Technological prospection of anti-inflammatory vanilic acid activity, with emphasis on its semisynthetic derivative Isopropyl Vanilate

Detalhes bibliográficos
Autor(a) principal: Nogueira, Kerolayne Melo
Data de Publicação: 2021
Outros Autores: Souza, Luan Kelves Miranda de, Medeiros, Jand Venes Rolim
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/13451
Resumo: Inflammation is the body's response to harmful stimuli such as infections, trauma, or injury. The inflammatory cascade can lead to the development of numerous diseases, and the current drug-therapeutic intervention consists of the use of corticosteroids and non-steroidal anti-inflammatory drugs. However, the use of these is associated with several serious side effects, so it is necessary to search for new alternatives that can minimize this effect. In this prospecting, the objective was to conduct a study on biological activities already described for vanillic acid, with special emphasis on its semi-synthetic derivative of isopropyl vanylate as an anti-inflammatory agent. For this, information was obtained on patent documents based on the INPI, USPTO and EPO databases, using the keywords: vanillic acid, anti-inflammatory agents, isopropyl vanylate, always used in the search field related to the summary of works. As results obtained in the present technological prospection study, it was found that in the international patent databases the documents related to the theme were very scarce and some had a higher number of patents, on vanillic acid, few refer to its anti- inflammatory, and no documents were found on the use of isopropyl vanillate as an anti-inflammatory agent, reinforcing the innovative character of research involving its use in this technology.
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spelling Technological prospection of anti-inflammatory vanilic acid activity, with emphasis on its semisynthetic derivative Isopropyl VanilateProspección tecnológica de la actividad del Ácido Vanílico antIinflamatorio, con énfasis en su derivado semisintético de vanilato de isopropiloProspecção tecnológica da atividade anti-inflamatória do Acído Vanílico, com ênfase em seu derivado semissintético Vanilato de IsopropilaVanillic acidIsopropyl vanylateInflammation.Ácido vanílicoVanilato de isopropiloInflamación.Ácido vanilicoVanilato de isopropilaInflamação.Inflammation is the body's response to harmful stimuli such as infections, trauma, or injury. The inflammatory cascade can lead to the development of numerous diseases, and the current drug-therapeutic intervention consists of the use of corticosteroids and non-steroidal anti-inflammatory drugs. However, the use of these is associated with several serious side effects, so it is necessary to search for new alternatives that can minimize this effect. In this prospecting, the objective was to conduct a study on biological activities already described for vanillic acid, with special emphasis on its semi-synthetic derivative of isopropyl vanylate as an anti-inflammatory agent. For this, information was obtained on patent documents based on the INPI, USPTO and EPO databases, using the keywords: vanillic acid, anti-inflammatory agents, isopropyl vanylate, always used in the search field related to the summary of works. As results obtained in the present technological prospection study, it was found that in the international patent databases the documents related to the theme were very scarce and some had a higher number of patents, on vanillic acid, few refer to its anti- inflammatory, and no documents were found on the use of isopropyl vanillate as an anti-inflammatory agent, reinforcing the innovative character of research involving its use in this technology.La inflamación es la respuesta del cuerpo a estímulos dañinos como infecciones, traumatismos o lesiones. La cascada inflamatoria puede conducir al desarrollo de numerosas enfermedades, y la intervención farmacoterapéutica actual consiste en el uso de corticosteroides y antiinflamatorios no esteroideos. Sin embargo, el uso de estos se asocia a varios efectos secundarios graves, por lo que es necesario buscar nuevas alternativas que puedan minimizar este efecto. En esta prospección, el objetivo fue realizar un estudio sobre las actividades biológicas ya descritas para el ácido vainílico, con especial énfasis en su derivado semisintético de vanilato de isopropilo como agente antiinflamatorio. Para ello, se obtuvo información sobre documentos de patente basados ​​en las bases de datos del INPI, USPTO y EPO, utilizando las palabras clave: ácido vainílico, agentes antiinflamatorios, vanilato de isopropilo, siempre utilizados en el campo de búsqueda relacionado con el resumen de trabajos. Como resultados obtenidos en el presente estudio de prospección tecnológica, se encontró que en las bases de datos internacionales de patentes los documentos relacionados con el tema eran muy escasos y algunos tenían un mayor número de patentes, sobre el ácido vainílico, pocos se refieren a su antiinflamatorio, y no se encontraron documentos sobre el uso de isopropil vainilla como agente antiinflamatorio, lo que refuerza el carácter innovador de las investigaciones que involucran su uso en esta tecnología.Inflamação é a resposta do corpo à estímulos nocivos tais como: infecções, traumas ou lesões. A cascata inflamatória pode levar ao desenvolvimento de inúmeras doenças, e a intervenção farmacoterapêutica atual consiste no uso de corticosteroides e de anti-inflamatórios não-esteroides. Entretanto, a utilização destes está associada a vários efeitos secundários graves, por isso é necessária a busca por novas alternativas que possam minimizar esse efeito. Nesta prospecção, objetivou-se realizar um estudo sobre atividades biológicas já descritas para o ácido vanílico, com especial destaque para o seu derivado semissintético vanilato de isopropila