Remote organs respond differently to curcumin treatment after intestinal ischemia/reperfusion injury
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/9660 |
Resumo: | We aimed investigate the effects of 45 min of ischemia followed by 72 h of intestinal reperfusion (IR) in the ileum, liver, lungs, and kidneys in Wistar rats and the responses of these organs to curcumin treatment. Ischemia was induced by occluding the superior mesenteric artery. Rats were treated orally with 40 mg/kg curcumin. We analyzed oxidative stress and inflammation in the ileum, liver, lungs, and kidneys. Intestinal IR led to a reduction of reduced glutathione levels in the intestine, lungs, and kidneys and increased lipid hydroperoxide levels in all organs. An increase in the enzymatic activity of catalase was observed in all organs, and an increase in superoxide dismutase activity was observed in the ileum and lungs. Glutathione s-transferase levels increased only in the kidneys. Myeloperoxidase increased in all four organs, and n-acetyl-glycosaminidase increased only in the ileum and lungs. Curcumin prevented all of the changes in the ileum and liver. In the lungs, curcumin had no effect on n-acetyl-glycosaminidase. Curcumin did not prevent the changes in reduced glutathione, lipid hydroperoxides, or myeloperoxidase in the kidneys. Intestinal IR caused oxidative stress and inflammation in the ileum, lungs, and kidneys and to a lesser degree in the liver. Because of its systemic distribution, curcumin prevented changes mainly in the ileum, lungs, and liver and to a lesser degree in the kidneys. |
id |
UNIFEI_87ae84a1f197108690999207d2e4afcb |
---|---|
oai_identifier_str |
oai:ojs.pkp.sfu.ca:article/9660 |
network_acronym_str |
UNIFEI |
network_name_str |
Research, Society and Development |
repository_id_str |
|
spelling |
Remote organs respond differently to curcumin treatment after intestinal ischemia/reperfusion injuryLos órganos remotos responden de manera diferente al tratamiento con curcumina después de una lesión por isquemia/reperfusión intestinalÓrgãos remotos respondem de maneira diferente ao tratamento com curcumina após lesão de isquemia/reperfusão intestinalOxidative stressInflammationSuperior Mesenteric Artery.Estrés oxidativoInflamaciónArteria Mesentérica Superior.Estresse oxidativoInflamaçãoArtéria Mesentérica Superior.We aimed investigate the effects of 45 min of ischemia followed by 72 h of intestinal reperfusion (IR) in the ileum, liver, lungs, and kidneys in Wistar rats and the responses of these organs to curcumin treatment. Ischemia was induced by occluding the superior mesenteric artery. Rats were treated orally with 40 mg/kg curcumin. We analyzed oxidative stress and inflammation in the ileum, liver, lungs, and kidneys. Intestinal IR led to a reduction of reduced glutathione levels in the intestine, lungs, and kidneys and increased lipid hydroperoxide levels in all organs. An increase in the enzymatic activity of catalase was observed in all organs, and an increase in superoxide dismutase activity was observed in the ileum and lungs. Glutathione s-transferase levels increased only in the kidneys. Myeloperoxidase increased in all four organs, and n-acetyl-glycosaminidase increased only in the ileum and lungs. Curcumin prevented all of the changes in the ileum and liver. In the lungs, curcumin had no effect on n-acetyl-glycosaminidase. Curcumin did not prevent the changes in reduced glutathione, lipid hydroperoxides, or myeloperoxidase in the kidneys. Intestinal IR caused oxidative stress and inflammation in the ileum, lungs, and kidneys and to a lesser degree in the liver. Because of its systemic distribution, curcumin prevented changes mainly in the ileum, lungs, and liver and to a lesser degree in the kidneys.Nuestro objetivo fue investigar los efectos de 45 min de isquemia seguidos de 72 h de reperfusión intestinal (IR) en el íleon, hígado, pulmones