Impact of 10-valent pneumococcal conjugate (PCV 10) vaccination on incidence and mortality rates of pneumococcal meningitis in children under 5 in Brazil

Detalhes bibliográficos
Autor(a) principal: Nóbrega, Mércia de França
Data de Publicação: 2021
Outros Autores: Medeiros, Larissa Mercielly Nóbrega, Sáfadi, Marco Aurélio Palazzi
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/12438
Resumo: The objective of this study was to assess the impact of 10-valent pneumococcal conjugate (PCV10) vaccination on the incidence and mortality of pneumococcal meningitis in children under 5 in Brazil. A descriptive ecological, population-based quantitative study of secondary data from SINAN records for 2003-2009 and 2011-2017 and on vaccine coverage for 2011-2017 was conducted. The study was approved under permit CAAE 23629719.6.0000.5181. After PCV10 vaccine introduction, a substantial consistent reduction in incidence of and mortality rates of pneumococcal meningitis (70.33% Northeast, 69.49% Southeast) was observed across all regions of Brazil. Although the Human Development Index (HDI) improved during the study period, lethality rates remained high (North = 34.45% pre versus 40.08% post-vaccination), with no clear pattern of reduction associated with improved HDI in Brazil. In the final years of the study, a concerning decline in vaccination coverage rates was evident. Only the South (96.52%) and Mid-West (96.17%) regions attained the ≥ 95% vaccine coverage recommended by the Ministry of Health. This situation highlights the need for urgent measures to restore coverage rates and prevent recrudescence in cases and deaths associated with potentially preventable diseases.
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spelling Impact of 10-valent pneumococcal conjugate (PCV 10) vaccination on incidence and mortality rates of pneumococcal meningitis in children under 5 in BrazilImpacto de la vacuna 10-valente neumocócica conjugada (PCV 10) sobre las tasas de incidencia y de mortalidad causadas por la meningitis neumocócica en niños menores de cinco años en BrasilImpacto da vacinação pneumocócica conjugada 10 valente (PCV 10) nas taxas de incidência e de mortalidade por meningite pneumocócica em menores de cinco anos no BrasilCobertura vacinalEpidemiologiaMeningite pneumocócicaMortalidade.Cobertura de vacunaciónEpidemiologíaMeningitis neumocócicaMortalidad.Vaccination coverageEpidemiologyMeningitisPneumococcalMortality.The objective of this study was to assess the impact of 10-valent pneumococcal conjugate (PCV10) vaccination on the incidence and mortality of pneumococcal meningitis in children under 5 in Brazil. A descriptive ecological, population-based quantitative study of secondary data from SINAN records for 2003-2009 and 2011-2017 and on vaccine coverage for 2011-2017 was conducted. The study was approved under permit CAAE 23629719.6.0000.5181. After PCV10 vaccine introduction, a substantial consistent reduction in incidence of and mortality rates of pneumococcal meningitis (70.33% Northeast, 69.49% Southeast) was observed across all regions of Brazil. Although the Human Development Index (HDI) improved during the study period, lethality rates remained high (North = 34.45% pre versus 40.08% post-vaccination), with no clear pattern of reduction associated with improved HDI in Brazil. In the final years of the study, a concerning decline in vaccination coverage rates was evident. Only the South (96.52%) and Mid-West (96.17%) regions attained the ≥ 95% vaccine coverage recommended by the Ministry of Health. This situation highlights the need for urgent measures to restore coverage rates and prevent recrudescence in cases and deaths associated with potentially preventable diseases.El estudio tuvo como objetivo evaluar el impacto que la vacunación neumocócica conjugada 10-valente (PCV10) tuvo sobre la incidencia y mortalidad por meningitis neumocócica en niños menores de 5 años en Brasil. Se trata de un estudio ecológico, con base poblacional y descriptivo, que utiliza datos secundarios por medio de un enfoque cuantitativo, a través de registros del SINAN durante los períodos que van de 2003 a 2009 y de 2011 a 2017 y de la cobertura de la vacunación en el período 2011-2017. Opinión favorable, CAAE: 