Misoprostol as an abortive trigger in Moebius Syndrome in low-income people in Brazil

Detalhes bibliográficos
Autor(a) principal: Bacelar , Lara Isobel Vieira
Data de Publicação: 2022
Outros Autores: Sousa, Jucilene da Silva, Pacheco, Nágila Iane, Sousa, Amália Ramos de, Rodrigues, Isabelle Vasconcelos, Machado, Fernando Henrique Lima Sa, Rodrigues , Jorgiane Pereira, Pessoa, Diego Rodrigues, Lopes, Danielle Costa, Mendes, Luiza Aragão Paiva Pires Ferreira
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/26572
Resumo: Introduction: Misoprostol is a prostaglandin E1 analogue with valence-restricted abortifacient properties, which is correlated with the presence of congenital abnormalities in newborns exposed in the uterus and, in Brazil, many women use inappropriate abortion methods. Objective: to establish a survey of data on Moebius syndrome in unsuccessful abortion attempts due to the use of misoprostol by low-income women. Methodology: For the preparation of this article, bibliographic research was carried out in search of articles available in the databases: Scientific Electronic, Scielo, Google Scholar, Brazilian Journal on Health Promotion, published between the years 2012 - 2021. Results and Discussions: The pharmacological action of Cytotec or Prostokos is direct on the prostaglandin receptors, acting on cervical collagen, causing changes in its physicochemical structure, and as a consequence, softening, erasing and maturation of the uterine cervix, in addition to promoting and stimulating uterine contraction. If the abortion attempt is not successful, it results in a disruptive vascular effect, causing damage to the nuclei and cells of the cranial nerves, occurring in the fourth week of pregnancy, impairing the development of limbs and organs, presenting a greater disposition to aggression and vulnerability to the manifestation of fetal malformations. Moébius Syndrome can manifest soon after birth, the child presents throughout the day a limitation when closing the eyelids and when sleeping cannot close them completely due to the abducens nerve paralysis. Conclusion: The need for greater investment in research on the proposed topic is affirmed.
id UNIFEI_5e243ad3496b621d42c02ea1bebfb71a
oai_identifier_str oai:ojs.pkp.sfu.ca:article/26572
network_acronym_str UNIFEI
network_name_str Research, Society and Development
repository_id_str
spelling Misoprostol as an abortive trigger in Moebius Syndrome in low-income people in BrazilEl misoprostol como desencadenante abortivo em el síndrome de Moebiusen personas de bajos ingresosen BrasilMisoprostol como acarretador abortivo na Síndrome de Moebius em pessoas de baixa renda no BrasilMoebius SyndromeMisoprostolAbortion.Síndrome de MoebiusMisoprostolAborto.Sindrome de MoebiusMisoprostolAborto.Introduction: Misoprostol is a prostaglandin E1 analogue with valence-restricted abortifacient properties, which is correlated with the presence of congenital abnormalities in newborns exposed in the uterus and, in Brazil, many women use inappropriate abortion methods. Objective: to establish a survey of data on Moebius syndrome in unsuccessful abortion attempts due to the use of misoprostol by low-income women. Methodology: For the preparation of this article, bibliographic research was carried out in search of articles available in the databases: Scientific Electronic, Scielo, Google Scholar, Brazilian Journal on Health Promotion, published between the years 2012 - 2021. Results and Discussions: The pharmacological action of Cytotec or Prostokos is direct on the prostaglandin receptors, acting on cervical collagen, causing changes in its physicochemical structure, and as a consequence, softening, erasing and maturation of the uterine cervix, in addition to promoting and stimulating uterine contraction. If the abortion attempt is not successful, it results in a disruptive vascular effect, causing damage to the nuclei and cells of the cranial nerves, occurring in the fourth week of pregnancy, impairing the development of limbs and organs, presenting a greater disposition to aggression and vulnerability to the manifestation of fetal malformations. Moébius Syndrome can manifest soon after birth, the child presents throughout the day a limitation when closing the eyelids and when sleeping cannot close them completely due to the abducens nerve paralysis. Conclusion: The need for greater investment in research on the proposed topic is affirmed.Introducción: El misoprostol es un análogo de la prostaglandina E1 con propiedades abortivas de valencia restringida, que se correlaciona con la presencia de anomalías congénitas en recién nacidos expuestos en el útero y, en Brasil, muchas mujeres utilizan métodos de aborto inadecuados. Objetivo: establecer un relevamiento de datos sobre el síndrome de Moebius en intentos