Exploiting the antibacterial effects of nine formulations of intracanal medication and irrigants against several bacterial strains

Detalhes bibliográficos
Autor(a) principal: Coutinho, Thais Machado de Carvalho
Data de Publicação: 2022
Outros Autores: Campello, Andrea Fagundes, Brum, Sileno Correa, Pereira, Carlos Henrique Sardenberg, Provenzano, José Claudio, Alves, Flávio Rodrigues Ferreira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/29999
Resumo: Elimination of intraradicular infection is essential for the success of endodontic treatment. This study evaluated the antibacterial effects of nine different formulations of intracanal medication and irrigating solutions, based on calcium hydroxide (Ca(OH)2), calcium sulfate (CaSO4), and a chlorhexidine (CHX), against nine bacterial strains. Aerobic or facultative anaerobic bacteria were grown in trypticase-soy broth and the anaerobic strain was grown in pre-reduced anaerobically sterilized brain heart infusion. The evaluation was performed by using the agar diffusion test in aerobic and anaerobic conditions using plates containing mitis-salivarius agar or trypticase-soy agar. The results showed that practically all substances tested had some antibacterial activity, except for calcium hydroxide and calcium sulfate when associated only with glycerin, which did not show any bacterial growth inhibition. On average, the drugs that showed the greatest antibacterial effects were 2% chlorhexidine and calcium hydroxide paste in camphorated paramonochlorophenol (CPMC) /glycerin and 0.12% chlorhexidine. It was concluded that 0.12% CHX as intracanal medication based on 2% CHX gel showed better antimicrobial action of the substances tested on bacterial species of endodontic infection.
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spelling Exploiting the antibacterial effects of nine formulations of intracanal medication and irrigants against several bacterial strains Exploración de los efectos antibacterianos de nueve formulaciones de medicamentos intracanal y irrigantes contra varias cepas bacterianasExplorando os efeitos antibacterianos de nove formulações de medicação intracanal e irrigantes contra várias cepas bacterianas Intracanal medicationAuxiliary chemical substanceAntibacterial activityEndodontic treatment.Medicación intracanalSustancia química auxiliarActividad antibacterialTratamiento de endodoncia.Medicação intracanalSubstância química auxiliarAtividade antibacterianaTratamento endodôntico.Elimination of intraradicular infection is essential for the success of endodontic treatment. This study evaluated the antibacterial effects of nine different formulations of intracanal medication and irrigating solutions, based on calcium hydroxide (Ca(OH)2), calcium sulfate (CaSO4), and a chlorhexidine (CHX), against nine bacterial strains. Aerobic or facultative anaerobic bacteria were grown in trypticase-soy broth and the anaerobic strain was grown in pre-reduced anaerobically sterilized brain heart infusion. The evaluation was performed by using the agar diffusion test in aerobic and anaerobic conditions using plates containing mitis-salivarius agar or trypticase-soy agar. The results showed that practically all substances tested had some antibacterial activity, except for calcium hydroxide and calcium sulfate when associated only with glycerin, which did not show any bacterial growth inhibition. On average, the drugs that showed the greatest antibacterial effects were 2% chlorhexidine and calcium hydroxide paste in camphorated paramonochlorophenol (CPMC) /glycerin and 0.12% chlorhexidine. It was concluded that 0.12% CHX as intracanal medication based on 2% CHX gel showed better antimicrobial action of the substances tested on bacterial species of endodontic infection.La eliminación de la infección intrarradicular es fundamental para el éxito del tratamiento endodóntico. Este estudio evaluó los efectos antibacterianos de nueve formulaciones diferentes de medicación intracanal y solución de irrigación, a base de hidróxido de calcio (Ca(OH)2), sulfato de calcio(CaSO4) y clorhexidina (CHX) contra nueve cepas bacterianas. Se cultivaron bacterias aeróbicas o anaeróbicas facultativas en caldo de tripticasa-soja y la cepa anaeróbica se cultivó en infusión de cerebro y corazón esterilizada anaeróbicamente y reducida previamente. La evaluación se realizó mediante la prueba de difusión en agar en condiciones aeróbicas y anaeróbicas utilizando placas que contenían agar mitis-salivarius o agar tripticasa-soja. Los resultados mostraron que prácticamente todas las sustancias ensayadas tenían alguna actividad antibacteriana, excepto el hidróxido de calcio y el sulfato de calcio cuando se asociaron solo con glicerina, que no mostraron inhibición del crecimiento bacteriano. Se concluyó que la solución de clorhexidina al 0,12% como la medicación intracanal a base de gel de clorhexidina al 2% mostraron mejor acción antimicrobiana de las sustancias ensayadas sobre especies bacterianas de infección endodóntica.A eliminação da infecção intrarradicular é essencial para o sucesso do tratamento endodôntico. Este estudo avaliou os efeitos antibacterianos de nove diferentes formulações de medicações intracanais e solução irrigadora, a base de hidróxido de cálcio (Ca(OH)2), sulfato de cálcio (CaSO4) e clorexidina (CHX) contra nove cepas bacterianas. Bactérias aeróbicas ou anaeróbicas facultativas foram cultivadas em caldo tripticase-soja e a cepa anaeróbia foi cultivada em infusão de cérebro-coração anaeróbia pré-reduzida esterilizada. A avaliação foi realizada por meio do teste de difusão em ágar em condições aeróbicas e anaeróbicas utilizando placas contendo ágar mitis-salivarius ou ágar tripticase-soja. Os resultados mostraram que praticamente todas as substâncias testadas apresentaram alguma atividade antibacteriana, exceto o hidróxido de cálcio e o sulfato de cálcio quando associados apenas à glicerina, que não apresentaram inibição do crescimento bacteriano. Concluiu-se que a solução de clorexidina a 