Study of the modulator effect of oil chia (Salvia hispanica L.) associated with benzo(a)pyrene and doxorubicin hydrochloride
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/27254 |
Resumo: | Chia (Salvia hispanica L.) is a Mexican plant belonging to the Lamiaceae family, representing one of the four main seeds cultivated by pre-Columbian peoples, mainly the Aztecs who used it as a medicine and nutritional component. Currently, it has been rediscovered, they are rich in polyunsaturated fatty acids, with antioxidant activity and essential compounds for organism maintenance. Various benefits are attributed to this plant including the reduction of cardiovascular problems, psoriasis, depression, Alzheimer’s, diabetes, arthritis and cancer. Considering the widespread use of chia oil (OC) in today’s society, it was justified to investigate the modulating effect of this oil when combined with benzo(a)pyrene and doxorubicin hydrochloride, using the SMART (Somatic Mutation and Recombination Test), a test able to detect mutation and somatic recombination activities, with loss of heterozygosis, which can be observed in the forms of different trichomes present in the wings of Drosophila melanogaster. The results obtained indicate that chia oil reduced the frequency of mutations by 97% in the number of spots induced by benzo(a)pyrene (BaP) and doxorubicin hydrochloride (DRX), showing an antigenotoxic effect. |
id |
UNIFEI_6451281a8a333971b2b74cb77f060231 |
---|---|
oai_identifier_str |
oai:ojs.pkp.sfu.ca:article/27254 |
network_acronym_str |
UNIFEI |
network_name_str |
Research, Society and Development |
repository_id_str |
|
spelling |
Study of the modulator effect of oil chia (Salvia hispanica L.) associated with benzo(a)pyrene and doxorubicin hydrochlorideEstudio del efecto modulador de aceite de chía (Salvia hispanica L.) benzo(a)pireno y doxorubicina clorhidratoEstudo do efeito modulador do óleo de chia (Salvia hispanica L.) associada benzo(a)pireno e cloridrato de doxorrubicinaAntioxidanteMutaçãoEfeito antigenotóxicoDrosophila melanogasterTeste de Mutação Somática e Recombinação.AntioxidanteMupciónEfecto antigenotóxicoDrosophila melanogasterMutación somática y prueba de recombinación.AntioxidantMutationAntigenotoxic effectDrosophila melanogasterSomatic Mutation and Recombination Test.Chia (Salvia hispanica L.) is a Mexican plant belonging to the Lamiaceae family, representing one of the four main seeds cultivated by pre-Columbian peoples, mainly the Aztecs who used it as a medicine and nutritional component. Currently, it has been rediscovered, they are rich in polyunsaturated fatty acids, with antioxidant activity and essential compounds for organism maintenance. Various benefits are attributed to this plant including the reduction of cardiovascular problems, psoriasis, depression, Alzheimer’s, diabetes, arthritis and cancer. Considering the widespread use of chia oil (OC) in today’s society, it was justified to investigate the modulating effect of this oil when combined with benzo(a)pyrene and doxorubicin hydrochloride, using the SMART (Somatic Mutation and Recombination Test), a test able to detect mutation and somatic recombination activities, with loss of heterozygosis, which can be observed in the forms of different trichomes present in the wings of Drosophila melanogaster. The results obtained indicate that chia oil reduced the frequency of mutations by 97% in the number of spots induced by benzo(a)pyrene (BaP) and doxorubicin hydrochloride (DRX), showing an antigenotoxic effect.La chía (Salvia hispanica L.) es una planta mexicana perteneciente a la familia Lamiaceae, que representa una de las cuatro principales semillas cultivadas por los pueblos precolombinos, principalmente los Astecas que la utilizaban como medicina y componente nutricional. Actualmente, se ha recordado, los ellas son ricos en ácidos grasos poliinsaturados, con actividad