Leishmaniasis: effect of enalaprilat on the production of (ON) and cytokines in vitro

Detalhes bibliográficos
Autor(a) principal: Araújo, Cristiane Ferreira Lopes de
Data de Publicação: 2021
Outros Autores: Nunes, Josué Ribeiro da Silva, Santos, Rogério Alexandre Nunes dos, Rios-Santos, Fabricio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/12949
Resumo: Leishmaniasis is neglected diseases; the drugs used have significant toxic effects that compromise patient compliance, and increased loss of efficacy due to increased resistant infectious strains. Assays on Swiss mice infected with Leishmania brasiliensis and treated with Angiotensin-Suppressing Enzyme (ACE) inhibitors showed that, in addition to the classical effects on the cardiovascular system, some of these inhibitors had effects on nonhemodynamic, immunomediated functions such as cytokine production. In this study, the effect of enalaprilate on nitric oxide (NO) production and cytokines were evaluated, i.e., interleukins-10 and 12 and IFN-γ in J774 A.1 macrophages infected by Leishmania braziliensis. Enalaprilate demonstrated in vitro immunomodulatory capacity, increasing the release of NO to induce IL-12 and IFN-γ also decreasing il-10 release.
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spelling Leishmaniasis: effect of enalaprilat on the production of (ON) and cytokines in vitroLeishmaniasis: Efecto de enalaprilat en la producción de óxido nítrico (NO) y citoquinas in vitroLeishmanioses: efeito de enalaprilato na produção de oxido nítrico (ON) e citocinas in vitroLeishmaniasisEnalaprilatoImunomodulaçãoCitocinas.LeishmaniasisEnalaprilatoInmunomodulaciónCitoquinas.LeishmaniasisEnalaprilateImmunomodulationCytokines.Leishmaniasis is neglected diseases; the drugs used have significant toxic effects that compromise patient compliance, and increased loss of efficacy due to increased resistant infectious strains. Assays on Swiss mice infected with Leishmania brasiliensis and treated with Angiotensin-Suppressing Enzyme (ACE) inhibitors showed that, in addition to the classical effects on the cardiovascular system, some of these inhibitors had effects on nonhemodynamic, immunomediated functions such as cytokine production. In this study, the effect of enalaprilate on nitric oxide (NO) production and cytokines were evaluated, i.e., interleukins-10 and 12 and IFN-γ in J774 A.1 macrophages infected by Leishmania braziliensis. Enalaprilate demonstrated in vitro immunomodulatory capacity, increasing the release of NO to induce IL-12 and IFN-γ also decreasing il-10 release.La leishmaniasis son enfermedades desatendidas, los fármacos utilizados tienen efectos tóxicos significativos que comprometen el cumplimiento del paciente, y una mayor pérdida de eficacia debido al aumento de las cepas infecciosas resistentes. Los ensayos en ratones Swiss infectados con Leishmania brasiliensis y tratados con inhibidores de la enzima supresora de angiotensina (ECA) mostraron que, además de los efectos clásicos sobre el sistema cardiovascular, algunos de estos inhibidores tenían efectos sobre funciones no biodinámicas e inmunomediadas, como la producción de citoquinas. En este estudio, se evaluó el efecto del enalapriato en la producción de óxido nítrico (NO) y las citoquinas, es decir, interleukins-10 y 12 y IFN-γ en macrófagos J774 a.1 infectados por Leishmania braziliensis. Enalaprilate demostró capacidad inmunomoduladora in vitro, aumentando la liberación de NO para inducir IL-12 e IFN-γ también disminuyendo la liberación de il-10.As Leishmanioses são doenças negligenciadas, os medicamentos usados têm efeitos tóxicos significativos que comprometem a conformidade do paciente, e aumento da perda de eficácia devido ao aumento de cepas infecciosas resistentes. Ensaios em camundongos swiss infectados com Leishmania brasiliensis e tratados com inibidores de Enzima Conversora de Angiotensina (ACE) mostraram que, além dos efeitos clássicos sobre o sistema cardiovascular, alguns desses inibidores, apresentaram efeitos sobre funções não hemodinâmicas, imunomediadas, como a produção de citocinas. Neste estudo, foram avaliados o efeito do enalaprilato na produção de óxido nítrico (NO), e nas citocinas, ou seja, interleucinas-10 e 12 e IFN-γ nos macrófagos J774 A.1 infectados por Leishmania braziliensis. O enalaprilato demonstrou capacidade imunomodulatória in vitro, aumentando a liberação de NO para