Frequency and specificity of erythrocyte alloimmunization in patients at a reference hospital in Alagoas, Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Research, Society and Development |
| Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/33555 |
Resumo: | Objective: To determine the frequency and specificity of erythrocyte alloimmunization in patients treated by hemotherapy at the University Hospital Professor Alberto Antunes - UFAL, Maceió-Alagoas, in the period 2013-2018. Methods: Retrospective analysis all patient records with request for red blood cell concentrate (RBC) with a positive erythrocyte antibody test. Results: The incidence of erythrocyte alloimmunization was higher in women n=144 (80.45%) than in men n=35 (19.55%). We detected 13 antibodies, the most frequent specificities identified were anti-D (35.20%), anti-M (12.30%) and anti-E (7.82%). The combination of antibodies occurred in twenty-six cases with prevalence for combinations of antibodies of the Rh system, anti-D + anti-C (23.08%). The highest incidence of alloantibodies was observed in pregnant women. Conclusion: The population studied had high levels of alloimmunization through the Rh System, greater specificity of alloimmunization in women through anti-D and higher rate of alloimmunization among men over the age of 40. Further studies are necessary for a better understanding of red blood cell alloimmunization for population of Alagoas. |
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Frequency and specificity of erythrocyte alloimmunization in patients at a reference hospital in Alagoas, BrazilFrecuencia y especificidad de la aloinmunización eritrocitaria en pacientes de un hospital de referencia en Alagoas, BrasilFrequência e especificidade da aloimunização eritrocitária em pacientes de um hospital de referência em Alagoas, BrasilAloinmunizaciónAnticuerposAntígenosEnfermedades hematológicasTransfusión.AloimunizaçãoAnticorposAntígenosDoenças hematológicasTransfusão.AlloimmunizationAntibodiesAntigensHematological diseasesTransfusion.Objective: To determine the frequency and specificity of erythrocyte alloimmunization in patients treated by hemotherapy at the University Hospital Professor Alberto Antunes - UFAL, Maceió-Alagoas, in the period 2013-2018. Methods: Retrospective analysis all patient records with request for red blood cell concentrate (RBC) with a positive erythrocyte antibody test. Results: The incidence of erythrocyte alloimmunization was higher in women n=144 (80.45%) than in men n=35 (19.55%). We detected 13 antibodies, the most frequent specificities identified were anti-D (35.20%), anti-M (12.30%) and anti-E (7.82%). The combination of antibodies occurred in twenty-six cases with prevalence for combinations of antibodies of the Rh system, anti-D + anti-C (23.08%). The highest incidence of alloantibodies was observed in pregnant women. Conclusion: The population studied had high levels of alloimmunization through the Rh System, greater specificity of alloimmunization in women through anti-D and higher rate of alloimmunization among men over the age of 40. Further studies are necessary for a better understanding of red blood cell alloimmunization for population of Alagoas.Objetivo: Determinar la frecuencia y especificidad de la aloinmunización eritrocitaria en pacientes tratados por hemoterapia en el Hospital Universitario Profesor Alberto Antunes - UFAL, Maceió-Alagoas, en el período 2013-2018. Método: Análisis retrospectivo de todas las historias clínicas de los pacientes que solicitaron concentrado de glóbulos rojos (RBC) con prueba de anticuerpos contra eritrocitos positiva. Resultados: La incidencia de aloinmunización eritrocitaria fue mayor en mujeres n=144 (80,45%) que en hombres n=35 (19,55%). Detectamos 13 anticuerpos, siendo las especificidades más frecuentemente identificadas anti-D (35,20%), anti-M (12,30%) y anti-E (7,82%). La combinación de anticuerpos ocurrió en veintiséis casos con predominio para combinaciones de anticuerpos del sistema Rh, anti-D + anti-C (23,08%). La mayor incidencia de aloanticuerpos se observó en mujeres embarazadas. Conclusión: La población