Pharmacological activities and their relationship with the oxidative stress of Morinda Citrifolia L. (Rubiaceae): an integrative review

Detalhes bibliográficos
Autor(a) principal: Gomes-Sousa, Nathália Cássia
Data de Publicação: 2021
Outros Autores: Nunes, Lucas dos Santos, Martins, Hanna Patrícia dos Santos, Percário, Sandro, Dolabela, Maria Fâni
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/14149
Resumo: The present work made an analysis of pharmacological studies of Morinda citrifolia L. and the role of oxidative stress. The research was carried out on the Capes and PubMed Journals Portal. Initially, titles, abstracts were read and those that had no relation to the topic and in duplicate were excluded. After this process, the works were read in full and the information was extracted. A total of 517 articles were found, after reading the titles and abstracts, 39 articles were selected and at the end 28 were included. Regarding the activities evaluated, 9 articles evaluated the antioxidant and anti-inflammatory activity; 5 antitumor and cytotoxicity; 3 antimicrobials; 3 antileishmania; and 8 articles that researched about different activities. According to the studies analyzed, this species has anti-inflammatory, hypotensive potential, prevention of pancreatitis, hepatoprotective and cytoprotective, and such activities seem to be related to the presence of metabolites with antioxidant activity. The antitumor activity may be related to the oxidizing activity of anthraquinones. The role of oxidative stress in the hypoglycemic and anti-obesity effects of the species still needs to be further investigated. In summary, most of the biological activities attributed to M. citrifolia can be related to the presence of compounds with antioxidant potential.
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spelling Pharmacological activities and their relationship with the oxidative stress of Morinda Citrifolia L. (Rubiaceae): an integrative reviewActividades farmacológicas y su relación com el estrés oxidativo de Morinda Citrifolia L. (Rubiaceae): una revisión integradoraAtividades farmacológicas e sua relação com o estresse oxidativo de Morinda citrifolia L. (Rubiaceae): uma revisão integrativaMorinda citrifoliaEstresse oxidativoFlavonoideIridoideAntraquinona.Morinda citrifoliaOxidative stressFlavonoidIridoideAnthraquinone.Morinda citrifoliaEstrés oxidativoFlavonoideIridoideAntraquinona.The present work made an analysis of pharmacological studies of Morinda citrifolia L. and the role of oxidative stress. The research was carried out on the Capes and PubMed Journals Portal. Initially, titles, abstracts were read and those that had no relation to the topic and in duplicate were excluded. After this process, the works were read in full and the information was extracted. A total of 517 articles were found, after reading the titles and abstracts, 39 articles were selected and at the end 28 were included. Regarding the activities evaluated, 9 articles evaluated the antioxidant and anti-inflammatory activity; 5 antitumor and cytotoxicity; 3 antimicrobials; 3 antileishmania; and 8 articles that researched about different activities. According to the studies analyzed, this species has anti-inflammatory, hypotensive potential, prevention of pancreatitis, hepatoprotective and cytoprotective, and such activities seem to be related to the presence of metabolites with antioxidant activity. The antitumor activity may be related to the oxidizing activity of anthraquinones. The role of oxidative stress in the hypoglycemic and anti-obesity effects of the species still needs to be further investigated. In summary, most of the biological activities attributed to M. citrifolia can be related to the presence of compounds with antioxidant potential.El presente trabajo realizó un análisis de los estudios farmacológicos de Morinda citrifolia L. y el papel del estrés oxidativo. La investigación se realizó en el Portal de Revistas Capes y PubMed. Inicialmente se leyeron títulos, resúmenes y se excluyeron aquellos que no tuvieran relación con el tema y por duplicado. Luego de este proceso, se leyeron las obras íntegramente y se extrajo la información. Se encontraron un total de 517 artículos, luego de la lectura de títulos y resúmenes se seleccionaron 39 artículos y al final se incluyeron 28. En cuanto a las actividades evaluadas, 9 artículos evaluaron la actividad antioxidante y antiinflamatoria; 5 antitumoral y citotoxicidad; 3 antimicrobianos; 3 antileishmania; y 8 artículos que investigaron sobre diferentes actividades. Según los estudios analizados, esta especie tiene potencial antiinflamatorio, hipotensor, preventivo de pancreatitis, hepatoprotector y citoprotector, y dichas actividades parecen estar relacionadas con la presencia de metabolitos con actividad antioxidante. La actividad antitumoral puede estar relacionada con la actividad oxidante de las antraquinonas. El papel del estrés oxidativo en los efectos hipoglucémicos y antiobesidad de la especie aún necesita ser investigado más a fondo. En resumen, la mayoría de las actividades biológicas atribuidas a M. citrifolia pueden estar relacionadas con la presencia de compuestos con potencial antioxidante.O presente trabalho fez uma análise de estudos farmacológicos de Morinda citrifolia L. e o papel do estresse oxidativo. A pesquisa foi realizada no Portal de Periódicos da Capes e PubMed. Inicialmente, foram lidos os títulos, resumos e excluídos os que não tinham relação com o tema e em duplicidade. Após esse processo, os trabalhos foram lidos na íntegra e realizada a extração das informações. Foram encontrados no total 517 artigos, após a leitura dos títulos e resumos, foram selecionados 39 artigos e ao final incluídos 28. Em relação às atividades avaliadas, 9 artigos avaliaram a atividade antioxidante e anti-inflamatória; 5 antitumoral e citotoxicidade; 3 antimicrobianos; 3 antileishmania; e 8 artigos que pesquisaram sobre diferentes atividades. De acordo com os estudos analisados esta