enquanto agente anti-inflamatório. Para isso, foram obtidas informações sobre documentos de patentes nas bases INPI, USPTO e EPO, com o uso das palavras-chave: ácido vanílico, agentes anti-inflamatórios, vanilato de isopropila, sempre utilizados no campo de busca relativo ao resumo dos trabalhos. Como resultados obtidos no presente estudo prospecção tecnológica  verificou-se que nas bases de dados internacionais de patente os documentos referentes à temática eram muito escassos e algumas tinham um maior número de patentes, sobre o ácido vanílico, poucas referem-se a sua atividade anti-inflamatória, e não foram encontrados documentos sobre a utilização do vanilato de isopropila como agente anti-inflamatório, reforçando o caráter inovador das pesquisas que envolvem o seu uso nesta tecnologia.Research, Society and Development2021-03-18info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1345110.33448/rsd-v10i3.13451Research, Society and Development; Vol. 10 No. 3; e35910313451Research, Society and Development; Vol. 10 Núm. 3; e35910313451Research, Society and Development; v. 10 n. 3; e359103134512525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/13451/12072Copyright (c) 2021 Kerolayne Melo Nogueira; Luan Kelves Miranda de Souza; Jand Venes Rolim Medeiroshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessNogueira, Kerolayne Melo Souza, Luan Kelves Miranda de Medeiros, Jand Venes Rolim 2021-03-28T12:03:35Zoai:ojs.pkp.sfu.ca:article/13451Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:34:47.134098Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Technological prospection of anti-inflammatory vanilic acid activity, with emphasis on its semisynthetic derivative Isopropyl Vanilate
Prospección tecnológica de la actividad del Ácido Vanílico antIinflamatorio, con énfasis en su derivado semisintético de vanilato de isopropilo
Prospecção tecnológica da atividade anti-inflamatória do Acído Vanílico, com ênfase em seu derivado semissintético Vanilato de Isopropila
title Technological prospection of anti-inflammatory vanilic acid activity, with emphasis on its semisynthetic derivative Isopropyl Vanilate
spellingShingle Technological prospection of anti-inflammatory vanilic acid activity, with emphasis on its semisynthetic derivative Isopropyl Vanilate
Nogueira, Kerolayne Melo
Vanillic acid
Isopropyl vanylate
Inflammation.
Ácido vanílico
Vanilato de isopropilo
Inflamación.
Ácido vanilico
Vanilato de isopropila
Inflamação.
title_short Technological prospection of anti-inflammatory vanilic acid activity, with emphasis on its semisynthetic derivative Isopropyl Vanilate
title_full Technological prospection of anti-inflammatory vanilic acid activity, with emphasis on its semisynthetic derivative Isopropyl Vanilate
title_fullStr Technological prospection of anti-inflammatory vanilic acid activity, with emphasis on its semisynthetic derivative Isopropyl Vanilate
title_full_unstemmed Technological prospection of anti-inflammatory vanilic acid activity, with emphasis on its semisynthetic derivative Isopropyl Vanilate
title_sort Technological prospection of anti-inflammatory vanilic acid activity, with emphasis on its semisynthetic derivative Isopropyl Vanilate
author Nogueira, Kerolayne Melo
author_facet Nogueira, Kerolayne Melo
Souza, Luan Kelves Miranda de
Medeiros, Jand Venes Rolim
author_role author
author2 Souza, Luan Kelves Miranda de
Medeiros, Jand Venes Rolim
author2_role author
author
dc.contributor.author.fl_str_mv Nogueira, Kerolayne Melo
Souza, Luan Kelves Miranda de
Medeiros, Jand Venes Rolim
dc.subject.por.fl_str_mv Vanillic acid
Isopropyl vanylate
Inflammation.
Ácido vanílico
Vanilato de isopropilo
Inflamación.
Ácido vanilico
Vanilato de isopropila
Inflamação.
topic Vanillic acid
Isopropyl vanylate
Inflammation.
Ácido vanílico
Vanilato de isopropilo
Inflamación.
Ácido vanilico
Vanilato de isopropila
Inflamação.
description Inflammation is the body's response to harmful stimuli such as infections, trauma, or injury. The inflammatory cascade can lead to the development of numerous diseases, and the current drug-therapeutic intervention consists of the use of corticosteroids and non-steroidal anti-inflammatory drugs. However, the use of these is associated with several serious side effects, so it is necessary to search for new alternatives that can minimize this effect. In this prospecting, the objective was to conduct a study on biological activities already described for vanillic acid, with special emphasis on its semi-synthetic derivative of isopropyl vanylate as an anti-inflammatory agent. For this, information was obtained on patent documents based on the INPI, USPTO and EPO databases, using the keywords: vanillic acid, anti-inflammatory agents, isopropyl vanylate, always used in the search field related to the summary of works. As results obtained in the present technological prospection study, it was found that in the international patent databases the documents related to the theme were very scarce and some had a higher number of patents, on vanillic acid, few refer to its anti- inflammatory, and no documents were found on the use of isopropyl vanillate as an anti-inflammatory agent, reinforcing the innovative character of research involving its use in this technology.
publishDate 2021
dc.date.none.fl_str_mv 2021-03-18
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/13451
10.33448/rsd-v10i3.13451
url https://rsdjournal.org/index.php/rsd/article/view/13451
identifier_str_mv 10.33448/rsd-v10i3.13451
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/13451/12072
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 3; e35910313451
Research, Society and Development; Vol. 10 Núm. 3; e35910313451
Research, Society and Development; v. 10 n. 3; e35910313451
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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