The influence of the selective serotonin reuptake inhibitors fluoxetine, sertraline and citalopram on the regeneration process

Detalhes bibliográficos
Autor(a) principal: Siqueira, Letícia da Costa
Data de Publicação: 2021
Outros Autores: Souza, Karinne da Costa, Leite, Micaella Rodrigues Guimarães, Ferreira, Ítalo Augusto Silva, Andrade, Ana Luiza Dias Leite de, Esteves, Alessandra, Rossi Junior, Wagner Costa
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/24319
Resumo: Although bone tissue regeneration is a well-defined process, complications inherent to the treatment of fractures are still observed, one of them being the participation of serotonin in bone formation and remodeling. This is a hormone responsible for the regulation of several physiological processes and is correlated with the etiology of depression, whose treatment is given, especially, through the use of selective serotonin reuptake inhibitors (SSRI), which are related to an increased risk of fracture and bone loss. Thus, the aim of this study was to analyze the action of Fluoxetine, Sertraline and Citalopram in the bone regeneration process. Thirty-five Wistar rats were used, in which bone defects of 2 to 3 mm in length were made in the fibula. The animals received Fluoxetine Hydrochloride 60 days before the fracture was made, and Sertraline Hydrochloride and Citalopram Hydrochloride 40 days before, and continued for another 30 days after the procedure. Control animals received saline solution. The results show that the bone defect regeneration process occurred more effectively in animals belonging to the control group, when compared to the other treated groups. The same data were observed regarding the serum alkaline phosphatase rate, statistically different when compared to animals treated with SSRIs. These data allow us to suggest that Fluoxetine, Sertraline and Citalopram seem to negatively interfere in the bone regeneration process, leading to a delay and non-complete consolidation of fractures with bone loss.
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spelling The influence of the selective serotonin reuptake inhibitors fluoxetine, sertraline and citalopram on the regeneration processLa influencia de los inhibidores selectivos de la recaptación de serotonina fluoxetina, sertralina y citalopram en el proceso de regeneraciónA influência dos inibidores seletivos da recaptação de serotonina, fluoxetina sertralina e citalopram no processo de regeneração ósseaSertralinaFluoxetinaCitalopramRegeneraciòn óseaCuración de fractura.SertralineFluoxetineCitalopramBone regenerationFracture healing.SertralinaFluoxetinaCitalopramRegeneração ósseaConsolidação da fratura.Although bone tissue regeneration is a well-defined process, complications inherent to the treatment of fractures are still observed, one of them being the participation of serotonin in bone formation and remodeling. This is a hormone responsible for the regulation of several physiological processes and is correlated with the etiology of depression, whose treatment is given, especially, through the use of selective serotonin reuptake inhibitors (SSRI), which are related to an increased risk of fracture and bone loss. Thus, the aim of this study was to analyze the action of Fluoxetine, Sertraline and Citalopram in the bone regeneration process. Thirty-five Wistar rats were used, in which bone defects of 2 to 3 mm in length were made in the fibula. The animals received Fluoxetine Hydrochloride 60 days before the fracture was made, and Sertraline Hydrochloride and Citalopram Hydrochloride 40 days before, and continued for another 30 days after the procedure. Control animals received saline solution. The results show that the bone defect regeneration process occurred more effectively in animals belonging to the control group, when compared to the other treated groups. The same data were observed regarding the serum alkaline phosphatase rate, statistically different when compared to animals treated with SSRIs. These data allow us to suggest that Fluoxetine, Sertraline and Citalopram seem to negatively interfere in the bone regeneration process, leading to a delay and non-complete consolidation of fractures with bone loss.Si bien la regeneración del tejido óseo es un proceso bien definido, aún se observan complicaciones inherentes al tratamiento de las fracturas, siendo una de ellas la participación de la serotonina en la formación y remodelación ósea. Esta es una hormona responsable de la regulación de varios procesos fisiológicos y se correlaciona con la etiología de la depresión, cuyo tratamiento se da, especialmente, mediante el