antioxidante y compuestos esenciales para el mantenimiento del organismo. A esta planta se le atribuyen varios beneficios, incluyendo la reducción de problemas cardiovasculares, psoriasis, depresión, Alzheimer, diabetes, artritis y cáncer. Teniendo en cuenta el uso generalizado del aceite de chía (OC) en la sociedad actual, se justificó investigar el efecto modulador de este aceite cuando se combina con clorhidrato de benzo(a)pireno y doxorrubicina, utilizando SMART (Mutación somática y prueba de recombinación), una prueba capaz de detectar la mutación somática y las actividades de recombinación, con pérdida de heterocigotos, que se pueden observar en las formas de diferentes hogares tricomas presentes en las alas del Drosophila melanogaster. Los resultados indicaron que el aceite de chía redujo las frecuencias de mutaciones causadas por benzo(a)pireno (BaP) y doxorubicina clorhidrato (DRX), presentando así efecto antigenotóxico.Chia (Salvia hispanica L.) é uma planta mexicana pertencente à família Lamiaceae, representando uma das quatro principais sementes cultivadas por povos pré-colombianos, principalmente os Astecas que a usaram como um medicamento e componente nutricional. Atualmente, foi redescoberta, elas são ricas em ácidos graxos poli-insaturados, com atividade antioxidante e compostos essenciais para a manutenção do organismo. Vários benefícios são atribuídos a essa planta, incluindo a redução de problemas cardiovasculares, psoríase, depressão, Alzheimer, diabetes, artrite e câncer. Considerando o uso generalizado de óleo de chia (OC) na sociedade atual, justificou-se a investigar o efeito modulador deste óleo quando combinado com benzo(a)pireno e cloridrato de doxorubicina, utilizando o SMART (Teste de Mutação Somática e Recombinação), um teste capaz de detectar atividades de mutação e recombinação somática, com perda de heterozigose, que pode ser observada nas formas de diferentes tricomas presentes nas asas da Drosophila melanogaster. Os resultados obtidos indicaram que o óleo de Chia reduziu as frequências de mutações ocasionadas pelo benzo(a)pireno (BaP) e cloridrato de doxorrubicina (DRX), apresentando assim efeito antigenotóxico.Research, Society and Development2022-03-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2725410.33448/rsd-v11i4.27254Research, Society and Development; Vol. 11 No. 4; e23611427254Research, Society and Development; Vol. 11 Núm. 4; e23611427254Research, Society and Development; v. 11 n. 4; e236114272542525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/27254/23863Copyright (c) 2022 Zaira Rosa Guterres; Tiago Felipe de Senes Lopes; Danielly Ferreira de Queiróz; Lilliam May Grespan Estodutto da Silva; Ludovico Migliolohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessGuterres, Zaira RosaLopes, Tiago Felipe de Senes Queiróz, Danielly Ferreira de Silva, Lilliam May Grespan Estodutto da Migliolo, Ludovico 2022-03-27T17:17:09Zoai:ojs.pkp.sfu.ca:article/27254Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:45:03.227623Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Study of the modulator effect of oil chia (Salvia hispanica L.) associated with benzo(a)pyrene and doxorubicin hydrochloride Estudio del efecto modulador de aceite de chía (Salvia hispanica L.) benzo(a)pireno y doxorubicina clorhidrato Estudo do efeito modulador do óleo de chia (Salvia hispanica L.) associada benzo(a)pireno e cloridrato de doxorrubicina |
title |
Study of the modulator effect of oil chia (Salvia hispanica L.) associated with benzo(a)pyrene and doxorubicin hydrochloride |
spellingShingle |
Study of the modulator effect of oil chia (Salvia hispanica L.) associated with benzo(a)pyrene and doxorubicin hydrochloride Guterres, Zaira Rosa Antioxidante Mutação Efeito antigenotóxico Drosophila melanogaster Teste de Mutação Somática e Recombinação. Antioxidante Mupción Efecto antigenotóxico Drosophila melanogaster Mutación somática y prueba de recombinación. Antioxidant Mutation Antigenotoxic effect Drosophila melanogaster Somatic Mutation and Recombination Test. |
