Bioactive agents with biomimmetic remineralizing action

Detalhes bibliográficos
Autor(a) principal: Tomaz, Pedro Luis dos Santos
Data de Publicação: 2022
Outros Autores: Santos, Marcio Luiz dos, Pereira, Regina Mara Silva
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/33006
Resumo: Dental caries is considered by the WHO to be the second most common disease in the world. Considering that its action is due to enamel demineralization carried out through the metabolism of carbohydrates by dental biofilm bacteria, the use of fluoride toothpastes was established as an effective method of control. Fluoride toothpastes are an integral part of individual care to prevent caries. However, even with its proven effectiveness, there is still a prevalence of the disease. Therefore, different bioactive agents are being studied, looking for an action that is fluoride auxiliary, equivalent or even better. This review aimed to carry out a bibliographic survey of the last five years on the different bioactive agents used in the biomimetic remineralization process of different dental tissues and in the modulation of caries disease, both in vitro and in vivo studies. Different bioactive agents used for enamel remineralization were addressed in this review, including various forms of calcium phosphate as well as self-assembling peptides. Of the 275 studies found, 45 studies met the inclusion criteria and were used for this review. Published studies demonstrate the potential of different bioactive agents in the biomimetic remineralization of enamel. However, further studies are needed to further substantiate existing results and to extend and refine the application of these agents in modern oral hygiene.
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spelling Bioactive agents with biomimmetic remineralizing action Agentes bioactivos con acción remineralizante biomimética Agentes bioativos com ação biomimética remineralizante BiomimeticsTooth remineralizationDental caries.BiobiméticoRemineralização dentáriaCárie dentaria.biomiméticosRemineralización dental Caries dental.Dental caries is considered by the WHO to be the second most common disease in the world. Considering that its action is due to enamel demineralization carried out through the metabolism of carbohydrates by dental biofilm bacteria, the use of fluoride toothpastes was established as an effective method of control. Fluoride toothpastes are an integral part of individual care to prevent caries. However, even with its proven effectiveness, there is still a prevalence of the disease. Therefore, different bioactive agents are being studied, looking for an action that is fluoride auxiliary, equivalent or even better. This review aimed to carry out a bibliographic survey of the last five years on the different bioactive agents used in the biomimetic remineralization process of different dental tissues and in the modulation of caries disease, both in vitro and in vivo studies. Different bioactive agents used for enamel remineralization were addressed in this review, including various forms of calcium phosphate as well as self-assembling peptides. Of the 275 studies found, 45 studies met the inclusion criteria and were used for this review. Published studies demonstrate the potential of different bioactive agents in the biomimetic remineralization of enamel. However, further studies are needed to further substantiate existing results and to extend and refine the application of these agents in modern oral hygiene.La caries dental es considerada por la OMS como la segunda enfermedad más común en el mundo. Considerando que su acción se debe a la desmineralización del esmalte realizada a través del metabolismo de los carbohidratos por las bacterias del biofilm dental, se estableció el uso de dentífricos fluorados como un método efectivo de control. Las pastas dentales con flúor son una parte integral del cuidado individual para prevenir la caries. Sin embargo, incluso con su eficacia comprobada, todavía existe una prevalencia de la enfermedad. Por lo tanto, se están estudiando diferentes agentes bioactivos, buscando una acción que sea auxiliar del fluoruro, equivalente o incluso mejor. Esta revisión tuvo como objetivo realizar un levantamiento bibliográfico de los últimos cinco años sobre los diferentes agentes bioactivos utilizados en el proceso de remineralización biomimética de diferentes tejidos dentarios y en la modulación de la enfermedad de caries, tanto en estudios in vitro como in vivo. En esta revisión se abordaron diferentes agentes bioactivos utilizados para la remineralización del esmalte, incluidas varias formas de fosfato de calcio, así como péptidos de autoensamblaje. De los 275 estudios encontrados, 45 cumplieron con los criterios de inclusión y se utilizaron para esta revisión. Los estudios publicados demuestran el potencial de diferentes agentes bioactivos en la remineralización biomimética del esmalte. Sin embargo, se necesitan más estudios para fundamentar aún más los resultados existentes y ampliar y refinar la aplicación de estos agentes en la higiene oral moderna.A cárie dentária é considerada pela Organização Mundial de Saúde a segunda doença mais comum no mundo. Considerando que sua ação se deve à desmineralização do esmalte realizada através do metabolismo de carboidratos pelas bactérias do biofilme dental, o uso de dentifrícios fluoretados se estabeleceu como um método