y riñones en ratas Wistar y las respuestas de estos órganos al tratamiento con curcumina. La isquemia se indujo ocluyendo la arteria mesentérica superior. Las ratas se trataron con 40 mg / kg de curcumina. Analizamos el estrés oxidativo y la inflamación. La IR intestinal produjo una reducción de los niveles de glutatión en el intestino, los pulmones y los riñones y un aumento de los niveles de hidroperóxido de lípidos en todos los órganos. Se observó un aumento de la actividad enzimática de la catalasa en todos los órganos y un aumento de la actividad de la superóxido dismutasa en el íleon y los pulmones. Los niveles de glutatión s-transferasa aumentaron solo en los riñones. La mieloperoxidasa aumentó en los cuatro órganos y la n-acetil-glicosaminidasa aumentó sólo en el íleon y los pulmones. La curcumina previno todos los cambios en el íleon y el hígado. En los pulmones, la curcumina no tuvo ningún efecto sobre la n-acetil-glicosaminidasa. La curcumina no previno los cambios en el glutatión reducido, los hidroperóxidos de lípidos o la mieloperoxidasa en los riñones. La IR intestinal provocó estrés oxidativo e inflamación en el íleon, los pulmones y los riñones y, en menor grado, en el hígado. Debido a su distribución sistémica, la curcumina previno cambios principalmente en el íleon, pulmones e hígado y en menor grado en los riñones.Nosso objetivo foi investigar os efeitos de 45 min de isquemia seguidos por 72 h de reperfusão intestinal (IR) no íleo, fígado, pulmões e rins em ratos Wistar e as respostas desses órgãos ao tratamento com curcumina. A isquemia foi induzida pela oclusão da artéria mesentérica superior. Os ratos foram tratados por via oral com 40 mg/kg de curcumina. Analisamos o estresse oxidativo e a inflamação no íleo, fígado, pulmões e rins. A IR intestinal levou a uma redução dos níveis reduzidos de glutationa no intestino, pulmões e rins e aumentou os níveis de hidroperóxidos lipídicos em todos os órgãos. Um aumento na atividade enzimática da catalase foi observado em todos os órgãos, e um aumento na atividade da superóxido dismutase foi observado no íleo e nos pulmões. Os níveis de glutationa s-transferase aumentaram apenas nos rins. A mieloperoxidase aumentou em todos os quatro órgãos e a n-acetil-glicosaminidase aumentou apenas no íleo e nos pulmões. A curcumina evitou todas as alterações no íleo e no fígado. Nos pulmões, a curcumina não teve efeito sobre a n-acetil-glicosaminidase. A curcumina não preveniu as mudanças na redução da glutationa, hidroperóxidos lipídicos ou mieloperoxidase nos rins. A IR intestinal causou estresse oxidativo e inflamação no íleo, nos pulmões e nos rins e em menor grau no fígado. Devido à sua distribuição sistêmica, a curcumina evitou alterações principalmente no íleo, pulmões e fígado e, em menor grau, nos rins.Research, Society and Development2020-11-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/966010.33448/rsd-v9i11.9660Research, Society and Development; Vol. 9 No. 11; e1519119660Research, Society and Development; Vol. 9 Núm. 11; e1519119660Research, Society and Development; v. 9 n. 11; e15191196602525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/9660/8629Copyright (c) 2020 Elouisa Bringhentti; Stephanie Carvalho Borges; Camila Quaglio Neves; Nilza Cristina Buttowhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBringhentti, Elouisa Borges, Stephanie CarvalhoNeves, Camila Quaglio Buttow, Nilza Cristina 2020-12-10T23:37:57Zoai:ojs.pkp.sfu.ca:article/9660Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:31:53.092900Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Remote organs respond differently to curcumin treatment after intestinal ischemia/reperfusion injury Los órganos remotos responden de manera diferente al tratamiento con curcumina después de una lesión por isquemia/reperfusión intestinal Órgãos remotos respondem de maneira diferente ao tratamento com curcumina após lesão de isquemia/reperfusão intestinal |