estudiada presentó altos niveles de aloinmunización por el Sistema Rh, mayor especificidad de aloinmunización en mujeres por anti-D y mayor tasa de aloinmunización en hombres mayores de 40 años. Son necesarios nuevos estudios para una mejor comprensión de la aloinmunización eritrocitaria en la población de Alagoas.Objetivo: Determinar a frequência e especificidade da aloimunização eritrocitária em pacientes tratados por hemoterapia no Hospital Universitário Professor Alberto Antunes - UFAL, Maceió-Alagoas, no período de 2013-2018. Método: Análise retrospectiva de todos os prontuários de pacientes com solicitação de concentrado de hemácias (CH) com teste de anticorpos eritrocitários positivo. Resultados: A incidência de aloimunização eritrocitária foi maior em mulheres n = 144 (80,45%) do que em homens n = 35 (19,55%). Detectamos 13 anticorpos, sendo as especificidades identificadas com maior frequência anti-D (35,20%), anti-M (12,30%) e anti-E (7,82%). A combinação de anticorpos ocorreu em vinte e seis casos com prevalência para combinações de anticorpos do sistema Rh, anti-D + anti-C (23,08%). A maior incidência de aloanticorpos foi observada em mulheres grávidas. Conclusão: A população estudada apresentou altos níveis de aloimunização pelo Sistema Rh, maior especificidade de aloimunização em mulheres por anti-D e maior índice de aloimunização em homens acima de 40 anos. Novos estudos são necessários para um melhor entendimento da aloimunização eritrocitária na população alagoanaResearch, Society and Development2022-08-18info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3355510.33448/rsd-v11i11.33555Research, Society and Development; Vol. 11 No. 11; e134111133555Research, Society and Development; Vol. 11 Núm. 11; e134111133555Research, Society and Development; v. 11 n. 11; e1341111335552525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/33555/28277Copyright (c) 2022 Kledson Lopes Barbosa; Erika Elita Araújo Lessa; Margareth Alves Soares; Walkíria de Araújo Souza; Audemário de Gusmão Lins Filho; Krisley Rodrigues Lima Pereira; Kelly Patrícia Alexandre Chagas; Cinthya Pereira Leite Costa de Araújo; Djana Maria de Lima Brêda; Luciana de Andrade Pereirahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBarbosa, Kledson LopesLessa, Erika Elita Araújo Soares, Margareth Alves Souza, Walkíria de Araújo Lins Filho, Audemário de Gusmão Pereira, Krisley Rodrigues LimaChagas, Kelly Patrícia AlexandreAraújo, Cinthya Pereira Leite Costa deBrêda, Djana Maria de LimaPereira, Luciana de Andrade 2022-09-05T13:24:46Zoai:ojs.pkp.sfu.ca:article/33555Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:49:10.097247Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
| dc.title.none.fl_str_mv |
Frequency and specificity of erythrocyte alloimmunization in patients at a reference hospital in Alagoas, Brazil Frecuencia y especificidad de la aloinmunización eritrocitaria en pacientes de un hospital de referencia en Alagoas, Brasil Frequência e especificidade da aloimunização eritrocitária em pacientes de um hospital de referência em Alagoas, Brasil |
| title |
Frequency and specificity of erythrocyte alloimmunization in patients at a reference hospital in Alagoas, Brazil |
| spellingShingle |
Frequency and specificity of erythrocyte alloimmunization in patients at a reference hospital in Alagoas, Brazil Barbosa, Kledson Lopes Aloinmunización Anticuerpos Antígenos Enfermedades hematológicas Transfusión. Aloimunização Anticorpos Antígenos Doenças hematológicas Transfusão. Alloimmunization Antibodies Antigens Hematological diseases Transfusion. |
| title_short |
Frequency and specificity of erythrocyte alloimmunization in patients at a reference hospital in Alagoas, Brazil |
| title_full |
Frequency and specificity of erythrocyte alloimmunization in patients at a reference hospital in Alagoas, Brazil |
| title_fullStr |
Frequency and specificity of erythrocyte alloimmunization in patients at a reference hospital in Alagoas, Brazil |
| title_full_unstemmed |
Frequency and specificity of erythrocyte alloimmunization in patients at a reference hospital in Alagoas, Brazil |
| title_sort |