uso de inhibidores selectivos de la recaptación de serotonina (ISRS), que se relacionan con un mayor riesgo de fractura y pérdida ósea. Así, el objetivo de este estudio fue analizar la acción de Fluoxetina, Sertralina y Citalopram en el proceso de regeneración ósea. Se utilizaron treinta y cinco ratas Wistar, en las que se realizaron defectos óseos de 2 a 3 mm de longitud en el peroné. Los animales recibieron clorhidrato de fluoxetina 60 días antes de que se produjera la fractura, y clorhidrato de sertralina y clorhidrato de citalopram 40 días antes, y continuaron durante otros 30 días después del procedimiento. Los animales de control recibieron solución salina. Los resultados muestran que el proceso de regeneración del defecto óseo ocurrió de manera más efectiva en los animales que pertenecen al grupo de control, en comparación con los otros grupos tratados. Se observaron los mismos datos con respecto a la tasa de fosfatasa alcalina sérica, estadísticamente diferente en comparación con los animales tratados con ISRS. Estos datos nos permiten sugerir que la fluoxetina, la sertralina y el citalopram parecen interferir negativamente en el proceso de regeneración ósea, provocando un retraso y consolidación incompleta de las fracturas con pérdida ósea.Embora a regeneração do tecido ósseo seja um processo bem definido, ainda são observadas complicações inerentes ao tratamento de fraturas, sendo um deles a participação da serotonina na formação e remodelação óssea. Esta é um hormônio responsável pela regulação de vários processos fisiológicos e está correlacionada com a etiologia da depressão, cujo tratamento se dá, especialmente, pelo uso de inibidores seletivos da recaptação de serotonina (ISRS), os quais se relacionam com aumento ao risco de fratura e perda óssea. Assim, o objetivo deste estudo foi analisar a ação da Fluoxetina, Sertralina e do Citalopram no processo de regeneração óssea. Foram utilizados 35 ratos Wistar, nos quais foram confeccionados defeitos ósseos de 2 a 3 mm de comprimento na fíbula. Os animais receberam Cloridrato de Fluoxetina 60 dias antes da confecção da fratura, e Cloridrato de Sertralina e Bromidrato de Citalopram 40 dias antes, e se prolongou por mais 30 dias após o procedimento. Os animais controle receberam solução salina. Os resultados mostram que o processo de regeneração do defeito ósseo se deu de maneira mais efetiva nos animais pertencentes ao grupo controle, quando comparado aos demais grupos tratados. Os mesmos dados foram observados quanto à taxa sérica de fosfatase alcalina, diferente estatisticamente quando comparada com os animais tratados com os ISRS. Estes dados permitem sugerir que a Fluoxetina, a Sertralina e o Citalopram parecem interferir negativamente no processo de regeneração óssea, levando a um atraso e a não consolidação total das fraturas com perda óssea.Research, Society and Development2021-12-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2431910.33448/rsd-v10i17.24319Research, Society and Development; Vol. 10 No. 17; e96101724319Research, Society and Development; Vol. 10 Núm. 17; e96101724319Research, Society and Development; v. 10 n. 17; e961017243192525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/24319/21389Copyright (c) 2021 Letícia da Costa Siqueira; Karinne da Costa Souza; Micaella Rodrigues Guimarães Leite; Ítalo Augusto Silva Ferreira; Ana Luiza Dias Leite de Andrade; Alessandra Esteves; Wagner Costa Rossi Juniorhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSiqueira, Letícia da Costa Souza, Karinne da Costa Leite, Micaella Rodrigues Guimarães Ferreira, Ítalo Augusto Silva Andrade, Ana Luiza Dias Leite de Esteves, AlessandraRossi Junior, Wagner Costa 2022-01-01T11:11:08Zoai:ojs.pkp.sfu.ca:article/24319Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:42:55.032329Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv The influence of the selective serotonin reuptake inhibitors fluoxetine, sertraline and citalopram on the regeneration process
La influencia de los inhibidores selectivos de la recaptación de serotonina fluoxetina, sertralina y citalopram en el proceso de regeneración
A influência dos inibidores seletivos da recaptação de serotonina, fluoxetina sertralina e citalopram no processo de regeneração óssea
title The influence of the selective serotonin reuptake inhibitors fluoxetine, sertraline and citalopram on the regeneration process
spellingShingle The influence of the selective serotonin reuptake inhibitors fluoxetine, sertraline and citalopram on the regeneration process
Siqueira, Letícia da Costa
Sertralina
Fluoxetina
Citalopram
Regeneraciòn ósea
Curación de fractura.