title |
Remote organs respond differently to curcumin treatment after intestinal ischemia/reperfusion injury |
spellingShingle |
Remote organs respond differently to curcumin treatment after intestinal ischemia/reperfusion injury Bringhentti, Elouisa Oxidative stress Inflammation Superior Mesenteric Artery. Estrés oxidativo Inflamación Arteria Mesentérica Superior. Estresse oxidativo Inflamação Artéria Mesentérica Superior. |
title_short |
Remote organs respond differently to curcumin treatment after intestinal ischemia/reperfusion injury |
title_full |
Remote organs respond differently to curcumin treatment after intestinal ischemia/reperfusion injury |
title_fullStr |
Remote organs respond differently to curcumin treatment after intestinal ischemia/reperfusion injury |
title_full_unstemmed |
Remote organs respond differently to curcumin treatment after intestinal ischemia/reperfusion injury |
title_sort |
Remote organs respond differently to curcumin treatment after intestinal ischemia/reperfusion injury |
author |
Bringhentti, Elouisa |
author_facet |
Bringhentti, Elouisa Borges, Stephanie Carvalho Neves, Camila Quaglio Buttow, Nilza Cristina |
author_role |
author |
author2 |
Borges, Stephanie Carvalho Neves, Camila Quaglio Buttow, Nilza Cristina |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Bringhentti, Elouisa Borges, Stephanie Carvalho Neves, Camila Quaglio Buttow, Nilza Cristina |
dc.subject.por.fl_str_mv |
Oxidative stress Inflammation Superior Mesenteric Artery. Estrés oxidativo Inflamación Arteria Mesentérica Superior. Estresse oxidativo Inflamação Artéria Mesentérica Superior. |
topic |
Oxidative stress Inflammation Superior Mesenteric Artery. Estrés oxidativo Inflamación Arteria Mesentérica Superior. Estresse oxidativo Inflamação Artéria Mesentérica Superior. |
description |
We aimed investigate the effects of 45 min of ischemia followed by 72 h of intestinal reperfusion (IR) in the ileum, liver, lungs, and kidneys in Wistar rats and the responses of these organs to curcumin treatment. Ischemia was induced by occluding the superior mesenteric artery. Rats were treated orally with 40 mg/kg curcumin. We analyzed oxidative stress and inflammation in the ileum, liver, lungs, and kidneys. Intestinal IR led to a reduction of reduced glutathione levels in the intestine, lungs, and kidneys and increased lipid hydroperoxide levels in all organs. An increase in the enzymatic activity of catalase was observed in all organs, and an increase in superoxide dismutase activity was observed in the ileum and lungs. Glutathione s-transferase levels increased only in the kidneys. Myeloperoxidase increased in all four organs, and n-acetyl-glycosaminidase increased only in the ileum and lungs. Curcumin prevented all of the changes in the ileum and liver. In the lungs, curcumin had no effect on n-acetyl-glycosaminidase. Curcumin did not prevent the changes in reduced glutathione, lipid hydroperoxides, or myeloperoxidase in the kidneys. Intestinal IR caused oxidative stress and inflammation in the ileum, lungs, and kidneys and to a lesser degree in the liver. Because of its systemic distribution, curcumin prevented changes mainly in the ileum, lungs, and liver and to a lesser degree in the kidneys. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-11-08 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/9660 10.33448/rsd-v9i11.9660 |
url |
https://rsdjournal.org/index.php/rsd/article/view/9660 |
identifier_str_mv |
10.33448/rsd-v9i11.9660 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/9660/8629 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 9 No. 11; e1519119660 Research, Society and Development; Vol. 9 Núm. 11; e1519119660 Research, Society and Development; v. 9 n. 11; e1519119660 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
_version_ |
1797052662772924416 |