0,12% como medicação intracanal à base de gel de clorexidina a 2% apresentaram melhor ação antimicrobiana das substâncias testadas sobre as espécies bacterianas de infecção endodôntica.Research, Society and Development2022-06-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2999910.33448/rsd-v11i8.29999Research, Society and Development; Vol. 11 No. 8; e33211829999Research, Society and Development; Vol. 11 Núm. 8; e33211829999Research, Society and Development; v. 11 n. 8; e332118299992525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/29999/26571Copyright (c) 2022 Thais Machado de Carvalho Coutinho; Andrea Fagundes Campello; Sileno Correa Brum; Carlos Henrique Sardenberg Pereira; José Claudio Provenzano; Flávio Rodrigues Ferreira Alveshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCoutinho, Thais Machado de CarvalhoCampello, Andrea Fagundes Brum, Sileno Correa Pereira, Carlos Henrique Sardenberg Provenzano, José Claudio Alves, Flávio Rodrigues Ferreira 2022-07-01T13:34:06Zoai:ojs.pkp.sfu.ca:article/29999Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:46:54.596798Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Exploiting the antibacterial effects of nine formulations of intracanal medication and irrigants against several bacterial strains
Exploración de los efectos antibacterianos de nueve formulaciones de medicamentos intracanal y irrigantes contra varias cepas bacterianas
Explorando os efeitos antibacterianos de nove formulações de medicação intracanal e irrigantes contra várias cepas bacterianas
title Exploiting the antibacterial effects of nine formulations of intracanal medication and irrigants against several bacterial strains
spellingShingle Exploiting the antibacterial effects of nine formulations of intracanal medication and irrigants against several bacterial strains
Coutinho, Thais Machado de Carvalho
Intracanal medication
Auxiliary chemical substance
Antibacterial activity
Endodontic treatment.
Medicación intracanal
Sustancia química auxiliar
Actividad antibacterial
Tratamiento de endodoncia.
Medicação intracanal
Substância química auxiliar
Atividade antibacteriana
Tratamento endodôntico.
title_short Exploiting the antibacterial effects of nine formulations of intracanal medication and irrigants against several bacterial strains
title_full Exploiting the antibacterial effects of nine formulations of intracanal medication and irrigants against several bacterial strains
title_fullStr Exploiting the antibacterial effects of nine formulations of intracanal medication and irrigants against several bacterial strains
title_full_unstemmed Exploiting the antibacterial effects of nine formulations of intracanal medication and irrigants against several bacterial strains
title_sort Exploiting the antibacterial effects of nine formulations of intracanal medication and irrigants against several bacterial strains
author Coutinho, Thais Machado de Carvalho
author_facet Coutinho, Thais Machado de Carvalho
Campello, Andrea Fagundes
Brum, Sileno Correa
Pereira, Carlos Henrique Sardenberg
Provenzano, José Claudio
Alves, Flávio Rodrigues Ferreira
author_role author
author2 Campello, Andrea Fagundes
Brum, Sileno Correa
Pereira, Carlos Henrique Sardenberg
Provenzano, José Claudio
Alves, Flávio Rodrigues Ferreira
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Coutinho, Thais Machado de Carvalho
Campello, Andrea Fagundes
Brum, Sileno Correa
Pereira, Carlos Henrique Sardenberg
Provenzano, José Claudio
Alves, Flávio Rodrigues Ferreira
dc.subject.por.fl_str_mv Intracanal medication
Auxiliary chemical substance
Antibacterial activity
Endodontic treatment.
Medicación intracanal
Sustancia química auxiliar
Actividad antibacterial
Tratamiento de endodoncia.
Medicação intracanal
Substância química auxiliar
Atividade antibacteriana
Tratamento endodôntico.
topic Intracanal medication
Auxiliary chemical substance
Antibacterial activity
Endodontic treatment.
Medicación intracanal
Sustancia química auxiliar
Actividad antibacterial
Tratamiento de endodoncia.
Medicação intracanal
Substância química auxiliar
Atividade antibacteriana
Tratamento endodôntico.
description Elimination of intraradicular infection is essential for the success of endodontic treatment. This study evaluated the antibacterial effects of nine different formulations of intracanal medication and irrigating solutions, based on calcium hydroxide (Ca(OH)2), calcium sulfate (CaSO4), and a chlorhexidine (CHX), against nine bacterial strains. Aerobic or facultative anaerobic bacteria were grown in trypticase-soy broth and the anaerobic strain was grown in pre-reduced anaerobically sterilized brain heart infusion. The evaluation was performed by using the agar diffusion test in aerobic and anaerobic conditions using plates containing mitis-salivarius agar or trypticase-soy agar. The results showed that practically all substances tested had some antibacterial activity, except for calcium hydroxide and calcium sulfate when associated only with glycerin, which did not show any bacterial growth inhibition. On average, the drugs that showed the greatest antibacterial effects were 2% chlorhexidine and calcium hydroxide paste in camphorated paramonochlorophenol (CPMC) /glycerin and 0.12% chlorhexidine. It was concluded that 0.12% CHX as intracanal medication based on 2% CHX gel showed better antimicrobial action of the substances tested on bacterial species of endodontic infection.
publishDate 2022
dc.date.none.fl_str_mv 2022-06-20
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/29999
10.33448/rsd-v11i8.29999
url https://rsdjournal.org/index.php/rsd/article/view/29999
identifier_str_mv 10.33448/rsd-v11i8.29999
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/29999/26571
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 8; e33211829999
Research, Society and Development; Vol. 11 Núm. 8; e33211829999
Research, Society and Development; v. 11 n. 8; e33211829999
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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