Preoperative risk score and in-hospital death following isolated myocardial revascularization surgery

Detalhes bibliográficos
Autor(a) principal: Rosan, Raphael Paris
Data de Publicação: 2022
Outros Autores: Farsky, Pedro Silvio, França, João Ítalo Dias, Amato, Vivian Lerner
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
DOI: 10.33448/rsd-v11i2.25828
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/25828
Resumo: Cardiovascular disease is the leading cause of death in Brazil. The risk of in-hospital death after coronary artery bypass grafting (CABG) can be assessed by identifying preoperative factors and quantified through scores. This investigation analyzed associated with mortality in the hospital phase after isolated CABG, to develop a preoperative risk score (PRS) for postoperative in-hospital death. This observational, retrospective, single-center study examined comorbidities and complementary exams of 9,826 patients who underwent isolated CABG between January 1, 1999 and December 31, 2017 were analyzed to identify their correlation with postoperative in-hospital death. A total of 9,826 patients were divided into the construction group (7,860; 80%) and validation group (1,966; 20%). The mean age of the patients was 62.43 years. Most patients were men (70.2%). Fifteen independently related factors were identified for hospital mortality. The final logistic model was calculated in the construction group with a C-statistic of 0.745 (95% confidence interval [CI], 0.720–0.770). In the validation group, the score was tested by obtaining an area under the receiver operating curve of 0.716 (95% [CI], 0.666–0.767). Death occurred in 489 patients (5%). The risk of death ranged from 1.2% in those considered to be low risk (PRS <85) to 16.3% among those considered to be very high risk (PRS >211). The PRS score satisfactorily discriminated among patients who exhibited low, intermediate, high, and very high risk of death in the postoperative period. PRS could serve as an auxiliary tool in the preoperative period for surgical teams.
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spelling Preoperative risk score and in-hospital death following isolated myocardial revascularization surgeryEvaluación del riesgo de muerte intrahospitalaria en cirugía de revascularización miocárdica aislada mediante ERPOAvaliação do risco de óbito intra-hospitalar em cirurgia de revascularização miocárdia isolada através do ERPOCardiovascular diseaseCoronary artery bypass graftingPreoperative risk score.Enfermedad cardiovascularBypass aortocoronarioScore de riesgo preoperatorio.Doença cardiovascularCirurgia de revascularização do miocárdioEscore de risco pré-operatório.Cardiovascular disease is the leading cause of death in Brazil. The risk of in-hospital death after coronary artery bypass grafting (CABG) can be assessed by identifying preoperative factors and quantified through scores. This investigation analyzed associated with mortality in the hospital phase after isolated CABG, to develop a preoperative risk score (PRS) for postoperative in-hospital death. This observational, retrospective, single-center study examined comorbidities and complementary exams of 9,826 patients who underwent isolated CABG between January 1, 1999 and December 31, 2017 were analyzed to identify their correlation with postoperative in-hospital death. A total of 9,826 patients were divided into the construction group (7,860; 80%) and validation group (1,966; 20%). The mean age of the patients was 62.43 years. Most patients were men (70.2%). Fifteen independently related factors were identified for hospital mortality. The final logistic model was calculated in the construction group with a C-statistic of 0.745 (95% confidence interval [CI], 0.720–0.770). In the validation group, the score was tested by obtaining an area under the receiver operating curve of 0.716 (95% [CI], 0.666–0.767). Death occurred in 489 patients (5%). The risk of death ranged from 1.2% in those considered to be low risk (PRS <85) to 16.3% among those considered to be very high risk (PRS >211). The PRS score satisfactorily discriminated among patients who exhibited low, intermediate, high, and very high risk of death in the postoperative period. PRS could serve as an auxiliary tool in the preoperative period for surgical teams.La enfermedad cardiovascular es la principal causa de muerte en Brasil. El riesgo de muerte en el hospital después de un injerto de derivación de la arteria coronaria (CABG) se puede evaluar mediante la identificación de factores preoperatorios y cuantificar a través de puntuaciones. Esta investigación analizó la mortalidad asociada a la fase hospitalaria después de