fallidos de aborto por uso de misoprostol en mujeres de escasos recursos. Metodología: Para la elaboración de este artículo, se realizó una investigación bibliográfica en busca de artículos disponibles en las bases de datos: Scientific Electronic, Scielo, Google Scholar, Brazilian Journal on Health Promotion, publicados entre los años 2012 - 2021. Resultados y Discusiones: El La acción farmacológica de Cytotec o Prostokos es directa sobre los receptores de prostaglandinas, actuando sobre el colágeno cervical, provocando cambios en su estructura fisicoquímica, y como consecuencia, ablandamiento, borrado y maduración del cuello uterino, además de promover y estimular la contracción uterina. Si el intento de aborto no tiene éxito, resulta en un efecto vascular disruptivo, causando daño a los núcleos y células de los nervios craneales, ocurriendo en la cuarta semana de embarazo, perjudicando el desarrollo de miembros y órganos, presentando una mayor disposición a la agresión. y vulnerabilidad a la manifestación de malformaciones fetales. El Síndrome de Moébius puede manifestarse al poco tiempo del nacimiento, el niño presenta durante todo el día una limitación al cerrar los párpados y al dormir no puede cerrarlos por completo debido a la parálisis del nervio motor ocular externo. Conclusión: Se afirma la necesidad de una mayor inversión en investigación sobre el tema propuesto.Introdução: O misoprostol é um análogo da prostaglandina E1 com propriedades abortivas de valência restringida, que está correlacionado à presença de anormalidades congênita em recém-nascidos expostos no útero e, no Brasil, muitas mulheres utilizam de métodos abortivos inapropriados. Objetivo: estabelecer um levantamento de dados sobre a síndrome de Moebius em tentativas frustradas de aborto pelo uso do misoprostol por mulheres de baixa renda. Metodologia: Para a elaboração do presente artigo, realizou-se pesquisas bibliográficas em busca de artigos disponíveis nas bases dedados: Scientific Electronic, Scielo, Google Scholar, Revista Brasileira em Promoção Da Saúde, publicadas entre os anos de 2012 – 2021. Resultados e Discussões: A ação farmacológica do Cytotec ou Prostokos é direta nos receptores das prostaglandinas, atuando no colágeno cervical, provocando mudanças na sua estrutura físicoquímica, e como consequência, amolecimento, apagamento e maturação do colo uterino, além de promover e estimular a contração uterina. A tentativa de abortamento se não bem sucedida resulta em feito vascular disruptivo, causando danos aos núcleos e células dos nervos cranianos transcorridos na quarta semana de gravidez prejudicando o desenvolvimento de membros e órgãos apresentando maior disposição às agressões e vulnerabilidade para a manifestação de malformações fetais. A Síndrome de Moébius pode se manifestar logo após o nascimento, a criança apresenta ao longo do dia uma limitação ao fechar as pálpebras e ao dormir não consegue fechá-las por completo em razão da paralisia do nervo abducente. Conclusão: Afirma-se a necessidade de maior investimento em pesquisas sobre o tema proposto.Research, Society and Development2022-02-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2657210.33448/rsd-v11i3.26572Research, Society and Development; Vol. 11 No. 3; e24911326572Research, Society and Development; Vol. 11 Núm. 3; e24911326572Research, Society and Development; v. 11 n. 3; e249113265722525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/26572/23209Copyright (c) 2022 Lara Isobel Vieira Bacelar ; Jucilene da Silva Sousa; Nágila Iane Pacheco; Amália Ramos de Sousa; Isabelle Vasconcelos Rodrigues; Fernando Henrique Lima Sa Machado; Jorgiane Pereira Rodrigues ; Diego Rodrigues Pessoa; Danielle Costa Lopes; Luiza Aragão Paiva Pires Ferreira Mendeshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBacelar , Lara Isobel Vieira Sousa, Jucilene da Silva Pacheco, Nágila Iane Sousa, Amália Ramos de Rodrigues, Isabelle Vasconcelos Machado, Fernando Henrique Lima Sa Rodrigues , Jorgiane Pereira Pessoa, Diego Rodrigues Lopes, Danielle Costa Mendes, Luiza Aragão Paiva Pires Ferreira 2022-03-09T13:44:38Zoai:ojs.pkp.sfu.ca:article/26572Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:44:34.778921Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Misoprostol as an abortive trigger in Moebius Syndrome in low-income people in Brazil
El misoprostol como desencadenante abortivo em el síndrome de Moebiusen personas de bajos ingresosen Brasil
Misoprostol como acarretador abortivo na Síndrome de Moebius em pessoas de baixa renda no Brasil
title Misoprostol as an abortive trigger in Moebius Syndrome in low-income people in Brazil
spellingShingle Misoprostol as an abortive trigger in Moebius Syndrome in low-income people in Brazil
Bacelar , Lara Isobel Vieira
Moebius Syndrome
Misoprostol
Abortion.
