Bioactive potential of riparina synthetic analogs: a systematic review
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/23510 |
Resumo: | Objective: To carry out a systematic review of studies with synthetic analogues of Aniba riparia, riparins A, B, C, D, E and F, in order to highlight the pharmacological potentials already elucidated. Methodology: Three databases were used to select the articles to be included in the Embase, Pubmed and Web of Science review, with the following simplified search strategy (Riparin or Aniba riparia), at the end of the selection, resulting in 10 articles for the elaboration of this work. Results: Publications of studies with synthetic derivatives were identified between the years 2014 to 2021. Most of the researches used riparin A, followed by B, and all were pre-clinical studies. Important pharmacological effects have been reported, such as antibacterial, antifungal, anti-inflammatory, antinociceptive, antitumor, immunomodulatory, antiprotozoal, antiparasitic, anxiolytic and antioxidant activities. Discussion: Studies carried out with synthetic analogues have placed them as possible therapeutic tools, considering the important pharmacological activities already reported. Conclusion: However, considering that the literature already reports six synthetic riparins, the number of articles published aimed at elucidating possible pharmacological activities seems small, even though they are promising candidates for the development of research aimed at discovering new drugs. |
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Bioactive potential of riparina synthetic analogs: a systematic reviewPotencial bioactivo de los análogos sintéticos de riparina: una revisión sistemáticaPotencial bioativo dos análogos sintéticos das riparinas: uma revisão sistemáticaAniba ripariaBioprospecçãoAções farmacológicas.Aniba ripariaBioprospecciónAcciones farmacológicas.Aniba ripariaBioprospectingPharmacologic actions.Objective: To carry out a systematic review of studies with synthetic analogues of Aniba riparia, riparins A, B, C, D, E and F, in order to highlight the pharmacological potentials already elucidated. Methodology: Three databases were used to select the articles to be included in the Embase, Pubmed and Web of Science review, with the following simplified search strategy (Riparin or Aniba riparia), at the end of the selection, resulting in 10 articles for the elaboration of this work. Results: Publications of studies with synthetic derivatives were identified between the years 2014 to 2021. Most of the researches used riparin A, followed by B, and all were pre-clinical studies. Important pharmacological effects have been reported, such as antibacterial, antifungal, anti-inflammatory, antinociceptive, antitumor, immunomodulatory, antiprotozoal, antiparasitic, anxiolytic and antioxidant activities. Discussion: Studies carried out with synthetic analogues have placed them as possible therapeutic tools, considering the important pharmacological activities already reported. Conclusion: However, considering that the literature already reports six synthetic riparins, the number of articles published aimed at elucidating possible pharmacological activities seems small, even though they are promising candidates for the development of research aimed at discovering new drugs.Objetivo: Realizar una revisión sistemática de estudios con análogos sintéticos de Aniba riparia, riparinas A, B, C, D, E y F, con el fin de resaltar los potenciales farmacológicos ya dilucidados. Metodología: Se utilizaron tres bases de datos para seleccionar los artículos a incluir en la revisión Embase, Pubmed y Web of Science, con la siguiente estrategia de búsqueda simplificada (Riparin o Aniba riparia), al final de la selección, resultando en 10 artículos para la elaboración de este trabajo. Resultados: Se identificaron publicaciones de estudios con derivados sintéticos entre los años 2014 a 2021. La mayoría de las investigaciones utilizaron riparina A, seguida de B, y todas fueron estudios preclínicos. Se han reportado efectos farmacológicos importantes, tales como actividades antibacterianas, antifúngicas, antiinflamatorias, antinociceptivas, antitumorales, inmunomoduladoras, antiprotozoarias, antiparasitarias, ansiolíticas y antioxidantes. Discusión: Los estudios realizados con análogos sintéticos los han colocado como posibles herramientas terapéuticas, considerando las importantes actividades farmacológicas ya reportadas. Conclusión: Sin embargo, considerando que la literatura ya reporta seis riparinas sintéticas, el número de artículos publicados para dilucidar posibles actividades farmacológicas es pequeño, aunque son candidatos prometedores para el desarrollo de investigaciones dirigidas al descubrimiento de nuevos fármacos.Objetivo: Realizar uma revisão sistemática dos estudos com os análogos sintéticos da Aniba riparia, as riparinas A, B, C, D, E e F, com o intuito de evidenciar os potenciais farmacológicos já elucidados. Metodologia: Utilizou-se três bases de dados para seleção dos artigos a serem incluídos na revisão Embase, Pubmed e Web of Science, com a seguinte estratégia de busca simplificada (Riparin or Aniba riparia), ao final da seleção, resultou em 10 artigos para a elaboração deste trabalho. Resultados: As publicações dos estudos com derivados sintéticos foram identificadas entre os anos de 2014 a 2021. Sendo que a maioria das pesquisas utilizavam a riparina A, seguida pela B, e todos tratavam-se de estudos pré-clínicos. Foram relatados importantes efeitos farmacológicos, como as atividades antibacteriana, antifúngica, anti-inflamatória, antinociceptiva, antitumoral, imunomoduladora, antiprotozoário, antiparasitária, ansiolítica