title_short |
Study of the modulator effect of oil chia (Salvia hispanica L.) associated with benzo(a)pyrene and doxorubicin hydrochloride |
title_full |
Study of the modulator effect of oil chia (Salvia hispanica L.) associated with benzo(a)pyrene and doxorubicin hydrochloride |
title_fullStr |
Study of the modulator effect of oil chia (Salvia hispanica L.) associated with benzo(a)pyrene and doxorubicin hydrochloride |
title_full_unstemmed |
Study of the modulator effect of oil chia (Salvia hispanica L.) associated with benzo(a)pyrene and doxorubicin hydrochloride |
title_sort |
Study of the modulator effect of oil chia (Salvia hispanica L.) associated with benzo(a)pyrene and doxorubicin hydrochloride |
author |
Guterres, Zaira Rosa |
author_facet |
Guterres, Zaira Rosa Lopes, Tiago Felipe de Senes Queiróz, Danielly Ferreira de Silva, Lilliam May Grespan Estodutto da Migliolo, Ludovico |
author_role |
author |
author2 |
Lopes, Tiago Felipe de Senes Queiróz, Danielly Ferreira de Silva, Lilliam May Grespan Estodutto da Migliolo, Ludovico |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Guterres, Zaira Rosa Lopes, Tiago Felipe de Senes Queiróz, Danielly Ferreira de Silva, Lilliam May Grespan Estodutto da Migliolo, Ludovico |
dc.subject.por.fl_str_mv |
Antioxidante Mutação Efeito antigenotóxico Drosophila melanogaster Teste de Mutação Somática e Recombinação. Antioxidante Mupción Efecto antigenotóxico Drosophila melanogaster Mutación somática y prueba de recombinación. Antioxidant Mutation Antigenotoxic effect Drosophila melanogaster Somatic Mutation and Recombination Test. |
topic |
Antioxidante Mutação Efeito antigenotóxico Drosophila melanogaster Teste de Mutação Somática e Recombinação. Antioxidante Mupción Efecto antigenotóxico Drosophila melanogaster Mutación somática y prueba de recombinación. Antioxidant Mutation Antigenotoxic effect Drosophila melanogaster Somatic Mutation and Recombination Test. |
description |
Chia (Salvia hispanica L.) is a Mexican plant belonging to the Lamiaceae family, representing one of the four main seeds cultivated by pre-Columbian peoples, mainly the Aztecs who used it as a medicine and nutritional component. Currently, it has been rediscovered, they are rich in polyunsaturated fatty acids, with antioxidant activity and essential compounds for organism maintenance. Various benefits are attributed to this plant including the reduction of cardiovascular problems, psoriasis, depression, Alzheimer’s, diabetes, arthritis and cancer. Considering the widespread use of chia oil (OC) in today’s society, it was justified to investigate the modulating effect of this oil when combined with benzo(a)pyrene and doxorubicin hydrochloride, using the SMART (Somatic Mutation and Recombination Test), a test able to detect mutation and somatic recombination activities, with loss of heterozygosis, which can be observed in the forms of different trichomes present in the wings of Drosophila melanogaster. The results obtained indicate that chia oil reduced the frequency of mutations by 97% in the number of spots induced by benzo(a)pyrene (BaP) and doxorubicin hydrochloride (DRX), showing an antigenotoxic effect. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-03-17 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/27254 10.33448/rsd-v11i4.27254 |
url |
https://rsdjournal.org/index.php/rsd/article/view/27254 |
identifier_str_mv |
10.33448/rsd-v11i4.27254 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/27254/23863 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 4; e23611427254 Research, Society and Development; Vol. 11 Núm. 4; e23611427254 Research, Society and Development; v. 11 n. 4; e23611427254 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
_version_ |
1797052707080503296 |