Anxiolytic activity of ferulic acid in the light-dark test in zebrafish
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/19894 |
Resumo: | The anxiety disorders belong to a group of mental disorders in which the patients present excessive fear and worry. Studies with ferulic acid have shown positive results on treating depressive symptoms. As many antidepressive drugs are effective in treating anxiety, the objective of the present study was to evaluate ferulic acid’s anxiolytic activity and possible mechanism of action in the light-dark test in zebrafish. To evaluate anxiolytic activity, the light-dark preference test was performed after exposure of the animals to ferulic acid or positive control (clonazepam or fluoxetine). Ferulic acid increased the time spent in the clear compartment at concentrations of 250 and 500 mg/L, not differing from the groups exposed to clonazepam or fluoxetine. To evaluate the possible mechanism of action, pre-exposure to flumazenil was carried out, followed by exposure to ferulic acid or positive control, with subsequent testing. Pre-exposure to flumazenil caused a significant reduction in the time spent in the clear compartment of ferulic acid and clonazepam groups but did not alter the effect of exposure to fluoxetine. These results suggest that ferulic acid promotes an anxiolytic effect, possibly through an action at the benzodiazepine binding site at the GABAA receptor. |
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Anxiolytic activity of ferulic acid in the light-dark test in zebrafishActividad ansiolítica del ácido ferúlico en la prueba de luz-oscuridad en zebrafishAtividade ansiolítica do ácido ferúlico no teste claro-escuro em zebrafish ZebrafishFerulic AcidAnxiety.ZebrafishÁcido ferúlicoAnsiedad.ZebrafishÁcido ferúlicoAnsiedade.The anxiety disorders belong to a group of mental disorders in which the patients present excessive fear and worry. Studies with ferulic acid have shown positive results on treating depressive symptoms. As many antidepressive drugs are effective in treating anxiety, the objective of the present study was to evaluate ferulic acid’s anxiolytic activity and possible mechanism of action in the light-dark test in zebrafish. To evaluate anxiolytic activity, the light-dark preference test was performed after exposure of the animals to ferulic acid or positive control (clonazepam or fluoxetine). Ferulic acid increased the time spent in the clear compartment at concentrations of 250 and 500 mg/L, not differing from the groups exposed to clonazepam or fluoxetine. To evaluate the possible mechanism of action, pre-exposure to flumazenil was carried out, followed by exposure to ferulic acid or positive control, with subsequent testing. Pre-exposure to flumazenil caused a significant reduction in the time spent in the clear compartment of ferulic acid and clonazepam groups but did not alter the effect of exposure to fluoxetine. These results suggest that ferulic acid promotes an anxiolytic effect, possibly through an action at the benzodiazepine binding site at the GABAA receptor.Los trastornos de ansiedad pertenecen a un grupo de trastornos mentales en los que los pacientes muestran un miedo y una preocupación excesivos. Los estudios con ácido ferúlico mostraron resultados positivos para tratar los síntomas depresivos. Partiendo del hecho de que muchos fármacos antidepresivos son eficaces en el tratamiento de la ansiedad, el objetivo del presente estudio fue evaluar la actividad ansiolítica y su posible mecanismo de acción en la prueba de luz/oscuridad del zebrafish. Para evaluar la actividad ansiolítica, se realizó la prueba de preferencia luz-oscuridad después de exponer a los animales a ácido ferúlico o control positivo (clonazepam o fluoxetina). El ácido ferúlico aumentó el tiempo de permanencia en el compartimento de luz a concentraciones de 250 y 500 mg/L, sin diferenciarse de los grupos expuestos a clonazepam o fluoxetina. Para evaluar el posible mecanismo de acción se realizó una preexposición a flumazenil, seguida de exposición a ácido ferúlico o control positivo, con posterior realización de la misma prueba. El resultado mostró que la preexposición al flumazenil promovió una reducción significativa en el tiempo de permanencia en el compartimento de luz en el grupo expuesto al ácido ferúlico y al clonazepam, pero no cambió el efecto de la exposición a la fluoxetina. Estos resultados sugieren que el ácido ferúlico promueve un efecto ansiolítico, posiblemente a través de una acción en el sitio de unión de las benzodiacepinas en el receptor GABAA.Os distúrbios de ansiedade pertencem a um grupo de transtornos mentais onde os pacientes apresentam medo e preocupação excessivos. Estudos com ácido ferúlico têm demonstrado resultados positivos para tratar sintomas depressivos. Como muitas drogas antidepressivas são eficientes no tratamento de ansiedade, o objetivo do presente estudo foi avaliar a atividade ansiolítica e seu possível mecanismo de ação no teste claro/escuro em zebrafish. Para avaliar a atividade ansiolítica, foi realizado o teste de preferência claro-escuro após a exposição dos animais ao ácido ferúlico ou controle positivo (clonazepam ou fluoxetina). O