Therapeutic potencial of mesenquimal stem cells in equine laminitis

Detalhes bibliográficos
Autor(a) principal: Mendes, Ana Beatriz dos Santos
Data de Publicação: 2021
Outros Autores: Silva, Ana Thays dos Santos da, Castro, Lohane Leonel de, Silva , Kissya Ellen Alves da, Araripe, Marcio Gomes de Alencar
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/18902
Resumo: Laminitis is a very common disease in the clinical routine of horses, which causes, among other symptoms, pain and lameness, being an important cause of euthanasia. In this condition, there is a weakening of the connection between the horny case and the distal phalanx, resulting in the sinking and palmar / plantar rotation of this bone. Several mechanisms are involved in the pathogenesis of laminitis, which include vascular, enzymatic, traumatic, glucose deprivation and endocrinopathic theories, so that it can occur secondarily to several other diseases, such as colic and equine metabolic disease. However, the compression of the mechanisms that govern changes in the pathophysiology of this disease is quite complex, and is not yet fully understood. This factor limits the development of effective therapies for curing laminitis. The diagnosis can be made through the evaluation of the animal's history, clinical signs, physical examination and complementary exams, such as radiography, anesthetic blocks, venography, thermography, among other methods. Therapy should involve pain control and stabilization of laminar tissue, and varies according to the stage of development of the disease, especially the acute and chronic phases. Thus, regenerative medicine, which includes the use of mesenchymal stem cells, has gained considerable prominence in recent years, since it has a positive influence on the cure of various orthopedic injuries in horses.
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spelling Therapeutic potencial of mesenquimal stem cells in equine laminitisPotencial terapêutico de células madre mesenquimales em laminitis equinaPotencial terapêutico de células-tronco mesenquimais na laminite equinaEquinoLaminiteCélulas-tronco mesenquimais.EquinoLaminitisCélulas madre mesenquimales.EquineLaminitisMesenchymal stem cells.Laminitis is a very common disease in the clinical routine of horses, which causes, among other symptoms, pain and lameness, being an important cause of euthanasia. In this condition, there is a weakening of the connection between the horny case and the distal phalanx, resulting in the sinking and palmar / plantar rotation of this bone. Several mechanisms are involved in the pathogenesis of laminitis, which include vascular, enzymatic, traumatic, glucose deprivation and endocrinopathic theories, so that it can occur secondarily to several other diseases, such as colic and equine metabolic disease. However, the compression of the mechanisms that govern changes in the pathophysiology of this disease is quite complex, and is not yet fully understood. This factor limits the development of effective therapies for curing laminitis. The diagnosis can be made through the evaluation of the animal's history, clinical signs, physical examination and complementary exams, such as radiography, anesthetic blocks, venography, thermography, among other methods. Therapy should involve pain control and stabilization of laminar tissue, and varies according to the stage of development of the disease, especially the acute and chronic phases. Thus, regenerative medicine, which includes the use of mesenchymal stem cells, has gained considerable prominence in recent years, since it has a positive influence on the cure of various orthopedic injuries in horses.La laminitis es una enfermedad muy común en la rutina clínica de los caballos, que provoca, entre otros síntomas, dolor y cojera, y es una importante causa de eutanasia. En esta condición, hay un debilitamiento de la conexión entre la caja corneal y la falange distal, lo que resulta en el hundimiento y la rotación palmar / plantar de este hueso. Varios mecanismos están involucrados en la patogenia de la laminitis, incluyendo teorías vasculares, enzimáticas, traumáticas, de privación de glucosa y endocrinopáticas, por lo que puede ocurrir como consecuencia de varias otras enfermedades, como los cólicos y la enfermedad metabólica equina. Sin embargo, la compresión de los mecanismos que gobiernan los cambios que se producen en la fisiopatología de esta enfermedad es bastante compleja, y aún no se ha dilucidado por completo. Este factor limita el desarrollo de terapias efectivas para curar la laminitis. El diagnóstico se puede realizar mediante la evaluación de la historia del animal, signos clínicos, exploración física y pruebas complementarias, como radiografía, bloqueos anestésicos, venografía, termografía, entre otros métodos. La terapia debe implicar el control del dolor y la estabilización del tejido laminar, y varía según el estadio de desarrollo de la enfermedad, especialmente las fases aguda y crónica. Así, la medicina regenerativa, que incluye el uso de células madre mesenquimales, ha ganado un protagonismo considerable en los últimos años, ya que tiene una influencia positiva en la curación de diversas lesiones ortopédicas en caballos.A laminite é uma doença bastante frequente na rotina clínica de equinos, que provoca, entre outros sintomas, dor e claudicação, sendo uma causa importante de eutanásia. Nesta afecção, ocorre o enfraquecimento da ligação entre o estojo córneo e a falange distal, resultando no afundamento e na rotação palmar/plantar desse osso. Diversos mecanismos estão envolvidos na patogênese da laminite, que incluem as teorias vascular, a enzimática, a traumática, a de privação de glicose e a endocrinopática, de modo que pode