e antioxidante. Discussão: Os estudos realizados com os análogos sintéticos têm colocado as mesmas como possíveis ferramentas terapêuticas, considerando as importantes atividades farmacológicas já relatadas. Conclusão: Contudo, considerando que a literatura já relata seis riparinas sintéticas, o número de artigos publicados voltados para elucidação de possíveis atividades farmacológicas parece reduzido, mesmo sendo promissoras candidatas para o desenvolvimento de pesquisas direcionadas para descobertas de novos fármacos.Research, Society and Development2021-12-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2351010.33448/rsd-v10i16.23510Research, Society and Development; Vol. 10 No. 16; e328101623510Research, Society and Development; Vol. 10 Núm. 16; e328101623510Research, Society and Development; v. 10 n. 16; e3281016235102525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/23510/20978Copyright (c) 2021 Duanne Mendes Gomes; Paulo Monteiro Araujo; Sávio Freire da Silva; Veridiana Rebelo dos Santos; Stanley Juan Chavez Gutierrez; Lyghia Maria Araújo Meirelles; Maria das Graças Freire de Medeiros Carvalhohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessGomes, Duanne MendesAraujo, Paulo MonteiroSilva, Sávio Freire daSantos, Veridiana Rebelo dosGutierrez, Stanley Juan ChavezMeirelles, Lyghia Maria AraújoCarvalho, Maria das Graças Freire de Medeiros 2021-12-20T11:03:07Zoai:ojs.pkp.sfu.ca:article/23510Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:42:21.532951Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Bioactive potential of riparina synthetic analogs: a systematic review Potencial bioactivo de los análogos sintéticos de riparina: una revisión sistemática Potencial bioativo dos análogos sintéticos das riparinas: uma revisão sistemática |
title |
Bioactive potential of riparina synthetic analogs: a systematic review |
spellingShingle |
Bioactive potential of riparina synthetic analogs: a systematic review Gomes, Duanne Mendes Aniba riparia Bioprospecção Ações farmacológicas. Aniba riparia Bioprospección Acciones farmacológicas. Aniba riparia Bioprospecting Pharmacologic actions. |
title_short |
Bioactive potential of riparina synthetic analogs: a systematic review |
title_full |
Bioactive potential of riparina synthetic analogs: a systematic review |
title_fullStr |
Bioactive potential of riparina synthetic analogs: a systematic review |
title_full_unstemmed |
Bioactive potential of riparina synthetic analogs: a systematic review |
title_sort |
Bioactive potential of riparina synthetic analogs: a systematic review |
author |
Gomes, Duanne Mendes |
author_facet |
Gomes, Duanne Mendes Araujo, Paulo Monteiro Silva, Sávio Freire da Santos, Veridiana Rebelo dos Gutierrez, Stanley Juan Chavez Meirelles, Lyghia Maria Araújo Carvalho, Maria das Graças Freire de Medeiros |
author_role |
author |
author2 |
Araujo, Paulo Monteiro Silva, Sávio Freire da Santos, Veridiana Rebelo dos Gutierrez, Stanley Juan Chavez Meirelles, Lyghia Maria Araújo Carvalho, Maria das Graças Freire de Medeiros |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Gomes, Duanne Mendes Araujo, Paulo Monteiro Silva, Sávio Freire da Santos, Veridiana Rebelo dos Gutierrez, Stanley Juan Chavez Meirelles, Lyghia Maria Araújo Carvalho, Maria das Graças Freire de Medeiros |
dc.subject.por.fl_str_mv |
Aniba riparia Bioprospecção Ações farmacológicas. Aniba riparia Bioprospección Acciones farmacológicas. Aniba riparia Bioprospecting Pharmacologic actions. |
topic |
Aniba riparia Bioprospecção Ações farmacológicas. Aniba riparia Bioprospección Acciones farmacológicas. Aniba riparia Bioprospecting Pharmacologic actions. |
description |
Objective: To carry out a systematic review of studies with synthetic analogues of Aniba riparia, riparins A, B, C, D, E and F, in order to highlight the pharmacological potentials already elucidated. Methodology: Three databases were used to select the articles to be included in the Embase, Pubmed and Web of Science review, with the following simplified search strategy (Riparin or Aniba riparia), at the end of the selection, resulting in 10 articles for the elaboration of this work. Results: Publications of studies with synthetic derivatives were identified between the years 2014 to 2021. Most of the researches used riparin A, followed by B, and all were pre-clinical studies. Important pharmacological effects have been reported, such as antibacterial, antifungal, anti-inflammatory, antinociceptive, antitumor, immunomodulatory, antiprotozoal, antiparasitic, anxiolytic and antioxidant activities. Discussion: Studies carried out with synthetic analogues have placed them as possible therapeutic tools, considering the important pharmacological activities already reported. Conclusion: However, considering that the literature already reports six synthetic riparins, the number of articles published aimed at elucidating possible pharmacological activities seems small, even though they are promising candidates for the development of research aimed at discovering new drugs. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-12-13 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/23510 10.33448/rsd-v10i16.23510 |
url |
https://rsdjournal.org/index.php/rsd/article/view/23510 |
identifier_str_mv |
10.33448/rsd-v10i16.23510 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/23510/20978 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 16; e328101623510 Research, Society and Development; Vol. 10 Núm. 16; e328101623510 Research, Society and Development; v. 10 n. 16; e328101623510 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
_version_ |
1797052698057506816 |