ácido ferúlico aumentou o tempo de permanência no compartimento claro nas concentrações de 250 e 500 mg/L, não diferindo dos grupos expostos ao clonazepam ou fluoxetina. Para avaliar o possível mecanismo de ação, foi realizada a pré-exposição ao flumazenil, seguido da exposição ao ácido ferúlico ou controle positivo, com posterior realização do mesmo teste. O resultado demonstrou que a pré-exposição ao flumazenil promoveu uma redução significativa do tempo de permanência no compartimento claro no grupo exposto com ácido ferúlico e clonazepam, mas não alterou o efeito da exposição a fluoxetina. Estes resultados sugerem que o ácido ferúlico promove um efeito ansiolítico, possivelmente através de uma ação no sitio de ligação benzodiazepínico no receptor GABAA.Research, Society and Development2021-09-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1989410.33448/rsd-v10i11.19894Research, Society and Development; Vol. 10 No. 11; e582101119894Research, Society and Development; Vol. 10 Núm. 11; e582101119894Research, Society and Development; v. 10 n. 11; e5821011198942525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/19894/17878Copyright (c) 2021 Susi Mara Soecki Sborgi; Lillian Caroline Fernandes; Anderson Gustavo Santos; Marcelo Machado Ferro; Edmar Miyoshihttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSborgi, Susi Mara SoeckiFernandes, Lillian CarolineSantos, Anderson GustavoFerro, Marcelo MachadoMiyoshi, Edmar 2021-10-23T19:01:11Zoai:ojs.pkp.sfu.ca:article/19894Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:39:41.280679Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Anxiolytic activity of ferulic acid in the light-dark test in zebrafish Actividad ansiolítica del ácido ferúlico en la prueba de luz-oscuridad en zebrafish Atividade ansiolítica do ácido ferúlico no teste claro-escuro em zebrafish |
title |
Anxiolytic activity of ferulic acid in the light-dark test in zebrafish |
spellingShingle |
Anxiolytic activity of ferulic acid in the light-dark test in zebrafish Sborgi, Susi Mara Soecki Zebrafish Ferulic Acid Anxiety. Zebrafish Ácido ferúlico Ansiedad. Zebrafish Ácido ferúlico Ansiedade. |
title_short |
Anxiolytic activity of ferulic acid in the light-dark test in zebrafish |
title_full |
Anxiolytic activity of ferulic acid in the light-dark test in zebrafish |
title_fullStr |
Anxiolytic activity of ferulic acid in the light-dark test in zebrafish |
title_full_unstemmed |
Anxiolytic activity of ferulic acid in the light-dark test in zebrafish |
title_sort |
Anxiolytic activity of ferulic acid in the light-dark test in zebrafish |
author |
Sborgi, Susi Mara Soecki |
author_facet |
Sborgi, Susi Mara Soecki Fernandes, Lillian Caroline Santos, Anderson Gustavo Ferro, Marcelo Machado Miyoshi, Edmar |
author_role |
author |
author2 |
Fernandes, Lillian Caroline Santos, Anderson Gustavo Ferro, Marcelo Machado Miyoshi, Edmar |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Sborgi, Susi Mara Soecki Fernandes, Lillian Caroline Santos, Anderson Gustavo Ferro, Marcelo Machado Miyoshi, Edmar |
dc.subject.por.fl_str_mv |
Zebrafish Ferulic Acid Anxiety. Zebrafish Ácido ferúlico Ansiedad. Zebrafish Ácido ferúlico Ansiedade. |
topic |
Zebrafish Ferulic Acid Anxiety. Zebrafish Ácido ferúlico Ansiedad. Zebrafish Ácido ferúlico Ansiedade. |
description |
The anxiety disorders belong to a group of mental disorders in which the patients present excessive fear and worry. Studies with ferulic acid have shown positive results on treating depressive symptoms. As many antidepressive drugs are effective in treating anxiety, the objective of the present study was to evaluate ferulic acid’s anxiolytic activity and possible mechanism of action in the light-dark test in zebrafish. To evaluate anxiolytic activity, the light-dark preference test was performed after exposure of the animals to ferulic acid or positive control (clonazepam or fluoxetine). Ferulic acid increased the time spent in the clear compartment at concentrations of 250 and 500 mg/L, not differing from the groups exposed to clonazepam or fluoxetine. To evaluate the possible mechanism of action, pre-exposure to flumazenil was carried out, followed by exposure to ferulic acid or positive control, with subsequent testing. Pre-exposure to flumazenil caused a significant reduction in the time spent in the clear compartment of ferulic acid and clonazepam groups but did not alter the effect of exposure to fluoxetine. These results suggest that ferulic acid promotes an anxiolytic effect, possibly through an action at the benzodiazepine binding site at the GABAA receptor. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-09-11 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/19894 10.33448/rsd-v10i11.19894 |
url |
https://rsdjournal.org/index.php/rsd/article/view/19894 |
identifier_str_mv |
10.33448/rsd-v10i11.19894 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/19894/17878 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 11; e582101119894 Research, Society and Development; Vol. 10 Núm. 11; e582101119894 Research, Society and Development; v. 10 n. 11; e582101119894 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
_version_ |
1797052688489250816 |