Síndrome de Moebius
Misoprostol
Aborto.
Sindrome de Moebius
Misoprostol
Aborto.
title_short Misoprostol as an abortive trigger in Moebius Syndrome in low-income people in Brazil
title_full Misoprostol as an abortive trigger in Moebius Syndrome in low-income people in Brazil
title_fullStr Misoprostol as an abortive trigger in Moebius Syndrome in low-income people in Brazil
title_full_unstemmed Misoprostol as an abortive trigger in Moebius Syndrome in low-income people in Brazil
title_sort Misoprostol as an abortive trigger in Moebius Syndrome in low-income people in Brazil
author Bacelar , Lara Isobel Vieira
author_facet Bacelar , Lara Isobel Vieira
Sousa, Jucilene da Silva
Pacheco, Nágila Iane
Sousa, Amália Ramos de
Rodrigues, Isabelle Vasconcelos
Machado, Fernando Henrique Lima Sa
Rodrigues , Jorgiane Pereira
Pessoa, Diego Rodrigues
Lopes, Danielle Costa
Mendes, Luiza Aragão Paiva Pires Ferreira
author_role author
author2 Sousa, Jucilene da Silva
Pacheco, Nágila Iane
Sousa, Amália Ramos de
Rodrigues, Isabelle Vasconcelos
Machado, Fernando Henrique Lima Sa
Rodrigues , Jorgiane Pereira
Pessoa, Diego Rodrigues
Lopes, Danielle Costa
Mendes, Luiza Aragão Paiva Pires Ferreira
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bacelar , Lara Isobel Vieira
Sousa, Jucilene da Silva
Pacheco, Nágila Iane
Sousa, Amália Ramos de
Rodrigues, Isabelle Vasconcelos
Machado, Fernando Henrique Lima Sa
Rodrigues , Jorgiane Pereira
Pessoa, Diego Rodrigues
Lopes, Danielle Costa
Mendes, Luiza Aragão Paiva Pires Ferreira
dc.subject.por.fl_str_mv Moebius Syndrome
Misoprostol
Abortion.
Síndrome de Moebius
Misoprostol
Aborto.
Sindrome de Moebius
Misoprostol
Aborto.
topic Moebius Syndrome
Misoprostol
Abortion.
Síndrome de Moebius
Misoprostol
Aborto.
Sindrome de Moebius
Misoprostol
Aborto.
description Introduction: Misoprostol is a prostaglandin E1 analogue with valence-restricted abortifacient properties, which is correlated with the presence of congenital abnormalities in newborns exposed in the uterus and, in Brazil, many women use inappropriate abortion methods. Objective: to establish a survey of data on Moebius syndrome in unsuccessful abortion attempts due to the use of misoprostol by low-income women. Methodology: For the preparation of this article, bibliographic research was carried out in search of articles available in the databases: Scientific Electronic, Scielo, Google Scholar, Brazilian Journal on Health Promotion, published between the years 2012 - 2021. Results and Discussions: The pharmacological action of Cytotec or Prostokos is direct on the prostaglandin receptors, acting on cervical collagen, causing changes in its physicochemical structure, and as a consequence, softening, erasing and maturation of the uterine cervix, in addition to promoting and stimulating uterine contraction. If the abortion attempt is not successful, it results in a disruptive vascular effect, causing damage to the nuclei and cells of the cranial nerves, occurring in the fourth week of pregnancy, impairing the development of limbs and organs, presenting a greater disposition to aggression and vulnerability to the manifestation of fetal malformations. Moébius Syndrome can manifest soon after birth, the child presents throughout the day a limitation when closing the eyelids and when sleeping cannot close them completely due to the abducens nerve paralysis. Conclusion: The need for greater investment in research on the proposed topic is affirmed.
publishDate 2022
dc.date.none.fl_str_mv 2022-02-20
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/26572
10.33448/rsd-v11i3.26572
url https://rsdjournal.org/index.php/rsd/article/view/26572
identifier_str_mv 10.33448/rsd-v11i3.26572
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/26572/23209
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 3; e24911326572
Research, Society and Development; Vol. 11 Núm. 3; e24911326572
Research, Society and Development; v. 11 n. 3; e24911326572
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
_version_ 1797052705465696256