Sertraline
Fluoxetine
Citalopram
Bone regeneration
Fracture healing.
Sertralina
Fluoxetina
Citalopram
Regeneração óssea
Consolidação da fratura.
title_short The influence of the selective serotonin reuptake inhibitors fluoxetine, sertraline and citalopram on the regeneration process
title_full The influence of the selective serotonin reuptake inhibitors fluoxetine, sertraline and citalopram on the regeneration process
title_fullStr The influence of the selective serotonin reuptake inhibitors fluoxetine, sertraline and citalopram on the regeneration process
title_full_unstemmed The influence of the selective serotonin reuptake inhibitors fluoxetine, sertraline and citalopram on the regeneration process
title_sort The influence of the selective serotonin reuptake inhibitors fluoxetine, sertraline and citalopram on the regeneration process
author Siqueira, Letícia da Costa
author_facet Siqueira, Letícia da Costa
Souza, Karinne da Costa
Leite, Micaella Rodrigues Guimarães
Ferreira, Ítalo Augusto Silva
Andrade, Ana Luiza Dias Leite de
Esteves, Alessandra
Rossi Junior, Wagner Costa
author_role author
author2 Souza, Karinne da Costa
Leite, Micaella Rodrigues Guimarães
Ferreira, Ítalo Augusto Silva
Andrade, Ana Luiza Dias Leite de
Esteves, Alessandra
Rossi Junior, Wagner Costa
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Siqueira, Letícia da Costa
Souza, Karinne da Costa
Leite, Micaella Rodrigues Guimarães
Ferreira, Ítalo Augusto Silva
Andrade, Ana Luiza Dias Leite de
Esteves, Alessandra
Rossi Junior, Wagner Costa
dc.subject.por.fl_str_mv Sertralina
Fluoxetina
Citalopram
Regeneraciòn ósea
Curación de fractura.
Sertraline
Fluoxetine
Citalopram
Bone regeneration
Fracture healing.
Sertralina
Fluoxetina
Citalopram
Regeneração óssea
Consolidação da fratura.
topic Sertralina
Fluoxetina
Citalopram
Regeneraciòn ósea
Curación de fractura.
Sertraline
Fluoxetine
Citalopram
Bone regeneration
Fracture healing.
Sertralina
Fluoxetina
Citalopram
Regeneração óssea
Consolidação da fratura.
description Although bone tissue regeneration is a well-defined process, complications inherent to the treatment of fractures are still observed, one of them being the participation of serotonin in bone formation and remodeling. This is a hormone responsible for the regulation of several physiological processes and is correlated with the etiology of depression, whose treatment is given, especially, through the use of selective serotonin reuptake inhibitors (SSRI), which are related to an increased risk of fracture and bone loss. Thus, the aim of this study was to analyze the action of Fluoxetine, Sertraline and Citalopram in the bone regeneration process. Thirty-five Wistar rats were used, in which bone defects of 2 to 3 mm in length were made in the fibula. The animals received Fluoxetine Hydrochloride 60 days before the fracture was made, and Sertraline Hydrochloride and Citalopram Hydrochloride 40 days before, and continued for another 30 days after the procedure. Control animals received saline solution. The results show that the bone defect regeneration process occurred more effectively in animals belonging to the control group, when compared to the other treated groups. The same data were observed regarding the serum alkaline phosphatase rate, statistically different when compared to animals treated with SSRIs. These data allow us to suggest that Fluoxetine, Sertraline and Citalopram seem to negatively interfere in the bone regeneration process, leading to a delay and non-complete consolidation of fractures with bone loss.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-21
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/24319
10.33448/rsd-v10i17.24319
url https://rsdjournal.org/index.php/rsd/article/view/24319
identifier_str_mv 10.33448/rsd-v10i17.24319
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/24319/21389
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 17; e96101724319
Research, Society and Development; Vol. 10 Núm. 17; e96101724319
Research, Society and Development; v. 10 n. 17; e96101724319
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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