Comparison between methods of treatment of intestinal mucositis in animal model – systematic literature review

• Autor(a) principal: Oliveira, Jennifer Kelly Silva de
• Data de Publicação: 2020
• Outros Autores: Paiva, Daniel Felipe Fernandes, Araújo, Aurigena Antunes de, Silva, Gabriel Gomes da, Oliveira, Francisca Jennifer Duarte de, Silva, Luana Amorim Morais da, Silva, Camila Alexandre, Xavier Filho, Luiz Gustavo
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Research, Society and Development
• DOI: 10.33448/rsd-v9i9.7221
• Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/7221
• topic: Tratamento farmacológico; Modelos animais; Flurouracila.; Quimioterapia; Modelos animales; Fluorouracilo.; Drug therapy; Models, animal; Fluorouracil.

Introduction: mucositis is one of the most common side effects that manifest during chemotherapy treatments against severe cancers. Such treatments have prominent drug 5-Fluorouracil (5-FU). However, patients undergoing anti-cancer treatments that include 5-FU and other cytotoxic drugs in chemotherapy suffer severe side effects. Objectives: the present article aims to assess which is the most promising treatment, in an animal model, to prevent intestinal mucositis induced by 5-FU. Methodology: a digital search was carried out in the main online databases in the health field, such as: “Pubmed”, “BVS”, “ScienceDirect”, “SciELO” and MEDLINE”. The search strategy in all databases was to enter the descriptors “treatment AND intestinal mucositis AND 5-Fluorouracil”. Results: at that time, 191 articles were found. After analyzing the inclusion and exclusion criteria, 51 articles were chosen for a thorough analysis of the methodology and results. As for the analysis parameters of the articles in this review, the following will be included: the methodology used; the possible study biases; and the results obtained from histological, enzymatic, cytosine, and, above all, clinical analyzes. The working groups that used as substances were analyzed: probiotics; phytotherapy; allopathic; selenium and others. Conclusion:  it was possible to perceive more promising results in the group of probiotics, especially Bidens pilosa L. (Asteraceae).