una CABG aislada, para desarrollar una puntuación de riesgo preoperatorio (PRS) para la muerte intrahospitalaria posoperatoria. Este estudio observacional, retrospectivo, unicéntrico, examinó las comorbilidades y los exámenes complementarios de 9826 pacientes que se sometieron a CABG aislada entre el 1 de enero de 1999 y el 31 de diciembre de 2017 para identificar su correlación con la muerte hospitalaria postoperatoria. Un total de 9826 pacientes se dividieron en el grupo de construcción (7860; 80%) y el grupo de validación (1966; 20%). La edad media de los pacientes fue de 62,43 años. La mayoría de los pacientes eran hombres (70,2%). Se identificaron quince factores relacionados de forma independiente para la mortalidad hospitalaria. El modelo logístico final se calculó en el grupo de construcción con una estadística C de 0,745 (intervalo de confianza [IC] del 95 %, 0,720–0,770). En el grupo de validación, se probó la puntuación obteniendo un área bajo la curva operativa del receptor de 0,716 (95 % [IC], 0,666–0,767). La muerte ocurrió en 489 pacientes (5%). El riesgo de muerte varió del 1,2% en los considerados de bajo riesgo (PRS <85) al 16,3% en los considerados de muy alto riesgo (PRS >211). La puntuación PRS discriminó satisfactoriamente entre los pacientes que presentaban un riesgo de muerte en el postoperatorio bajo, intermedio, alto y muy alto. La PRS podría servir como herramienta auxiliar en el preoperatorio de los equipos quirúrgicos.A doença cardiovascular é a principal causa de morte no Brasil. O risco de óbito intra-hospitalar após cirurgia de revascularização do miocárdio (RM) pode ser avaliado pela identificação de fatores pré-operatórios e quantificado por meio de escores. Esta investigação analisou a mortalidade na fase hospitalar após CRM isolada, para desenvolver um escore de risco pré-operatório (PRS) para óbito intra-hospitalar pós-operatório. Este estudo observacional, retrospectivo, unicêntrico examinou comorbidades e exames complementares de 9.826 pacientes submetidos à CRM isolada entre 1º de janeiro de 1999 e 31 de dezembro de 2017 e foram analisados para identificar sua correlação com óbito intra-hospitalar pós-operatório. Um total de 9.826 pacientes foi dividido em grupo de construção (7.860; 80%) e grupo de validação (1.966; 20%). A média de idade dos pacientes foi de 62,43 anos sendo a maioria homens (70,2%). Quinze fatores independentemente relacionados foram identificados para a mortalidade hospitalar. O modelo logístico final foi calculado no grupo de construção com uma estatística C de 0,745 (intervalo de confiança de 95% [IC], 0,720–0,770). No grupo de validação, o escore foi testado obtendo-se uma área sob a curva operacional do receptor de 0,716 (95% [IC], 0,666–0,767). A morte ocorreu em 489 pacientes (5%). O risco de óbito variou de 1,2% nos considerados de baixo risco (PRS <85) a 16,3% nos considerados de altíssimo risco (PRS >211). O escore PRS discriminou satisfatoriamente os pacientes que apresentaram risco baixo, intermediário, alto e muito alto de óbito no pós-operatório, podendo servir como ferramenta auxiliar no pré-operatório para as equipes cirúrgicas.Research, Society and Development2022-01-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2582810.33448/rsd-v11i2.25828Research, Society and Development; Vol. 11 No. 2; e34211225828Research, Society and Development; Vol. 11 Núm. 2; e34211225828Research, Society and Development; v. 11 n. 2; e342112258282525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/25828/22613Copyright (c) 2022 Raphael Paris Rosan; Pedro Silvio Farsky; João Ítalo Dias França; Vivian Lerner Amatohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessRosan, Raphael Paris Farsky, Pedro Silvio França, João Ítalo Dias Amato, Vivian Lerner 2022-02-07T01:42:50Zoai:ojs.pkp.sfu.ca:article/25828Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:44:01.215713Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Preoperative risk score and in-hospital death following isolated myocardial revascularization surgery
Evaluación del riesgo de muerte intrahospitalaria en cirugía de revascularización miocárdica aislada mediante ERPO
Avaliação do risco de óbito intra-hospitalar em cirurgia de revascularização miocárdia isolada através do ERPO
title Preoperative risk score and in-hospital death following isolated myocardial revascularization surgery
spellingShingle Preoperative risk score and in-hospital death following isolated myocardial revascularization surgery
Preoperative risk score and in-hospital death following isolated myocardial revascularization surgery
Rosan, Raphael Paris
Cardiovascular disease
Coronary artery bypass grafting
Preoperative risk score.