23629719.6.0000.5181. En el período posterior a la introducción de la vacuna PCV10, hubo una reducción substancial (en la Región Nordeste de 70,33% y en la Región Sudeste de 69,49%) de las tasas de incidencia y mortalidad causadas por la meningitis neumocócica. Esta reducción fue consistente en todas las regiones del país. Hubo una mejora en el Índice de Desarrollo Humano durante el período de estudio, sin embargo, las tasas de letalidad se mantuvieron altas (Región Norte, de 34,45% a 40,08%), sin una clara tendencia a la baja en correlación con el aumento del IDH en el país en su conjunto. En los últimos años del estudio, se registró una caída preocupante de las tasas de la cobertura de vacunación. Solo en las Regiones Sur (96,52%) y Centro-Oeste (96,17%) se logró alcanzar la cobertura de vacunación recomendada por el Ministerio de la Salud, igual o superior al 95%. Se destaca la necesidad de medidas urgentes para elevar el alcance de estas coberturas con el fin de evitar el recrudecimiento de los casos y muertes asociadas a enfermedades potencialmente prevenibles.O estudo objetivou avaliar o impacto da vacinação pneumocócica conjugada 10-valente (PCV10) sobre a incidência e a mortalidade por meningite pneumocócica em menores de 5 anos de idade no Brasil. Trata-se de um estudo ecológico, de base populacional e descritivo, por meio de dados secundários mediante uma abordagem quantitativa, através dos registros do SINAN nos períodos de 2003 a 2009 e 2011 a 2017 e a cobertura vacinal de 2011-2017. Parecer favorável, CAAE: 23629719.6.0000.5181. No período posterior à introdução da vacina PCV10 observou-se uma diminuição substancial das taxas de incidência e de mortalidade (redução na Região Nordeste 70,33% e Região Sudeste 69,49%), atribuídas à meningite pneumocócica, consistente em todas as regiões do País. Houve melhora do Índice de Desenvolvimento Humano durante o período do estudo, contudo, as taxas de letalidade se mantiveram elevadas (região Norte 34,45% para 40,08%), sem uma tendência clara de diminuição correlacionada ao aumento do IDH no país como um todo. Nos últimos anos do estudo, evidenciou-se preocupante queda das taxas de cobertura vacinal. Apenas as Regiões Sul (96,52%) e Centro-Oeste (96,17%), conseguiram atingir a cobertura vacinal preconizada pelo Ministério da Saúde igual ou maior que 95%. Destacando a necessidade de medidas urgentes de resgate destas coberturas para não ser observada recrudescência de casos e mortes associadas a doenças potencialmente preveníveis.Research, Society and Development2021-02-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1243810.33448/rsd-v10i2.12438Research, Society and Development; Vol. 10 No. 2; e21310212438Research, Society and Development; Vol. 10 Núm. 2; e21310212438Research, Society and Development; v. 10 n. 2; e213102124382525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/12438/11166Copyright (c) 2021 Mércia de França Nóbrega; Larissa Mercielly Nóbrega Medeiros; Marco Aurélio Palazzi Sáfadihttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessNóbrega, Mércia de França Medeiros, Larissa Mercielly Nóbrega Sáfadi, Marco Aurélio Palazzi 2021-03-02T09:32:39Zoai:ojs.pkp.sfu.ca:article/12438Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:34:00.914782Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Impact of 10-valent pneumococcal conjugate (PCV 10) vaccination on incidence and mortality rates of pneumococcal meningitis in children under 5 in Brazil
Impacto de la vacuna 10-valente neumocócica conjugada (PCV 10) sobre las tasas de incidencia y de mortalidad causadas por la meningitis neumocócica en niños menores de cinco años en Brasil
Impacto da vacinação pneumocócica conjugada 10 valente (PCV 10) nas taxas de incidência e de mortalidade por meningite pneumocócica em menores de cinco anos no Brasil
title Impact of 10-valent pneumococcal conjugate (PCV 10) vaccination on incidence and mortality rates of pneumococcal meningitis in children under 5 in Brazil
spellingShingle Impact of 10-valent pneumococcal conjugate (PCV 10) vaccination on incidence and mortality rates of pneumococcal meningitis in children under 5 in Brazil
Nóbrega, Mércia de França
Cobertura vacinal
Epidemiologia
Meningite pneumocócica
Mortalidade.