espécie possui potencial anti-inflamatório, hipotensor, prevenção de pancreatite, hepatoprotetor e citoprotetor, e tais atividades parecem estar relacionadas a presença de metabólitos com atividade antioxidantes. A atividade antitumoral pode estar relacionada à atividade oxidante das antraquinonas. A participação do estresse oxidativo no efeito hipoglicemiante e antiobesidade da espécie ainda precisa ser melhor investigada. Em síntese, a maioria das atividades biológicas atribuídas a M. citrifolia pode ser relacionada a presença de compostos com potencial antioxidante.Research, Society and Development2021-04-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1414910.33448/rsd-v10i4.14149Research, Society and Development; Vol. 10 No. 4; e30210414149Research, Society and Development; Vol. 10 Núm. 4; e30210414149Research, Society and Development; v. 10 n. 4; e302104141492525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/14149/12705Copyright (c) 2021 Nathália Cássia Gomes-Sousa; Lucas dos Santos Nunes; Hanna Patrícia dos Santos Martins; Sandro Percário; Maria Fâni Dolabelahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessGomes-Sousa, Nathália Cássia Nunes, Lucas dos SantosMartins, Hanna Patrícia dos Santos Percário, SandroDolabela, Maria Fâni 2021-04-25T11:21:26Zoai:ojs.pkp.sfu.ca:article/14149Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:35:20.443017Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Pharmacological activities and their relationship with the oxidative stress of Morinda Citrifolia L. (Rubiaceae): an integrative review
Actividades farmacológicas y su relación com el estrés oxidativo de Morinda Citrifolia L. (Rubiaceae): una revisión integradora
Atividades farmacológicas e sua relação com o estresse oxidativo de Morinda citrifolia L. (Rubiaceae): uma revisão integrativa
title Pharmacological activities and their relationship with the oxidative stress of Morinda Citrifolia L. (Rubiaceae): an integrative review
spellingShingle Pharmacological activities and their relationship with the oxidative stress of Morinda Citrifolia L. (Rubiaceae): an integrative review
Gomes-Sousa, Nathália Cássia
Morinda citrifolia
Estresse oxidativo
Flavonoide
Iridoide
Antraquinona.
Morinda citrifolia
Oxidative stress
Flavonoid
Iridoide
Anthraquinone.
Morinda citrifolia
Estrés oxidativo
Flavonoide
Iridoide
Antraquinona.
title_short Pharmacological activities and their relationship with the oxidative stress of Morinda Citrifolia L. (Rubiaceae): an integrative review
title_full Pharmacological activities and their relationship with the oxidative stress of Morinda Citrifolia L. (Rubiaceae): an integrative review
title_fullStr Pharmacological activities and their relationship with the oxidative stress of Morinda Citrifolia L. (Rubiaceae): an integrative review
title_full_unstemmed Pharmacological activities and their relationship with the oxidative stress of Morinda Citrifolia L. (Rubiaceae): an integrative review
title_sort Pharmacological activities and their relationship with the oxidative stress of Morinda Citrifolia L. (Rubiaceae): an integrative review
author Gomes-Sousa, Nathália Cássia
author_facet Gomes-Sousa, Nathália Cássia
Nunes, Lucas dos Santos
Martins, Hanna Patrícia dos Santos
Percário, Sandro
Dolabela, Maria Fâni
author_role author
author2 Nunes, Lucas dos Santos
Martins, Hanna Patrícia dos Santos
Percário, Sandro
Dolabela, Maria Fâni
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Gomes-Sousa, Nathália Cássia
Nunes, Lucas dos Santos
Martins, Hanna Patrícia dos Santos
Percário, Sandro
Dolabela, Maria Fâni
dc.subject.por.fl_str_mv Morinda citrifolia
Estresse oxidativo
Flavonoide
Iridoide
Antraquinona.
Morinda citrifolia
Oxidative stress
Flavonoid
Iridoide
Anthraquinone.
Morinda citrifolia
Estrés oxidativo
Flavonoide
Iridoide
Antraquinona.
topic Morinda citrifolia
Estresse oxidativo
Flavonoide
Iridoide
Antraquinona.
Morinda citrifolia
Oxidative stress
Flavonoid
Iridoide
Anthraquinone.
Morinda citrifolia
Estrés oxidativo
Flavonoide
Iridoide
Antraquinona.
description The present work made an analysis of pharmacological studies of Morinda citrifolia L. and the role of oxidative stress. The research was carried out on the Capes and PubMed Journals Portal. Initially, titles, abstracts were read and those that had no relation to the topic and in duplicate were excluded. After this process, the works were read in full and the information was extracted. A total of 517 articles were found, after reading the titles and abstracts, 39 articles were selected and at the end 28 were included. Regarding the activities evaluated, 9 articles evaluated the antioxidant and anti-inflammatory activity; 5 antitumor and cytotoxicity; 3 antimicrobials; 3 antileishmania; and 8 articles that researched about different activities. According to the studies analyzed, this species has anti-inflammatory, hypotensive potential, prevention of pancreatitis, hepatoprotective and cytoprotective, and such activities seem to be related to the presence of metabolites with antioxidant activity. The antitumor activity may be related to the oxidizing activity of anthraquinones. The role of oxidative stress in the hypoglycemic and anti-obesity effects of the species still needs to be further investigated. In summary, most of the biological activities attributed to M. citrifolia can be related to the presence of compounds with antioxidant potential.
publishDate 2021
dc.date.none.fl_str_mv 2021-04-11
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/14149
10.33448/rsd-v10i4.14149
url https://rsdjournal.org/index.php/rsd/article/view/14149
identifier_str_mv 10.33448/rsd-v10i4.14149
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/14149/12705
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 4; e30210414149
Research, Society and Development; Vol. 10 Núm. 4; e30210414149
Research, Society and Development; v. 10 n. 4; e30210414149
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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