Enfermedad cardiovascular
Bypass aortocoronario
Score de riesgo preoperatorio.
Doença cardiovascular
Cirurgia de revascularização do miocárdio
Escore de risco pré-operatório.
Rosan, Raphael Paris
Cardiovascular disease
Coronary artery bypass grafting
Preoperative risk score.
Enfermedad cardiovascular
Bypass aortocoronario
Score de riesgo preoperatorio.
Doença cardiovascular
Cirurgia de revascularização do miocárdio
Escore de risco pré-operatório.
title_short Preoperative risk score and in-hospital death following isolated myocardial revascularization surgery
title_full Preoperative risk score and in-hospital death following isolated myocardial revascularization surgery
title_fullStr Preoperative risk score and in-hospital death following isolated myocardial revascularization surgery
Preoperative risk score and in-hospital death following isolated myocardial revascularization surgery
title_full_unstemmed Preoperative risk score and in-hospital death following isolated myocardial revascularization surgery
Preoperative risk score and in-hospital death following isolated myocardial revascularization surgery
title_sort Preoperative risk score and in-hospital death following isolated myocardial revascularization surgery
author Rosan, Raphael Paris
author_facet Rosan, Raphael Paris
Rosan, Raphael Paris
Farsky, Pedro Silvio
França, João Ítalo Dias
Amato, Vivian Lerner
Farsky, Pedro Silvio
França, João Ítalo Dias
Amato, Vivian Lerner
author_role author
author2 Farsky, Pedro Silvio
França, João Ítalo Dias
Amato, Vivian Lerner
author2_role author
author
author
dc.contributor.author.fl_str_mv Rosan, Raphael Paris
Farsky, Pedro Silvio
França, João Ítalo Dias
Amato, Vivian Lerner
dc.subject.por.fl_str_mv Cardiovascular disease
Coronary artery bypass grafting
Preoperative risk score.
Enfermedad cardiovascular
Bypass aortocoronario
Score de riesgo preoperatorio.
Doença cardiovascular
Cirurgia de revascularização do miocárdio
Escore de risco pré-operatório.
topic Cardiovascular disease
Coronary artery bypass grafting
Preoperative risk score.
Enfermedad cardiovascular
Bypass aortocoronario
Score de riesgo preoperatorio.
Doença cardiovascular
Cirurgia de revascularização do miocárdio
Escore de risco pré-operatório.
description Cardiovascular disease is the leading cause of death in Brazil. The risk of in-hospital death after coronary artery bypass grafting (CABG) can be assessed by identifying preoperative factors and quantified through scores. This investigation analyzed associated with mortality in the hospital phase after isolated CABG, to develop a preoperative risk score (PRS) for postoperative in-hospital death. This observational, retrospective, single-center study examined comorbidities and complementary exams of 9,826 patients who underwent isolated CABG between January 1, 1999 and December 31, 2017 were analyzed to identify their correlation with postoperative in-hospital death. A total of 9,826 patients were divided into the construction group (7,860; 80%) and validation group (1,966; 20%). The mean age of the patients was 62.43 years. Most patients were men (70.2%). Fifteen independently related factors were identified for hospital mortality. The final logistic model was calculated in the construction group with a C-statistic of 0.745 (95% confidence interval [CI], 0.720–0.770). In the validation group, the score was tested by obtaining an area under the receiver operating curve of 0.716 (95% [CI], 0.666–0.767). Death occurred in 489 patients (5%). The risk of death ranged from 1.2% in those considered to be low risk (PRS <85) to 16.3% among those considered to be very high risk (PRS >211). The PRS score satisfactorily discriminated among patients who exhibited low, intermediate, high, and very high risk of death in the postoperative period. PRS could serve as an auxiliary tool in the preoperative period for surgical teams.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-27
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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format article
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dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/25828
10.33448/rsd-v11i2.25828
url https://rsdjournal.org/index.php/rsd/article/view/25828
identifier_str_mv 10.33448/rsd-v11i2.25828
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/25828/22613
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
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rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 2; e34211225828
Research, Society and Development; Vol. 11 Núm. 2; e34211225828
Research, Society and Development; v. 11 n. 2; e34211225828
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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dc.identifier.doi.none.fl_str_mv 10.33448/rsd-v11i2.25828