ocorrer secundariamente a diversas outras doenças, como cólica e doença metabólica equina. Entretanto, a compressão dos mecanismos que regem as alterações ocorridas na fisiopatologia dessa doença é bastante complexa, e ainda não está completamente elucidada. Esse fator limita o desenvolvimento de terapias eficazes para a cura da laminite. O diagnóstico pode ser feito por meio da avaliação do histórico do animal, sinais clínicos, exame físico e dos exames complementares, como radiografia, bloqueios anestésicos, venografia, termografia, entre outros métodos. A terapia deve envolver o controle da dor e estabilização do tecido laminar, e varia de acordo com o estágio de desenvolvimento da doença, principalmente, as fases aguda e crônica. Dessa forma, a medicina regenerativa, que inclui a utilização de células-tronco mesenquimais, tem ganhado bastante destaque nos últimos anos, uma vez que apresenta uma influência positiva na cura de várias lesões ortopédicas em equinos.Research, Society and Development2021-08-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1890210.33448/rsd-v10i10.18902Research, Society and Development; Vol. 10 No. 10; e436101018902Research, Society and Development; Vol. 10 Núm. 10; e436101018902Research, Society and Development; v. 10 n. 10; e4361010189022525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/18902/16990Copyright (c) 2021 Ana Beatriz dos Santos Mendes; Ana Thays dos Santos da Silva; Lohane Leonel de Castro; Kissya Ellen Alves da Silva ; Marcio Gomes de Alencar Araripehttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMendes, Ana Beatriz dos Santos Silva, Ana Thays dos Santos da Castro, Lohane Leonel de Silva , Kissya Ellen Alves da Araripe, Marcio Gomes de Alencar 2021-10-02T21:49:16Zoai:ojs.pkp.sfu.ca:article/18902Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:38:55.500373Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Therapeutic potencial of mesenquimal stem cells in equine laminitis
Potencial terapêutico de células madre mesenquimales em laminitis equina
Potencial terapêutico de células-tronco mesenquimais na laminite equina
title Therapeutic potencial of mesenquimal stem cells in equine laminitis
spellingShingle Therapeutic potencial of mesenquimal stem cells in equine laminitis
Mendes, Ana Beatriz dos Santos
Equino
Laminite
Células-tronco mesenquimais.
Equino
Laminitis
Células madre mesenquimales.
Equine
Laminitis
Mesenchymal stem cells.
title_short Therapeutic potencial of mesenquimal stem cells in equine laminitis
title_full Therapeutic potencial of mesenquimal stem cells in equine laminitis
title_fullStr Therapeutic potencial of mesenquimal stem cells in equine laminitis
title_full_unstemmed Therapeutic potencial of mesenquimal stem cells in equine laminitis
title_sort Therapeutic potencial of mesenquimal stem cells in equine laminitis
author Mendes, Ana Beatriz dos Santos
author_facet Mendes, Ana Beatriz dos Santos
Silva, Ana Thays dos Santos da
Castro, Lohane Leonel de
Silva , Kissya Ellen Alves da
Araripe, Marcio Gomes de Alencar
author_role author
author2 Silva, Ana Thays dos Santos da
Castro, Lohane Leonel de
Silva , Kissya Ellen Alves da
Araripe, Marcio Gomes de Alencar
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Mendes, Ana Beatriz dos Santos
Silva, Ana Thays dos Santos da
Castro, Lohane Leonel de
Silva , Kissya Ellen Alves da
Araripe, Marcio Gomes de Alencar
dc.subject.por.fl_str_mv Equino
Laminite
Células-tronco mesenquimais.
Equino
Laminitis
Células madre mesenquimales.
Equine
Laminitis
Mesenchymal stem cells.
topic Equino
Laminite
Células-tronco mesenquimais.
Equino
Laminitis
Células madre mesenquimales.
Equine
Laminitis
Mesenchymal stem cells.
description Laminitis is a very common disease in the clinical routine of horses, which causes, among other symptoms, pain and lameness, being an important cause of euthanasia. In this condition, there is a weakening of the connection between the horny case and the distal phalanx, resulting in the sinking and palmar / plantar rotation of this bone. Several mechanisms are involved in the pathogenesis of laminitis, which include vascular, enzymatic, traumatic, glucose deprivation and endocrinopathic theories, so that it can occur secondarily to several other diseases, such as colic and equine metabolic disease. However, the compression of the mechanisms that govern changes in the pathophysiology of this disease is quite complex, and is not yet fully understood. This factor limits the development of effective therapies for curing laminitis. The diagnosis can be made through the evaluation of the animal's history, clinical signs, physical examination and complementary exams, such as radiography, anesthetic blocks, venography, thermography, among other methods. Therapy should involve pain control and stabilization of laminar tissue, and varies according to the stage of development of the disease, especially the acute and chronic phases. Thus, regenerative medicine, which includes the use of mesenchymal stem cells, has gained considerable prominence in recent years, since it has a positive influence on the cure of various orthopedic injuries in horses.
publishDate 2021
dc.date.none.fl_str_mv 2021-08-15
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/18902
10.33448/rsd-v10i10.18902
url https://rsdjournal.org/index.php/rsd/article/view/18902
identifier_str_mv 10.33448/rsd-v10i10.18902
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/18902/16990
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 10; e436101018902
Research, Society and Development; Vol. 10 Núm. 10; e436101018902
Research, Society and Development; v. 10 n. 10; e436101018902
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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