Cobertura de vacunación
Epidemiología
Meningitis neumocócica
Mortalidad.
Vaccination coverage
Epidemiology
Meningitis
Pneumococcal
Mortality.
title_short Impact of 10-valent pneumococcal conjugate (PCV 10) vaccination on incidence and mortality rates of pneumococcal meningitis in children under 5 in Brazil
title_full Impact of 10-valent pneumococcal conjugate (PCV 10) vaccination on incidence and mortality rates of pneumococcal meningitis in children under 5 in Brazil
title_fullStr Impact of 10-valent pneumococcal conjugate (PCV 10) vaccination on incidence and mortality rates of pneumococcal meningitis in children under 5 in Brazil
title_full_unstemmed Impact of 10-valent pneumococcal conjugate (PCV 10) vaccination on incidence and mortality rates of pneumococcal meningitis in children under 5 in Brazil
title_sort Impact of 10-valent pneumococcal conjugate (PCV 10) vaccination on incidence and mortality rates of pneumococcal meningitis in children under 5 in Brazil
author Nóbrega, Mércia de França
author_facet Nóbrega, Mércia de França
Medeiros, Larissa Mercielly Nóbrega
Sáfadi, Marco Aurélio Palazzi
author_role author
author2 Medeiros, Larissa Mercielly Nóbrega
Sáfadi, Marco Aurélio Palazzi
author2_role author
author
dc.contributor.author.fl_str_mv Nóbrega, Mércia de França
Medeiros, Larissa Mercielly Nóbrega
Sáfadi, Marco Aurélio Palazzi
dc.subject.por.fl_str_mv Cobertura vacinal
Epidemiologia
Meningite pneumocócica
Mortalidade.
Cobertura de vacunación
Epidemiología
Meningitis neumocócica
Mortalidad.
Vaccination coverage
Epidemiology
Meningitis
Pneumococcal
Mortality.
topic Cobertura vacinal
Epidemiologia
Meningite pneumocócica
Mortalidade.
Cobertura de vacunación
Epidemiología
Meningitis neumocócica
Mortalidad.
Vaccination coverage
Epidemiology
Meningitis
Pneumococcal
Mortality.
description The objective of this study was to assess the impact of 10-valent pneumococcal conjugate (PCV10) vaccination on the incidence and mortality of pneumococcal meningitis in children under 5 in Brazil. A descriptive ecological, population-based quantitative study of secondary data from SINAN records for 2003-2009 and 2011-2017 and on vaccine coverage for 2011-2017 was conducted. The study was approved under permit CAAE 23629719.6.0000.5181. After PCV10 vaccine introduction, a substantial consistent reduction in incidence of and mortality rates of pneumococcal meningitis (70.33% Northeast, 69.49% Southeast) was observed across all regions of Brazil. Although the Human Development Index (HDI) improved during the study period, lethality rates remained high (North = 34.45% pre versus 40.08% post-vaccination), with no clear pattern of reduction associated with improved HDI in Brazil. In the final years of the study, a concerning decline in vaccination coverage rates was evident. Only the South (96.52%) and Mid-West (96.17%) regions attained the ≥ 95% vaccine coverage recommended by the Ministry of Health. This situation highlights the need for urgent measures to restore coverage rates and prevent recrudescence in cases and deaths associated with potentially preventable diseases.
publishDate 2021
dc.date.none.fl_str_mv 2021-02-11
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/12438
10.33448/rsd-v10i2.12438
url https://rsdjournal.org/index.php/rsd/article/view/12438
identifier_str_mv 10.33448/rsd-v10i2.12438
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/12438/11166
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 2; e21310212438
Research, Society and Development; Vol. 10 Núm. 2; e21310212438
Research, Society and Development; v. 10 n. 2; e21310212438
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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