Influence of constant lighting, melatonin and geldanamycin under mice testicle over 60 days
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Research, Society and Development |
| DOI: | 10.33448/rsd-v10i2.12731 |
| Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/12731 |
Resumo: | Melatonin (N-acetyl-5-methoxytryptamine) is a hormone secreted by the pineal gland. In men, melatonin affects reproductive regulation in three main ways. First, it regulates the secretion of GnRH and LH. Second, it regulates testosterone synthesis and testicular maturation. Third, as a potent deputare of free radical that is both lipophilic and hydrophilic. The mammalian testis is an organ susceptible to environmental and therapeutic toxic agents that compromise spermatogenesis, the present study aimed to analyse the influence of constant illumination, melatonin and geldanamycin under the testis of rats treated for 60 days. Males were randomly divided into 4 groups, each consisting of 5 animals, which are: Group I - control rats (untreated); Group II - rats subjected to constant illumination for 60 days; Group III - rats subjected to constant illumination for 60 days and treated with melatonin for 60 days; Group IV - rats subjected to constant illumination for 60 days, treated with melatonin and geldanamycin for 60 days. Exposure to constant illumination affects the development of germinal epithelium, as well as decreased weight of the testicles, Leydig, Sertoli, and testosterone cells. Melatonin and geldanamycin treatment have a protective effect against constant illumination, reducing testicular damage when taken together. |
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Research, Society and Development |
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Influence of constant lighting, melatonin and geldanamycin under mice testicle over 60 daysInfluencia de la iluminación constante, melatonina y geldanamicina bajo el testículo de ratones durante 60 díasInfluência de constante iluminação, melatonina e geldanamicina sob o testículo de rato por mais de 60 diasTestículoMelatoninaIluminação constanteGeldanamicinaLeydig.TestisMelatoninConstant illuminationGeldanamycinLeydig.TestículoMelatoninaIluminación ConstanteGeldanamicinaLeydig.Melatonin (N-acetyl-5-methoxytryptamine) is a hormone secreted by the pineal gland. In men, melatonin affects reproductive regulation in three main ways. First, it regulates the secretion of GnRH and LH. Second, it regulates testosterone synthesis and testicular maturation. Third, as a potent deputare of free radical that is both lipophilic and hydrophilic. The mammalian testis is an organ susceptible to environmental and therapeutic toxic agents that compromise spermatogenesis, the present study aimed to analyse the influence of constant illumination, melatonin and geldanamycin under the testis of rats treated for 60 days. Males were randomly divided into 4 groups, each consisting of 5 animals, which are: Group I - control rats (untreated); Group II - rats subjected to constant illumination for 60 days; Group III - rats subjected to constant illumination for 60 days and treated with melatonin for 60 days; Group IV - rats subjected to constant illumination for 60 days, treated with melatonin and geldanamycin for 60 days. Exposure to constant illumination affects the development of germinal epithelium, as well as decreased weight of the testicles, Leydig, Sertoli, and testosterone cells. Melatonin and geldanamycin treatment have a protective effect against constant illumination, reducing testicular damage when taken together.La melatonina (N-acetil-5-metoxitriptamina) es una hormona secretada por la glándula pineal. En los hombres, la melatonina afecta la regulación reproductiva de tres formas principales. Primero, regula la secreción de GnRH y LH. En segundo lugar, regula la síntesis de testosterona y la maduración testicular. En tercer lugar, como un potente deputare de radicales libres que es tanto lipofílico como hidrofílico. El testículo de mamífero es un órgano susceptible a agentes tóxicos ambientales y terapéuticos que comprometen la espermatogénesis, el presente estudio tuvo como objetivo analizar la influencia de la iluminación constante, melatonina y geldanamicina debajo de los testículos de ratas tratadas durante 60 días. Los machos se dividieron aleatoriamente en 4 grupos, cada uno de los cuales constaba de 5 animales, que son: Grupo I - ratas de control (sin tratar); Grupo II: ratas sometidas a iluminación constante durante 60 días; Grupo III: ratas sometidas a iluminación constante durante 60 días y tratadas con melatonina durante 60 días; Grupo IV: ratas sometidas a iluminación constante durante 60 días, tratadas con melatonina y geldanamicina durante 60 días. La exposición a una iluminación constante afecta el desarrollo del epitelio germinal, así como la disminución del peso de los testículos, las células de Leydig, Sertoli y de testosterona. El tratamiento con melatonina y geldanamicina tiene