia Nunes, Rosueti Diógenes de Oliveira Filhohttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessTorres, Ellys Cristina Eleonor PereiraOliveira, Jéssica Costa deNunes, Luanne EugêniaSouza Neto, Franciso Ernesto deOliveira-Filho, Rosueti Diógenes de2020-09-18T01:42:11Zoai:ojs.pkp.sfu.ca:article/6988Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:29:53.174404Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Use of metformin hydrochloride in gestational diabetes: a systematic review
Uso de clorhidrato de metformina en diabetes gestacional: una revisión sistemática
Utilização do cloridrato de metformina no diabetes gestacional: uma revisão sistemática
title Use of metformin hydrochloride in gestational diabetes: a systematic review
spellingShingle Use of metformin hydrochloride in gestational diabetes: a systematic review
Torres, Ellys Cristina Eleonor Pereira
Diabetes gestacional
Metformina
Gestantes
Revisão sistemática.
Gestational Diabetes
Metformin
Pregnant women
Systematic review.
Diabetes gestacional
Metformina
Mujeres embarazadas
Revisión sistemática.
title_short Use of metformin hydrochloride in gestational diabetes: a systematic review
title_full Use of metformin hydrochloride in gestational diabetes: a systematic review
title_fullStr Use of metformin hydrochloride in gestational diabetes: a systematic review
title_full_unstemmed Use of metformin hydrochloride in gestational diabetes: a systematic review
title_sort Use of metformin hydrochloride in gestational diabetes: a systematic review
author Torres, Ellys Cristina Eleonor Pereira
author_facet Torres, Ellys Cristina Eleonor Pereira
Oliveira, Jéssica Costa de
Nunes, Luanne Eugênia
Souza Neto, Franciso Ernesto de
Oliveira-Filho, Rosueti Diógenes de
author_role author
author2 Oliveira, Jéssica Costa de
Nunes, Luanne Eugênia
Souza Neto, Franciso Ernesto de
Oliveira-Filho, Rosueti Diógenes de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Torres, Ellys Cristina Eleonor Pereira
Oliveira, Jéssica Costa de
Nunes, Luanne Eugênia
Souza Neto, Franciso Ernesto de
Oliveira-Filho, Rosueti Diógenes de
dc.subject.por.fl_str_mv Diabetes gestacional
Metformina
Gestantes
Revisão sistemática.
Gestational Diabetes
Metformin
Pregnant women
Systematic review.
Diabetes gestacional
Metformina
Mujeres embarazadas
Revisión sistemática.
topic Diabetes gestacional
Metformina
Gestantes
Revisão sistemática.
Gestational Diabetes
Metformin
Pregnant women
Systematic review.
Diabetes gestacional
Metformina
Mujeres embarazadas
Revisión sistemática.
description Gestational Diabetes Mellitus is a condition characterized by an increase in blood glucose levels, which can be initiated or diagnosed during pregnancy. This process occurs due to the production of high levels of hormones by the placenta, most of which are harmful to the action of insulin in the cells increasing the blood sugar level and can affect the growth and well-being of the fetus. Among the drugs used, Metformin Hydrochloride is an oral hypoglycemic drug used to treat Diabetes Mellitus. The present study aimed to elaborate a systematic review on the use of metformin hydrochloride in the treatment of gestational diabetes mellitus. The searches were carried out in the SciElo and Google Acadêmico databases. 763 articles were found in the initial research and after the analysis of the pre-analytical phases, only 6 were selected, since they met the inclusion criteria. After extracting the data, a relationship was made between the use of metformin with the various forms of therapy used in the studies and it was shown that metformin is a drug well applied as monotherapy, being used by 40 % of individuals in one of the studies analyzed and it is also well accepted in combination therapy with insulin in patients who have resistance to it, due to metformin being a drug with easy access and easy dosage. It is concluded that metformin is a safe, effective, low-cost and widely accepted drug for pregnant women who use it in the treatment of gestational Diabetes Mellitus.
publishDate 2020
dc.date.none.fl_str_mv 2020-08-14
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/6988
10.33448/rsd-v9i9.6988
url https://rsdjournal.org/index.php/rsd/article/view/6988
identifier_str_mv 10.33448/rsd-v9i9.6988
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/6988/6247
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 9 No. 9; e122996988
Research, Society and Development; Vol. 9 Núm. 9; e122996988
Research, Society and Development; v. 9 n. 9; e122996988
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
_version_ 1797052655992832000