eficaz de controle. Os cremes dentais com flúor são parte integrante do cuidado individual para prevenir a cárie. No entanto, mesmo com sua eficácia comprovada, há prevalência da doença. Por isso, diferentes agentes bioativos estão sendo estudados, buscando uma ação que seja auxiliar do flúor, equivalente ou até melhor. Esta revisão teve como objetivo realizar um levantamento bibliográfico dos últimos cinco anos sobre os diferentes agentes bioativos utilizados no processo de remineralização biomimética de diferentes tecidos dentários e na modulação da doença cárie, tanto em estudos in vitro como in vivo. Diferentes agentes bioativos usados para remineralização do esmalte foram abordados nesta revisão, incluindo várias formas de fosfato de cálcio, bem como peptídeos de automontagem. Dos 275 estudos encontrados, 45 estudos preencheram os critérios de inclusão e foram utilizados para esta revisão. Estudos publicados demonstram o potencial de diferentes agentes bioativos na remineralização biomimética do esmalte. No entanto, mais estudos são necessários para fundamentar os resultados existentes e para ampliar e refinar a aplicação desses agentes na higiene bucal moderna.Research, Society and Development2022-08-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3300610.33448/rsd-v11i10.33006Research, Society and Development; Vol. 11 No. 10; e407111033006Research, Society and Development; Vol. 11 Núm. 10; e407111033006Research, Society and Development; v. 11 n. 10; e4071110330062525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/33006/27918Copyright (c) 2022 Pedro Luis dos Santos Tomaz; Marcio Luiz dos Santos; Regina Mara Silva Pereirahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessTomaz, Pedro Luis dos Santos Santos, Marcio Luiz dos Pereira, Regina Mara Silva 2022-08-12T22:23:03Zoai:ojs.pkp.sfu.ca:article/33006Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:48:47.699077Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Bioactive agents with biomimmetic remineralizing action
Agentes bioactivos con acción remineralizante biomimética
Agentes bioativos com ação biomimética remineralizante
title Bioactive agents with biomimmetic remineralizing action
spellingShingle Bioactive agents with biomimmetic remineralizing action
Tomaz, Pedro Luis dos Santos
Biomimetics
Tooth remineralization
Dental caries.
Biobimético
Remineralização dentária
Cárie dentaria.
biomiméticos
Remineralización dental
Caries dental.
title_short Bioactive agents with biomimmetic remineralizing action
title_full Bioactive agents with biomimmetic remineralizing action
title_fullStr Bioactive agents with biomimmetic remineralizing action
title_full_unstemmed Bioactive agents with biomimmetic remineralizing action
title_sort Bioactive agents with biomimmetic remineralizing action
author Tomaz, Pedro Luis dos Santos
author_facet Tomaz, Pedro Luis dos Santos
Santos, Marcio Luiz dos
Pereira, Regina Mara Silva
author_role author
author2 Santos, Marcio Luiz dos
Pereira, Regina Mara Silva
author2_role author
author
dc.contributor.author.fl_str_mv Tomaz, Pedro Luis dos Santos
Santos, Marcio Luiz dos
Pereira, Regina Mara Silva
dc.subject.por.fl_str_mv Biomimetics
Tooth remineralization
Dental caries.
Biobimético
Remineralização dentária
Cárie dentaria.
biomiméticos
Remineralización dental
Caries dental.
topic Biomimetics
Tooth remineralization
Dental caries.
Biobimético
Remineralização dentária
Cárie dentaria.
biomiméticos
Remineralización dental
Caries dental.
description Dental caries is considered by the WHO to be the second most common disease in the world. Considering that its action is due to enamel demineralization carried out through the metabolism of carbohydrates by dental biofilm bacteria, the use of fluoride toothpastes was established as an effective method of control. Fluoride toothpastes are an integral part of individual care to prevent caries. However, even with its proven effectiveness, there is still a prevalence of the disease. Therefore, different bioactive agents are being studied, looking for an action that is fluoride auxiliary, equivalent or even better. This review aimed to carry out a bibliographic survey of the last five years on the different bioactive agents used in the biomimetic remineralization process of different dental tissues and in the modulation of caries disease, both in vitro and in vivo studies. Different bioactive agents used for enamel remineralization were addressed in this review, including various forms of calcium phosphate as well as self-assembling peptides. Of the 275 studies found, 45 studies met the inclusion criteria and were used for this review. Published studies demonstrate the potential of different bioactive agents in the biomimetic remineralization of enamel. However, further studies are needed to further substantiate existing results and to extend and refine the application of these agents in modern oral hygiene.
publishDate 2022
dc.date.none.fl_str_mv 2022-08-05
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dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/33006
10.33448/rsd-v11i10.33006
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dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 10; e407111033006
Research, Society and Development; Vol. 11 Núm. 10; e407111033006
Research, Society and Development; v. 11 n. 10; e407111033006
2525-3409
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