un efecto protector contra la iluminación constante, reduciendo el daño testicular cuando se toman juntas.A melatonina (N-acetil-5-metoxitriptamina) é um hormônio secretado pela glândula pineal. Nos homens, a melatonina afeta a regulação reprodutiva de três maneiras principais. Primeiro, ele regula a secreção de GnRH e LH. Em segundo lugar, regula a síntese de testosterona e a maturação testicular. Terceiro, como um potente representante do radical livre que é tanto lipofílico quanto hidrofílico. O testículo de mamíferos é um órgão suscetível a agentes tóxicos ambientais e terapêuticos que comprometem a espermatogênese, o presente estudo teve como objetivo analisar a influência da iluminação constante, melatonina e geldanamicina sob o testículo de ratos tratados por 60 dias. Os machos foram divididos aleatoriamente em 4 grupos, cada um composto por 5 animais, sendo eles: Grupo I - ratos controle (não tratados); Grupo II - ratos submetidos à iluminação constante por 60 dias; Grupo III - ratos submetidos à iluminação constante por 60 dias e tratados com melatonina por 60 dias; Grupo IV - ratos submetidos à iluminação constante por 60 dias, tratados com melatonina e geldanamicina por 60 dias. A exposição à iluminação constante afeta o desenvolvimento do epitélio germinativo, bem como a diminuição do peso dos testículos, células de Leydig, Sertoli e testosterona. O tratamento com melatonina e geldanamicina tem um efeito protetor contra a iluminação constante, reduzindo os danos testiculares quando tomados em conjunto.Research, Society and Development2021-02-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1273110.33448/rsd-v10i2.12731Research, Society and Development; Vol. 10 No. 2; e47710212731Research, Society and Development; Vol. 10 Núm. 2; e47710212731Research, Society and Development; v. 10 n. 2; e477102127312525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/12731/11504Copyright (c) 2021 Marcos Aurélio Santos da Costa; Anna Carolina Lopes de Lira; Geovanna Hachyra Facundo Guedes; José Anderson da Silva Gomes; Jennyfer Martins de Carvalho; Maria Luísa Figueira de Oliveira; Maria Eduarda da Silva; Bárbara Silva Gonzaga; Pedro Vinícius Silva Novis; Diana Babini Lapa de Albuquerque Britto; Bruno Mendes Tenório; Carina Scanoni Maia; Juliana Pinto de Medeiros; Fernanda das Chagas Angelo Mendes Tenoriohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCosta, Marcos Aurélio Santos da Lira, Anna Carolina Lopes de Guedes, Geovanna Hachyra Facundo Gomes, José Anderson da Silva Carvalho, Jennyfer Martins de Oliveira, Maria Luísa Figueira de Silva, Maria Eduarda da Gonzaga, Bárbara Silva Novis, Pedro Vinícius Silva Britto, Diana Babini Lapa de Albuquerque Tenório, Bruno MendesMaia, Carina Scanoni Medeiros, Juliana Pinto de Tenorio, Fernanda das Chagas Angelo Mendes 2021-03-02T09:32:39Zoai:ojs.pkp.sfu.ca:article/12731Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:34:13.877932Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
| dc.title.none.fl_str_mv |
Influence of constant lighting, melatonin and geldanamycin under mice testicle over 60 days Influencia de la iluminación constante, melatonina y geldanamicina bajo el testículo de ratones durante 60 días Influência de constante iluminação, melatonina e geldanamicina sob o testículo de rato por mais de 60 dias |
| title |
Influence of constant lighting, melatonin and geldanamycin under mice testicle over 60 days |
| spellingShingle |
Influence of constant lighting, melatonin and geldanamycin under mice testicle over 60 days Influence of constant lighting, melatonin and geldanamycin under mice testicle over 60 days Costa, Marcos Aurélio Santos da Testículo Melatonina Iluminação constante Geldanamicina Leydig. Testis Melatonin Constant illumination Geldanamycin Leydig. Testículo Melatonina Iluminación Constante Geldanamicina Leydig. Costa, Marcos Aurélio Santos da Testículo Melatonina Iluminação constante Geldanamicina Leydig. Testis Melatonin Constant illumination Geldanamycin Leydig. Testículo Melatonina Iluminación Constante Geldanamicina Leydig. |
| title_short |
Influence of constant lighting, melatonin and geldanamycin under mice testicle over 60 days |
| title_full |
Influence of constant lighting, melatonin and geldanamycin under mice testicle over 60 days |
| title_fullStr |
Influence of constant lighting, melatonin and geldanamycin under mice testicle over 60 days Influence of constant lighting, melatonin and geldanamycin under mice testicle over 60 days |
| title_full_unstemmed |
Influence of constant lighting, melatonin and geldanamycin under mice testicle over 60 days Influence of constant lighting, melatonin and geldanamycin under mice testicle over 60 days |
| title_sort |
Influence of constant lighting, melatonin and geldanamycin under mice testicle over 60 days |
| author |
Costa, Marcos Aurélio Santos da |
| author_facet |
