Therapeutic potencial of mesenquimal stem cells in equine laminitis
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/18902 |
Resumo: | Laminitis is a very common disease in the clinical routine of horses, which causes, among other symptoms, pain and lameness, being an important cause of euthanasia. In this condition, there is a weakening of the connection between the horny case and the distal phalanx, resulting in the sinking and palmar / plantar rotation of this bone. Several mechanisms are involved in the pathogenesis of laminitis, which include vascular, enzymatic, traumatic, glucose deprivation and endocrinopathic theories, so that it can occur secondarily to several other diseases, such as colic and equine metabolic disease. However, the compression of the mechanisms that govern changes in the pathophysiology of this disease is quite complex, and is not yet fully understood. This factor limits the development of effective therapies for curing laminitis. The diagnosis can be made through the evaluation of the animal's history, clinical signs, physical examination and complementary exams, such as radiography, anesthetic blocks, venography, thermography, among other methods. Therapy should involve pain control and stabilization of laminar tissue, and varies according to the stage of development of the disease, especially the acute and chronic phases. Thus, regenerative medicine, which includes the use of mesenchymal stem cells, has gained considerable prominence in recent years, since it has a positive influence on the cure of various orthopedic injuries in horses. |
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Therapeutic potencial of mesenquimal stem cells in equine laminitisPotencial terapêutico de células madre mesenquimales em laminitis equinaPotencial terapêutico de células-tronco mesenquimais na laminite equinaEquinoLaminiteCélulas-tronco mesenquimais.EquinoLaminitisCélulas madre mesenquimales.EquineLaminitisMesenchymal stem cells.Laminitis is a very common disease in the clinical routine of horses, which causes, among other symptoms, pain and lameness, being an important cause of euthanasia. In this condition, there is a weakening of the connection between the horny case and the distal phalanx, resulting in the sinking and palmar / plantar rotation of this bone. Several mechanisms are involved in the pathogenesis of laminitis, which include vascular, enzymatic, traumatic, glucose deprivation and endocrinopathic theories, so that it can occur secondarily to several other diseases, such as colic and equine metabolic disease. However, the compression of the mechanisms that govern changes in the pathophysiology of this disease is quite complex, and is not yet fully understood. This factor limits the development of effective therapies for curing laminitis. The diagnosis can be made through the evaluation of the animal's history, clinical signs, physical examination and complementary exams, such as radiography, anesthetic blocks, venography, thermography, among other methods. Therapy should involve pain control and stabilization of laminar tissue, and varies according to the stage of development of the disease, especially the acute and chronic phases. Thus, regenerative medicine, which includes the use of mesenchymal stem cells, has gained considerable prominence in recent years, since it has a positive influence on the cure of various orthopedic injuries in horses.La laminitis es una enfermedad muy común en la rutina clínica de los caballos, que provoca, entre otros síntomas, dolor y cojera, y es una importante causa de eutanasia. En esta condición, hay un debilitamiento de la conexión entre la caja corneal y la falange distal, lo que resulta en el hundimiento y la rotación palmar / plantar de este hueso. Varios mecanismos están involucrados en la patogenia de la laminitis, incluyendo teorías vasculares, enzimáticas, traumáticas, de privación de glucosa y endocrinopáticas, por lo que puede ocurrir como consecuencia de varias otras enfermedades, como los cólicos y la enfermedad metabólica equina. Sin embargo, la compresión de los mecanismos que gobiernan los cambios que se producen en la fisiopatología de esta enfermedad es bastante compleja, y aún no se ha dilucidado por completo. Este factor limita el desarrollo de terapias efectivas para curar la laminitis. El diagnóstico se puede realizar mediante la evaluación de la historia del animal, signos clínicos, exploración física y pruebas complementarias, como radiografía, bloqueos anestésicos, venografía, termografía, entre otros métodos. La terapia debe implicar el control del dolor y la estabilización del tejido laminar, y varía según el estadio de desarrollo de la enfermedad, especialmente las fases aguda y crónica. Así, la medicina regenerativa, que incluye el uso de células madre mesenquimales, ha ganado un protagonismo considerable en los últimos años, ya que tiene una influencia positiva en la curación de diversas lesiones ortopédicas en caballos.A laminite é uma doença bastante frequente na rotina clínica de equinos, que provoca, entre outros sintomas, dor e claudicação, sendo uma causa importante de eutanásia. Nesta afecção, ocorre o enfraquecimento da ligação entre o estojo córneo e a falange distal, resultando no afundamento e na rotação palmar/plantar desse osso. Diversos mecanismos estão envolvidos na patogênese da laminite, que incluem as teorias vascular, a enzimática, a traumática, a de privação de glicose e a endocrinopática, de modo que pode ocorrer secundariamente a diversas outras doenças, como cólica e doença metabólica equina. Entretanto, a compressão dos mecanismos que regem as