Frequency and specificity of erythrocyte alloimmunization in patients at a reference hospital in Alagoas, Brazil |
| author |
Barbosa, Kledson Lopes |
| author_facet |
Barbosa, Kledson Lopes Lessa, Erika Elita Araújo Soares, Margareth Alves Souza, Walkíria de Araújo Lins Filho, Audemário de Gusmão Pereira, Krisley Rodrigues Lima Chagas, Kelly Patrícia Alexandre Araújo, Cinthya Pereira Leite Costa de Brêda, Djana Maria de Lima Pereira, Luciana de Andrade |
| author_role |
author |
| author2 |
Lessa, Erika Elita Araújo Soares, Margareth Alves Souza, Walkíria de Araújo Lins Filho, Audemário de Gusmão Pereira, Krisley Rodrigues Lima Chagas, Kelly Patrícia Alexandre Araújo, Cinthya Pereira Leite Costa de Brêda, Djana Maria de Lima Pereira, Luciana de Andrade |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Barbosa, Kledson Lopes Lessa, Erika Elita Araújo Soares, Margareth Alves Souza, Walkíria de Araújo Lins Filho, Audemário de Gusmão Pereira, Krisley Rodrigues Lima Chagas, Kelly Patrícia Alexandre Araújo, Cinthya Pereira Leite Costa de Brêda, Djana Maria de Lima Pereira, Luciana de Andrade |
| dc.subject.por.fl_str_mv |
Aloinmunización Anticuerpos Antígenos Enfermedades hematológicas Transfusión. Aloimunização Anticorpos Antígenos Doenças hematológicas Transfusão. Alloimmunization Antibodies Antigens Hematological diseases Transfusion. |
| topic |
Aloinmunización Anticuerpos Antígenos Enfermedades hematológicas Transfusión. Aloimunização Anticorpos Antígenos Doenças hematológicas Transfusão. Alloimmunization Antibodies Antigens Hematological diseases Transfusion. |
| description |
Objective: To determine the frequency and specificity of erythrocyte alloimmunization in patients treated by hemotherapy at the University Hospital Professor Alberto Antunes - UFAL, Maceió-Alagoas, in the period 2013-2018. Methods: Retrospective analysis all patient records with request for red blood cell concentrate (RBC) with a positive erythrocyte antibody test. Results: The incidence of erythrocyte alloimmunization was higher in women n=144 (80.45%) than in men n=35 (19.55%). We detected 13 antibodies, the most frequent specificities identified were anti-D (35.20%), anti-M (12.30%) and anti-E (7.82%). The combination of antibodies occurred in twenty-six cases with prevalence for combinations of antibodies of the Rh system, anti-D + anti-C (23.08%). The highest incidence of alloantibodies was observed in pregnant women. Conclusion: The population studied had high levels of alloimmunization through the Rh System, greater specificity of alloimmunization in women through anti-D and higher rate of alloimmunization among men over the age of 40. Further studies are necessary for a better understanding of red blood cell alloimmunization for population of Alagoas. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-08-18 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
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https://rsdjournal.org/index.php/rsd/article/view/33555 10.33448/rsd-v11i11.33555 |
| url |
https://rsdjournal.org/index.php/rsd/article/view/33555 |
| identifier_str_mv |
10.33448/rsd-v11i11.33555 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/33555/28277 |
| dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
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openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Research, Society and Development |
| publisher.none.fl_str_mv |
Research, Society and Development |
| dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 11; e134111133555 Research, Society and Development; Vol. 11 Núm. 11; e134111133555 Research, Society and Development; v. 11 n. 11; e134111133555 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
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Universidade Federal de Itajubá (UNIFEI) |
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UNIFEI |
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UNIFEI |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
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rsd.articles@gmail.com |
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1797052720940580864 |