Costa, Marcos Aurélio Santos da Costa, Marcos Aurélio Santos da Lira, Anna Carolina Lopes de Guedes, Geovanna Hachyra Facundo Gomes, José Anderson da Silva Carvalho, Jennyfer Martins de Oliveira, Maria Luísa Figueira de Silva, Maria Eduarda da Gonzaga, Bárbara Silva Novis, Pedro Vinícius Silva Britto, Diana Babini Lapa de Albuquerque Tenório, Bruno Mendes Maia, Carina Scanoni Medeiros, Juliana Pinto de Tenorio, Fernanda das Chagas Angelo Mendes Lira, Anna Carolina Lopes de Guedes, Geovanna Hachyra Facundo Gomes, José Anderson da Silva Carvalho, Jennyfer Martins de Oliveira, Maria Luísa Figueira de Silva, Maria Eduarda da Gonzaga, Bárbara Silva Novis, Pedro Vinícius Silva Britto, Diana Babini Lapa de Albuquerque Tenório, Bruno Mendes Maia, Carina Scanoni Medeiros, Juliana Pinto de Tenorio, Fernanda das Chagas Angelo Mendes |
| author_role |
author |
| author2 |
Lira, Anna Carolina Lopes de Guedes, Geovanna Hachyra Facundo Gomes, José Anderson da Silva Carvalho, Jennyfer Martins de Oliveira, Maria Luísa Figueira de Silva, Maria Eduarda da Gonzaga, Bárbara Silva Novis, Pedro Vinícius Silva Britto, Diana Babini Lapa de Albuquerque Tenório, Bruno Mendes Maia, Carina Scanoni Medeiros, Juliana Pinto de Tenorio, Fernanda das Chagas Angelo Mendes |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Costa, Marcos Aurélio Santos da Lira, Anna Carolina Lopes de Guedes, Geovanna Hachyra Facundo Gomes, José Anderson da Silva Carvalho, Jennyfer Martins de Oliveira, Maria Luísa Figueira de Silva, Maria Eduarda da Gonzaga, Bárbara Silva Novis, Pedro Vinícius Silva Britto, Diana Babini Lapa de Albuquerque Tenório, Bruno Mendes Maia, Carina Scanoni Medeiros, Juliana Pinto de Tenorio, Fernanda das Chagas Angelo Mendes |
| dc.subject.por.fl_str_mv |
Testículo Melatonina Iluminação constante Geldanamicina Leydig. Testis Melatonin Constant illumination Geldanamycin Leydig. Testículo Melatonina Iluminación Constante Geldanamicina Leydig. |
| topic |
Testículo Melatonina Iluminação constante Geldanamicina Leydig. Testis Melatonin Constant illumination Geldanamycin Leydig. Testículo Melatonina Iluminación Constante Geldanamicina Leydig. |
| description |
Melatonin (N-acetyl-5-methoxytryptamine) is a hormone secreted by the pineal gland. In men, melatonin affects reproductive regulation in three main ways. First, it regulates the secretion of GnRH and LH. Second, it regulates testosterone synthesis and testicular maturation. Third, as a potent deputare of free radical that is both lipophilic and hydrophilic. The mammalian testis is an organ susceptible to environmental and therapeutic toxic agents that compromise spermatogenesis, the present study aimed to analyse the influence of constant illumination, melatonin and geldanamycin under the testis of rats treated for 60 days. Males were randomly divided into 4 groups, each consisting of 5 animals, which are: Group I - control rats (untreated); Group II - rats subjected to constant illumination for 60 days; Group III - rats subjected to constant illumination for 60 days and treated with melatonin for 60 days; Group IV - rats subjected to constant illumination for 60 days, treated with melatonin and geldanamycin for 60 days. Exposure to constant illumination affects the development of germinal epithelium, as well as decreased weight of the testicles, Leydig, Sertoli, and testosterone cells. Melatonin and geldanamycin treatment have a protective effect against constant illumination, reducing testicular damage when taken together. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-02-24 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://rsdjournal.org/index.php/rsd/article/view/12731 10.33448/rsd-v10i2.12731 |
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https://rsdjournal.org/index.php/rsd/article/view/12731 |
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10.33448/rsd-v10i2.12731 |
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eng |
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eng |
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https://rsdjournal.org/index.php/rsd/article/view/12731/11504 |
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https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
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openAccess |
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application/pdf |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development; Vol. 10 No. 2; e47710212731 Research, Society and Development; Vol. 10 Núm. 2; e47710212731 Research, Society and Development; v. 10 n. 2; e47710212731 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
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Universidade Federal de Itajubá (UNIFEI) |
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UNIFEI |
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UNIFEI |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
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rsd.articles@gmail.com |
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1822178491750154240 |
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10.33448/rsd-v10i2.12731 |