alterações ocorridas na fisiopatologia dessa doença é bastante complexa, e ainda não está completamente elucidada. Esse fator limita o desenvolvimento de terapias eficazes para a cura da laminite. O diagnóstico pode ser feito por meio da avaliação do histórico do animal, sinais clínicos, exame físico e dos exames complementares, como radiografia, bloqueios anestésicos, venografia, termografia, entre outros métodos. A terapia deve envolver o controle da dor e estabilização do tecido laminar, e varia de acordo com o estágio de desenvolvimento da doença, principalmente, as fases aguda e crônica. Dessa forma, a medicina regenerativa, que inclui a utilização de células-tronco mesenquimais, tem ganhado bastante destaque nos últimos anos, uma vez que apresenta uma influência positiva na cura de várias lesões ortopédicas em equinos.Research, Society and Development2021-08-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1890210.33448/rsd-v10i10.18902Research, Society and Development; Vol. 10 No. 10; e436101018902Research, Society and Development; Vol. 10 Núm. 10; e436101018902Research, Society and Development; v. 10 n. 10; e4361010189022525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/18902/16990Copyright (c) 2021 Ana Beatriz dos Santos Mendes; Ana Thays dos Santos da Silva; Lohane Leonel de Castro; Kissya Ellen Alves da Silva ; Marcio Gomes de Alencar Araripehttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMendes, Ana Beatriz dos Santos Silva, Ana Thays dos Santos da Castro, Lohane Leonel de Silva , Kissya Ellen Alves da Araripe, Marcio Gomes de Alencar 2021-10-02T21:49:16Zoai:ojs.pkp.sfu.ca:article/18902Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:38:55.500373Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Therapeutic potencial of mesenquimal stem cells in equine laminitis Potencial terapêutico de células madre mesenquimales em laminitis equina Potencial terapêutico de células-tronco mesenquimais na laminite equina |
title |
Therapeutic potencial of mesenquimal stem cells in equine laminitis |
spellingShingle |
Therapeutic potencial of mesenquimal stem cells in equine laminitis Mendes, Ana Beatriz dos Santos Equino Laminite Células-tronco mesenquimais. Equino Laminitis Células madre mesenquimales. Equine Laminitis Mesenchymal stem cells. |
title_short |
Therapeutic potencial of mesenquimal stem cells in equine laminitis |
title_full |
Therapeutic potencial of mesenquimal stem cells in equine laminitis |
title_fullStr |
Therapeutic potencial of mesenquimal stem cells in equine laminitis |
title_full_unstemmed |
Therapeutic potencial of mesenquimal stem cells in equine laminitis |
title_sort |
Therapeutic potencial of mesenquimal stem cells in equine laminitis |
author |
Mendes, Ana Beatriz dos Santos |
author_facet |
Mendes, Ana Beatriz dos Santos Silva, Ana Thays dos Santos da Castro, Lohane Leonel de Silva , Kissya Ellen Alves da Araripe, Marcio Gomes de Alencar |
author_role |
author |
author2 |
Silva, Ana Thays dos Santos da Castro, Lohane Leonel de Silva , Kissya Ellen Alves da Araripe, Marcio Gomes de Alencar |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Mendes, Ana Beatriz dos Santos Silva, Ana Thays dos Santos da Castro, Lohane Leonel de Silva , Kissya Ellen Alves da Araripe, Marcio Gomes de Alencar |
dc.subject.por.fl_str_mv |
Equino Laminite Células-tronco mesenquimais. Equino Laminitis Células madre mesenquimales. Equine Laminitis Mesenchymal stem cells. |
topic |
Equino Laminite Células-tronco mesenquimais. Equino Laminitis Células madre mesenquimales. Equine Laminitis Mesenchymal stem cells. |
description |
Laminitis is a very common disease in the clinical routine of horses, which causes, among other symptoms, pain and lameness, being an important cause of euthanasia. In this condition, there is a weakening of the connection between the horny case and the distal phalanx, resulting in the sinking and palmar / plantar rotation of this bone. Several mechanisms are involved in the pathogenesis of laminitis, which include vascular, enzymatic, traumatic, glucose deprivation and endocrinopathic theories, so that it can occur secondarily to several other diseases, such as colic and equine metabolic disease. However, the compression of the mechanisms that govern changes in the pathophysiology of this disease is quite complex, and is not yet fully understood. This factor limits the development of effective therapies for curing laminitis. The diagnosis can be made through the evaluation of the animal's history, clinical signs, physical examination and complementary exams, such as radiography, anesthetic blocks, venography, thermography, among other methods. Therapy should involve pain control and stabilization of laminar tissue, and varies according to the stage of development of the disease, especially the acute and chronic phases. Thus, regenerative medicine, which includes the use of mesenchymal stem cells, has gained considerable prominence in recent years, since it has a positive influence on the cure of various orthopedic injuries in horses. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08-15 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/18902 10.33448/rsd-v10i10.18902 |
url |
https://rsdjournal.org/index.php/rsd/article/view/18902 |
identifier_str_mv |
10.33448/rsd-v10i10.18902 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/18902/16990 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 10; e436101018902 Research, Society and Development; Vol. 10 Núm. 10; e436101018902 Research, Society and Development; v. 10 n. 10; e436101018902 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052686122614784 |