induzir IL-12 e IFN-γ também diminuindo a liberação do IL-10.Research, Society and Development2021-03-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1294910.33448/rsd-v10i3.12949Research, Society and Development; Vol. 10 No. 3; e26410312949Research, Society and Development; Vol. 10 Núm. 3; e26410312949Research, Society and Development; v. 10 n. 3; e264103129492525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/12949/11967Copyright (c) 2021 Cristiane Ferreira Lopes de Araújo; Josué Ribeiro da Silva Nunes; Rogério Alexandre Nunes dos Santos; Fabricio Rios-Santoshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessAraújo, Cristiane Ferreira Lopes de Nunes, Josué Ribeiro da SilvaSantos, Rogério Alexandre Nunes dos Rios-Santos, Fabricio2021-03-28T12:03:35Zoai:ojs.pkp.sfu.ca:article/12949Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:34:23.791956Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Leishmaniasis: effect of enalaprilat on the production of (ON) and cytokines in vitro
Leishmaniasis: Efecto de enalaprilat en la producción de óxido nítrico (NO) y citoquinas in vitro
Leishmanioses: efeito de enalaprilato na produção de oxido nítrico (ON) e citocinas in vitro
title Leishmaniasis: effect of enalaprilat on the production of (ON) and cytokines in vitro
spellingShingle Leishmaniasis: effect of enalaprilat on the production of (ON) and cytokines in vitro
Araújo, Cristiane Ferreira Lopes de
Leishmaniasis
Enalaprilato
Imunomodulação
Citocinas.
Leishmaniasis
Enalaprilato
Inmunomodulación
Citoquinas.
Leishmaniasis
Enalaprilate
Immunomodulation
Cytokines.
title_short Leishmaniasis: effect of enalaprilat on the production of (ON) and cytokines in vitro
title_full Leishmaniasis: effect of enalaprilat on the production of (ON) and cytokines in vitro
title_fullStr Leishmaniasis: effect of enalaprilat on the production of (ON) and cytokines in vitro
title_full_unstemmed Leishmaniasis: effect of enalaprilat on the production of (ON) and cytokines in vitro
title_sort Leishmaniasis: effect of enalaprilat on the production of (ON) and cytokines in vitro
author Araújo, Cristiane Ferreira Lopes de
author_facet Araújo, Cristiane Ferreira Lopes de
Nunes, Josué Ribeiro da Silva
Santos, Rogério Alexandre Nunes dos
Rios-Santos, Fabricio
author_role author
author2 Nunes, Josué Ribeiro da Silva
Santos, Rogério Alexandre Nunes dos
Rios-Santos, Fabricio
author2_role author
author
author
dc.contributor.author.fl_str_mv Araújo, Cristiane Ferreira Lopes de
Nunes, Josué Ribeiro da Silva
Santos, Rogério Alexandre Nunes dos
Rios-Santos, Fabricio
dc.subject.por.fl_str_mv Leishmaniasis
Enalaprilato
Imunomodulação
Citocinas.
Leishmaniasis
Enalaprilato
Inmunomodulación
Citoquinas.
Leishmaniasis
Enalaprilate
Immunomodulation
Cytokines.
topic Leishmaniasis
Enalaprilato
Imunomodulação
Citocinas.
Leishmaniasis
Enalaprilato
Inmunomodulación
Citoquinas.
Leishmaniasis
Enalaprilate
Immunomodulation
Cytokines.
description Leishmaniasis is neglected diseases; the drugs used have significant toxic effects that compromise patient compliance, and increased loss of efficacy due to increased resistant infectious strains. Assays on Swiss mice infected with Leishmania brasiliensis and treated with Angiotensin-Suppressing Enzyme (ACE) inhibitors showed that, in addition to the classical effects on the cardiovascular system, some of these inhibitors had effects on nonhemodynamic, immunomediated functions such as cytokine production. In this study, the effect of enalaprilate on nitric oxide (NO) production and cytokines were evaluated, i.e., interleukins-10 and 12 and IFN-γ in J774 A.1 macrophages infected by Leishmania braziliensis. Enalaprilate demonstrated in vitro immunomodulatory capacity, increasing the release of NO to induce IL-12 and IFN-γ also decreasing il-10 release.
publishDate 2021
dc.date.none.fl_str_mv 2021-03-14
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/12949
10.33448/rsd-v10i3.12949
url https://rsdjournal.org/index.php/rsd/article/view/12949
identifier_str_mv 10.33448/rsd-v10i3.12949
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/12949/11967
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 3; e26410312949
Research, Society and Development; Vol. 10 Núm. 3; e26410312949
Research, Society and Development; v. 10 n. 3; e26410312949
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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